Article
Cardiac & Cardiovascular Systems
Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte, Rudiger Pfeifer, Volkhard Kurowski, Reimer Riessen, Anne Daubmann, Stephan Braune, Gerold Soffker, Eric Bibiza-Freiwald, Karl Wegscheider, Heribert Schunkert, Holger Thiele, Stefan Kluge
Summary: This study found that hypothermic temperature control after IHCA did not improve survival nor functional outcome. The study may have been underpowered to detect clinically important differences between hypothermic temperature control and normothermia.
Review
Multidisciplinary Sciences
Chaitanya B. Medicherla, Ariane Lewis
Summary: Cardiac arrest can cause hypoxic-anoxic ischemic brain injury, leading to various outcomes such as reduced consciousness and memory deficits. High-quality CPR and induced hypothermia can improve prognosis. Neuroprognostication after cardiac arrest is challenging and requires a multimodal approach.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Critical Care Medicine
Filippo Annoni, Fuhong Su, Lorenzo Peluso, Ilaria Lisi, Enrico Caruso, Francesca Pischiutta, Elisa Gouvea Bogossian, Bruno Garcia, Hassane Njimi, Jean-Louis Vincent, Nicolas Gaspard, Lorenzo Ferlini, Jacques Creteur, Elisa R. R. Zanier, Fabio Silvio Taccone
Summary: Prognosis after resuscitation from cardiac arrest (CA) is poor, but hypertonic sodium lactate (HSL) infusion may have beneficial effects on brain and cardiac injury. This study aimed to test the effects of HSL infusion in an experimental model of CA.
Article
Critical Care Medicine
Johannes Grand, Christian Hassager, Henrik Schmidt, Simon Molstrom, Benjamin Nyholm, Henrik Frederiksen Hoigaard, Jordi S. Dahl, Martin Meyer, Rasmus P. Beske, Laust Obling, Jesper Kjaergaard, Jacob E. Moller
Summary: This study assessed the association between cardiac index (CI) and mixed venous oxygen saturation (SvO2) with outcomes in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA). The results showed that lower SvO2 and a combination of lower CI and lower SvO2 were associated with increased risk of mortality and renal failure.
Article
Anesthesiology
Giovanni Babini, Koen Ameloot, Markus B. Skrifvars
Summary: Postcardiac arrest myocardial dysfunction (PCAMD) is a common complication in post-resuscitation care that affects survival and neurological outcomes. Both mechanical and electrical factors contribute to PCAMD, with a complex pathophysiology involving multiple factors such as myocyte energy failure, impaired contractility, and inflammatory responses. Comprehensive hemodynamic evaluations are important to differentiate benign and malignant forms of myocardial dysfunction and circulatory shock.
MINERVA ANESTESIOLOGICA
(2021)
Article
Emergency Medicine
Kasha Bornstein, Brit Long, Alessandra Della Porta, Guy Weinberg
Summary: This article responds to the updated AHA and ILCOR adult ACLS recommendations in late 2019, summarizing and evaluating the evidence surrounding epinephrine for cardiac arrest. It emphasizes the potential harms and lack of improvement in long-term outcomes such as neurologic function.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Critical Care Medicine
Claudio Sandroni, Daniele Natalini, Jerry P. Nolan
Summary: Most patients who die after cardiac arrest do so because of hypoxic-ischemic brain injury. Temperature control targeted at hypothermia was initially shown to improve neurological outcome and mortality in comatose patients after cardiac arrest, but recent studies have questioned its neuroprotective effects. The largest study conducted so far on temperature control showed no benefit of targeting a temperature of 33 degrees C compared with normal temperature or fever control. Current recommendations emphasize monitoring core temperature and actively preventing fever in patients who are comatose after cardiac arrest.
