Article
Radiology, Nuclear Medicine & Medical Imaging
Liqiang Zhang, Hongyu Pan, Zhi Liu, Jueni Gao, Xinyi Xu, Linlin Wang, Jie Wang, Yi Tang, Xu Cao, Yubo Kan, Zhipeng Wen, Jianjun Chen, Dingde Huang, Shanxiong Chen, Yongmei Li
Summary: This study aims to develop a clinical radiomics-integrated model based on [F-18]FDG PET and multi-modal MRI for predicting the ATRX mutation status of IDH-mutant LGGs. By extracting radiomics features from different types of images and using the random forest algorithm, the model achieved promising predictive performance in both the training and test groups.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Chao Lu, Kailiang Wang, Fei Meng, Yihe Wang, Yongzhi Shan, Penghu Wei, Guoguang Zhao
Summary: Patients with epileptogenic hypothalamic hamartoma exhibit reduced glucose metabolism and gray matter volume predominantly in the ipsilateral neocortex, as well as overall metabolic reduction in the cerebellum. Hypometabolism in the neocortex is more distributed ipsilaterally than contralaterally to the hamartoma. The characteristics of glucose hypometabolism differ based on seizure type and sex, suggesting potential involvement of specific brain pathways in seizure propagation in these patients.
FRONTIERS OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Tan, Chi Qi, Yanyan Cao, Danjie Cai, Wujian Mao, Haojun Yu, Xiuli Sui, Guobing Liu, Hongcheng Shi
Summary: This study validates the efficacy of ultralow-dose [F-18]FDG PET/CT (0.37 MBq/kg) and compares it to imaging at half-dose (1.85 MBq/kg). The results show no significant differences between the two groups in terms of dynamic and static parameters, and the ultralow-dose group has a higher lesion detection rate.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Koa, Austin J. Borja, Mahmoud Aly, Sayuri Padmanabhan, Joseph Tran, Vincent Zhang, Chaitanya Rojulpote, Sheila K. Pierson, Mark-Avery Tamakloe, Johnson S. Khor, Thomas J. Werner, David C. Fajgenbaum, Abass Alavi, Mona-Elisabeth Revheim
Summary: Castleman disease is a rare hematologic condition involving lymphadenopathy and clinical abnormalities, classified into UCD and MCD; MCD is further divided based on etiological driver; FDG-PET/CT plays an important role in differential diagnosis and monitoring treatment responses.
INSIGHTS INTO IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jianan Zhang, Ruixue Cui, Jian Li, Xinxin Cao, Yaping Luo
Summary: In this retrospective study of 38 RDD patients, the clinical and [F-18]FDG PET/CT features were characterized. RDD commonly affected the upper respiratory tract, cutaneous/subcutaneous lesions, lymph nodes, bones, central nervous system, and cardiovascular system. In PET/CT, RDD lesions showed FDG avidity, and the SUVmax of the hottest lesion in an individual patient was correlated with C-reactive protein levels and hemoglobin levels. The overall response rate of the first-line treatment was 80.8% for newly diagnosed RDD patients and 72.7% for relapsed/progressive RDD patients.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kailin Qiao, Xueting Qin, Shuai Fu, Jiazhong Ren, Jing Jia, Xinying Hu, Yuanyuan Tao, Shuanghu Yuan, Yuchun Wei
Summary: The uptake of [F-18]AlF-NOTA-FAPI-04 and [F-18]FDG imaging tracers varies in malignant and inflammatory lung lesions, with lower uptake observed in inflammatory lesions. This difference in uptake can be valuable for distinguishing between malignancy and various inflammatory findings.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Borges-Rosa, Manuel Oliveira-Santos, Rodolfo Silva, Andreia Gomes, Jose de Almeida, Gracinda Costa, Lino Goncalves, Maria Joao Ferreira
Summary: In patients with biopsy-proven sarcoidosis, cardiac involvement detected by [18F]FDG-PET or CMR is associated with a higher risk of cardiovascular events, regardless of symptoms. Patients with probable CS had a higher prevalence of heart failure, atrial fibrillation, coronary disease, and valvular disease compared to those without cardiac involvement. Probable CS patients had significantly higher rates of heart failure hospitalizations, uncontrolled arrhythmias, and pacemaker implantation during follow-up, with a trend towards increased all-cause mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moath Said Alfawara, Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Fares Alahdab, Mahmoud Al Rifai, Mahwash Kassi, Talal Alnabelsi, William A. Zoghbi, Mouaz H. Al-Mallah
