Article
Urology & Nephrology
Masoud Barah, Vikram Kilambi, John J. Friedewald, Sanjay Mehrotra
Summary: Reducing discard is crucial for the US transplantation system, and shorter cold ischemia time and closer proximity to the donor increase the acceptability of marginal organs.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Simon Ville, Marine Lorent, Clarisse Kerleau, Anders Asberg, Christophe Legendre, Emmanuel Morelon, Fanny Buron, Valerie Garrigue, Moglie Le Quintrec, Sophie Girerd, Marc Ladriere, Laetitia Albano, Antoine Sicard, Denis Glotz, Carmen Lefaucheur, Julien Branchereau, David Jacobi, Magali Giral
Summary: The study found a lower incidence of delayed graft function in patients whose kidney clamping occurred between midnight and noon, while the declamping time was not associated with kidney graft outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adam Hosszu, Akos R. R. Toth, Tamas Lakat, Ganna Stepanova, Zsuzsanna Antal, Laszlo J. J. Wagner, Attila J. J. Szabo, Andrea Fekete
Summary: Kidney transplantation is the preferred treatment for end-stage kidney disease, and optimizing organ condition is crucial due to the shortage of transplantable organs. This study demonstrated that supplementing the preservation solution with the S1R agonist fluvoxamine reduced cold and warm ischemic injury, improved kidney function, mitigated histological injury, and reduced inflammation. The results suggest that S1R agonists have great potential in improving organ preservation and alleviating the problem of organ shortages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey, Max Y. Zhang, Winnie Liu, Aaron Haig, Patrick McLeod, Jacqueline Arp, Alp Sener
Summary: In the experiment, it was found that preserving renal grafts in STS-supplemented UW solution can protect against prolonged cold IRI by suppressing apoptotic and inflammatory pathways, improving graft function, and prolonging recipient survival. This novel therapeutic strategy may help minimize the detrimental clinical outcome of prolonged cold IRI in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Bartlomiej J. Witczak, Soren E. Pischke, Anna Reisaeter, Karsten Midtvedt, Judith K. Ludviksen, Kristian Heldal, Trond Jenssen, Anders Hartmann, Anders Asberg, Tom E. Mollnes
Summary: Early complement activation, assessed by plasma TCC levels, is associated with impaired long-term patient and graft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Raphael Porret, Raphael P. H. Meier, Josip Mikulic, Manuel Pascual, Vincent Aubert, Thomas Harr, Dela Golshayan, Yannick D. D. Muller, Swiss Transplant Cohort Study
Summary: The study found that atopy is associated with better long-term patient and graft survival after kidney transplantation, independently of age and living donor donation. However, it does not affect the occurrence of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Elizabeth M. Sonnenberg, Jesse Y. Hsu, Jordana B. Cohen, Vishnu S. Potluri, Zhi Geng, Matthew H. Levine, Peter L. Abt, Peter P. Reese
Summary: This study found that kidney transplants from deceased donors with persistent acute kidney injury (AKI) did not have clinically meaningful differences in graft survival and function compared to transplants from donors without kidney injury.
Review
Urology & Nephrology
James Ashcroft, Philippa Leighton, Tegwen R. Elliott, Sarah A. Hosgood, Michael L. Nicholson, Vasilis Kosmoliaptsis
Summary: EVs have shown promise as therapeutic targets to improve kidney transplant outcomes and as potential biomarkers for accurate diagnosis of graft injuries. Research progress has been made, but challenges remain to be addressed, including methodological issues and clinical translation.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Hanno Maassen, Leonie H. Venema, Marc G. Weiss, Tobias M. Huijink, H. Sijbrand Hofker, Anna K. Keller, Tom E. Mollnes, Marco Eijken, Soren E. Pischke, Bente Jespersen, Harry van Goor, Henri G. D. Leuvenink
Summary: Kidney extraction time has a detrimental effect on post-transplantation outcome. This study aimed to improve the flush-out and decrease ischemic injury by adding hydrogen sulphide (H2S) to the flush medium. The addition of H2S during flush out and static cold storage resulted in a reduction in pro-inflammatory cytokines without affecting renal function or injury markers.
Review
Transplantation
Dermot Michael Wildes, Caoimhe S. Costigan, Mairead Kinlough, Joan Flynn, Niamh Dolan, Michael Riordan, Clodagh Sweeney, Maria Stack, Mary Waldron, Orla Walsh, Kathleen M. Gorman, Atif Awan
Summary: Adolescence is a crucial period of transformation for patients, guardians, and clinicians. There is a lack of specific models for transitional care tailored to kidney transplant recipients. Further research and validation studies are needed to determine the optimal approach for providing effective transitional care to these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
You Luo, Zhanwen Dong, Xiao Hu, Zuofu Tang, Jinhua Zhang, Weiming Deng, Xiangling Wei, Bin Miao, Feng Qin, Ning Na
Summary: In this study involving 561 kidney transplant cases, it was found that cold ischemia time (CIT) negatively affected the incidence of delayed graft function, and the donor death category had an impact on the relationship between CIT and eGFR.
