Article
Materials Science, Ceramics
Adrian Stiller, Markus Engblom, Oskar Karlstrom, Mika Linden, Leena Hupa
Summary: Bioactive glasses are effective grafting materials for bone tissue repair, but predicting their degradation behavior in vivo remains challenging. This study investigates the effect of flow rate on the dissolution behavior of bioactive glass S53P4. The findings demonstrate that flow rate significantly affects the glass dissolution rate, ion release, and reaction layer development, emphasizing the importance of dynamic dissolution tests.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Materials Science, Ceramics
Polina Sinitsyna, Oskar Karlstrom, Leena Hupa
Summary: The size of bioactive glass microspheres has a significant impact on their dissolution characteristics, with smaller microspheres being more inert and larger microspheres developing typical silica-rich and calcium phosphate layers on their surfaces after static and dynamic dissolution.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fadi N. Barrak, Siwei Li, Ali A. Mohammed, Connor Myant, Julian R. Jones
Summary: This study assessed the impact of the dissolution products of S53P4 bioactive glass (BG) on the cellular response to dental implant particles. The results showed that the presence of Ti-6Al-4V implant particles induced significant inflammation in all tested cell types. The S53P4 BG dissolution products suppressed the particle-induced inflammation and potentially influenced macrophage polarization behavior.
JOURNAL OF DENTISTRY
(2022)
Article
Materials Science, Ceramics
Lais Costa Alves da Silva, Floriano Guimaraes Neto, Satya Sthefany Cordeiro Pimentel, Raquel da Silva Palacios, Francielle Sato, Karina Miyuki Retamiro, Nilma Souza Fernandes, Celso Vataru Nakamura, Franciana Pedrochi, Alysson Steimacher
Summary: This study successfully prepared borate glasses doped with silver, which showed improved bioactivity and excellent antibacterial properties. The addition of silver enhanced the alkalinity of the glasses in simulated body fluid and led to the formation of hydroxyapatite and fluorapatite phases. Antibacterial tests demonstrated the efficiency of silver-doped borate glasses against both gram-negative and gram-positive bacteria.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Microbiology
Peng Zhou, Brittny L. Garcia, Georgios A. Kotsakis
Summary: This study evaluated the antibacterial and antibiofilm effects of the parent compound 45S5 and S53P4 against various anaerobic and aerobic bacteria associated with osteomyelitis. The results showed that 45S5 was as effective as S53P4, and possibly even more capable of limiting bacterial infections.
Article
Cell & Tissue Engineering
R. Bjorkenheim, E. Jamsen, E. Eriksson, P. Uppstu, L. Aalto-Setala, L. Hupa, K. K. Eklund, M. Ainola, N. C. Lindfors, J. Pajarinen
Summary: Bioactive glasses (BAG), particularly the BAG-S53P4 scaffold, have shown potential as bone substitutes with anti-inflammatory and osteogenic properties. The addition of poly(DL-lactide-co-glycolide) (PLGA) coating may enhance mechanical strength while modulating ion release and immunomodulatory properties of the scaffold.
EUROPEAN CELLS & MATERIALS
(2021)
Article
Materials Science, Ceramics
Polina Sinitsyna, Oskar Karlstrom, Christoffer Sevonius, Leena Hupa
Summary: Microspheres based on bioactive glass S53P4 were successfully produced through flame-spraying. Compared to conventional irregular-shaped particles, bioactive glass microspheres (BGMs) have advantages. The experimental characterization and dissolution test results suggest that BGMs have good bioactivity and thermal properties, and have great potential for future clinical applications.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Biotechnology & Applied Microbiology
Jie Wang, Baohui Yang, Shuai Guo, Sen Yu, Haopeng Li
Summary: In this study, a novel sandblasting surface modification process was used to manufacture titanium alloy materials with bioactive sandblasted surfaces, and their surface morphology and physicochemical properties were systematically characterized. The osseointegration between titanium alloy materials with bioactive sandblasted surfaces and bone interfaces was analyzed and evaluated through in vitro experiments with osteoblast co-culture and in vivo experiments with a rabbit model. The results showed that the titanium alloy material with bioactive sandblasted surface exhibited satisfactory bioactivity and osteoinductivity, promoting trabecular bone growth on its surface and improving the osseointegration between the material and bone interface.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Matthias Schumacher, Pamela Habibovic, Sabine van Rijt
Summary: The slow and disorganized formation of a functional vascular network in large bone defect regeneration can cause delayed healing or implant failure. This study introduces a promising strategy by immobilizing the pro-angiogenic growth factor VEGF on nanosized bioactive glass particles using a binding peptide, which can induce angiogenesis and overcome the problem of insufficient neovascularization.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Automation & Control Systems
Michela Sanguedolce, Giovanna Rotella, Federica Curcio, Riccardo Pelaccia, Vincenzina Siciliani, Roberta Cassano, Leonardo Orazi, Luigino Filice
Summary: Biomedical implants can cause significant perturbation to the human body, but functionalizing and coating implant surfaces can improve biocompatibility and provide additional functions such as corrosion protection, osteointegration, and drug delivery. In this study, a composite of chitosan and bioactive glass nanoparticles was used to coat Ti6Al4V alloy samples processed with different methods. Experiments were conducted to investigate the relationship between substrate surface conditions and the effectiveness of the coating in terms of scratch resistance, aiming to provide guidelines for improving substrate-coating performances.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Engineering, Biomedical
M. Schumacher, P. Habibovic, S. van Rijt
Summary: Mesoporous bioactive glasses have promising properties for regenerative medicine due to their bioactivity and degradability, which are influenced by synthesis parameters and glass stoichiometry. Control of degradation and bioactivity over a broad range can be achieved through glass stoichiometry, allowing targeted material selection for specific regenerative medicine applications.