Summary: This study evaluated the use of serum beta-hydroxybutyrate (BHB) to identify adequate suppression of the left ventricle (LV) in patients undergoing cardiac inflammatory/infectious studies. The results showed that serum BHB level can be used to determine sufficient LV suppression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyung Ju Lee, Hye Joo Son, Mijin Yun, Jung Won Moon, Yoo Na Kim, Ji Young Woo, Suk Hyun Lee
Summary: Prone position PET/CT is more valuable than standard supine position PET/CT in evaluating lung nodules, reducing respiratory motion artefacts and enabling more precise measurements of PET parameters.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Kai Wang, Xiaobin Zhao, Leilei Yuan, Qian Chen, Qun Wang, Lin Ai
Summary: An asymmetric F-18-FDG metabolic pattern exists in patients with anti-LGI1 encephalitis, and varied regional metabolic differences were revealed bilaterally in specific cerebral areas.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Virginia Liberini, Michael Messerli, Lars Husmann, Ken Kudura, Hannes Grunig, Alexander Maurer, Stephan Skawran, Erika Orita, Daniele A. Pizzuto, Desiree Deandreis, Reinhard Dummer, Joanna Mangana, Daniela Mihic-Probst, Niels Rupp, Martin W. Huellner
Summary: BSREM detects significantly more ITM than OSEM, with higher SUVmax, higher TBR, and less blurring. BSREM is particularly helpful in small and less avid lesions, which are more often missed with OSEM.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
K. S. M. van der Geest, G. Treglia, A. W. J. M. Glaudemans, E. Brouwer, F. Jamar, R. H. J. A. Slart, O. Gheysens
Summary: [18F]FDG-PET/CT scanning can effectively diagnose polymyalgia rheumatica by identifying significant uptake of FDG at specific anatomic sites. The technique shows promise as an important diagnostic tool for patients with suspected PMR, but standardized interpretation criteria and procedural recommendations are necessary for its use.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Weishan Zhang, Zhe Liu, Xiaoyi Duan, Yan Li, Cong Shen, Youmin Guo, Jian Yang
Summary: F-18-FDG PET/CT is a valuable method for differentiating MPE from BPE in lung cancer patients, with pleural SUVmax, thoracic lymph nodes, and sex being important factors for diagnosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth K. A. Triumbari, Elizabeth J. de Koster, Vittoria Rufini, Simona M. Fragomeni, Giorgia Garganese, Angela Collarino
Summary: This study aimed to determine the role of F-18-FDG PET/CT in vulvar cancer patients and found that it has diagnostic value for lymph node staging. Larger prospective studies are needed to confirm these results and evaluate the diagnostic value of standardized semiquantitative analysis compared with qualitative analysis.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Rong Niu, Yuetao Wang, Xiaoliang Shao, Zhenxing Jiang, Jianfeng Wang, Xiaonan Shao
Summary: The study reveals a significant association between SUV index and malignant risk of GGNs, with higher SUV index linked to lower probability of GGN malignancy. The trend of increasing SUV index is correlated with a reduction in malignant risk, indicating that SUV index is an independent factor for predicting malignancy risk of GGNs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthony J. Young, Austin R. Pantel, Varsha Viswanath, Tiffany L. Dominguez, Mehran Makvandi, Hsiaoju Lee, Shihong Li, Erin K. Schubert, Daniel A. Pryma, Michael D. Farwell, Robert H. Mach, Fiona Simpkins, Lilie L. Lin, David A. Mankoff, Robert K. Doot
Summary: The PARP family of proteins is involved in various functions, including the DNA damage response. PARP inhibitors have shown therapeutic efficacy in cancer treatment, and F-18-fluorthanatrace uptake can serve as a biomarker for response to PARP inhibitor therapy. SUVmax and SUVpeak are robust measures of PARP-1 binding.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Computer Science, Information Systems
Phawis Thammasorn, Stephanie K. Schaub, Daniel S. Hippe, Matthew B. Spraker, Jan C. Peeken, Landon S. Wootton, Paul E. Kinahan, Stephanie E. Combs, Wanpracha A. Chaovalitwongse, Matthew J. Nyflot
Summary: This paper introduces an improved Deepsurv model that utilizes a projection loss as a regularizing objective to enhance survival prediction performance. The experiments demonstrate the superior performance and robustness of the regularized Deepsurv model on multiple medical datasets.
