Article
Clinical Neurology
Qing-Zhang Tuo, Shashank Masaldan, Adam Southon, Celeste Mawal, Scott Ayton, Ashley Bush, Peng Lei, Abdel Ali Belaidi
Summary: The emergence of ferroptosis as a cell death pathway associated with brain disorders highlights the importance of developing therapeutics targeting the brain and protecting neurons. Selenium compounds have shown to be effective in inhibiting ferroptosis, with organic selenium compounds like methylselenocysteine providing protection against neuronal damage in ischemia-reperfusion injury in vivo. This suggests the potential use of ferroptosis inhibitors and specific selenium compounds in preventing neuronal damage in ischemic stroke and other related brain diseases.
Article
Biochemistry & Molecular Biology
Erick Bahena Culhuac, Mona M. M. Y. Elghandour, Moyosore J. Adegbeye, Alberto Barbabosa-Pliego, Abdelfattah Z. M. Salem
Summary: This review analyzed the effect of dietary selenium on oxidative stress in horses by considering past and recent bibliographic sources. The findings suggest that selenium, as an important antioxidant, can regulate oxidative stress in horses when the body is under stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Chemistry, Applied
Damiano Tanini, Antonella Capperucci
Summary: The synthesis and study of organoselenium compounds have received extensive attention, with selenium-containing organic molecules being widely used in organic synthesis, materials science, and medicinal chemistry. Selenols are a versatile class of molecules that easily undergo various transformations and play important roles in chemical sciences.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Medicine, Research & Experimental
Shaobo Wang, Yin Chen, Songling Hang, Yong Liu, Jining Gao, Yinghui Huang, Wei Sun, Junping Wang, Cheng Wang, Jinghong Zhao
Summary: This study demonstrates an effective therapeutic option by using Se@BSA nanoparticles to treat IRI-induced AKI. By correcting selenium deficiency and inhibiting inflammatory responses, Se@BSA nanoparticles show promising results in mitigating AKI and preventing fibrosis formation.
Article
Chemistry, Inorganic & Nuclear
Kaustav Banerjee, Debojit Bhattacherjee, Sulendar K. Mahato, Abu Sufian, Krishna Pada Bhabak
Summary: The synthesis and antioxidant activities of three new classes of ionic organoselenium compounds with cationic benzimidazolium and imidazolium ring systems containing selenocyanates as counterions were described. Mechanistic studies showed the feasibility of cyclization processes in the presence of potassium selenocyanate (KSeCN). The cyclic selenazolium and selenazinium compounds exhibited significantly higher antioxidant activities than the corresponding acyclic selenocyanates, possibly due to their cationic nature which may target and scavenge mitochondrial ROS in the cellular medium.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Kamil Demircan, Qian Sun, Ylva Bengtsson, Petra Seemann, Johan Vallon-Christersson, Martin Malmberg, Lao H. Saal, Lisa Ryd, Waldemar B. Minich, Ake Borg, Jonas Manjer, Lutz Schomburg
Summary: The presence of SELENOP autoantibodies in breast cancer patients is associated with poor prognosis, particularly in patients with low selenium levels. These autoantibodies may disrupt the transport function of SELENOP, leading to an increased risk of recurrence and mortality.
Article
Agriculture, Dairy & Animal Science
Zhenxin Wang, Linglian Kong, Lixian Zhu, Xiyi Hu, Pengcheng Su, Zhigang Song
Summary: The study found that adding L-SM had a positive impact on the hatchability of breeder eggs and the selenium content in embryos, and it effectively improved the antioxidant enzyme activity of 1-day-old chicks.
Article
Biochemistry & Molecular Biology
Lingyu Xie, Yibin Xu, Xiaoqing Ding, Kaixuan Li, Shuang Liang, Danlei Li, Yongxia Wang, Aikun Fu, Weixiang Yu, Xiuan Zhan
Summary: Selenomethionine supplements in broiler breeders have higher deposition in eggs, reduce embryo mortality, and exhibit stronger antioxidative abilities in offspring compared to sodium selenite. This study aims to investigate the antioxidant activities and mechanisms of selenomethionine and sodium selenite on a chicken hepatocellular carcinoma cell line. Results showed that selenomethionine has better protective effects and antioxidant abilities than sodium selenite, and it activates the Nrf2 pathway and enhances the activities of major antioxidant enzymes.
