Letter
Gastroenterology & Hepatology
Jian Zhao, Kun Huang, Bowen Hu
Summary: This article is linked to Li et al papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Darrick K. Li, Loren Laine
Summary: This article is linked to Li et al. papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Khanh Ha, Xiaoxin Zheng, Chase W. Kessinger, Adam Mauskapf, Wenzhu Li, Yoichiro Kawamura, Makoto Orii, Scott A. Hilderbrand, Farouc A. Jaffer, Jason R. McCarthy
Summary: The study developed a near-infrared fluorescence probe based on tirofiban, which can rapidly and accurately visualize activated platelets in vivo, offering a potential new application for clinical diagnosis.
Article
Multidisciplinary Sciences
Narmeen Mallah, Maruxa Zapata-Cachafeiro, Carmelo Aguirre, Eguzkine Ibarra-Garcia, Itziar Palacios-Zabalza, Fernando Macias Garcia, Julio Iglesias Garcia, Maria Pineiro-Lamas, Luisa Ibanez, Xavier Vidal, Lourdes Vendrell, Luis Martin-Arias, Maria Sainz Gil, Veronica Velasco-Gonzalez, Angel Salgado-Barreira, Adolfo Figueiras
Summary: This study found that NSAID users carrying the e-NOS intron 4 wild type genotype or VNTR polymorphism have higher odds of upper gastrointestinal hemorrhage (UGIH), with similar results for aspirin exposure. However, non-aspirin NSAID users carrying the e-NOS intron 4 VNTR polymorphism have lower odds of UGIH, although the interaction estimates are not statistically significant. The odds of UGIH in NSAID or aspirin users do not modify according to patient's e-NOS intron 4 genotype, as suggested by this exploratory study.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Pharmacology & Pharmacy
Qing-Fan Lin, Jing-Hong Rao, Shi-Mu Luo, Qing-Mu Wang, Li-Feng Deng, Xuan Chen, Chang-Di Chen, You-Fang Chen
Summary: This study found that gene polymorphisms of eNOS were associated with the development of PAH in newborns with CHD in South Fujian. Specifically, the GT/TT genotype of eNOS rs1799983 was associated with a higher risk of PAH, and this may be due to decreased nitric oxide production.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Loren Laine, Ernst J. Kuipers, Alan N. Barkun
Summary: Personalized management strategies should be based on patient characteristics, nature of bleeding lesions, and clinical setting, including available resources.
Article
Pharmacology & Pharmacy
Marcela Forgerini, Gustavo Urbano, Tales Rubens de Nadai, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Patricia de Carvalho Mastroianni
Summary: The study found that genetic variants rs10306114 in PTGS1 and rs2070744 in NOS3 were associated with an increased risk of upper gastrointestinal bleeding. The presence of these genetic variants may modify the risk of upper gastrointestinal bleeding in low-dose aspirin and nonsteroidal anti-inflammatory drugs users.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Marwa M. M. Refaie, Maram El-Hussieny, Sayed Shehata, Nermeen N. Welson, Walaa Yehia Abdelzaher
Summary: This study found that nicorandil can alleviate MTX-induced hepatotoxicity and protect the liver by modulating the functions of the K-ATP channel, eNOS, and P-glycoprotein.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Review
Genetics & Heredity
Marcela Forgerini, Rosa Camila Lucchetta, Gustavo Urbano, Tales Rubens de Nadai, Patricia de Carvalho Mastroianni
Summary: Non-variceal upper gastrointestinal bleeding is a common and severe adverse drug reaction that may be associated with genetic polymorphisms. Further well-designed studies are needed to confirm this association and provide strong evidence for personalized medicine.
