Article
Medicine, General & Internal
Cosimo Bruni, Lavinia Mattolini, Lorenzo Tofani, Luna Gargani, Nicholas Landini, Nicola Roma, Gemma Lepri, Martina Orlandi, Serena Guiducci, Silvia Bellando-Randone, Chiara Romei, Yukai Wang, Marco Matucci-Cerinic
Summary: The study found that lung ultrasound (LUS) can be used as a tool to evaluate systemic sclerosis-related interstitial lung disease (SSc-ILD) and can be correlated with different methods of ILD evaluation.
Article
Rheumatology
Marco Di Battista, Andrea Delle Sedie, Chiara Romei, Laura Tavanti, Mattia Da Rio, Riccardo Morganti, Alessandra Della Rossa, Marta Mosca
Summary: This study assessed the changes in lung ultrasound (LUS) and high-resolution CT (HRCT) in SSc-ILD patients treated with NIN, and found that NIN treatment significantly reduced the number of B-lines and pleural line irregularities. Male gender, smoking habit, and baseline forced vital capacity <70% predicted were associated with worse LUS outcomes. A greater reduction in imaging abnormalities was observed in those who improved in functional and quality-of-life outcomes.
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Rheumatology
Robert Fairchild, Melody Chung, Diana Yang, Laurel Sharpless, Shufeng Li, Lorinda Chung
Summary: A novel lung ultrasonography examination technique and interpretation criteria were developed and tested for detecting SSc-ILD, showing high sensitivity and specificity with perfect agreement between ultrasonographer and nonultrasonographer readers.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Cosimo Bruni, Mariaelena Occhipinti, Michael Pienn, Gianna Camiciottoli, Maurizio Bartolucci, Silvia Laura Bosello, Christian Payer, Zoltan Balint, Anna Rita Larici, Alessandra Tottoli, Lorenzo Tofani, Enrico De Lorenzis, Gemma Lepri, Silvia Bellando-Randone, Amelia Spinella, Dilia Giuggioli, Francesco Masini, Giovanna Cuomo, Federico Lavorini, Stefano Colagrande, Horst Olschewski, Marco Matucci-Cerinic
Summary: Recent advancements have made it possible to quantitatively assess lung vascular and parenchymal changes in thoracic CT images using automated software tools. In this study, the researchers investigated the vessel parameters of patients with SSc and correlated them with interstitial lung disease (ILD) features. The results showed that the CT vessel parameters increased in parallel with ILD extent and functional impairment, suggesting that they may serve as a biomarker of SSc-ILD severity.
Article
Rheumatology
Luna Gargani, Chiara Romei, Cosimo Bruni, Gemma Lepri, Khadija El-Aoufy, Martina Orlandi, Luigia D'Errico, Giulia Bandini, Gennaro D'Angelo, Serena Guiducci, Lorenzo Dagna, Fabio Falaschi, Marco Matucci-Cerinic, Alberto Moggi-Pignone
Summary: Lung ultrasound (LUS) can accurately detect SSc-related ILD by evaluating B-lines and pleural line alterations. A cut-off value of >10 B-lines on the whole chest or >1 B-line on the postero-basal chest can be used for screening SSc-ILD. Assessing only the postero-basal chest seems to be the most effective approach, combining high sensitivity with less time consumption.
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Nicoleta Dima, Ioana Bratoiu, Ciprian Rezus, Alexandra Maria Burlui, Damiana Costin, Luana Andreea Macovei, Elena Rezus
Summary: Interstitial lung disease (ILD) is a serious manifestation of connective tissue diseases (CTD) that requires thorough evaluation and treatment. The prevalence of ILD in systemic lupus erythematosus (SLE) is still debated, but it is crucial to exclude an overlap syndrome for an accurate diagnosis. Increasing the identification of SLE-associated ILD cases is important, and various treatment options are being proposed. Systemic sclerosis (SSc)-associated ILD is a leading cause of mortality and should be investigated in all SSc patients. Progress has been made in the treatment of ILD, with tyrosine kinases inhibitor Nintedanib showing promising results in reducing the progression rate compared to placebo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Davide Mohammad Reza Beigi, Greta Pellegrino, Michele Loconte, Nicholas Landini, Monica Mattone, Gregorino Paone, Simona Truglia, Francesca Romana Di Ciommo, Ilaria Bisconti, Marius Cadar, Katia Stefanantoni, Valeria Panebianco, Fabrizio Conti, Valeria Riccieri
Summary: This study compared the qualitative and quantitative assessment of B-lines and pleural line alterations in SSc-ILD with CT analysis, and found that lung ultrasound may have potential value in detecting SSc-associated interstitial lung disease.
