Review
Gastroenterology & Hepatology
Jennifer Scott, Andrew M. Jones, Karen Piper Hanley, Varinder S. Athwal
Summary: This review provides a summary of the current understanding of cystic fibrosis-related liver disease (CFLD) in terms of its epidemiology, pathology, diagnosis, and management. The review highlights the heterogeneity of CFLD and the challenges in its diagnosis and treatment. The authors emphasize the lack of precise diagnostic strategies and effective therapies for CFLD, and the need for further research on its pathogenesis and disease detection.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Ji Hye Jun, Soo Young Park, Sohae Park, Hee Jung Park, Jae Yeon Kim, Gyu Tae Park, Si Hyun Bae, Jae Ho Kim, Gi Jin Kim
Summary: The hexapeptide WKYMVm demonstrates antifibrotic and angiogenic effects in a rat model of bile duct ligation (BDL), showing a reduction in collagen type I and alpha-smooth muscle actin expression and an increase in angiogenetic factors. Furthermore, WKYMVm alleviates hepatic fibrosis by inhibiting hepatic stellate cell activation and promotes hepatic regeneration via vascular remodeling, making it a potential therapeutic agent for liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Kathleen J. Ramos, Jenna Sykes, Sanja Stanojevic, Xiayi Ma, Joshua S. Ostrenga, Aliza Fink, Bradley S. Quon, Bruce C. Marshall, Albert Faro, Kristofer Petren, Alexander Elbert, Christopher H. Goss, Anne L. Stephenson
Summary: The study revealed that among patients with FEV1 < 40% predicted, there are lower rates of lung transplant and an increased risk of death without lung transplant for US patients compared with Canadian patients. This difference is more significant among US patients with Medicaid/Medicare health insurance and nonwhite patients, suggesting potential disparities in access to lung transplants among vulnerable populations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberta Catania, Alessandro Furlan, Andrew D. Smith, Jaideep Behari, Mitchell E. Tublin, Amir A. Borhani
Summary: The study found that MRI-derived liver surface nodularity (LSN) score can accurately detect advanced liver fibrosis in NAFLD patients. There is a strong correlation between LSN score and fibrosis stage, with 81% sensitivity and 88% specificity for detecting F3-F4 fibrosis.
EUROPEAN RADIOLOGY
(2021)
Article
Immunology
Teresa Fuchs, Dorothea Appelt, Helmut Ellemunter
Summary: People with Cystic Fibrosis (CF), particularly those who have undergone solid organ transplantation, have been prioritized for SARS-CoV-2 vaccination. This study investigates the antibody response of CF patients who have received liver or lung transplants and compares it to published data of non-CF solid organ transplant recipients. The results show varying response rates, with liver transplant recipients exhibiting a better immune response compared to lung transplant recipients. These findings highlight the importance of considering the distinct immune responses among CF patients with different organ transplant backgrounds and emphasize the need for booster vaccinations.
Article
Respiratory System
Marilyn J. Siegel, Daniel H. Leung, Jean P. Molleston, Wen Ye, Shruti M. Paranjape, A. Jay Freeman, Joseph J. Palermo, Janis Stoll, Prakash Masand, Boaz Karmazyn, Roger Harned, Simon C. Ling, Oscar M. Navarro, Wikrom Karnsakul, Adina Alazraki, Sarah Jane Schwarzenberg, Alex J. Towbin, Estella M. Alonso, Jennifer L. Nicholas, Nicole Green, Randolph K. Otto, John C. Magee, Michael R. Narkewicz
Summary: This study found that the heterogeneous pattern on liver ultrasound can identify CF children with a 30-50% risk of advanced cystic fibrosis liver disease (aCFLD). A score based on US pattern, age, and GPR can further refine the identification of high-risk individuals.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Biochemistry & Molecular Biology
Floris Haijer, Shiva Koets-Shajari, Janette Heegsma, Sandra Serna-Salas, Tjasso Blokzijl, Manon Buist-Homan, Han Moshage, Klaas Nico Faber
Summary: Liver fibrosis is caused by excessive proliferation and collagen production by hepatic stellate cells (HSCs) due to chronic liver injury. Hydroxyurea, an anti-proliferative drug, showed inhibitory effects on HSC proliferation and fibrosis development in both in vitro and in vivo experiments. This study provides evidence for the therapeutic potential of hydroxyurea in treating liver fibrosis.
Review
Pediatrics
Siddhartha G. Kapnadak, Kathleen J. Ramos, Elisabeth P. Dellon
Summary: Significant advancements in cystic fibrosis (CF) care have improved survival and quality of life, but many individuals still struggle with advanced cystic fibrosis lung disease (ACFLD) and the complexities of ongoing disease progression. Recent guidelines focus on enhancing care for ACFLD patients through improvements in medical, psychosocial, palliative, and lung transplant-related care.