BIOACTIVE MATERIALS
(2021)
Review
Materials Science, Ceramics
Ali Moeini, Turan Hassanzadeh Chinijani, Adrine Malek Khachatourian, Marcus Vinicius Lia Fook, Francesco Baino, Maziar Montazerian
Summary: There is a profound shift in using glass as a primarily passive material to one that instills active properties. Bioactive glasses and glass-ceramics have the potential to revolutionize cancer therapy in the 21st century through their ability to carry exotic elements and trigger efficient anticancer properties. The addition of dopants enhances bioactivity and induces novel functionalities not achievable with other biomaterials. This paper reviews and discusses the current knowledge on promising compositions, processing parameters, and applications of these biomaterials in treating cancer, while also highlighting the need for further research.
INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
(2023)
Article
Clinical Neurology
Jussi Sarin, Minna Vuorenmaa, Pekka K. Vallittu, Reidar Grenman, Pia Bostrom, Pilvi Riihila, Liisa Nissinen, Veli-Matti Kahari, Jaakko Pulkkinen
Summary: The study demonstrates that bioactive glass has an inhibitory effect on the viability of epidermal keratinocytes, suggesting potential benefits for cholesteatoma treatment.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Otorhinolaryngology
B. Krol, K. B. Cywka, M. B. Skarzynska, P. H. Skarzynski
Summary: The study demonstrates that obliteration of the mastoid process with S53P4 bioactive glass is a safe and effective treatment method, reducing postoperative cavity volume, preventing pathological bacterial growth, and avoiding recurrence of cholesteatoma.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Materials Science, Coatings & Films
S. Spriano, G. Riccucci, G. Orlygsson, C. H. Ng, E. Verne, F. P. Sehn, P. T. de Oliveira, S. Ferraris
Summary: Two bioactive glasses (SCNB and SCNA) were coated with chitosan using different methods of coating. The effects of these coatings were evaluated through various tests and experiments. The results showed that the coatings had different effects on the stability and bioactivity of the glasses, as well as on the biological outcome of cell cultures.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Otorhinolaryngology
Enni Sanmark, Lotta-Maria A. H. Oksanen, Noora Rantanen, Mari Lahelma, Veli-Jukka Anttila, Nina Atanasova, Antti-Pekka Hyvarinen, Teemu Kinnari, Ahmed Geneid
Summary: COVID-19 spreads through various aerosols produced in different surgical procedures, including CO2 laser in laryngeal surgery. However, microdebrider and cold dissection were found to produce lower aerosol concentrations compared to CO2 laser. Microdebrider was the least aerosol-generating technique among the three evaluated. A step-down algorithm from CO2 laser to microdebrider and cold instruments is recommended to reduce the risk of airborne infections among medical staff.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Sanna Viitasalo, Taru Ilmarinen, Leena-Maija Aaltonen, Jaana Hagstrom, Maija Hytonen, Sari Hammaren-Malmi, Petra Pietarinen, Pia Jarvenpaa, Teemu Kinnari, Ahmed Geneid, Markus Lilja
Summary: This retrospective study assessed the epidemiological information of patients treated for sinonasal inverted papilloma (SNIP) at Helsinki University Hospital between 1984 and 2014, and found a very low malignant transformation rate of SNIP. The study also revealed that SNIP patients were not prone to HPV-associated non-sinonasal malignancies. Additionally, endoscopic resection and attachment-oriented surgery have become the predominant approaches in SNIP treatment, with a reduced recurrence rate.
