Cytokine-Based Therapy in Psoriasis

Targeting the Interleukin-12/23 Cytokine Family in the Treatment of Psoriatic Disease

(2015) Neil H. Shear et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Development of the IL-12/23 antagonist ustekinumab in psoriasis: past, present, and future perspectives

(2011) Newman Yeilding et al.   Annals of the New York Academy of Sciences

Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesis

(2011) Robert Sabat et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Innate and Adaptive Interleukin-17–producing Lymphocytes in Chronic Inflammatory Lung Disorders

(2010) Bart M. Vanaudenaerde et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased IL-23 Expression in Palmoplantar Psoriasis and Hyperkeratotic Hand Dermatitis

(2010) Joseph V. Lillis et al.   ARCHIVES OF DERMATOLOGY

A novel role for IL-22R1 as a driver of inflammation

(2010) R. Savan et al.   BLOOD

Suppression of TNF-  and IL-1 Signaling Identifies a Mechanism of Homeostatic Regulation of Macrophages by IL-27

(2010) G. D. Kalliolias et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

(2010) G. Tonel et al.   JOURNAL OF IMMUNOLOGY

IL-23-Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A

(2010) H. L. Rizzo et al.   JOURNAL OF IMMUNOLOGY

IL-23 and IL-17A, but Not IL-12 and IL-22, Are Required for Optimal Skin Host Defense against Candida albicans

(2010) S. Kagami et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Psoriasis Bench to Bedside

(2009) Rajan P. Nair et al.   ARCHIVES OF DERMATOLOGY

Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin

(2009) C. Johansen et al.   BRITISH JOURNAL OF DERMATOLOGY

Long-term safety of biologics in dermatology

(2009) Xinaida T. Lima et al.   Dermatologic Therapy

Briakinumab

(2009) Xinaida Taligare Lima et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells

(2009) Kristine E. Nograles et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis

(2009) Vinod Chandran et al.   JOURNAL OF AUTOIMMUNITY

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis

(2009) Erin G. Harper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

(2009) Kerstin Wolk et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interleukin-23 and Th17 Cells in the Control of Gut Inflammation

(2009) Ivan Monteleone et al.   MEDIATORS OF INFLAMMATION

Properties and origin of human Th17 cells

(2009) Sergio Romagnani et al.   MOLECULAR IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autoimmune diseases induced by TNF-targeted therapies

(2008) Manuel Ramos-Casals et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Functional Characterization of IL-17F as a Selective Neutrophil Attractant in Psoriasis

(2008) Hideaki Watanabe et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

(2008) Craig L Leonardi et al.   LANCET

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

(2008) Brandi C. Jones et al.   STRUCTURE