FRONTIERS IN MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Samarra Badrouchi, Abdulaziz Ahmed, Mohamed Mongi Bacha, Ezzedine Abderrahim, Taieb Ben Abdallah
Summary: This study proposes a machine learning framework to predict graft survival after five years of kidney transplantation and determines the most influential parameters. The XGBoost algorithm was found to be the best model with high AUC and sensitivity. The framework can serve as a decision support system for Nephrologists to provide safer treatment recommendations and achieve positive kidney transplant outcomes.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Review
Immunology
Kurtis J. Swanson, Brenda Muth, Fahad Aziz, Neetika Garg, Maha Mohamed, Margaret Bloom, Didier Mandelbrot, Sandesh Parajuli
Summary: Kidney delayed graft function (K-DGF) is a common complication and associated with adverse outcomes. K-DGF in combined kidney-solid organ transplantation is understudied. Different transplant types have different rates of K-DGF occurrence, and specific risk factors may be more relevant to certain types of transplantation.
TRANSPLANTATION REVIEWS
(2022)
Article
Medicine, General & Internal
Joseba Salguero, Laura Chamorro, Enrique Gomez-Gomez, Patricia de Benito, Jose E. Robles, Juan P. Campos
Summary: Delayed graft function (DGF) development significantly contributes to graft loss in kidney transplants, particularly in grafts with KDRI >= 1.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Rongzhi Wang, Griffin Price, Mitchell Disharoon, Gabe Stidham, M. Chandler McLeod, Jessica Liu McMullin, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman, Song Ong, Herbert Chen
Summary: Persistent HPT is common after kidney transplantation and is associated with an increased risk of allograft failure. PTH levels should be closely monitored after transplantation to ensure appropriate treatment.
Article
Rheumatology
Celia A. J. Michielsens, Nathan den Broeder, Frank H. J. van den Hoogen, Elien A. M. Mahler, Steven Teerenstra, Desiree van der Heijde, Lise M. Verhoef, Alfons A. den Broeder
Summary: In patients with PsA and axSpA, a T2T TNFi strategy with tapering attempt is non-inferior to a T2T strategy without tapering in terms of the proportion of patients still in low disease activity (LDA) at 12 months, and results in a substantial reduction of TNFi use.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
E. R. Kurniawati, S. Teerenstra, N. P. A. Vranken, A. S. Sharma, J. G. Maessen, P. W. Weerwind
Summary: In this study, early repayment of oxygen debt during the first 24 hours of V-A ECMO was found to be associated with survival. The baseline oxygen debt value and the need for continuous kidney replacement therapy also appeared to have an impact on outcomes.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Julia I. P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk of atherosclerotic disease. The study found that hypoglycemia induces a sustained inflammatory response at the cellular and protein level, which is present in both individuals with type 2 diabetes and control subjects.
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Therese W. Fabricius, Giesje Nefs, Roy P. C. Kessels, Frans Pouwer, Steven Teerenstra, Cees J. Tack, Melanie M. Broadley, Peter L. Kristensen, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: This study suggests that IHSG level 2 hypoglycemia impairs cognitive function regardless of diabetes status, type of diabetes, or hypoglycemia awareness.
Review
Endocrinology & Metabolism
Clementine E. M. Verhulst, Therese W. Fabricius, Steven Teerenstra, Peter L. Kristensen, Cees J. Tack, Rory J. McCrimmon, Simon Heller, Mark L. Evans, Stephanie A. Amiel, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: This systematic review compared the activation thresholds for counterregulatory hormone and symptom responses to hypoglycaemia between individuals with type 1 diabetes and those without diabetes, using stepped hyperinsulinaemic-hypoglycaemic glucose clamps.
Article
Clinical Neurology
Roderick P. P. W. M. Maas, Steven Teerenstra, Manuela Lima, Paula Pires, Luis Pereira de Almeida, Judith van Gaalen, Dagmar Timmann, Jon Infante, Chiadi Onyike, Khalaf Bushara, Heike Jacobi, Kathrin Reetz, Magda M. Santana, Joana Afonso Ribeiro, Jeannette Huebener-Schmid, Jeroen J. de Vries, Matthis Synofzik, Ludger Schoels, Hector Garcia-Moreno, Paola Giunti, Jennifer Faber, Thomas Klockgether, Bart P. C. van de Warrenburg
Summary: This study investigated the temporal dynamics of SARA item scores in SCA3 patients and found differences in the progression patterns of axial and appendicular ataxia. Male patients showed a faster progression, and the omission of certain test items could lower sample size requirements for therapeutic trials.
MOVEMENT DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Marian Mitroiu, Steven Teerenstra, Katrien Oude Rengerink, Frank Petavy, Kit C. B. Roes
Summary: The aim of this study was to understand the relationship between estimands and efficacy analyses commonly used in clinical trials. Six clinical trials evaluating a new anti-depression treatment were re-analyzed using different analysis methods. The results showed that different analysis methods could be mapped to multiple estimands, with the strategy for intercurrent events being the major difference. The quantitative differences in population-level summaries between the estimands were 4-8 points. Not all estimands had a clinically meaningful interpretation and only a few analyses could target the same estimand. This emphasizes the importance of prospectively defining estimands and prescribing estimators precisely.