Article
Ecology
Pamela C. Koster, Juan Lapuente, Andrea Pizarro, Laura Prieto-Perez, Ramon Perez-Tanoira, Alejandro Dashti, Begona Bailo, Aly S. Muadica, David Gonzalez-Barrio, Rafael Calero-Bernal, Francisco Ponce-Gordo, David Carmena
Summary: Limited information is available about the diverse protist species in captive and semi-captive non-human primates in low- and medium-income countries. This study conducted molecular-based analysis on NHP populations in three different locations, revealing the presence of potentially pathogenic protist species including Giardia duodenalis, Blastocystis sp., Enterocytozoon bieneusi, and Balantioides coli. Zoonotic genotypes were identified within these species, suggesting possible human-NHP transmission.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE
(2022)
Article
Infectious Diseases
Felix Carrasco Calzada, John Jairo Aguilera-Correa, Juan Cuadros Gonzalez, Jaime Esteban Moreno, David Roca Biosca, Ramon Perez-Tanoira
Summary: A study conducted in Uganda isolated and tested the antimicrobial susceptibility of microorganisms causing urinary tract infections (UTI). The results showed a high prevalence of bacterial growth, with Enterococcus spp. and Escherichia coli being the most common uropathogens. The study suggests discontinuing the use of amoxicillin and ciprofloxacin as empirical treatments for UTIs in Uganda due to high resistance rates.
Article
Otorhinolaryngology
Jesper Rautiola, Hannu Laaksovirta, Ahmed Geneid, Taru Ilmarinen, Petra Pietarinen, Teemu J. Kinnari
Summary: This retrospective cohort study analyzed the role of otolaryngologists and phoniatricians in the diagnosis and treatment of amyotrophic lateral sclerosis (ALS), particularly in patients with bulbar-onset ALS (buALS). The study revealed that around 30% of buALS patients initially consulted an otolaryngologist or phoniatrician, and 45% underwent a swallowing study.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramon Perez-Tanoira, Monica Fernandez-Arias, Carmen Potel, Raquel Carballo-Fernandez, Sonia Perez-Castro, Mohamed Boutinguiza, Miguel Gorgolas, Fernando Lusquinos, Juan Pou
Summary: Silver nanoparticles have antimicrobial effects against various biofilms and may help prevent the development of peri-implantitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Otorhinolaryngology
Yasmine Sabry, Teemu Kinnari, Yehia Ashry, Maged Naguib, Ahmed Geneid
Summary: This study evaluated the outcomes of vocal-fold injection with calcium hydroxyapatite in patients with glottic insufficiency. The results showed that injection of calcium hydroxyapatite can significantly improve voice quality, with the improvement lasting for at least 1 year.
EGYPTIAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Infectious Diseases
Carlos Rescalvo-Casas, Marcos Hernando-Gozalo, Laura Seijas Pereda, Carlos Garcia Bertolin, Felipe Perez-Garcia, Juan Cuadros-Gonzalez, Ramon Perez-Tanoira
Summary: The aim of this study was to compare the sensitivity and specificity of the STANDARD(TM) F H. pylori Ag FIA stool antigen test (SD Biosensor) with the LIAISON(R) Meridian H. pylori SA for the diagnosis of H. pylori infection. A total of 133 stool samples from patients with suspected H. pylori infection were compared, showing that the STANDARD(TM) F H. pylori Ag FIA had a sensitivity of 97.8% and a specificity of 94.3%.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Mercedes Chozas, Alejandro Dashti, Laura Prieto-Perez, Ramon Perez-Tanoira, Elena Cobo, Begona Bailo, Marta del Palacio, Carolina Hernandez-Castro, David Gonzalez-Barrio, David Carmena, Pamela C. Koster
Summary: Microsporidia are common parasites in immunocompromised individuals, such as HIV-infected patients. In this study, we found two microsporidian pathogens, Enterocytozoon bieneusi and Encephalitozoon intestinalis, in HIV-positive patients in Madrid. In addition, we also identified various protist infections, including Blastocystis spp., Giardia duodenalis, and Cryptosporidium spp. These findings highlight the need to consider microsporidia and protist infections in the diagnosis of diarrhea in HIV-positive patients.
