Article
Chemistry, Multidisciplinary
Tingxizi Liang, Di Wen, Guojun Chen, Amanda Chan, Zhaowei Chen, Hongjun Li, Zejun Wang, Xiao Han, Liping Jiang, Jun-Jie Zhu, Zhen Gu
Summary: The lipid droplets in adipocytes have been demonstrated to be a controllable and biocompatible vehicle for delivering anticancer drugs, enhancing the therapeutic effect of cancer photodynamic therapy through various pathways. Loading a lipid-conjugated photosensitizer into the lipid droplets reduces its IC50 value by 6.0-fold. In vivo results show that engineered lipid droplets effectively inhibit tumor growth with minimal side effects.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao, Meng Meng
Summary: In this study, a tetrahedral DNA-based nanosystem was designed to load IR780, improving its solubility and stability for cancer phototherapy. The nanoformulation showed promising results in enhancing tumor targeting and anti-tumor effects of IR780, indicating potential for intravenous administration of IR780 in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Optics
Yuqing Zhang, Zeyu He, Xiaoyang Du, Jiayue Han, Hui Lin, Caijun Zheng, Jun Wang, Gang Yang, Silu Tao
Summary: In this study, we developed an organic upconversion device that can convert near-infrared light into green light. The device shows high efficiency and long wavelength detection, which has implications for long wavelength near-infrared bio-imaging in further research.
Review
Pharmacology & Pharmacy
Vikram Mohanlal Prajapat, Srushti Mahajan, Priti Gautam Paul, Mayur Aalhate, Arti Mehandole, Jitender Madan, Kamal Dua, Dinesh Kumar Chellappan, Sachin Kumar Singh, Pankaj Kumar Singh
Summary: Melanoma is an aggressive form of skin cancer with increasing incidence rates worldwide. Existing treatments, including chemotherapy, radiotherapy, immunotherapy, and targeted therapy, have improved outcomes but are associated with toxic effects and resistance. Recent advances in functional nanocarriers offer innovative and effective strategies for targeted delivery of nanotherapeutics in melanoma therapy. This review summarizes breakthroughs in nanocarrier-based treatments, highlighting lipids, polymers, and inorganic materials as main focuses, as well as the role of nanomedicine in photodynamic therapy, photothermal therapy, and the delivery of genes and natural therapeutics for melanoma treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Matteo Di Giosia, Alice Solda, Markus Seeger, Andrea Cantelli, Fabio Arnesano, Maria I. Nardella, Vincenzo Mangini, Francesco Valle, Marco Montalti, Francesco Zerbetto, Stefania Rapino, Matteo Calvaresi, Vasilis Ntziachristos
Summary: Fullerenes, specifically C-70@lysozyme, exhibit high photodynamic activity and excellent optical contrast, making them potential candidates for theranostic applications in monitoring cellular uptake and intracellular localization.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Zilin Zhu, Li Wei, Yidan Lai, Oliver W. L. Carter, Samya Banerjee, Peter J. Sadler, Huaiyi Huang
Summary: Rationally-designed glucose-appended Ir(III) photocatalysts were found to exhibit visible light-induced catalytic NAD(P)H oxidation in aqueous solution. Among them, the highly in vivo biocompatible complex Ir3 showed lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids while remaining non-toxic in the dark.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
P. S. Rajalakshmi, Syed Baseeruddin Alvi, Nazia Begum, Bantal Veeresh, Aravind Kumar Rengan
Summary: SPoD NPs, derived from spinach, demonstrate a combined PDT/PTT effect, effectively inhibiting cancer cell growth while preventing metastasis and tumor recurrence.
Article
Chemistry, Physical
Ning Wang, Guiqiang Zhang, Haifeng Sun, Yuan Tian, Jingcheng Hao, Jiwei Cui
Summary: Nanoparticles derived from mung beans were found to effectively deliver model antigens and adjuvants, promoting the activation of CTLs and inhibiting tumor growth in vivo, offering a promising approach for cancer immunotherapy.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yameng Li, Yingjie Ding, Yifan Zhang, Zhiyue Sun, Jiao Liu, Mengxia Dai, Jiayi Feng, Bin Li, Chaozhan Wang, Yinmao Wei, Ji-Wei Shen
Summary: In this study, a novel nanomaterial UCFS@Fe-TA was developed for simultaneous photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) triggered by single 808 nm laser. The nanomaterial exhibited intense red emission and faster generation of reactive oxygen species at higher temperatures, resulting in efficient tumor suppression.
