Article
Cardiac & Cardiovascular Systems
Olga Shaihov-Teper, Eilon Ram, Nimer Ballan, Rafael Y. Brzezinski, Nili Naftali-Shani, Rula Masoud, Tamar Ziv, Nir Lewis, Yeshai Schary, La-Paz Levin-Kotler, David Volvovitch, Elchanan M. Zuroff, Sergei Amunts, Neta Regev-Rudzki, Leonid Sternik, Ehud Raanani, Lior Gepstein, Jonathan Leor
Summary: This study revealed, for the first time, a distinctive proinflammatory, profibrotic, and proarrhythmic signature of epicardial fat-derived extracellular vesicles in patients with atrial fibrillation, uncovering another pathway by which epicardial fat promotes the development of atrial myopathy and fibrillation.
Article
Geriatrics & Gerontology
Maria Cespon-Fernandez, Sergio Raposeiras-Roubin, Emad Abu-Assi, Maria Melendo-Viu, Enrique Garcia-Campo, Andres Iniguez-Romo
Summary: The study found that treatment with ACEi or ARB did not improve outcomes in terms of survival and cardiovascular events in older patients with AF. More randomized clinical trials specifically in the older AF patient population are needed to address this issue conclusively.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Zhijie Liu, Ning Bian, Shaorong Wu, Yantao Cao, Yiting Su, Wenying Li, Hairui Li, Xianwu Lan, Can Jiang, Yiming Fan, Jun Guo, Dongdong Chen
Summary: This study aimed to investigate the effects of ACEI/ARB and CCB on the risk of NOAF for hypertensive patients with PPI. The results showed that ACEI/ARB were associated with a lower risk of NOAF compared to CCB, and they also had better improvement in left atrial remodelling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Wei Xu, Yan-min Yang, Jun Zhu, Shuang Wu, Juan Wang, Han Zhang, Xing-hui Shao
Summary: This study found that ACEI/ARB therapy was significantly associated with a reduced risk of all-cause death, cardiovascular death, and MAEs in ED patients with AF and hypertension.
BMC CARDIOVASCULAR DISORDERS
(2022)
Review
Medicine, General & Internal
Zhixiang Yu, Dong Zhang, Qiuhe Ji, Fu Yi
Summary: ACEIs/ARBs show good preventive effects on new-onset AF and AF after heart failure. They are particularly effective for preventing secondary AF, especially postoperative AF. However, for patients with hypertension and myocardial infarction, ACEIs/ARBs may not be the best treatment option for preventing AF.
Article
Multidisciplinary Sciences
Mona Mohamed Taha, Heba Mahdy-Abdallah, Eman Mohamed Shahy, Mona Adel Helmy, Lamia Samir ElLaithy
Summary: Diabetic nephropathy (DN) is the main cause of chronic kidney disease in patients with type 2 diabetes mellitus (T2DM). This study assessed potential biomarkers, including cystatin-c and hemeoxygenase, as well as genetic factors, ACE I/D polymorphism and ACE G2350A genotypes, in predicting kidney disease susceptibility in T2DM patients. The results showed significant elevations in cystatin-c and hemeoxygenase levels in diabetic groups compared to controls, and an association between G2350A genotype of ACE gene and increased cystatin-c and hemeoxygenase levels.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Livia da Agostini, Warlley R. Cunha, Nayara N. T. Silva, Andre S. Melo, Luciana B. Moreira, Tamires C. Almeida, Vanessa A. Belo, Wendel Coura-Vital, Luiz Fernando de M. Teixeira, Angelica A. Lima, Glenda Nicioli da Silva
Summary: This study investigated the association between gene polymorphisms and hypertension and found that hypertension is associated with age, education, smoking, obesity, and high levels of triglycerides, sodium, glucose, and uric acid. Furthermore, ACE gene polymorphisms are associated with elevated levels of triglycerides, urea, and glucose.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Cheng Liu, Jingxian Pei, Yanxian Lai, Tianwang Guan, Abudurexiti Zeyaweiding, Tutiguli Maimaiti, Haiyan Zhao, Yan Shen
