Psoriasis: from pathogenesis to novel therapeutic approaches

Efalizumab

(2009) James E Frampton et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Ustekinumab: Treatment of Adult Moderate-to-Severe Chronic Plaque Psoriasis

(2009) James V Scanlon et al.   ANNALS OF PHARMACOTHERAPY

Golimumab, a new human tumor necrosis factor α antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: Twenty-four-week efficacy and safety results of a randomized, placebo-controlled study

(2009) Arthur Kavanaugh et al.   ARTHRITIS AND RHEUMATISM

Coeliac disease associated with psoriasis

(2009) S. Birkenfeld et al.   BRITISH JOURNAL OF DERMATOLOGY

Certolizumab pegol for the management of Crohn's disease in adults

(2009) Anastasia Rivkin   CLINICAL THERAPEUTICS

A new era in the management of psoriasis? The biologics: facts and controversies

(2009) Carlos Ferrándiz et al.   CLINICS IN DERMATOLOGY

How are TH1 and TH2 effector cells made?

(2009) Derk Amsen et al.   CURRENT OPINION IN IMMUNOLOGY

Long-term efficacy of biologics in dermatology

(2009) Leslie Castelo-Soccio et al.   Dermatologic Therapy

Long-term efficacy of biologics in the treatment of psoriasis: what do we really know?

(2009) Eihab A. Alwawi et al.   Dermatologic Therapy

Efficacy of Efalizumab in Psoriasis Patients Previously Treated with Tumour Necrosis Factor Blockers

(2009) A. Costanzo et al.   DERMATOLOGY

The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis

(2009) Kerstin Wolk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased expression of IL-12p70 and IL-23 by multiple dendritic cell and macrophage subsets in plaque psoriasis

(2009) Nikhil Yawalkar et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

IL-6 Signaling in Psoriasis Prevents Immune Suppression by Regulatory T Cells

(2009) W. A. Goodman et al.   JOURNAL OF IMMUNOLOGY

Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate the Pharmacologic Effect of CP-690,550 in Patients With Psoriasis

(2009) Mary G. Boy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis

(2009) Erin G. Harper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

(2009) Antonella Di Cesare et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

(2009) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines

(2009) Consuelo Ortega et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial

(2009) Alice Gottlieb et al.   LANCET

Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project

(2009) Kenneth R Carson et al.   LANCET ONCOLOGY

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

(2009) Rafael de Cid et al.   NATURE GENETICS

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

(2009) Roberta Caruso et al.   NATURE MEDICINE

Ustekinumab

(2009) Kristian Reich et al.   NATURE REVIEWS DRUG DISCOVERY

β-Defensin-2 Protein Is a Serum Biomarker for Disease Activity in Psoriasis and Reaches Biologically Relevant Concentrations in Lesional Skin

(2009) Patrick A. M. Jansen et al.   PLoS One

Psoriasis – as an autoimmune disease caused by molecular mimicry

(2009) Helgi Valdimarsson et al.   TRENDS IN IMMUNOLOGY

Certolizumab pegol in active rheumatoid arthritis

(2009) Aarat M. Patel et al.   Current Rheumatology Reports

Safety and Efficacy of ABT-874, a Fully Human Interleukin 12/23 Monoclonal Antibody, in the Treatment of Moderate to Severe Chronic Plaque Psoriasis

(2008) Alexa B. Kimball   ARCHIVES OF DERMATOLOGY

Antimicrobial peptides and self-DNA in autoimmune skin inflammation

(2008) Michel Gilliet et al.   CURRENT OPINION IN IMMUNOLOGY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

A polymer-type water-soluble peptidoglycan exhibited both Toll-like receptor 2- and NOD2-agonistic activities, resulting in synergistic activation of human monocytic cells

(2008) Mizuho Natsuka et al.   Innate Immunity

Dynamic frequency of CD4+CD25+Foxp3+ Treg cells in Psoriasis vulgaris

(2008) Ling Chen et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A multicenter, open‐label study of repeat courses of intramuscular alefacept in combination with other psoriasis therapies in patients with chronic plaque psoriasis

(2008) Gerald G. Krueger et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Human interleukin 17–producing cells originate from a CD161+CD4+T cell precursor

(2008) Lorenzo Cosmi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis

(2008) Chizuko Koga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis

(2008) Rajan P. Nair et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Resident and “Inflammatory” Dendritic Cells in Human Skin

(2008) Lisa C. Zaba et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

(2008) Craig L Leonardi et al.   LANCET

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

(2008) Kim A Papp et al.   LANCET

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

(2008) Giovanni Monteleone et al.   TRENDS IN IMMUNOLOGY

Fine Mapping of the Psoriasis Susceptibility Locus PSORS1 Supports HLA-C as the Susceptibility Gene in the Han Chinese Population

(2008) Xing Fan et al.   PLoS Genetics