Article
Radiology, Nuclear Medicine & Medical Imaging
Austin R. Pantel, Varsha Viswanath, Mark Muzi, Robert K. Doot, David A. Mankoff
Summary: Kinetic analysis in dynamic PET imaging allows estimation of biologic processes related to disease, going beyond static uptake measures. This two-part continuing education paper reviews principles and methodology of kinetic modeling in part I and showcases benefits of kinetic modeling in oncologic imaging through case examples in part II.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Austin R. Pantel, Varsha Viswanath, Mark Muzi, Robert K. Doot, David A. Mankoff
Summary: PET enables noninvasive imaging of regional in vivo cancer biology. By engineering a radiotracer to target specific biologic processes of relevance to cancer (e.g., cancer metabolism, blood flow, proliferation, and tumor receptor expression or ligand binding), PET can detect cancer spread, characterize the cancer phenotype, and assess its response to treatment. However, static imaging at a single time point may not utilize all the information that PET cancer imaging can provide, and reliance on static imaging measures alone may lead to misleading results. This review introduces the principles and examples of kinetic analysis for oncologic PET imaging, highlighting the added benefits over static imaging.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael L. Richardson, Behrang Amini, Paul E. Kinahan
RADIOLOGIC CLINICS OF NORTH AMERICA
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Chaya S. Moskowitz, Mattea L. Welch, Michael A. Jacobs, Brenda F. Kurland, Amber L. Simpson
Summary: This article reviews common issues in radiomic research, with a focus on study design and statistical analysis considerations, and proposes approaches to avoid these pitfalls.
Article
Cell Biology
Robert K. Doot, Anthony J. Young, Ilya M. Nasrallah, Reagan R. Wetherill, Andrew Siderowf, Robert H. Mach, Jacob G. Dubroff
Summary: Neuroinflammation is an important factor in neurodegenerative diseases and is mediated by microglia. This study used [F-18]NOS PET imaging to measure neuroinflammation in idiopathic Parkinson's disease patients and found increased oxidative stress as a marker of inflammation in early-stage disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
William Hunter, Sergei Dolinsky, Paul Kinahan, Robert Miyaoka
Summary: We evaluated the 3-D spatial, energy, and timing resolution of the BING PET detector. The BING detector consists of stacked slats of LYSO scintillator with silicon-photomultiplier (SiPM) arrays to determine interaction positions and timing. The performance of the BING detector was measured and it showed effective resolution for a small field of view PET system.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abhejit Rajagopal, Yutaka Natsuaki, Kristen Wangerin, Mahdjoub Hamdi, Hongyu An, John J. Sunderland, Richard Laforest, Paul E. Kinahan, Peder E. Z. Larson, Thomas A. Hope
Summary: In this article, a deep learning technique is demonstrated to generate realistic PET sinograms from whole-body MRI data for PET/MRI reconstruction algorithm development. The synthetic PET data generated can be used interchangeably with real PET data for PET quantification, achieving small errors in comparison between CTAC and MRAC methods.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Paul E. Kinahan
Meeting Abstract
Neurosciences
Corinde Wiers, Anthony Young, Juliana Byanyima, Xinyi Li, Robert Doot, Sianneh Vesslee, Rishika Reddy, Zhenhao Shi, Reagan Wetherill, Timothy Pond, Nora Volkow, Henry Kranzler, Jacob Dubroff
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Ali Nabavizadeh, Stephen Bagley, Robert Doot, Jeffrey B. Ware, Anthony Young, Satyam Ghodasara, Chao Zhao, Hannah Anderson, Erin Schubert, Fraser Henderson, Austin Pantel, H. Isaac Chen, John Y. K. Lee, Nduka M. Amankulor, Donald M. O'Rourke, Arati Desai, MacLean Nasrallah, Steven Brem
JOURNAL OF NUCLEAR MEDICINE
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Austin Pantel, Mehran Makvandi, Hyoung Kim, Joanna Weeks, Drew Torigian, Nawar Latif, Lainie Martin, Janos Tanyi, Mark Morgan, Robert Doot, Lilie Lin, David Mankoff, Robert Mach, Fiona Simpkins
JOURNAL OF NUCLEAR MEDICINE
(2022)
Meeting Abstract
Oncology
Ali Nabavizadeh, Stephen Bagley, Jeffrey B. Ware, Robert K. Doot, Anthony Young, Satyam Ghodasara, Chao Zhao, Hannah Anderson, Erin Schubert, Erica L. Carpenter, Jacob Till, Fraser Henderson, Austin R. Pantel, Isaac Chen, John Yk Lee, Nduka Amankulor, Donald O'Rourke, Arati Desai, MacLean Nasrallah, Steven Brem
Article
Oncology
Hsiaoju S. Lee, Sally W. Schwarz, Erin K. Schubert, Delphine L. Chen, Robert K. Doot, Mehran Makvandi, Lilie L. Lin, Elizabeth S. McDonald, David A. Mankoff, Robert H. Mach
Summary: This article describes the development of F-18-FTT as a radiotracer for imaging PARP-1 expression levels in breast and ovarian cancer patients. It also discusses the preparation and submission of an exploratory investigational new drug application to the FDA and the need for a commercialization strategy to overcome financial barriers in multicenter clinical trials.
RADIOLOGY-IMAGING CANCER
(2022)