Article
Biochemistry & Molecular Biology
Alexandra Nagy, Erik Palmer, Lorinc Polivka, Noemi Eszes, Krisztina Vincze, Eniko Barczi, Aniko Bohacs, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Gyoergy Nagy, Emese Kiss, Pal Maurovich-Horvat, Veronika Mueller
Summary: This study evaluated the clinical characteristics and predictors of lung function changes in SSc-ILD patients treated in a real-world setting. The results showed that untreated patients had the most prominent functional decline, and a normal body mass index was associated with a significant risk of deterioration. The majority of patients improved or were stable during follow-up.
Article
Biochemistry & Molecular Biology
Caterina Oriana Aragona, Antonio Giovanni Versace, Carmelo Ioppolo, Daniela La Rosa, Rita Lauro, Maria Concetta Tringali, Simona Tomeo, Guido Ferlazzo, William Neal Roberts, Alessandra Bitto, Natasha Irrera, Gianluca Bagnato
Summary: This review discusses recent advancements in the treatment of systemic sclerosis-associated interstitial lung disease, including new molecular targets and approved drugs to slow disease progression. The focus is on personalized treatment strategies based on emerging pathogenic features of the disease.
Article
Health Care Sciences & Services
Chiara Pellicano, Marzia Miglionico, Laura Romaggioli, Amalia Colalillo, Lorenzo Vantaggio, Cecilia Napodano, Cinzia Calla, Francesca Gulli, Mariapaola Marino, Umberto Basile, Edoardo Rosato
Summary: This study found that SSc patients have increased levels of CH50 and serum C2 compared to healthy controls. These findings may be associated with disease severity and the severity of skin and lung fibrosis in SSc patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Hye Jin Jang, Ala Woo, Song Yee Kim, Seung Hyun Yong, Youngmok Park, Kyungsoo Chung, Su Hwan Lee, Ah Young Leem, Sang Hoon Lee, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Moo Suk Park
Summary: This study aimed to identify risk factors for mortality and compare the clinical characteristics of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). The study found that approximately 10% of SSc-ILD patients showed disease progression, and ILD was detected within less than five years from the first visit. Therefore, careful monitoring of symptoms and signs from an early stage and long-term surveillance are necessary.
ANNALS OF MEDICINE
(2023)
Article
Rheumatology
Sabrina Hoa, Murray Baron, Marie Hudson
Summary: This international survey reveals regional variations in SSc-ILD screening and significant heterogeneity among rheumatologists and respirologists in the treatment of subclinical SSc-ILD. High-quality research is needed to produce evidence-based guidelines and harmonize the approach to identification and treatment of subclinical SSc-ILD.
Review
Biochemistry & Molecular Biology
Joe E. Mouawad, Carol Feghali-Bostwick
Summary: Systemic sclerosis, also known as scleroderma, is an autoimmune disorder that affects the connective tissues and has a high mortality rate. Fibrosis, particularly in the lungs, is a hallmark of the disease and is currently the leading cause of death. Understanding the molecular mechanisms involved in lung fibrosis is essential for developing potential therapies to improve patient outcomes and quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Qiang Li, Laura Wallace, Padmaja Patnaik, Margarida Alves, Martina Gahlemann, Veronika Kohlbrenner, Christina Raabe, Jocelyn R. Wang, Elizabeth M. Garry
Summary: The study found low prevalence estimates and incidence rates for SSc and SSc-ILD in the US, with newly diagnosed SSc-ILD patients receiving more immunosuppressive therapy and having more comorbidities compared to newly diagnosed SSc patients.