Article
Chemistry, Multidisciplinary
Liping Zuo, Weidong Nie, Songmao Yu, Wanru Zhuang, Guanghao Wu, Houli Liu, Lili Huang, Danshu Shi, Xin Sui, Yongheng Li, Hai-Yan Xie
Summary: The study encapsulated HAL and 3BP in microparticles collected from X-ray-irradiated tumor cells, allowing for specific targeting and recognition of tumor cells. This led to efficient accumulation of PpIX and increased oxygen supply, resulting in improved PDT outcomes by disrupting mitochondria with sufficient ROS.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Xue-Quan Zhou, Peiyuan Wang, Vadde Ramu, Liyan Zhang, Suhua Jiang, Xuezhao Li, Selda Abyar, Panagiota Papadopoulou, Yang Shao, Ludovic Bretin, Maxime A. A. Siegler, Francesco Buda, Alexander Kros, Jiangli Fan, Xiaojun Peng, Wen Sun, Sylvestre Bonnet
Summary: This article reports that the metallophilic interaction between cyclometalated palladium complexes generates supramolecular nanostructures in living mice with long circulation time and efficient tumour accumulation rate. Green light activation leads to efficient tumour destruction due to the self-assembled palladium complexes.
Review
Chemistry, Multidisciplinary
Jiang Ouyang, Angel Xie, Jun Zhou, Runcong Liu, Liqiang Wang, Haijun Liu, Na Kong, Wei Tao
Summary: Traditional treatments like chemotherapy and surgery often have severe side effects and cause pain. The emergence of nanomedicines and minimally invasive therapies has brought hope to patients with malignant diseases. Minimally invasive nanomedicines combine the advantages of nanomedicines and minimally invasive therapies, effectively targeting pathological cells and minimizing side effects. This review provides a comprehensive overview of the research status and challenges of minimally invasive nanomedicines and their applications in various fields.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Shafee Alkanawati, Marina Machtakova, Katharina Landfester, Heloise Therien-Aubin
Summary: The development of responsive nanogel systems for drug delivery is challenging but promising due to their high stability in aqueous media and ability to respond to biochemical cues. In this study, multistimuli-responsive nanogels were synthesized using bio-orthogonal and reversible reactions, allowing for selective release of encapsulated cargos. These nanogels were pH-responsive and could be controlled for reversible release of payloads, and additionally responsive to enzymatic cleavage and oxidoreductive cues.
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Zhuo Li, Shan Lu, Wenzhen Liu, Tao Dai, Jianxi Ke, Xingjun Li, Renfu Li, Yuxiang Zhang, Zhuo Chen, Xueyuan Chen
Summary: The research team designed a bio-inorganic nanohybrid that combines lysozyme with the UCNP-PDT system to enhance the efficiency against drug-resistant bacteria. The nanoplatform achieves strong bactericidal capacity and significant bacteriostasis on methicillin-resistant S. aureus through rapid adhesion to bacteria, intelligently bacteria-responsive LYZ release, and synergistic LYZ-PDT effect.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Churat Weeraphan, Pongsakorn Thawornpan, Supinya Thanapongpichat, Kanitta Srinoun, Aung Win Tun, Chantragan Srisomsap, Jisnuson Svasti, Hansuk Buncherd
Summary: The magnetic fraction of fly ash was used as a catalyst for degrading ethidium bromide in aqueous solution with a degradation efficiency of 98% achieved under optimal conditions. The catalyst showed good stability and reusability, making it a cost-effective alternative for removing ethidium bromide.
ANALYTICAL LETTERS
(2022)
Article
Oncology
Siriporn Keeratichamroen, Kriengsak Lirdprapamongkol, Sanit Thongnest, Jutatip Boonsombat, Pornsuda Chawengrum, Thiwaree Sornprachum, Jitnapa Sirirak, Chris Verathamjamras, Narittira Ornnork, Somsak Ruchirawat, Jisnuson Svasti
Summary: Lung cancer is a major cause of death worldwide due to drug resistance and disease recurrence. The study found that three compounds isolated from Gymnanthemum extensum, vernodalin, vernolepin, and vernolide, exhibited anti-proliferative and apoptosis-inducing effects on human lung cancer cells. The compounds may exert their anti-tumor activity through the JAK2/STAT3 pathway.