Review
Multidisciplinary Sciences
Theresa Henson, Cameron Rawaduzy, Marco Salazar, Adonai Sebastian, Harli Weber, Fawaz Al-Mufti, Stephan A. Mayer
Summary: Historically, the outcome after out-of-hospital cardiac arrest has been grim with a 10% overall survival rate upon admission to hospital. By incorporating therapeutic temperature modulation, aggressive prevention of secondary brain injury, and improved access to advanced cardiovascular support, mortality rates have decreased. The current standard of care for assessing neurological status in patients emphasizes a multimodal approach with elements like neurological examination, EEG, biomarker testing, and imaging.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Critical Care Medicine
Thomas Madelaine, Martin Cour, Pascal Roy, Benoit Vivien, Julien Charpentier, Florence Dumas, Nicolas Deye, Eric Bonnefoy, Pierre-Yves Gueugniaud, Joel Coste, Alain Cariou, Laurent Argaud
Summary: The BDCA score allows early detection of patients with a high probability of experiencing BD, which may help increase organ donation after OHCA.
Review
Medicine, Research & Experimental
Samantha Fernandez Hernandez, Brooke Barlow, Vera Pertsovskaya, Carolina B. Maciel
Summary: Cardiac arrest (CA) is a critical public health issue with a significant impact on American population. Temperature control is currently the only evidence-based intervention for hypoxic-ischemic brain injury (HIBI), the main determinant of outcome after CA. However, conflicting evidence and complications challenge its implementation across diverse CA survivor population. Future clinical trials are needed to address knowledge gaps and evaluate different temperature targets and methods.
ADVANCES IN THERAPY
(2023)
Article
Medicine, General & Internal
Chukwuemeka Umeh, Rakesh C. Gupta, Rahul Gupta, Harpreet Kaur, Shadi Kazourra, Stella Maguwudze, Adrian Torbela, Shipra Saigal
Summary: Acetone is a naturally occurring chemical in the environment, but poisoning can occur through contact with products containing acetone. Acetone toxicity affects nearly all body systems and can cause serious health problems, including cardiac arrest and multi-organ dysfunction.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maria Tsivilika, Dimitrios Kavvadas, Sofia Karachrysafi, Katerina Kotzampassi, Vasilis Grosomanidis, Eleni Doumaki, Soultana Meditskou, Antonia Sioga, Theodora Papamitsou
Summary: This study investigates the potential kidney injuries and damages caused by cardiac arrest. The results indicate that the kidneys suffer severe damages after cardiac arrest, but acute kidney injury is not the leading cause of death in such cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Clinical Neurology
Steven Galetta
Summary: The study shows that early absence of epileptiform activity, continuous background amplitude with reactivity, and later stimulus-induced rhythmic periodic or ictal discharges (SIRPIDs) strongly predict favorable long-term outcomes in patients after cardiac arrest. While SIRPIDs may indicate brain reactivity, they are not associated with cerebral hyperperfusion, and therefore do not require aggressive treatment in later stages.
Article
Critical Care Medicine
Jenny A. Shih, Hannah K. Robertson, Mahmoud S. Issa, Anne V. Grossestreuer, Michael W. Donnino, Katherine M. Berg, Ari Moskowitz
Summary: This single-center retrospective study of adult patients admitted to the hospital between 2014-2018 who suffered an IHCA found that almost 72% of patients developed ARDS within 3 days of ROSC. While ARDS patients had fewer alive-and-ventilator free days in unadjusted analysis, this association was not significant after multivariate adjustment. There was also no significant difference in hospital mortality and length of stay between ARDS and non-ARDS groups.
Article
Cardiac & Cardiovascular Systems
Maryam Y. Naim, Heather M. Griffis, Robert A. Berg, Richard N. Bradley, Rita V. Burke, David Markenson, Bryan F. McNally, Vinay M. Nadkarni, Lihai Song, Kimberly Vellano, Victoria Vetter, Joseph W. Rossano
Summary: The study found that RB-CPR was associated with improved neurologically favorable survival compared with CO-CPR in pediatric OHCA, supporting current guidelines recommending RB-CPR as the preferred CPR modality for pediatric OHCA.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
