Orthopaedic implant failure: aseptic implant loosening–the contribution and future challenges of mouse models in translational research

What experimental approaches (eg, in vivo, in vitro, tissue retrieval) are effective in investigating the biologic effects of particles?

(2016) Mathias Bostrom et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

How prevalent are implant wear and osteolysis, and how has the scope of osteolysis changed since 2000?

(2016) Amanda Marshall et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms

(2013) J. Gallo et al.   Acta Biomaterialia

More than 50% reduction of wear in polyethylene liners with alumina heads compared to cobalt-chrome heads in hip replacements

(2013) Jon Dahl et al.   Acta Orthopaedica

RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and α-CGRP deficiency

(2013) Max D. Kauther et al.   BIOMATERIALS

Adverse Local Tissue Reaction Associated With a Modular Hip Hemiarthroplasty

(2013) Michael R. Whitehouse et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Direct subcutaneous injection of polyethylene particles over the murine calvaria results in dramatic osteolysis

(2013) Allison J. Rao et al.   INTERNATIONAL ORTHOPAEDICS

Acetabular Components in Total Hip Arthroplasty: Is There Evidence That Cementless Fixation Is Better?

(2013) Nader Toossi et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Prevalence of Adverse Reactions to Metal Debris Following Metal-on-Metal THA

(2013) Masahiro Hasegawa et al.   ORTHOPEDICS

Metal Ion Concentrations in Body Fluids after Implantation of Hip Replacements with Metal-on-Metal Bearing – Systematic Review of Clinical and Epidemiological Studies

(2013) Albrecht Hartmann et al.   PLoS One

The clinical implications of elevated blood metal ion concentrations in asymptomatic patients with MoM hip resurfacings: a cohort study

(2013) David J Langton et al.   BMJ Open

A comparison of polyethylene wear between cobalt-chrome ball heads and alumina ball heads after total hip arthroplasty: a 10-year follow-up

(2013) ShiJun Wang et al.   Journal of Orthopaedic Surgery and Research

Extracellular Matrix Degradation and Tissue Remodeling in Periprosthetic Loosening and Osteolysis: Focus on Matrix Metalloproteinases, Their Endogenous Tissue Inhibitors, and the Proteasome

(2013) Spyros A. Syggelos et al.   Biomed Research International

Independent predictors of failure up to 7.5 years after 35 386 single-brand cementless total hip replacements

(2013) S. S. Jameson et al.   Bone & Joint Journal

Revision joint replacement, wear particles, and macrophage polarization

(2012) Allison J. Rao et al.   Acta Biomaterialia

Metal-on-metal hips: cobalt can induce an endotoxin-like response

(2012) Alison Jane Tyson-Capper et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of direct estrogen receptor signaling in wear particle-induced osteolysis

(2012) Christophe Nich et al.   BIOMATERIALS

Genetic susceptibility to aseptic loosening following total hip arthroplasty: a systematic review

(2012) A. Del Buono et al.   BRITISH MEDICAL BULLETIN

The 2012 John Charnley Award: Clinical Multicenter Studies of the Wear Performance of Highly Crosslinked Remelted Polyethylene in THA

(2012) Charles R. Bragdon et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Inhibitory Effect of Adenovirus-Mediated siRNA-Targeting BMPR-IB on UHMWPE-Induced Bone Destruction in the Murine Air Pouch Model

(2012) Yang Wang et al.   CONNECTIVE TISSUE RESEARCH

Inhibition of p38 Mitogen-Activated Protein Kinase Down-regulates the Inflammatory Osteolysis Response to Titanium Particles in a Murine Osteolysis Model

(2012) Desheng Chen et al.   INFLAMMATION

Is there evidence for accelerated polyethylene wear in uncemented compared to cemented acetabular components? A systematic review of the literature

(2012) Hugo C. van der Veen et al.   INTERNATIONAL ORTHOPAEDICS

Local effect of IL-4 delivery on polyethylene particle induced osteolysis in the murine calvarium

(2012) Allison J. Rao et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Pseudotumors in Association with Well-Functioning Metal-on-Metal Hip Prostheses

(2012) Alister J Hart et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Blockade of JNK and NFAT pathways attenuates orthopedic particle-stimulated osteoclastogenesis of human osteoclast precursors and murine calvarial osteolysis

(2012) Yasuhiro Yamanaka et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation

(2012) Lyndsey Burton et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Micromechanical characterisation of failure in acrylic bone cement: The effect of barium sulphate agglomerates

(2012) N. Shearwood-Porter et al.   Journal of the Mechanical Behavior of Biomedical Materials

Failure rates of metal-on-metal hip resurfacings: analysis of data from the National Joint Registry for England and Wales