PHARMACOGENOMICS JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Meina Lv, Xiaochun Zheng, Tingting Wu, Wenjun Chen, Shaojun Jiang, Hongqin Zhang, Fangda Xu, Jinhua Zhang
Summary: An established score named (ABC)(2)D was developed to predict the risk of gastrointestinal bleeding, incorporating seven risk factors. The (ABC)(2)D score outperformed the CRUSADE score in predicting acute gastrointestinal bleeding risk. This new risk-scoring model may help identify patients at significant risk of gastrointestinal bleeding.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Krzysztof Myrda, Mariusz Gasior, Dariusz Dudek, Bartlomiej Nawrotek, Jacek Niedziela, Wojciech Wojakowski, Marek Gierlotka, Marek Grygier, Janina Stepinska, Adam Witkowski, Maciej Lesiak, Jacek Legutko
Summary: The study revealed that the use of GPIs in patients with MI complicated by CS can reduce the mortality rate during the 12-month follow-up period without increasing in-hospital adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Plant Sciences
Kh Ahammad Uz Zaman, Jae Hyeon Park, Lela DeVine, Zhenquan Hu, Xiaohua Wu, Hyung Sik Kim, Shugeng Cao
Summary: New compounds were isolated from the fungus Xylaria sp. FM1005, collected from leather coral in the offshore region of the Big Island, Hawaii. Compounds 1 and 2 showed antiplatelet activity and were not cytotoxic to A2780 and HEK 293 cells.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Gastroenterology & Hepatology
Elena Piazuelo, Paula Esquivias, Alba De Martino, Carmelo Cebrian, Blanca Conde, Sonia Santander, Sonia Emperador, Maria Asuncion Garcia-Gonzalez, Patricia Carrera-Lasfuentes, Angel Lanas
DIGESTIVE DISEASES AND SCIENCES
(2016)
Article
Pharmacology & Pharmacy
Eduardo Chueca, Nadezda Apostolova, Juan V. Esplugues, Maria A. Garcia-Gonzalez, Angel Lanas, Elena Piazuelo
FRONTIERS IN PHARMACOLOGY
(2016)
Meeting Abstract
Gastroenterology & Hepatology
Carla Gargallo, Angel Lanas, Patricia Carrera, Angel Ferrandez, Enrique Quintero, Marta Carrillo-Palau, Inmaculada Alonso-Abreu, Pilar Roncales, Maria Asuncion Garcia Gonzalez
Article
Oncology
Patricia Carrera-Lasfuentes, Angel Lanas, Luis Bujanda, Mark Strunk, Enrique Quintero, Santos Santolaria, Rafael Benito, Federico Sopena, Elena Piazuelo, Concha Thomson, Angeles Perez-Aisa, David Nicolas-Perez, Elizabeth Hijona, Jesus Espinel, Rafael Campo, Marisa Manzano, Fernando Geijo, Maria Pellise, Manuel Zaballa, Ferran Gonzalez-Huix, Jorge Espinos, Llucia Tito, Luis Barranco, Mauro D'Amato, Maria Asuncion Garcia-Gonzalez
Article
Pharmacology & Pharmacy
Pilar Jimenez, Eduardo Chueca, Maira Arruebo, Mark Strunk, Estela Solanas, Trinidad Serrano, Maria A. Garcia-Gonzalez, Angel Lanas
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Oncology
Carla J. Gargallo, Angel Lanas, Patricia Carrera-Lasfuentes, Angel Ferrandez, Enrique Quintero, Marta Carrillo, Inmaculada Alonso-Abreu, Maria Asuncion Garcia-Gonzalez
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
Sophie K. M. Heinrichs, Timo Hess, Jessica Becker, Lutz Hamann, Yogesh K. Vashist, Katja Butterbach, Thomas Schmidt, Hakan Alakus, Iurii Krasniuk, Aksana Hoeblinger, Philipp Lingohr, Monika Ludwig, Alexander F. Hagel, Claus W. Schildberg, Lothar Veits, Ugne Gyvyte, Katharina Weise, Vitalia Schueller, Anne C. Boehmer, Julia Schroeder, Jan Gehlen, Nicole Kreuser, Sebastian Hofer, Hauke Lang, Florian Lordick, Peter Malfertheiner, Markus Moehler, Oliver Pech, Nikolaos Vassos, Ernst Rodermann, Jakob R. Izbicki, Martin Kruschewski, Katja Ott, Ralf R. Schumann, Michael Vieth, Elisabeth Mangold, Evita Gasenko, Limas Kupcinskas, Hermann Brenner, Peter Grimminger, Luis Bujanda, Federico Sopena, Jesus Espinel, Concha Thomson, Angeles Perez-Aisa, Rafael Campo, Fernando Geijo, Daniela Collette, Christiane Bruns, Katharina Messerle, Ines Gockel, Markus M. Noethen, Hans Lippert, Karsten Ridwelski, Angel Lanas, Gisela Keller, Michael Knapp, Marcis Leja, Juozas Kupcinskas, Maria A. Garcia-Gonzalez, Marino Venerito, Johannes Schumacher
Article
Pathology
E. Chueca, A. Valero, C. Hordnler, A. Puertas, P. Carrera, M. A. Garcia-Gonzalez, M. Strunk, A. Lanas, E. Piazuelo
ANNALS OF DIAGNOSTIC PATHOLOGY
(2020)
Article
Gastroenterology & Hepatology
Carla J. Gargallo-Puyuelo, Angel Lanas, Patricia Carrera-Lasfuentes, Angel Ferrandez, Enrique Quintero, Marta Carrillo, Inmaculada Alonso-Abreu, Maria Asuncion Garcia-Gonzalez