Article
Chemistry, Medicinal
Pongtai Chaiputtanapun, Kriengsak Lirdprapamongkol, Bongkotrat Thanaussavadate, Thanyaporn Phongphankhum, Thanawit Thippong, Poomsith Thangsan, Phreeranat Montatip, Lukana Ngiwsara, Jisnuson Svasti, Pitak Chuawong
Summary: A series of compounds synthesized by Larock heteroannulation showed good cytotoxic activity against human lung cancer cells, through inhibition of tubulin polymerization, modulation of cell cycle, and downregulation of apoptosis-related proteins.
Article
Biochemistry & Molecular Biology
Phillip Nagley, Jisnuson Svasti, Akira Kikuchi
Summary: The Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) was established in 1972 with the goal of promoting collaboration and communication among biochemists in the region. Over the years, it has grown to include 21 constituent members and has organized regular scientific meetings and symposia. FAOBMB has also been involved in education, granting awards to high-achieving scientists and expanding its fellowships program to include educationists. Despite challenges, such as the recent COVID-19 pandemic, FAOBMB has adapted and continued to thrive through virtual communications and online conferences.
Article
Biochemistry & Molecular Biology
Kamolwan Watcharatanyatip, Somchai Chutipongtanate, Daranee Chokchaichamnankit, Churat Weeraphan, Kanokwan Mingkwan, Virat Luevisadpibul, David S. Newburg, Ardythe L. Morrow, Jisnuson Svasti, Chantragan Srisomsap
Summary: This study employed a translational proteomic approach to discover and develop a multiplex CCA biomarker assay. The identified biomarkers showed strong predictive performance for CCA diagnosis, indicating their potential use in identifying individuals at risk of CCA.
Article
Biochemistry & Molecular Biology
Lukana Ngiwsara, Phannee Sawangareetrakul, Duangrurdee Wattanasirichaigoon, Thipwimol Tim-Aroon, Prapai Dejkhamron, Voraratt Champattanachai, James R. Ketudat-Cairns, Jisnuson Svasti
Summary: This study investigated the effect of gentamicin on stop codon readthrough of IDUA variants and found that gentamicin significantly increased the expression and activity of IDUA. Changes in RNA secondary structure were observed in variants that responded to readthrough. Further studies in patient's skin fibroblasts and animal models are needed for personalized medicine.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Food Science & Technology
Kanokwan Nonthawong, Chantragan Srisomsap, Daranee Chokchaichamnankit, Jisnuson Svasti, Pharima Phiriyangkul
Summary: This study compared the proteins in fresh and powdered fish from skipjack tuna and Nile tilapia using proteomic approach. It identified potential allergens and discovered peptide markers for fish adulteration. Interestingly, the potential allergens in fish were similar to peptides from chicken powder and egg yolk powder.
Article
Engineering, Environmental
Pakakrong Sangsanoh, Sonthaya Chaiarwut, Chasuda Choipang, Jitti Niyompanich, Orawan Suwantong, Kriengsak Lirdprapamongkol, Jisnuson Svasti, Piyachat Chuysinuan, Supanna Techasakul, Pitt Supaphol
Summary: Semi-solid PVA-borax hydrogels containing CBD/β-CD inclusion complex were prepared for wound management. The inclusion complex was successfully prepared and loaded into PVA hydrogels. The hydrogels showed antibacterial capability against S. aureus and MRSA and improved antioxidant properties when CBD was added. The hydrogels were non-cytotoxic and suppressed NO production in cells. These findings highlight the potential biomedical application of these hydrogels.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Oncology
Siriporn Keeratichamroen, Thiwaree Sornprachum, Lukana Ngiwsara, Narittira Ornnork, Jisnuson Svasti
Summary: The tumor microenvironment has a significant impact on therapeutic responses. 3D in vitro culture of cancer cells mimics the complex 3D arrangement of tumors in vivo and provides insights into the mechanisms of microenvironmental influences on cellular functions and therapeutic efficacy. This study demonstrates that 3D-cultured A549 cells exhibit dormant cell characteristics and increased resistance to anticancer agents, suggesting the importance of 3D culture systems in searching for novel chemotherapeutic agents and therapeutic targets for cancer treatment.