Article
Cell Biology
Xin Liu, Junqiang Zhang, Wang Xie
Summary: This review summarizes the recent discoveries on the role of ferroptosis in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) to provide new strategies for its prevention and treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Fisheries
Aliakbar Ghaffarizadeh, Ebrahim Sotoudeh, Mansour Torfi Mozanzadeh, Ali Mohammad Sanati, Ahmad Ghasemi
Summary: This study examined the effects of dietary selenium nanoparticles (Se-N) on the performance of whiteleg shrimp juveniles. The results showed that supplementing the diet with Se-N improved the growth performance and feed conversion ratio of the shrimp. Increasing levels of Se-N in the diet also led to higher selenium levels in the shrimp's body. Additionally, Se-N supplementation increased the activities of certain enzymes and reduced oxidative stress in the shrimp.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Laura G. Sherlock, William C. McCarthy, Maya R. Grayck, Mack Solar, Andres Hernandez, Lijun Zheng, Cassidy Delaney, Trent E. Tipple, Clyde J. Wright, Eva S. Nozik
Summary: Exposure to selenium deficiency during pregnancy and lactation can impair weight gain and lung growth in offspring. Selenium deficiency reduces the levels and activity of multiple selenoproteins in the neonatal lung, affecting oxidative stress and cell signaling.
Review
Food Science & Technology
Frineth de la Luz Limon Aguilera, Sayra N. Serrano Sandoval, Mauricio Graciano-Palacios, Janet A. Gutierrez-Uribe, Anayansi Escalante-Aburto
Summary: Selenium in its organic form plays a crucial role in human metabolism, functioning as an antioxidant and reducing inflammatory biomarkers associated with overweight and obesity. Studies suggest that selenocompounds may have potential therapeutic effects for obesity. Various strategies have been developed worldwide to produce selenium-enriched foods and supplements, aiming to increase accessibility for consumers.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Yu Ah Hong, Cheol Whee Park
Summary: Reactive oxygen and nitrogen species play crucial roles in kidney injuries, making antioxidant agents, especially catalytic antioxidants that mimic antioxidant enzymes, effective in combating oxidative stress-related kidney diseases. Research has shown the effectiveness of several catalytic antioxidants in treating disease models associated with oxidative stress.
Article
Chemistry, Applied
Antonella Capperucci, Alessandra Petrucci, Cristina Faggi, Damiano Tanini
Summary: Selenols react with isocyanates to generate selenocarbamates in good yield under mild conditions, showing high selectivity over competing nucleophilic additions. The selenocarbamates exhibited thiol-peroxidase-like properties, enabling the reduction of hydrogen peroxide at the expense of thiols.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Surgery
Jae Seok Bae, Dong Ho Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Haeryoung Kim, Kyung Bun Lee, Yunhee Choi
Summary: This study compared the performances of MRE and TE in predicting severe complications after liver resection in HCC patients. The results showed that MRE had better predictive accuracy than TE for high comprehensive complication index (CCI) and diagnosing liver fibrosis. MRE measurement of liver stiffness was independently associated with high CCI after liver resection.
Article
Surgery
Hyeong Seok Kim, Youngmin Han, Jae Seung Kang, Yoo Jin Choi, Yoonhyeong Byun, Haeryoung Kim, Kyung Bun Lee, Hongbeom Kim, Wooil Kwon, Jin-Young Jang
Summary: This study evaluated the factors and prognosis of patients with intraductal papillary mucinous neoplasms (IPMN) after surgical resection. It found that invasive IPMN had a higher risk of recurrence and worse survival compared to low-grade dysplasia (LGD) and high-grade dysplasia (HGD). This suggests the need for more effective postoperative treatment strategies for invasive IPMN, and regular follow-up for recurrence in LGD and HGD patients after 5 years. Additionally, achieving negative or LGD margins is important to improve outcomes.
Article
Gastroenterology & Hepatology
Jae Seung Kang, Kyoung Bun Lee, Yoo Jin Choi, Yoonhyeong Byun, Youngmin Han, Hongbeom Kim, Wooil Kwon, Jin-Young Jang
Summary: Intracholecystic papillary neoplasm (ICPN) of the gallbladder is an exophytic intraepithelial neoplasm. Patients with ICPN were more likely to undergo resection at an earlier T stage. However, prognosis and recurrence rates were comparable to conventional gallbladder adenocarcinoma (GBC) after stage-matching analysis. Therefore, treatment strategies should follow the same protocols for both ICPN and GBC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sae-Jin Park, Jung Hoon Kim, Ijin Joo, Kyoung Bun Lee, Joon Koo Han
Summary: The study found that EPNI and TRG may be important factors affecting RFS and OS in patients with pancreatic ductal adenocarcinoma who underwent surgery after neoadjuvant FOLFIRINOX. EPNI and TRG were identified as significant predictors of early recurrence and overall survival, indicating their prognostic value in this context.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Ho Lee, Eun Sun Lee, Jae Seok Bae, Jae Young Lee, Joon Koo Han, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Haeryoung Kim, Kyung Bun Lee, Byung Ihn Choi