Summary: The study identified ACE2 genetic variants (rs2074192, rs4240157, and rs4646188) associated with increased risks of atrial fibrillation and cardioembolic stroke in Uygur patients with type 2 diabetes.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Plant Sciences
Carla Georgia Rodrigues Guimaraes Souto, Bethania Rosa Lorencone, Aline Aparecida Macedo Marques, Rhanany Alan Calloi Palozi, Paulo Vitor Moreira Romao, Lucas Pires Guarnier, Cleide Adriane Signor Tirloni, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Priscila Megda Joao Job Zago, Francislaine Aparecida dos Reis Livero, Emerson Luiz Botelho Lourenco, Denise Brentan Silva, Arquimedes Gasparotto Junior
Summary: The ethanolic extract of Talinum paniculatum showed significant cardiorenal protective effects in rats, normalizing electrocardiographic and hemodynamic alterations, and preventing ventricle remodeling. These effects were associated with serum antioxidant activity and angiotensin-converting enzyme (ACE) inhibition, indicating potential benefits for hypertensive patients with doxorubicin-induced cardiotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Kristina Jevnikar, Luka Lapajne, Daniel Petrovic, Andrej Meglic, Mateja Logar, Natasa Vidovic Valentincic, Mojca Globocnik Petrovic, Ines Cilensek, Polona Jaki Mekjavic
Summary: This study found that the presence of the AGTR2 rs1403543-AA genotype is associated with an increased risk of COVID-19 retinopathy. However, the genotype frequencies of other selected gene polymorphisms are not significantly associated with the presence or severity of COVID-19.
Article
Pharmacology & Pharmacy
Shuwei Wang, Qi Han, Zhaolan Wei, Yunyi Wang, Lingfu Deng, Mingqing Chen
Summary: The study found that exposure to formaldehyde can cause an increase in blood pressure and damage to the heart, aortic vessels, and kidneys. By blocking the ACE/AT1R axis using an ACE inhibitor, the increase in blood pressure and pathological changes caused by formaldehyde exposure can be alleviated. This result improves our understanding of the impact of formaldehyde exposure on the development of hypertension.
Article
Critical Care Medicine
Tim Lahm, Edward Hess, Anna E. Baron, Thomas M. Maddox, Mary E. Plomondon, Gaurav Choudhary, Bradley A. Maron, Roham T. Zamanian, Peter J. Leary
Summary: ACEIs and ARBs are associated with lower mortality in patients with pulmonary hypertension, while AA use is a marker of disease severity and may be used preferentially in sicker patients. ACEIs and ARBs may represent a novel treatment strategy for different PH phenotypes.
Article
Plant Sciences
Ayse Esra Karadag, Sevde Nur Biltekin, Betul Demirci, Fatih Demirci, Usman Ghani
Summary: This study evaluates the inhibitory activities of Rosa x damascena and Pelargonium graveolens essential oils, as well as their major constituent geraniol, against various enzymes. Geraniol shows the strongest inhibitory effect on ACE2 enzyme. R. damascena essential oil moderately inhibits cancer cell lines, and P. graveolens essential oil inhibits several cancer cell lines for the first time. Molecular docking reveals that geraniol binds to the active sites of target enzymes similar to known drugs. The findings suggest the potential of geraniol for drug development. The similar biological activities of these essential oils are attributed to their similar phytochemistry.