Article
Polymer Science
Piyachat Chuysinuan, Chalinan Pengsuk, Kriengsak Lirdprapamongkol, Thanyaluck Thanyacharoen, Supanna Techasakul, Jisnuson Svasti, Patcharakamon Nooeaid
Summary: This study developed a wound dressing made of natural- and biowaste-derived biopolymers loaded with turmeric extract, which has antibacterial, antioxidant, and anti-inflammatory activities. The dressing showed inhibitory effects on bacterial growth due to the controlled release of the turmeric extract. It also exhibited antioxidant activity by scavenging radicals and demonstrated anti-inflammatory effects by inhibiting nitric oxide production. This study suggests that the dressing has potential for wound healing.
Article
Polymer Science
Seubsakul Phuegyod, Sasivimon Pramual, Nungnit Wattanavichean, Supasuda Assawajaruwan, Taweechai Amornsakchai, Panithi Sukho, Jisnuson Svasti, Rudee Surarit, Nuttawee Niamsiri
Summary: In this study, 3D porous scaffolds of poly(hydroxybutyrate-co-hydroxyvalerate) with 50% HV content were fabricated and their in vitro proliferation of dental cells for tissue engineering application was evaluated. The results showed that the P(HB-50HV) scaffold exhibited excellent cell compatibility and could be applied as a biomaterial for periodontal tissue engineering and stem cell applications.
Article
Multidisciplinary Sciences
Churaibhon Wisessaowapak, Churat Weeraphan, Daranee Visitnonthachai, Daranee Chokchaichamnankit, Chantragan Srisomsap, Piyajit Watcharasit, Jisnuson Svasti, Jutamaad Satayavivad
Summary: We investigated the effect of prolonged arsenic treatment on insulin receptor substrate (IRS) proteins in human neuroblastoma SH-SY5Y cells. We found that arsenic accelerated the migration of IRS1 and IRS2 on SDS-PAGE, and this shift was dependent on phosphorylation. Using label-free mass spectrometry, we identified multiple phosphorylation sites on IRS1 and IRS2, and the phosphorylation levels were significantly reduced after arsenic treatment. These findings suggest that the impairment of IRS phosphorylation may contribute to arsenic-induced disruption of neuronal insulin signaling.
Article
Biochemistry & Molecular Biology
Benya Nontaleerak, Chatchakorn Eurtivong, Churat Weeraphan, Hansuk Buncherd, Daranee Chokchaichamnankit, Chantragan Srisomsap, Jisnuson Svasti, Rojana Sukchawalit, Skorn Mongkolsuk
Summary: This study found that oxidation of C104 in the NieR protein under NaOCl stress leads to the formation of a disulfide-linked dimer, altering the protein's conformation and thereby abolishing its DNA-binding ability and repressing the expression of target genes.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Pornsuda Chawengrum, Natthaorn Luepongpatthana, Sanit Thongnest, Jitnapa Sirirak, Jutatip Boonsombat, Kriengsak Lirdprapamongkol, Siriporn Keeratichamroen, Patcharin Kongwaen, Phreeranat Montatip, Prasat Kittakoop, Jisnuson Svasti, Somsak Ruchirawat
Summary: Anticopalic acid (ACP), together with its derivatives, showed cytotoxic activity against cancer cell lines. Compound 4p exhibited the highest activity against leukemia cell lines, while compound 4l showed activity against triple-negative breast cancer cell line MDA-MB-231. Mechanistic studies revealed that compound 4l induced cell death through non-apoptotic regulated cell death and decreased the phosphorylation of FAK protein.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Chantragan Srisomsap, Kanokwan Nonthawong, Daranee Chokchaichamnankit, Jisnuson Svasti, Pharima Phiriyangkul
Summary: A shotgun proteomic and in-silico analysis was conducted to identify and characterize the proteomes and potential allergens in processed and non-processed krill and whiteleg shrimp. The results showed that processed forms of both species had more identified proteins and potential allergens compared to non-processed forms. The identified proteins were mainly involved in organelle organization, intracellular, and cytoskeletal protein binding. Eleven potential allergens were identified in all samples, indicating common allergens in krill and shrimp. In-silico analysis revealed IgE epitopes on specific proteins and identified a potential allergen marker in different forms of krill and whiteleg shrimp.