Article
Immunology
Syong H. Nam-Cha, Elena Dominguez-Jurado, Selena L. Tinoco-Valencia, Ramon Perez-Tanoira, Noelia Morata-Moreno, Rocio Alfaro-Ruiza, Agustin Lara-Sanchez, Jaime Esteban, Rafael Lujan, Carlos Alonso-Moreno, Pedro Segui, Alberto Ocana, Angel Lopez Gonzalez, John J. Aguilera-Correa, Francisco C. Perez-Martinez, Milagros Molina Alarcon
Summary: This study aimed to translate clinical research outcomes based on metallodrugs into clinical practice for the treatment of MRSA. The novel metallodrug 2P-Pt showed antibacterial effect against MRSA and inhibited biofilm formation. These findings suggest that 2P-Pt may be a promising therapeutic alternative for MRSA infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
John Jairo Aguilera-Correa, Liisa Nohynek, Hanna-Leena Alakomi, Jaime Esteban, Kirsi-Marja Oksman-Caldentey, Riitta Puupponen-Pimiae, Teemu J. Kinnari, Ramon Perez-Tanoira
Summary: This study aimed to evaluate the effect of two arctic berry extracts on MRSA biofilm development and treatment. The results showed that all berry extracts except for the raspberry press cake hydrothermal extract prevented biofilm development of three MRSA strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Ramon Perez-Tanoira, Marta del Palacio Tamarit, Ana Maria Vicente Montana, David Carmena, Pamela Koster, Miguel Gorgolas, Jose R. Fortes Alen, Alfonso Cabello-Ubeda, Laura Prieto-Perez
Summary: Human intestinal spirochetosis (HIS) can cause gastrointestinal symptoms, especially in low-income countries, people living with HIV, and men who have sex with men (MSM). A retrospective review of 165 patients diagnosed with HIS in Madrid, Spain revealed that most patients were MSM, and symptomatic cases were more likely among those who engaged in chemsex. The most common complaint among symptomatic patients was diarrhea. Age under 41 was associated with increased odds of symptoms. Treatment with metronidazole or doxycycline showed improvement in symptomatic patients without concomitant gastrointestinal infection.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Felix Carrasco Calzada, John Jairo Aguilera, Jaime Esteban Moreno, Juan Cuadros Gonzalez, David Roca Biosca, Laura Prieto-Perez, Ramon Perez-Tanoira
Summary: This study compared the differences in biofilm formation, antimicrobial sensitivity, virulence factors, and related genes of Enterococcus faecalis and Enterococcus faecium strains isolated from patients with urinary tract infection in hospitals in Uganda and Spain. The incidence of E. faecium was higher in Uganda, while E. faecalis was dominant in Spain. E. faecalis strains showed low resistance to ampicillin, imipenem, and nitrofurantoin, while E. faecium exhibited more than 25% resistance to these antibiotics. The presence of other genes, such as ace1, was also found to be involved in biofilm formation when the esp gene was absent.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Carlos Rescalvo-Casas, Ramon Perez-Tanoira, Rocio Fernandez Villegas, Marcos Hernando-Gozalo, Laura Seijas-Pereda, Felipe Perez-Garcia, Helena Moza Morinigo, Pena Gomez-Herruz, Teresa Arroyo, Rosa Gonzalez, Cristina Verdu Exposito, Lourdes Lledo Garcia, Juan Romanyk Cabrera, Juan Cuadros-Gonzalez
Summary: This study assessed the symptoms of long-COVID-19 and determined the percentage of patients who experienced reinfection up to 2 years after the initial onset of the disease. The results showed that chronic obstructive lung disease, dyspnea, higher LDH levels, and lower D-dimer levels were associated with long-COVID-19. The study also found that middle-aged adults were more susceptible to reinfection. These findings are important for predicting the clinical course of COVID-19 patients and emphasize the importance of prevention and control measures.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Medical Laboratory Technology
Kateryna Sidak, Ramon Perez-Tanoira, Pena Gomez-Herruz
Summary: Direct analysis of the blood culture bottle on the Maldi-TOF system enabled the identification of H. cinaedi as the cause of the bacteremia, which could not be grown in standard culture conditions. The treatment of H. cinaedi infection causing bacteremia is still debated, as the combination of ceftriaxone with doxycycline may not be effective due to bacterial translocation from the gastrointestinal tract. This type of bacteremia is associated with intestinal mucosal damage secondary to ulcerative colitis and primarily affects immunosuppressed patients.
ADVANCES IN LABORATORY MEDICINE-AVANCES EN MEDICINA DE LABORATORIO
(2022)