PHARMACEUTICAL STATISTICS
(2022)
Article
Medicine, General & Internal
Mariska Quirina Nikita Hackert, Jet W. Ankersmid, Noel Engels, Janine C. M. Prick, Steven Teerenstra, Sabine Siesling, Constance H. C. Drossaert, Luc J. A. Strobbe, Yvonne E. A. van Riet, Rene M. A. van den Dorpel, Willem Jan W. Bos, Paul B. van der Nat, Renske M. Van den Berg-Vos, Sander M. van Schaik, Mirjam M. Garvelink, Philip J. van der Wees, Cornelia F. Van Uden-Kraan
Summary: Within the value-based healthcare framework, a multicomponent intervention has been designed to support shared decision-making, including patient decision aids and training for health care professionals. The SHOUT study aims to examine the effectiveness and implementation of this intervention.
Article
Immunology
Sofie C. M. Tops, Eva Kolwijck, Evert L. Koldewijn, Diederik M. Somford, Filip J. M. Delaere, Menno A. van Leeuwen, Anthonius J. Breeuwsma, Thijn F. de Vocht, Hans J. H. P. Broos, Rob A. Schipper, Martijn G. Steffens, Steven Teerenstra, Marjolijn C. A. Wegdam-Blans, Els de Brauwer, Wouter van den Bijllaardt, Alexander C. A. P. Leenders, J. P. Michiel Sedelaar, Heiman F. L. Wertheim
Summary: This study compared the impact of empirical ciprofloxacin prophylaxis and culture-based prophylaxis on infectious complication rates after transrectal prostate biopsy. The results showed that culture-based prophylaxis can reduce the occurrence of infectious complications. However, infections can still occur even with adequate prophylaxis.
CLINICAL INFECTIOUS DISEASES
(2023)
Letter
Cardiac & Cardiovascular Systems
Tijn P. J. Jansen, Annemiek de Vos, Valeria Paradies, Peter Damman, Steven Teerenstra, Regina E. Konst, Aukelien Dimitriu-Leen, Angela H. E. M. Maas, Pieter C. Smits, Suzette E. Elias-Smale, Nieks van Royen
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Mathematical & Computational Biology
Steven Teerenstra, Jessica Kasza, Ruslan Leontjevas, Andrew B. Forbes
Summary: In randomized controlled trials, treatment-related clustering at follow-up can lead to correlated outcomes among different subjects. Adjusting for baseline measure in the analysis can reduce sample size requirements. We provide sample size formulas for various designs and investigate small sample properties.
STATISTICS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Julia I. P. W. van Heck, Therese Fabricius, Rinke Stienstra, Steven J. Teerenstra, Rory J. McCrimmon, Cees Tack, Ulrik E. Pedersen-Bjergaard, Bastiaan de Galan, Hypo RESOLVE Consortium
Summary: The aim of this study was to determine the duration and extent of the inflammatory response to hypoglycemia in individuals with type 1 diabetes and healthy controls. The results showed that hypoglycemia increased the counts of lymphocytes and monocytes, which remained elevated for one week. In addition, hypoglycemia also led to an increase in the release of pro-inflammatory cytokines and an elevation of circulating inflammatory proteins, both of which lasted for at least one week.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Paul J. T. Rood, Dharmanand Ramnarain, Annemarie W. Oldenbeuving, Brenda L. den Oudsten, Sjaak Pouwels, Lex M. van Loon, Steven Teerenstra, Peter Pickkers, Jolanda de Vries, Mark Van den Boogaard, Ala Nozari
Summary: This study examined the effects of a multicomponent non-pharmacological nursing intervention program on delirium in neurological ICU patients. The results showed that the intervention did not change the number of delirium-free and coma-free days alive after 28 days.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
T. P. J. Jansen, A. De Vos, P. Damman, V. Paradies, R. E. Konst, S. Teerenstra, S. C. H. Van Den Oord, A. Dimitriu-Leen, A. H. E. M. Maas, P. C. Smits, S. E. Elias-Smale, N. Van Royen
EUROPEAN HEART JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. M. Griffioen, S. C. H. Van den Oord, S. Teerenstra, R. Damman, N. Van Royen, R. J. M. Van Geuns
EUROPEAN HEART JOURNAL
(2022)
Article
Surgery
Kevin Ferrari, Alice Aarnink, Carole Ayav, Luc Frimat, Cecile Couchoud, Benoit Audry, Corinne Antoine, Sophie Girerd
Summary: Continuation of immunosuppressive therapy after kidney allograft failure is associated with less change in HLA-sensitization and does not increase patient mortality.
CLINICAL TRANSPLANTATION
(2024)
Article
Surgery
Sandeep Sainathan, John Ryan, Leonardo Mullinari, Pablo Sanchez
Summary: Patients undergoing lung transplantation for pulmonary venous-occlusive disease (PVOD) had better initial survival compared to those with primary pulmonary hypertension (PPHTN), but this advantage disappeared after 1 year. The use of donation after circulatory death donors was associated with lower short-term survival rates.
CLINICAL TRANSPLANTATION
(2024)