PEDIATRIC PULMONOLOGY
(2021)
Article
Medicine, General & Internal
Anna Engell Holm, Hans Henrik Lawaetz Schultz, Helle Krogh Johansen, Tania Pressler, Thomas Kromann Lund, Martin Iversen, Michael Perch
Summary: This study monitored the time of bacterial re-colonization in lung transplant patients with cystic fibrosis and found that 70% of patients were re-colonized by bacteria after 2 years, with no observed impact on survival rates from re-colonization or different bacterial species.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Respiratory System
Diego A. Calvopina, Peter J. Lewindon, Louise E. Ramm, Charlton Noble, Gunter F. Hartel, Daniel H. Leung, Grant A. Ramm
Summary: This study investigated the use of gamma-glutamyl transpeptidase-to-platelet ratio (GPR) as a non-invasive biomarker for detecting liver disease and fibrosis severity in children with CF-associated liver disease (CFLD). The results showed that GPR is a useful diagnostic tool for detecting the presence of CFLD, assessing fibrosis severity, and predicting complications of liver disease.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Gastroenterology & Hepatology
Huapeng Lin, Grace Lai-Hung Wong, Xinrong Zhang, Terry Cheuk-Fung Yip, Ken Liu, Yee Kit Tse, Vicki Wing-Ki Hui, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
Summary: This study aimed to determine the association between blood urea level and incident cirrhosis, hepatic decompensation, and hepatocellular carcinoma in patients with chronic liver disease. The results showed a U-shaped relationship between blood urea level and hepatic decompensation and cirrhosis, with both low and high urea levels associated with higher risks.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Slawomira Drzymala-Czyz, Krzysztof Dziedzic, Artur Szwengiel, Patrycja Krzyanowska-Jankowska, Jan K. Nowak, Agata Nowicka, Raisa Aringazina, Sylwia Drzymala, Nataliya Kashirskaya, Jaroslaw Walkowiak
Summary: This study revealed that serum bile acid concentrations were higher in CF patients compared to healthy subjects, and GDCA and DCA could differentiate the severity of liver involvement in CF patients. GDCA may be a candidate biomarker for validating the progression of non-cirrhotic liver disease in CF.
DIGESTIVE AND LIVER DISEASE
(2022)
Review
Pharmacology & Pharmacy
Alessandro Rimessi, Veronica A. M. Vitto, Simone Patergnani, Paolo Pinton
Summary: Cystic fibrosis is a genetic disorder characterized by airway issues and lung damage. Calcium signaling plays a crucial role in the pathophysiology of CF lung disease, with dysregulated calcium signals leading to impaired cell function and exacerbated inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Dmitrii Shek, Dishen Chen, Scott A. Read, Golo Ahlenstiel
Summary: Liver cancer, predicted to be the third most lethal cancer worldwide by 2030, is primarily caused by obesity, chronic alcohol abuse or viral hepatitis, with alcohol and high fat diet promoting intestinal permeability. Understanding the mechanisms by which liver cancers initiate and progress is crucial, and organoid culture offers advantages for studying the role of the gut-liver axis in cancer initiation and progression.
Article
Gastroenterology & Hepatology
Jihyun An, Hyung-Don Kim, Seon-Ok Kim, Ha Il Kim, Gi-Won Song, Han Chu Lee, Ju Hyun Shim
Summary: Compared to the general population, patients with liver cirrhosis have a lower prevalence of intracranial atherosclerosis, while the prevalence of extracranial atherosclerosis is similar. Thrombocytopenia and high coronary artery calcium score may be associated with intracranial atherosclerosis.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bronwyn Levvey, Shaf Keshavjee, Marcelo Cypel, Amanda Robinson, Michael Erasmus, Allan Glanville, Peter Hopkins, Michael Musk, Marshall Hertz, Kenneth McCurry, Dirk Van Raemdonck, Gregory Snell
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
E. N. Pavlisko, M. L. Neely, H. Kopetskie, D. Hwang, C. F. Farver, A. V. Arrossi, W. D. Wallace, P. Illei, M. Sever, J. Kirchner, C. W. Frankel, L. D. Snyder, T. Martinu, M. Y. Shino, N. Williams, M. A. Robien, L. G. Singer, M. Budev, W. Tsuang, P. D. Shah, J. M. Reynolds, S. Weigt, J. A. Belperio, S. M. Palmer, J. L. Todd
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Article
Respiratory System
Edward F. Nash, Peter G. Middleton, Jennifer L. Taylor-Cousar
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Surgery
Alim Hirji, Hedi Zhao, Maria B. Ospina, Jesus S. Lomelin, Kieran Halloran, Matthew Hubert, John Yee, Dale C. Lien, Robert D. Levy, Lianne G. Singer
CLINICAL TRANSPLANTATION
(2020)
Article
Surgery
Lisa Wickerson, Dmitry Rozenberg, Chaya Gottesman, Denise Helm, Sunita Mathur, Lianne G. Singer
CLINICAL TRANSPLANTATION
(2020)
Review
Surgery
Dmitry Rozenberg, Camila E. Orsso, Karan Chohan, Ani Orchanian-Cheff, Sahar Nourouzpour, John Michael Nicholson, Brenawen Elangeswaran, Andrei Vagaon, Lee Fidler, Lianne G. Singer, Sunita Mathur
TRANSPLANT INTERNATIONAL
(2020)
Article
Surgery
