Article
Pharmacology & Pharmacy
Shreen D. Nusair, Bayan Abandah, Qusai Y. Al-Share, Luay Abu-Qatouseh, Mohammad I. A. Ahmad
Summary: This study investigated the acute toxicity of Orellanine (OR) in human renal tubular cells and identified the IC50 of OR in other cells. Genes related to OR toxicity were identified using PCR and Western blotting, and the mechanism of OR toxicity was found to involve multiple pathways. These findings provide a theoretical basis for future treatment of mushroom poisoning.
Article
Pharmacology & Pharmacy
Jeremy Lecot, Morgane Cellier, Arnaud Courtois, Dominique Vodovar, Gael Le Roux, Anne Landreau, Magali Labadie, Chloe Bruneau, Alexis Descatha
Summary: This study summarizes 204 cases of amatoxin toxicity reported to two French Poison Centers from 2013 through 2019. The findings indicate that over one-third of patients developed acute renal injury, nine patients died, and five patients received a liver transplant.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Haijiao Li, Hongshun Zhang, Yizhe Zhang, Jing Zhou, Yu Yin, Qian He, Shaofeng Jiang, Peibin Ma, Yutao Zhang, Ke Wen, Yuan Yuan, Nan Lang, Bowen Cheng, Junjia Lu, Chengye Sun
Summary: This report provides an overview of mushroom poisonings in China, highlighting newly discovered toxic mushroom species and the different types of poisoning they can cause. It emphasizes the importance of promoting knowledge about safe consumption of mushrooms and the risks associated with consuming wild mushrooms, especially in southwestern provinces like Yunnan.
Article
Agriculture, Multidisciplinary
Chenggang Song, Mingyue Wu, Yanxin Zhang, Jie Li, Jian Yang, Dongsheng Wei, He Li, Lanping Guo, Jianchun Qin
Summary: Two new polyketides and a new natural product, along with 13 known compounds, were isolated from the edible mushroom Cortinarius purpurascens. These compounds exhibited excellent inhibition effects on glutamate dehydrogenase and significant antioxidant activities. Cortinarius caerulescens could be a novel resource for food selection and drug discovery.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Public, Environmental & Occupational Health
Haijiao Li, Yizhe Zhang, Hongshun Zhang, Jing Zhou, Jiaqi Liang, Yu Yin, Qian He, Shaofeng Jiang, Yutao Zhang, Yuan Yuan, Nan Lang, Bowen Cheng, Mei Wang, Chengye Sun
Summary: This report reveals the situation of mushroom poisoning incidents in China. In 2022, China CDC investigated 482 incidents across 21 provincial-level administrative divisions, resulting in 1,332 patients and 28 deaths with a case fatality rate of 2.1%. In addition, seven different clinical types of diseases and 13 different poisonous mushroom species were identified.
Review
Plant Sciences
Mark J. J. Lyons, Carsten Ehrhardt, John J. J. Walsh
Summary: Fungal metabolites, such as orellanine found in mushrooms, have potential as novel anticancer drugs. This review focuses on orellanine's historical significance, structural features, toxicomechanics, chromatographic analysis, synthesis, and chemotherapeutic potential. The toxicity mechanisms of orellanine in kidney tissue are still disputed, and its chromatographic analysis and biological evaluation face challenges. Despite these obstacles, orellanine has shown promising data in preclinical studies for metastatic clear cell renal cell carcinoma, leading to phase I/II trials in humans.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Food Science & Technology
Lili Chen, Liang Sun, Ronghua Zhang, Ningbo Liao, Xiaojuan Qi, Jiang Chen, Ting Liu
Summary: This study focused on the characteristics of wild mushroom poisoning in Zhejiang province, China, with 429 reported cases from 2016 to 2018. The incidence rate was 0.2526% and the case fatality rate was 0.47%. Digestive symptoms were universal, and the peak period of poisoning was from June to October annually. High-incidence areas were identified in Quzhou and Lishui, both with mild climate, more mountains, and abundant rainfall, showing a state of high-incidence aggregation.
FOOD SCIENCE & NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Chun-Feng Yang, Zhen Zhang, Xiao-Yan Zhang, Yu-Mei Li
Summary: Pediatric acute liver failure due to mushroom poisoning is rare and life-threatening, with plasma exchange and double plasma molecular adsorption system being potential treatment options, and their combination may be more effective.
ANNALS OF HEPATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jianyu Zhu, Leina Dou, Shibei Shao, Jiaqian Kou, Xuezhi Yu, Kai Wen, Zhanhui Wang, Wenbo Yu
Summary: A highly sensitive and automated magnetic bead (MB)-based chemiluminescence immunoassay (CLIA) was established for the early, rapid diagnosis of mushroom poisoning. This method showed high sensitivity, repeatability, and stability, making it a promising option for clinical diagnosis.
FRONTIERS IN CHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Behzad Karami Matin, Mohammad Amrollahi-Sharifabadi, Satar Rezaei, Afshar Heidari, Ali Kazemi-Karyani
Summary: This study investigated the epidemiology and estimated the costs of poisoning with cyclopeptide-containing mushrooms in Kermanshah province in 2018. The study found a significant financial burden on patients, the health system, and society as a whole due to the consumption of cyclopeptide-containing mushrooms.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Laura La Rosa, Serafina Corrias, Iginio Pintor, Sofia Cosentino
Summary: This study investigates the epidemiology and management of mushroom poisoning in Sardinia, focusing on the data of mushroom poisoning cases, including clinical presentation, seasonality, and the most common species involved. A total of 164 cases were identified, with peaks in autumn. The study highlights the importance of correct and rapid recognition of mushroom poisoning for patient prognosis. It also emphasizes the need for increased public awareness of the potential dangers of mushroom poisoning.
FOOD SCIENCE & NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Shreen D. Nusair, Esraa A. Zainalabdeen, Osama Y. Alshogran, Almuthanna Alkaraki
Summary: Mushroom poisoning is a global public health problem that can have serious toxic consequences on renal functions. This study found that parsley extract can ameliorate the acute toxicity of orellanine in rat kidneys, suggesting its potential as an adjunct therapy for toxicity-induced renal injury.
Article
Food Science & Technology
Boyuan Wang
Summary: This study addresses the classification and food safety issues of mushrooms using deep learning methods. A novel neural network model is proposed, and data augmentation techniques are employed to reduce the risk of overfitting. The results show that the proposed model achieves good performance in mushroom classification.
JOURNAL OF FOOD QUALITY
(2022)
Article
Toxicology
Yanguo Gao, Hongqiao Zhang, Hua Zhong, Suosuo Yang, Qiuyan Wang
Summary: This study retrospectively analyzed patients with acute mushroom poisoning and liver damage, showing that lactate and blood ammonia levels at admission can predict the prognosis of patients.
TOXICOLOGY RESEARCH
(2021)
Review
Public, Environmental & Occupational Health
James H. Diaz
Summary: The global epidemiology of nephrotoxic mushroom poisonings is increasing, with Cortinarius species being the most common cause of acute renal insufficiency and failure. New species of nephrotoxic mushrooms have been identified, such as Amanita proxima and Tricholoma equestre in Europe, and Amanita smithiana in the United States and Canada. Renal replacement therapies, including hemodialysis, are often used in managing nephrotoxic mushroom poisonings, with renal transplantation reserved for cases of extracorporeal treatment failures.
WILDERNESS & ENVIRONMENTAL MEDICINE
(2021)