(2012) Alison J Smith et al.   LANCET

Surgical options for hip OA: digging beneath the surface of implant survival

(2012) Sarah Onuora   Nature Reviews Rheumatology

Adverse reactions to metal-on-metal implants

(2012) Yrjö T. Konttinen et al.   Nature Reviews Rheumatology

Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells

(2011) Heon Goo Lee et al.   BIOMATERIALS

Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis

(2011) Max D Kauther et al.   BMC MUSCULOSKELETAL DISORDERS

Sensing disease and danger: A survey of vertebrate PRRs and their origins

(2011) John D. Hansen et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Vascular endothelial growth factor gene silencing suppresses wear debris-induced inflammation

(2011) Wei Zhang et al.   INTERNATIONAL ORTHOPAEDICS

Eleven- to 14-year Follow-up Results of Cementless Total Hip Arthroplasty Using a Third-generation Alumina Ceramic-on-ceramic Bearing

(2011) Nobuhiko Sugano et al.   JOURNAL OF ARTHROPLASTY

The Seven-Year Wear of Highly Cross-Linked Polyethylene in Total Hip Arthroplasty

(2011) Geraint E.R. Thomas et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Cross-linked versus conventional polyethylene for total hip replacement

(2011) P. R. T. Kuzyk et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles

(2011) Emmanuel Gibon et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Early Detection and Treatment of Wear Particle-Induced Inflammation and Bone Loss in a Mouse Calvarial Osteolysis Model Using HPMA Copolymer Conjugates

(2011) Ke Ren et al.   MOLECULAR PHARMACEUTICS

Oestrogen deficiency modulates particle-induced osteolysis

(2011) Christophe Nich et al.   ARTHRITIS RESEARCH & THERAPY

Distribution of polyethylene wear particles and bone fragments in periprosthetic tissue around total hip joint replacements

(2010) E. Zolotarevova et al.   Acta Biomaterialia

What Works Best, a Cemented or Cementless Primary Total Hip Arthroplasty?: Minimum 17-year Followup of a Randomized Controlled Trial

(2010) Kristoff Corten et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Continuous Infusion of UHMWPE Particles Induces Increased Bone Macrophages and Osteolysis

(2010) Pei-Gen Ren et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Severe osteolysis and soft tissue mass around total hip arthroplasty: Description of four cases and review of the literature with respect to clinico-radiographic and pathologic differential diagnosis

(2010) N. Fabbri et al.   EUROPEAN JOURNAL OF RADIOLOGY

The potential role of fibroblasts in periprosthetic osteolysis: Fibroblast response to titanium particles

(2010) Jianling Yao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Periprosthetic osteolysis: Characterizing the innate immune response to titanium wear-particles

(2010) Christine A. St. Pierre et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Pan-caspase inhibition suppresses polyethylene particle-induced osteolysis

(2009) Stefan Landgraeber et al.   APOPTOSIS

Future Young Patient Demand for Primary and Revision Joint Replacement: National Projections from 2010 to 2030

(2009) Steven M. Kurtz et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The Epidemiology of Bearing Surface Usage in Total Hip Arthroplasty in the United States

(2009) Kevin J Bozic et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis

(2009) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Investigation of relative micromotion at the stem—cement interface in total hip replacement

(2009) H-Y Zhang et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders

(2009) Masayuki Fukata et al.   SEMINARS IN IMMUNOLOGY

An in vivo murine model of continuous intramedullary infusion of polyethylene particles

(2008) Ting Ma et al.   BIOMATERIALS

A Systematic Comparison of the Actual, Potential, and Theoretical Health Effects of Cobalt and Chromium Exposures from Industry and Surgical Implants

(2008) Gemma M. Keegan et al.   CRITICAL REVIEWS IN TOXICOLOGY

Response of human osteoblasts exposed to wear particles generated at the interface of total hip stems and bone cement

(2008) Robert Lenz et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Continuous intramedullary polymer particle infusion using a murine femoral explant model

(2008) Steven G. Ortiz et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Successful Elbow Contracture Release Secondary to Melorheostosis

(2008) Hyun Sik Gong et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

(2008) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Tribology and total hip joint replacement: Current concepts in mechanical simulation

(2008) S. Affatato et al.   MEDICAL ENGINEERING & PHYSICS

Femoral stem wear in cemented total hip replacement

(2008) H-Y Zhang et al.   PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

The local inflammatory environment and microorganisms in “aseptic” loosening of hip prostheses

(2007) Caroline S. M. Hoenders et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Histomorphometric analysis of the intramedullary bone response to titanium particles in wild-type and IL-1R1 knock-out mice: A preliminary study

(2007) Bill Bragg et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Validation and quantification of anin vitro model of continuous infusion of submicron-sized particles

(2007) Steven G. Ortiz et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS