Review
Biochemistry & Molecular Biology
Chao-Yi Wu, Huang-Yu Yang, Jing-Long Huang, Jenn-Haung Lai
Summary: Monocytes and macrophages play a crucial role in the pathogenesis of juvenile idiopathic arthritis (JIA), with their activation being linked to inflammation regulation and tissue repair mechanisms in the disease process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Alessandra Alongi, Gabriella Giancane, Roberta Naddei, Valentina Natoli, Francesca Ridella, Marco Burrone, Silvia Rosina, Gaelle Chedeville, Ekaterina Alexeeva, Gerd Horneff, Ivan Foeldvari, Giovanni Filocamo, Tamas Constantin, Nicolino Ruperto, Angelo Ravelli, Alessandro Consolaro
Summary: This study aimed to investigate the frequency of a global assessment of disease activity (PhGA) >0 and an active joint count (AJC)=0 in children with juvenile idiopathic arthritis (JIA) and search for determinants of divergence between the two measures. The study found that many pediatric rheumatologists did not mark a score of 0 for patients who they found not to have active joints, and the presence of pain in joints not meeting the definition of active joint used in JIA was the main determinant of this phenomenon.
Article
Rheumatology
Rosemary G. Peterson, Rui Xiao, Karen E. James, Hannah Katcoff, Brian T. Fisher, Pamela F. Weiss
Summary: The study found significant variation in the use of biologics and glucocorticoids in children hospitalized with new-onset systemic JIA, with noticeable differences between hospitals. Despite increasing evidence supporting the use of biologics for improved outcomes, many children did not receive biologic treatment and a high rate of glucocorticoid exposure persisted.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Medicine, General & Internal
William G. Ambler, Kabita Nanda, Karen Brandt Onel, Susan Shenoi
Summary: This review focuses on the treatment options and potential future therapeutics for systemic juvenile idiopathic arthritis (SJIA). Recent advancements in targeted therapies have improved patient outcomes, but there are still subsets of patients with refractory disease and severe complications.
ANNALS OF MEDICINE
(2022)
Article
Pediatrics
Tingyan He, Yu Xia, Ying Luo, Jun Yang
Summary: This study aimed to evaluate the efficacy and potential adverse effects of JAKi in patients with systemic juvenile idiopathic arthritis (SJIA). The results showed that JAKi may be an alternative or adjuvant agent for patients with persistently active disease, glucocorticoid-related adverse reactions, or SJIA-MAS.
FRONTIERS IN PEDIATRICS
(2023)
Article
Rheumatology
Stephane Mitrovic, Nolan Hassold, Aly Kamissoko, Nicolas Rosine, Alexis Mathian, Guillaume Mercy, Edouard Pertuiset, Gaetane Nocturne, Bruno Fautrel, Isabelle Kone-Paut
Summary: A retrospective national survey revealed features of SpA in patients with SJIA/AOSD, with a prevalence of 6.58% in AOSD patients and 10% in SJIA patients. This suggests a possible overlap between SpA and AOSD that requires further study.
Article
Pediatrics
Melike Mehves Kaplan, Tuba Kurt, Merve Cansu Polat, Muge Sezer, Zahide Ekici Tekin, Elif celikel, Vildan Gungorer, Niluefer Tekgoz, Cueneyt Karagol, Serkan Coskun, Nimet Oner, Banu Celikel Acar
Summary: The aim of this study was to assess the predictors of relapse in patients with oligoarticular juvenile idiopathic arthritis (oJIA) who achieved clinical remission off medication. A retrospective observational study was conducted on 126 patients who achieved remission off medication. The study found that the number of intraarticular corticosteroid injections (IACIs) and the length of follow-up were significantly related to relapse in oJIA patients who achieved remission off medication.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Miladi Saoussen, Makhlouf Yasmine, Boussaa Hiba, Fazaa Alia, Ben Abdelghani Kawther, Laatar Ahmed
Summary: Musculoskeletal ultrasound (MSUS) is an important tool in pediatric rheumatology for detecting subclinical disease activity and treating patients during the window of opportunity. However, its role in assessing remission in JIA patients is not well-defined. This systematic review analyzes published literature on MSUS in JIA patients in remission, finding that abnormal MSUS findings, such as subclinical synovitis and Power Doppler signal, are common even in remission. Further studies are needed to better understand the implications and develop a standardized scoring system.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Medicine, General & Internal
Charlotte Girard-Guyonvarc'h, Mathilde Harel, Cem Gabay
Summary: This review summarizes the role and importance of IL-18 and IL-18BP in AOSD and sJIA. It is found that the imbalance of IL-18/IL-18BP is associated with the occurrence of these diseases, and treatment with recombinant IL-18BP shows potential therapeutic effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Gabriella Giancane, Riccardo Papa, Sebastiaan Vastert, Francesca Bagnasco, Joost F. Swart, Pierre Quartier, Jordi Anton, Sylvia Kamphuis, Helga Sanner, Mia Glerup, Fabrizio De Benedetti, Elena Tsitsami, Agustin Remesal, Estefania Moreno, Jaime De Inocencio, Charlotte Myrup, Chiara Pallotti, Isabelle Kone-Paut, Karin Franck-Larsson, Hakan Malmstrom, Susanna Cederholm, Angela Pistorio, Nico Wulffraat, Nicolino Ruperto
Summary: This study evaluated the long-term safety profile of anakinra in patients with sJIA. The results showed an overall decreasing incidence of adverse events over time.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Immunology
Elizabeth A. A. Crinzi, Emma K. K. Haley, Kerry E. E. Poppenberg, Kaiyu Jiang, Vincent M. M. Tutino, James N. N. Jarvis
Summary: This study reveals the impact of genetic risk variants on immune functions in polyarticular/oligoarticular forms of juvenile idiopathic arthritis (JIA) by analyzing genomics data and epigenetic marks. By identifying the cells affected and the genes impacted by JIA risk variants, this study provides important insights into the pathogenesis of JIA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Alberto Martini, Daniel J. Lovell, Salvatore Albania, Hermine Brunner, Kimme L. Hyrich, Susan D. Thompson, Nicolino Ruperto
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic condition of childhood, classified into seven categories. The pathogenesis of JIA involves autoimmune and autoinflammatory mechanisms, and the availability of new drugs has significantly improved treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Pediatrics
Boris Huegle, Manuela Krumrey-Langkammerer, Johannes-Peter Haas
Summary: Flares can occur in patients with JIA in remission or inactive disease on medication after infection with SARS-CoV-2. Treating physicians need to be aware of this fact, especially when counseling patients with rheumatic diseases about the respective dangers of COVID-19 and vaccination against SARS-CoV-2.
PEDIATRIC RHEUMATOLOGY
(2021)
Review
Rheumatology
Claas H. Hinze, Dirk Foell, Christoph Kessel
Summary: Systemic juvenile idiopathic arthritis (sJIA) is a disease characterized by severe systemic inflammation and arthritis. It poses challenges to rheumatologists treating pediatric and adult patients worldwide. Although treatment plans exist for classic sJIA, there is still a lack of clear treatment approaches for early sJIA without arthritis and complicated sJIA.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Pediatrics
Jerold Jeyaratnam, Nienke M. ter Haar, Helen J. Lachmann, Ozgur Kasapcopur, Amanda K. Ombrello, Donato Rigante, Fatma Dedeoglu, Ezgi H. Baris, Sebastiaan J. Vastert, Nico M. Wulffraat, Joost Frenkel
PEDIATRIC RHEUMATOLOGY
(2018)
Article
Pediatrics
Olha Halyabar, Margaret H. Chang, Michelle L. Schoettler, Marc A. Schwartz, Ezgi H. Baris, Leslie A. Benson, Catherine M. Biggs, Mark Gorman, Leslie Lehmann, Mindy S. Lo, Peter A. Nigrovic, Craig D. Platt, Gregory P. Priebe, Jared Rowe, Robert P. Sundel, Neeraj K. Surana, Katja G. Weinacht, Alison Mann, Jenny Chan Yuen, Patricia Meleedy-Rey, Amy Starmer, Taruna Banerjee, Fatma Dedeoglu, Barbara A. Degar, Melissa M. Hazen, Lauren A. Henderson
PEDIATRIC RHEUMATOLOGY
(2019)
Article
Pediatrics
Perran Boran, Hatice Ezgi Baris, Eda Kepenekli, Can Erzik, Ahmet Soysal, Duy M. Dinh
EUROPEAN JOURNAL OF PEDIATRICS
(2020)
Article
Allergy
Hatice Ezgi Baris, Ismail Ogulur, Bengu Akcam, Ayca Kiykim, Dilek Karagoz, Berkay Saraymen, Gamze Akgun, Sevgi Bilgic Eltan, Sezin Aydemir, Zeynep Akidagi, Esma Bentli, Ercan Nain, Nurhan Kasap, Dilek Baser, Derya Ufuk Altintas, Yildiz Camcioglu, Gozde Yesil, Ahmet Ozen, Mustafa Yavuz Koker, Elif Karakoc-Aydiner, Safa Baris
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Public, Environmental & Occupational Health
L. Qutranji, N. Y. Silahli, H. E. Baris, P. Boran
JOURNAL OF PUBLIC HEALTH
(2020)
Article
Dermatology
Flora Bradley, Michelle L. Bayer, Dominic O. Co, Yvonne Chiu, Adam M. Huber, Regina-Celeste Ahmad, Hatice E. Baris, Edward J. Oberle, Susan Kim
Summary: CAJDM is an important subset of juvenile dermatomyositis with a risk of progression to classic juvenile dermatomyositis. Skin disease in patients without muscle weakness is often difficult to control, requiring multiple systemic therapies. More studies are needed for long-term monitoring and treatment of recalcitrant skin disease in CAJDM.
PEDIATRIC DERMATOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Nicel Yildiz Silahli, Hatice Ezgi Baris, Lubna Qutranji, Eren Ozek, Perran Boran
Summary: The study found that compared to resident mother-infant dyads, refugee mother-infant dyads had higher rates of adolescent pregnancy, lower antenatal care attendance, and significantly higher preterm birth rates.
HEALTH CARE FOR WOMEN INTERNATIONAL
(2021)
Article
Psychiatry
Perran Boran, Melike Donmez, Ezgi Baris, Mahmut Caner Us, Zeynep Meva Altas, Anum Nisar, Najia Atif, Siham Sikander, Seyhan Hidiroglu, Dilsad Save, Atif Rahman
Summary: This study evaluated the feasibility and acceptability of a preventive group intervention for perinatal depression in Istanbul, Turkey. The intervention was integrated into routine antenatal educational classes and was valued by the participants. Although the study was not able to detect significant differences between the intervention and control conditions, there were trends towards reduction in anxiety and depressive symptoms favoring the intervention arm. A fully powered definitive randomized controlled trial of this intervention should be conducted.
Article
Clinical Neurology
Ozge Ulgen, Hatice Ezgi Baris, Oyku Ozboru Askan, Selda Kucuk Akdere, Can Ilgin, Hulya Ozdemir, Nural Bekiroglu, Kivilcim Gucuyener, Eren Ozek, Perran Boran
Summary: The study found that actigraphy at a medium threshold can accurately depict the sleep of typically developing preterm infants in the NICU, and aEEG may be an alternative adjunctive method for evaluating sleep/wake states.
Article
Obstetrics & Gynecology
Perran Boran, Melike Donmez, Najia Atif, Anum Nisar, Ezgi Baris, Mahmut Caner Us, Zeynep Meva Altas, Seyhan Hidiroglu, Dilsad Save, Atif Rahman
Summary: This study aims to adapt the Thinking Healthy Programme (THP) for universal use in pregnancy schools in Turkey and explore its acceptability and feasibility for both face-to-face and online delivery. The findings suggest that the THP-group version was acceptable to its target population and could be integrated into the existing antenatal care program in Turkey.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Pediatrics
Haticre Ezgi Baris, Nicel Yildiz Silahli, Nuriye Ayca Gul, Lubna Qutranji, Jeffrey Goldhagen, Perran Boran
Summary: Comparison between the emergency department presentations of Syrian refugee children and resident children in Istanbul, Turkey, reveals that refugee children have higher acuity conditions, younger age, higher rates of hospitalization, and longer NICU stays. Strategies to improve access to preventive healthcare services for young refugee children should be implemented to reduce the reliance on emergency and inpatient care and improve health outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
Hatice Ezgi Baris, Hakan Gunhan, Selda Kucuk, Fatma Nihal Durmus Kocaaslan, Oerran Boran
Summary: The study found that the long-term language development of children with ankyloglossia was not adversely affected. The duration of exclusive breastfeeding was not related to the severity of ankyloglossia. Both the Test of Early Language Development-Third Edition and the Denver II Test showed that these children were developmentally normal.
MARMARA MEDICAL JOURNAL
(2021)
Article
Pediatrics
Hatice Ezgi Baris, Perran Boran, Ayca Kiykim, Safa Baris, Ahmet Ozen, Elif Karakoc Aydiner
TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS
(2020)
Article
Allergy
Ayca Kiykim, Ezgi Gizem Yuce, Ezgi Baris, Ercan Nain, Sevgi Keles, Hacer Akturk, Mustafa Bakir, Ahmet Ozen, Safa Baris, Elif Karakoc Aydiner
ASTIM ALLERJI IMMUNOLOJI
(2017)