Journal
CLINICAL SCIENCE
Volume 124, Issue 5-6, Pages 351-370Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20120378
Keywords
diabetes; diabetic nephropathy; insulin; intracellular signalling; kidney; metabolic syndrome
Categories
Funding
- Kidney Research UK
- Medical Research Council
- Kidney Research UK [RP42/2010, RP22/2012] Funding Source: researchfish
- Medical Research Council [G0501901, MR/K010492/1] Funding Source: researchfish
- MRC [MR/K010492/1, G0501901] Funding Source: UKRI
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Ninety-one years ago insulin was discovered, which was one of the most important medical discoveries in the past century, transforming the lives of millions of diabetic patients. Initially insulin was considered only important for rapid control of blood glucose by its action on a restricted number of tissues; however, it has now become clear that this hormone controls an array of cellular processes in many different tissues. The present review will focus on the role of insulin in the kidney in health and disease.
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