Article
Rheumatology
George A. W. Bruyn, Heidi J. Siddle, Petra Hanova, Felicie Costantino, Annamaria Iagnocco, Andrea Delle Sedie, Marwin Gutierrez, Hilde B. Hammer, Elizabeth Jernberg, Damien Loeille, Mihaela C. Micu, Ingrid Moller, Carlos Pineda, Bethan Richards, Maria S. Stoenoiu, Takeshi Suzuki, Lene Terslev, Violeta Vlad, Robert Wonink, Maria-Antonietta d'Agostino, Richard J. Wakefield
JOURNAL OF RHEUMATOLOGY
(2019)
Article
Rheumatology
George A. Bruyn, Annamaria Iagnocco, Esperanza Naredo, Peter V. Balint, Marwin Gutierrez, Hilde B. Hammer, Paz Collado, Georgios Filippou, Wolfgang A. Schmidt, Sandrine Jousse-Joulin, Peter Mandl, Philip G. Conaghan, Richard J. Wakefield, Helen I. Keen, Lene Terslev, Maria Antonietta D'Agostino, Sibel Aydin, Marina Backhaus, Artur Bachta, Isabelle Chary-Valckenaere, Stavros Chrysidis, Nemanja Damjanov, Bhaskar Dasgupta, Emilio Filippucci, Frederique Gandjbachkh, Andrew Filer, Stephanie Finzel, Petra Hanova, Alojzija Hocevar, Cristina Hernandez Diaz, Kei Ikeda, Nevsun Inanc, Gurjit Kaeley, Marion Kortekaas, Gavin Lee, Damien Loeuille, Silvia Magni Manzoni, Clara Malattia, Mihaela Micu, Ingrid Moller, Carlos Pineda, Viviana Ravagnani, Bethan Richards, Johannes Roth, Valentin Schafer, Andrea delle Sedie, Marcin Skzudlarek, Nicolas Tzaribachev, Ilfita Sahbudin, Maria Stoenoiu, Giorgio Tamborrini, Violeta Vlad, Jelena Vojinovic, Ken Warrington, Daniel Windschall, Priscilla Wong, Pascal Zuferrey
JOURNAL OF RHEUMATOLOGY
(2019)
Article
Rheumatology
Peter Mandl, Paul Studenic, Emilio Filippucci, Artur Bachta, Marina Backhaus, David BonG, George A. W. Bruyn, Paz Collado, Nemanja Damjanov, Christian Dejaco, Andrea Delle-Sedie, Eugenio De Miguel, Christina Duftner, Irina Gessl, Marwin Gutierrez, Hilde B. Hammer, Cristina Hernandez-Diaz, Annmaria Iagnocco, Kei Ikeda, David Kane, Helen Keen, Stephen Kelly, Eszter Kovari, Ingrid Moeller, Uffe Moller-Dohn, Esperanza Naredo, Juan C. Nieto, Carlos Pineda, Alex Platzer, Ana Rodriguez, Wolfgang A. Schmidt, Gabriela Supp, Marcin Szkudlarek, Lene Terslev, Ralf Thiele, Richard J. Wakefield, Daniel Windschall, Maria-Antonietta D'Agostino, Peter Balint
Article
Rheumatology
Priscilla C. Wong, Gavin Lee, Andrea Delle Sedie, Petra Hanova, Nevsun Inanc, Sandrine Jousse-Joulin, Sarah Ohrndorf, Maria S. Stoenoiu, Helen I. Keen, Lene Terslev, Maria-Antonietta D'Agostino, George A. Bruyn
JOURNAL OF RHEUMATOLOGY
(2019)
Review
Rheumatology
Marwin Gutierrez, Carina Soto-Fajardo, Carlos Pineda, Alfonso Alfaro-Rodriguez, Lene Terslev, George Bruyn, Annamaria Iagnocco, Chiara Bertolazzi, Maria Antonietta D'Agostino, Andrea Delle Sedie
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Pharmacology & Pharmacy
Salvatore D'Angelo, Fabrizio Cantini, Roberta Ramonda, Luca Cantarini, Antonio Carletto, Maria Sole Chimenti, Andrea Delle Sedie, Rosario Foti, Roberto Gerli, Claudia Lomater, Ennio Lubrano, Antonio Marchesoni, Alen Zabotti, Carlo Salvarani, Rossana Scrivo, Raffaele Scarpa, Giuseppina Tramontano, Carlotta Nannini, Mariagrazia Lorenzin, Marta Fabbroni, Federica Martinis, Roberto Perricone, Linda Carli, Elisa Visalli, Guido Rovera, Fabio Massimo Perrotta, Luca Quartuccio, Alessio Altobelli, Luisa Costa, Laura Niccoli, Augusta Ortolan, Francesco Caso
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Critical Care Medicine
Luna Gargani, Cosimo Bruni, Chiara Romei, Paolo Frumento, Antonella Moreo, Gergely Agoston, Serena Guiducci, Silvia Bellando-Randone, Gemma Lepri, Laura Belloli, Alessandra Della Rossa, Andrea Delle Sedie, Chiara Stagnaro, Michele De Nes, Stefano Salvadori, Marta Mosca, Fabio Falaschi, Oscar Epis, Eugenio Picano, Marco Matucci-Cerinic
Review
Medicine, General & Internal
Garifallia Sakellariou, Carlo Alberto Scire, Antonella Adinolfi, Alberto Batticciotto, Alessandra Bortoluzzi, Andrea Delle Sedie, Orazio De Lucia, Christian Dejaco, Oscar Massimiliano Epis, Emilio Filippucci, Luca Idolazzi, Andrea Picchianti Diamanti, Alen Zabotti, Annamaria Iagnocco, Georgios Filippou
FRONTIERS IN MEDICINE
(2020)
Article
Rheumatology