Article
Multidisciplinary Sciences
Xiaofang Zeng, Anandharajan Rathinasabapathy, Dongliang Liu, Lihuang Zha, Xiangwei Liu, Yiyang Tang, Famei Li, Wenchao Lin, Zaixin Yu, Huiling Chen
Summary: The study found that hypertensive patients with COVID-19 are more likely to experience cardiac injury and severe disease phenotypes, including longer hospitalization time, higher rates of bilateral pneumonia, and electrolyte disorders. Cardiac injury markers such as creatine kinase and lactate dehydrogenase were also significantly increased in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Medical Laboratory Technology
Ya-Min Su, Jun Li, Yun-Feng Guo, Fei Cai, Xing-Xing Cai, Hai-Yan Pan, Xin-Tao Deng, Min Pan
CLINICAL LABORATORY
(2015)
Article
Cardiac & Cardiovascular Systems
Ying Xu, Hai-Liang Meng, Ya-Min Su, Chu Chen, Yin-Hao Huang, Xiao-Fei Li, Meng-Kan Fan, Yong-Jin Yan, Jie Wu, Min-Hui Jiang, Min Pan
CORONARY ARTERY DISEASE
(2015)
Letter
Cardiac & Cardiovascular Systems
Ya-Min Su, Shu-Ping Gao, Li-Jun Ge, Jian-Hua Zhu, Min Pan
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Review
Medicine, General & Internal
Meng-Kan Fan, Ya-Min Su, Xing-Xing Cai, Zhou-Shan Gu, Hai-Hua Geng, Hai-Yan Pan, Jian-Hua Zhu, Min Pan
Article
Pharmacology & Pharmacy
Ling-Ling Qian, Man-Qing Sun, Ru-Xing Wang, Tong Lu, Ying Wu, Shi-Peng Dang, Xu Tang, Yuan Ji, Xiao-Yu Liu, Xiao-Xi Zhao, Wen Wang, Qiang Chai, Min Pan, Fu Yi, Dai-Min Zhang, Hon-Chi Lee
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Hai-Yan Pan, Jian-Hua Zhu, Yong Gu, Xiao-Hong Yu, Min Pan, Hong-Yin Niu
BMC CARDIOVASCULAR DISORDERS
(2014)
Article
Multidisciplinary Sciences
Hai-Hua Geng, Rui Li, Ya-Min Su, Jie Xiao, Min Pan, Xing-Xing Cai, Xiao-Ping Ji
Article
Cardiac & Cardiovascular Systems
Qingquan Zhang, Mengkang Fan, Xueyan Cao, Haihua Geng, Yamin Su, Chunyu Wu, Haiyan Pan, Min Pan
Summary: This study used bioinformatics algorithms to explore the etiology and immune infiltration mechanisms of dilated cardiomyopathy (DCM). The results indicate that CD163 may serve as a diagnostic biomarker for DCM, and activated natural killer cells and eosinophils may be related to the occurrence of DCM.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zhu Zhang, Jiancheng Qi, Xiucai Fan, Min Pan
Summary: The study aimed to investigate the role of XAV939 in mouse hearts and provide a new treatment for improving the prognosis of myocardial infarction (MI). The results showed that XAV939 successfully blocked the activation of the Wnt/beta-catenin signalling pathway in cardiomyocytes, reducing fibrosis and apoptosis, promoting angiogenesis, decreasing myocardial infarct size, and improving cardiac function after MI.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Wenxin Liu, Xintao Deng, Yamin Su, Haihua Geng, Min Pan
Summary: The study demonstrated that Gypenosides can effectively reduce myocardial ischemia-reperfusion injury in rats by inhibiting cell apoptosis and maintaining mitochondrial membrane potential. Through regulating the expression of Bax and Bcl2 proteins, Gypenosides can suppress MPTP opening and the activation of downstream apoptotic pathways, thus reducing myocardial ischemia-reperfusion injury.
NEUROENDOCRINOLOGY LETTERS
(2021)
Article
Medical Laboratory Technology
Xiao-Yan Qiu, Shao-Tang Lu, Meng-Kan Fan, Hai-Hua Geng, Zhong-Yuan Han, Shu-Ping Gao, Hai-Yan Pan, Rong Huang, Min Pan
CLINICAL LABORATORY
(2019)
Article
Medicine, Research & Experimental
Ya-Min Su, Xing-Xing Cai, Hai-Hua Geng, Hong-Zhuan Sheng, Meng-Kan Fan, Min Pan
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2015)
Article
Oncology
Gui-Liang Shi, Xing-Xing Cai, Ya-Min Su, Chu Chen, Xin-Tao Deng, Hai-Yan Pan, Meng-Kan Fan, Jian-Hua Zhu, Min Pan
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2015)
Article
Medicine, Research & Experimental
Dong-Dong Zheng, Shun-Nian Ji, Chu Chen, Xin-Tao Deng, Ya-Min Su, Hai-Yan Pan, Xing-Xing Cai, Xiao-Fei Li, Jian-Hua Zhu, Min Pan
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2014)
Article
Medicine, Research & Experimental
Hai-Hua Geng, Rui Li, Ya-Min Su, Hai-Yan Pan, Min Pan, Xiao-Ping Ji
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2014)