Summary: Epidemiological studies suggest that having a first-degree relative with colorectal cancer (CRC) increases the risk of developing the disease. This study found significant differences in genotype distribution of CRC risk-related SNPs between first-degree relatives of CRC patients and individuals with no family history of CRC. Genotyping of CRC risk variants in first-degree relatives of CRC patients could help identify individuals at risk who may benefit from increased surveillance and CRC screening programs.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Carla J. Gargallo-Puyuelo, Rocio Aznar-Gimeno, Patricia Carrera-Lasfuentes, Angel Lanas, Angel Ferrandez, Enrique Quintero, Marta Carrillo, Inmaculada Alonso-Abreu, Luis M. Esteban, Maria de la Vega Rodrigalvarez-Chamarro, Rafael del Hoyo-Alonso, Maria Asuncion Garcia-Gonzalez
Summary: In this study, the predictive value of genetic risk scores (GRS) in the development of colorectal adenomas (CRA) was explored in Spanish Caucasian patients. Significant associations were found between high GRS values and CRA risk, with patients having higher GRS values showing a 2.3-2.6-fold increase in risk compared to those with middle values. Combining sex and age with GRS significantly improved the discriminatory accuracy of the models, with the best model achieving an AUC value of 0.665. The behavior of GRS varied depending on sex and age, indicating its potential importance in CRC risk stratification and screening program adaptation.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Laura Grasa, Eduardo Chueca, Samantha Arechavaleta, Maria Asuncion Garcia-Gonzalez, Maria Angeles Saenz, Alberto Valero, Carlos Hordnler, Angel Lanas, Elena Piazuelo
Summary: This study evaluated the effects of MCT inhibition in esophageal adenocarcinoma (EAC) cells. The results showed that MCT1 and MCT4 expression varied in different cancer cell lines. Inhibiting MCT1 reduced cell proliferation and increased apoptosis, while MCT4 expression levels influenced intracellular pH and NHE-1 expression.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Timo Hess, Carlo Maj, Jan Gehlen, Oleg Borisov, Stephan L. Haas, Ines Gockel, Michael Vieth, Guillaume Piessen, Hakan Alakus, Yogesh Vashist, Carina Pereira, Michael Knapp, Vitalia Schueller, Alexander Quaas, Heike I. Grabsch, Jessica Trautmann, Ewa Malecka-Wojciesko, Anna Mokrowiecka, Jan Speller, Andreas Mayr, Julia Schroeder, Axel M. Hillmer, Dominik Heider, Florian Lordick, Angeles Perez-Aisa, Rafael Campo, Jesus Espinel, Fernando Geijo, Concha Thomson, Luis Bujanda, Federico Sopena, Angel Lanas, Maria Pellise, Claudia Pauligk, Thorsten Oliver Goetze, Carolin Zelck, Julian Reingruber, Emadeldin Hassanin, Peter Elbe, Sandra Alsabeah, Mats Lindblad, Magnus Nilsson, Nicole Kreuser, Rene Thieme, Francesca Tavano, Roberta Pastorino, Dario Arzani, Roberto Persiani, Jin-On Jung, Henrik Nienhueser, Katja Ott, Ralf R. Schumann, Oliver Kumpf, Susen Burock, Volker Arndt, Anna Jakubowska, Malgorzta Lawniczak, Justyna Dabrowska, Olivier Cussenot, Anne Boland-Auge, Delphine Daian, Jean-Francois Deleuze, Erika Salvi, Maris Teder-Laving, Gianluca Tomasello, Margherita Ratti, Chiara Senti, Valli De Re, Agostino Steffan, Arnulf H. Hoelscher, Katharina Messerle, Christiane Josephine Bruns, Armands Sivins, Inga Bogdanova, Jurgita Skieceviciene, Justina Arstikyte, Markus Moehler, Hauke Lang, Peter P. Grimminger, Martin Kruschewski, Nikolaos Vassos, Claus Schildberg, Philipp Lingohr, Karsten Ridwelski, Hans Lippert, Nadine Fricker, Peter Krawitz, Per Hoffmann, Markus M. Noethen, Lothar Veits, Jakob R. Izbicki, Adrianna Mostowska, Federico Martinon-Torres, Daniele Cusi, Rolf Adolfsson, Geraldine Cancel-Tassin, Aksana Hoeblinger, Ernst Rodermann, Monika Ludwig, Gisela Keller, Andres Metspalu, Hermann Brenner, Joerg Heller, Markus Neef, Michael Schepke, Franz Ludwig Dumoulin, Lutz Hamann, Renato Cannizzaro, Michele Ghidini, Dominik Plassmann, Michael Geppert, Peter Malfertheiner, Olivier Gehlen, Tomasz Skoczylas, Marek Majewski, Jan Lubinski, Orazio Palmieri, Stefania Boccia, Anna Latiano, Nuria Aragones, Thomas Schmidt, Mario Dinis-Ribeiro, Rui Medeiros, Salah-Eddin Al-Batran, Marcis Leja, Juozas Kupcinskas, Maria A. Garcia-Gonzalez, Marino Venerito, Johannes Schumachera
Summary: This study characterized the genetic risk architecture of gastric cancer (GC) and its subtypes, and found that GC is genetically heterogenous. It also revealed the shared genetic aetiology between cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO).
Meeting Abstract
Gastroenterology & Hepatology
Carla Jerusalen Gargallo-Puyuelo, Patricia Carrera, Angel Lanas, Angel Ferrandez, Enrique Quintero, Inmaculada Alonso-Abreu, Marta Carrillo-Palau, Maria Asuncion Garcia Gonzalez
Article
Pharmacology & Pharmacy
P. Patrignani, A. Sacco, C. Sostres, A. Bruno, M. Dovizio, E. Piazuelo, L. Di Francesco, A. Contursi, M. Zucchelli, S. Schiavone, S. Tacconelli, C. Patrono, A. Lanas
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2017)