Sara Nysom Christiansen, Georgios Filippou, Carlo Alberto Scire, Peter Balint, George A. W. Bruyn, Nicola Dalbeth, Christian Dejaco, Andrea Delle Sedie, Emilio Filippucci, Hilde B. Hammer, Annamaria Iagnocco, Helen Keen, Eugene Y. Kissin, Juhani Koski, Peter Mandl, Julia Martin, Eugenio De Miguel, Ingrid Moller, Esperanza Naredo, Carlos Pineda, Wolfgang A. Schmidt, Sarah Stewart, Maria Antonietta D'Agostino, Lene Terslev
Summary: This study developed a new ultrasound definition and a semi-quantitative scoring system for gout-specific lesions, with good reliability shown in static image assessments. The re-defined aggregates and the scoring system both demonstrated good intra- and inter-reader reliability, paving the way for further assessments in patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Review
Rheumatology
Shereen Paramalingam, Kelly Morgan, Fabio Becce, Louise P. Diederichsen, Kei Ikeda, Peter Mandl, Sarah Ohrndorf, Andrea Delle Sedie, Veronika Sharp, Ai Lyn Tan, Lene Terslev, Richard J. Wakefield, George A. W. Bruyn, Maria-Antonietta D'Agostino, Helen Keen
Summary: This systematic review analyzes the utility of ultrasound, including elastography, in autoimmune myositis (AIM) and finds evidence supporting its good metric properties, such as criterion and construct validity. However, further studies are needed to determine discrimination, reliability, and feasibility in AIM.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Review
Rheumatology
Michael Hughes, Cosimo Bruni, Giovanna Cuomo, Andrea Delle Sedie, Luna Gargani, Marwin Gutierrez, Gemma Lepri, Barbara Ruaro, Tania Santiago, Yossra Suliman, Shinji Watanabe, Annamaria Iagnocco, Daniel Furst, Silvia Bellando-Randone
Summary: Ultrasound technology has been widely used in the study of systemic sclerosis, providing non-invasive and radiation-free insights into the disease. While offering novel perspectives on disease pathogenesis and measurement, there are still unmet needs that must be addressed for ultrasound to play a more central role in the clinical care and research of systemic sclerosis.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2021)
Article
Rheumatology
Ennio Lubrano, Andrea Delle Sedie, Marco Romanelli, Maria Sole Chimenti, Luca Bianchi, Stefano Piaserico, Catia De Felice, Dario Graceffa, Maria Ilenia De Andres, Salvatore Curatolo, Rosa Daniela Grembiale, Stefano Dastoli, Chiara Arcuri, Rosa Giuseppa Angileri, Francesca Prignano, Francesca Bandinelli, Elena Baldissera, Santo Raffaele Mercuri, Chiara Franchi, Matteo Longhi, Angela Patri, Francesco Caso, Giuseppe Passiu, Maria Antonia Montesu, Simone Parisi, Elena Stroppiana, Genoveffa Scotto di Luzio, Giovanni Italiano, Sergio Di Nuzzo, Daniele Santilli, Laura Bigi, Federica Lumetti, Concetto Paolo Agnusdei, Maria Grazia Ferrucci, Giuliana Gualberti, Francesca Marando, Roberta Ramonda, Francesco Cusano
Summary: This study involving 28 rheumatology or dermatology clinics in Italy found that PsA patients seen in dermatology settings had higher disease activity and shorter time from diagnosis to initiation of treatment, while those seen in rheumatology settings were more common. Additionally, the choice to visit a rheumatologist was positively associated with female gender and swollen joints.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
F. M. Perrotta, A. Delle Sedie, S. Scriffignano, P. Volpe, E. Cordisco, N. Milano, M. Gabini, E. Lubrano
Correction
Rheumatology
G. A. Bruyn, H. J. Siddle, P. Hanova, F. Costantino, A. Iagnocco, A. Delle Sedie
JOURNAL OF RHEUMATOLOGY
(2019)
Article
Rheumatology
A. Marchesoni, S. D'Angelo, M. Anzidei, R. Bortolotti, F. Cantini, D. Caramella, M. Carotti, M. S. Chimenti, A. Delle Sedie, C. G. Egan, M. Fabbroni, B. Frediani, E. Fusaro, M. Galeazzi, M. B. Gallazzi, S. Gentileschi, F. Gentili, R. Gerli, M. Gilio, F. Iannone, E. La Paglia, E. Lubrano, L. Macarini, I. Olivieri, R. Pellerito, R. Ramonda, C. Salvarani, E. Scarano, R. Scarpa, L. Spaggiari, A. Spano, J. P. Zawaideh, M. A. Mazzei
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2019)