Meghan Aversa, Tereza Martinu, Christopher Patriquin, Marcelo Cypel, David Barth, Rasheed Ghany, Jin Ma, Shaf Keshavjee, Lianne G. Singer, Kathryn Tinckam
Summary: The Toronto Lung Transplant Program has been using a desensitization regimen since 2008 for DSA-positive lung transplants, and long-term follow-up showed that allograft survival and CLAD-free survival of these patients were not significantly different from other lung transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Takashi Hirama, Lianne G. Singer, Sarah K. Brode, Theodore K. Marras, Shahid Husain
Summary: Among lung transplant recipients, treatment outcomes of NTM-PD showed that macrolide-containing anti-mycobacterial therapy may lead to clinical and radiological improvement, as well as culture conversion in some patients.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Health Care Sciences & Services
Lisa Wickerson, Denise Helm, Chaya Gottesman, Dmitry Rozenberg, Lianne G. Singer, Shaf Keshavjee, Aman Sidhu
Summary: This study evaluated the use and satisfaction of telerehabilitation during the COVID-19 pandemic among providers, lung transplant candidates, and recipients. The results showed high satisfaction among candidates and recipients, with physiotherapists identifying patient access to home exercise equipment as a major barrier.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Nutrition & Dietetics
Joanne Barrett, Georgina Slatter, Joanna L. Whitehouse, Edward F. Nash
Summary: Adults with CF have varying perceptions, experiences, and relationships with food and eating. Childhood eating experiences have a sustained effect on adult eating behaviors. Concerns about weight gain, body image, and dietary health implications are significant for patients.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Microbiology
Karmel Webb, Nur Masirah M. Zain, Iain Stewart, Andrew Fogarty, Edward F. Nash, Joanna L. Whitehouse, Alan R. Smyth, Andrew K. Lilley, Alan Knox, Paul Williams, Miguel Camara, Kenneth Bruce, Helen L. Barr
Summary: The presence and relative abundance of certain anaerobic bacteria in the sputum of adults with cystic fibrosis are associated with disease progression and decline in lung function.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Microbiology
Nur Masirah M. Zain, Karmel Webb, Iain Stewart, Nigel Halliday, David A. Barrett, Edward F. Nash, Joanna L. Whitehouse, David Honeybourne, Alan R. Smyth, Douglas L. Forrester, Alan J. Knox, Paul Williams, Andrew Fogarty, Miguel Camara, Kenneth D. Bruce, Helen L. Barr
Summary: The study revealed that levels of three AQs measured in sputum, plasma, and urine were consistently positively correlated with the live P. aeruginosa bacterial load measured by qPCR, and were more accurate compared to traditional culture methods. Further prospective studies are needed to assess the potential of systemic AQs as biomarkers of P. aeruginosa bacterial burden.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Cynthia L. Green, Brian C. Gulack, Shaf Keshavjee, Lianne G. Singer, Kenneth McCurry, Marie M. Budev, Tammy L. Reece, Anne O. Lidor, Scott M. Palmer, R. Duane Davis
Summary: A multicenter retrospective study found limited benefits of fundoplication for preventing bronchiolitis obliterans syndrome and improving survival compared to reflux disease without surgery after lung transplantation. However, the study had limitations in terms of sample size, follow-up duration, and potential selection bias, highlighting the need for a randomized, prospective study.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Dmitry Rozenberg, Lianne G. Singer
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Respiratory System
Edward F. Nash, Jocelyn Choyce, Victoria Carrolan, Edwin Justice, Karen L. Shaw, Alice Sitch, Hema Mistry, Joanna L. Whitehouse
Summary: This study assessed the effects of home monitoring on individuals with cystic fibrosis. The results indicate that home monitoring is effective in detecting pulmonary exacerbations and does not significantly impact hospital admissions or overall health. Despite the high cost of the equipment, home monitoring is found to be more cost-effective than routine care. Patients have a positive experience with home monitoring, feeling more empowered and reassured.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Surgery
Kevin Ferrari, Alice Aarnink, Carole Ayav, Luc Frimat, Cecile Couchoud, Benoit Audry, Corinne Antoine, Sophie Girerd
Summary: Continuation of immunosuppressive therapy after kidney allograft failure is associated with less change in HLA-sensitization and does not increase patient mortality.
CLINICAL TRANSPLANTATION
(2024)
Article
Surgery
Sandeep Sainathan, John Ryan, Leonardo Mullinari, Pablo Sanchez
Summary: Patients undergoing lung transplantation for pulmonary venous-occlusive disease (PVOD) had better initial survival compared to those with primary pulmonary hypertension (PPHTN), but this advantage disappeared after 1 year. The use of donation after circulatory death donors was associated with lower short-term survival rates.
CLINICAL TRANSPLANTATION
(2024)