Summary: Liver stiffness measured by 2D-SWE is a significant predictive factor for severe complications, and 2D-SWE has a significantly better diagnostic performance than TE in detecting liver fibrosis and severe complications.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Youngmin Han, Jin-Young Jang, Moon Young Oh, Hyeong Seok Kim, Yoonhyeong Byun, Jae Seung Kang, Se Hyung Kim, Kyoung-Bun Lee, Hongbeom Kim, Wooil Kwon
Summary: This study investigated the natural history of IPMN and proposed optimal treatment strategies based on malignancy risk prediction using a nomogram and decision model. Main duct and mixed-type IPMN have a high risk of malignancy (79.9%) and surgery is recommended, while branch duct IPMN is very indolent (5.9%) and surveillance may be appropriate. Decision-making regarding surgery or surveillance should consider patients' health status, malignancy risk, and institutional experience.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Hee Yoon, Jeong Min Lee, Mi Hye Yu, Bo Yun Hur, Robert Grimm, Steven Sourbron, Hersh Chandarana, Yohan Son, Susmita Basak, Kyoung-Bun Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: The study demonstrates that liver MRI using GRASP technique can provide sufficient spatial resolution for confident diagnosis and high temporal resolution for pharmacokinetic modeling. Significant differences in MRI-derived portal blood flow were found at different hepatic fibrosis stages.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sun Kyung Jeon, Jeong Min Lee, Eun Sun Lee, Mi Hye Yu, Ijin Joo, Jeong Hee Yoon, Jin-Young Jang, Kyoung Bun Lee, Sang Hyup Lee
Summary: This study found that R0 resection rates in patients with pancreatic cancer after neoadjuvant chemoradiotherapy were closely related to post-CRT CT resectability categorization, with different influencing factors for different types of cancer.
EUROPEAN RADIOLOGY
(2022)
Article
Critical Care Medicine
Eui Jun Lee, Bongjin Lee, You Sun Kim, Yu Hyeon Choi, Young Ho Kwak, June Dong Park
Summary: This study aimed to identify the factors that contribute to the differences in mortality rates predicted by PIM 3 and PELOD-2 tools. The results showed that oxygen saturation, partial pressure of CO2, base excess, platelet counts, and blood urea nitrogen levels were significant factors. Factors related to patient condition were also significantly associated with the prediction results.
ACUTE AND CRITICAL CARE
(2022)
Article
Emergency Medicine
Bongjin Lee, June Dong Park, Young Ho Kwak, Do Kyun Kim
Summary: This study analyzed the clinical significance of heart rate (HR) or respiratory rate (RR) higher than normal in pediatric triage, finding that deviations above normal are related to increased risks of hospitalization and ICU admission, while deviations below normal may not have the same association, with hospitalization rate decreasing and ICU admission rate increasing.
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Byuk Sung Ko, Sanghoon Jeon, Donghee Son, Sung-Hyuk Choi, Tae Gun Shin, You Hwan Jo, Seung Mok Ryoo, Youn-Jung Kim, Yoo Seok Park, Woon Yong Kwon, Gil Joon Suh, Tae Ho Lim, Won Young Kim
Summary: A machine learning model for predicting the risk of septic shock in advanced cancer patients has been proposed and compared with existing scoring systems. The results showed that the machine learning model outperformed the existing scores and could be an important tool for clinicians in determining appropriate levels of care for patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Emergency Medicine
Gil Joon Suh, Tae Gun Shin, Woon Yong Kwon, Kyuseok Kim, You Hwan Jo, Sung-Hyuk Choi, Sung Phil Chung, orean Shock Soc Investigators
Summary: This review focuses on the recent updates in the hemodynamic management of septic shock, emphasizing the importance of personalized management and proposing monitoring and intervention strategies according to different phases of shock.
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE
(2023)
Review
Clinical Neurology
Young Ho Kwak
Summary: Abusive head trauma (AHT) is the most severe form of physical abuse in children, causing devastating medical, social, and financial burdens. Early recognition and diagnosis of AHT are crucial for preventing further harm.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2022)
Article
Medicine, General & Internal
Yun-Suk Pak, Young Sun Ro, Se-Hyung Kim, So-Hyun Han, Sung-Keun Ko, Taehui Kim, Young Ho Kwak, Tag Heo, Sungwoo Moon
Summary: This study investigated the impact of emergency care-related health policies during the COVID-19 pandemic in Korea on the safety of patients visiting emergency departments. The findings suggest that implementing appropriate policies contributed to a reduction in in-hospital mortality among emergency patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Dong Hyun Choi, Jae Yun Jung, Dongbum Suh, Jea Yeon Choi, Se Uk Lee, Yoo Jin Choi, Young Ho Kwak, Do Kyun Kim
Summary: During the COVID-19 outbreak, there was a significant decrease in pediatric ED visits, which was associated with the stringency of government policies. The number of children visiting the ED decreased, but the proportion of admissions increased; exploring the changes in the number and characteristics of children visiting the ED can facilitate the effective operation of EDs.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)