Review
Medicine, General & Internal
Dimitrios A. Vrachatis, Konstantinos A. Papathanasiou, Dimitrios Kazantzis, Jorge Sanz-Sanchez, Sotiria G. Giotaki, Konstantinos Raisakis, Andreas Kaoukis, Charalampos Kossyvakis, Gerasimos Deftereos, Bernhard Reimers, Dimitrios Avramides, Gerasimos Siasos, Michael Cleman, George Giannopoulos, Alexandra Lansky, Spyridon Deftereos
Summary: This study found that inflammatory biomarkers, including neutrophil to lymphocyte ratio, high-sensitive CRP, IL-6, TNF-a, and RDW, were elevated in patients with coronary artery ectasia compared to healthy controls. The findings suggest that inflammatory dysregulation is involved in the pathogenesis of coronary artery ectasia and should be further investigated.
Article
Medical Laboratory Technology
Lulu Sun, Zhengbao Zhu, Mengyao Shi, Yiming Jia, Pinni Yang, Yu Wang, Fanghua Liu, Yonghong Zhang
Summary: The two-sample mendelian randomization study found that high Lp-PLA2 activity is a causal risk factor for CAD and MI, indicating that Lp-PLA2 activity may be a promising intervention target in reducing the risk of CAD and MI.
CLINICA CHIMICA ACTA
(2021)
Article
Pediatrics
Zhenli Cheng, Haobo Weng, Jing Zhang, Qijian Yi
Summary: This study found that Lp-PLA2 may be related to Kawasaki disease (KD) and the formation of coronary artery aneurysms (CAAs), and may serve as a potential diagnostic biomarker for KD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhao, Lin Sun, Zenglei Zhang, Kunqi Yang, Zuozhi Li, Man Wang, Yan Zeng, Xianliang Zhou, Weixian Yang
Summary: This study evaluated the impact of Lp(a) concentrations on clinical outcomes in patients with psoriasis and CAD. High levels of Lp(a) were found to be associated with a poor prognosis, especially in patients with diabetes and in men. These findings provide valuable information for risk stratification in patients with psoriasis and CAD.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Immunology
Feifei Si, Yaheng Lu, Yizhou Wen, Tingting Chen, Yingzi Zhang, Yanfeng Yang
Summary: Our study found that LL-37 levels were elevated in the serum of children with KD. Stimulation with LL-37 resulted in increased apoptosis in HCAECs and enhanced expression levels of TLR4, NLRP3, and inflammatory factors. Inhibition of TLR4 with TAK-242 alleviated LL-37-induced inflammation effects.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Multidisciplinary Sciences
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang
Summary: By investigating inflammatory signaling pathways in neuroblastoma, researchers have identified heterogeneity in dsRNA sensing and intratumoral inflammatory signaling, which has significant implications for immunotherapeutic strategies in this aggressive childhood cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medical Laboratory Technology
Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Qian Dong, Jing Sun, Ke- Fei Dou, Jian-Jun Li
Summary: The level of low-density lipoprotein-triglyceride (LDL-TG) is associated with cardiovascular events (CVEs) in patients with chronic coronary syndrome (CCS) receiving percutaneous coronary intervention (PCI), especially in combination with high-sensitivity C-reactive protein (hs-CRP) concentrations.
CLINICA CHIMICA ACTA
(2023)
Article
Biology
Mamoona Noreen, Muhammad Imran, Sher Zaman Safi, Muhammad Amjad Bashir, Sana Gul, Afrah Fahad Alkhuriji, Suliman Yousef Aloma, Hanan Mualla Alharbi, Muhammad Arshad
Summary: The study investigates the functional role of the 5180L polymorphism of TIRAP/MAL in susceptibility to CAD among Pakistani patients. Results show a significantly higher frequency of the LL180 genotype among healthy subjects compared to CAD patients, and a higher allele frequency of the 180L minor allele in controls than in CAD patients. The findings suggest a protective effect of the L180L coding variant of TIRAP/MAL against CAD.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Hayato Tada, Kan Yamagami, Kenji Sakata, Soichiro Usui, Masa-aki Kawashiri, Masayuki Takamura
Summary: Healthy lifestyle is associated with a lower risk of coronary artery disease regardless of Lp(a) levels.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Konstantinos Mourouzis, Gerasimos Siasos, Evangelos Oikonomou, Marina Zaromitidou, Vicky Tsigkou, Alexis Antonopoulos, Evanthia Bletsa, Panagiota Stampouloglou, Konstantinos Vlasis, Manolis Vavuranakis, Dimitris Tousoulis
Summary: The study found that elevated Lp-PLA2 levels are significantly associated with endothelial dysfunction and arterial stiffness in patients with stable coronary artery disease, independently of classical risk factors and medication.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Giovanni Zuliani, Judit Marsillach, Alessandro Trentini, Valentina Rosta, Carlo Cervellati
Summary: A wealth of evidence suggests that Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays a relevant role in atherogenesis and inflammation, which in turn are associated with the risk of developing dementia. The aim of this study was to evaluate whether serum Lp-PLA2 activity might be an early and/or late biomarker for different forms of dementia. We found that VAD patients had significantly higher levels of Lp-PLA2 activity compared to other groups, and MCI patients who converted to VAD also had higher levels of Lp-PLA2 activity. After adjusting for potential confounders, high levels of Lp-PLA2 activity were associated with the diagnosis of VAD, but not with other types of dementia.
Article
Biochemistry & Molecular Biology
Jonatan Warme, Martin O. Sundqvist, Marcus Hjort, Stefan Agewall, Olov Collste, Christina Ekenback, Mats Frick, Loghman Henareh, Claes Hofman-Bang, Jonas Spaak, Peder Sorensson, Shams Y-Hassan, Per Svensson, Bertil Lindahl, Robin Hofmann, Per Tornvall
Summary: Helicobacter pylori (Hp) infection is associated with protein biomarkers of inflammation and cardiovascular disease (CVD) in patients with myocardial infarction (MI) irrespective of the presence of obstructive coronary artery disease (CAD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, Gavriel Olshansky, Tingting Wang, Marta Brozynska, Mike Inouye, Nina S. McCarthy, Amir Ariff, Joseph Hung, Jennie Hui, John Beilby, Marie-Pierre Dube, Gerald F. Watts, Sonia Shah, Naomi R. Wray, Wei Ling Florence Lim, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Tenielle Porter, Michael Vacher, Ashley Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, Andrew J. Saykin, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, John Blangero, Peter J. Meikle, Eric K. Moses
Summary: This study integrated lipidomics and genomics to investigate the genetic architecture of lipid metabolism and identified genetic variants associated with coronary artery disease (CAD). Through GWAS and validation in multiple cohorts, a large number of genetic loci associated with lipid species were identified. These findings have important implications for understanding the pathogenesis of atherosclerosis and CAD, as well as other complex diseases.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Medicinal
Spyridon Simantiris, Charalampos Papastamos, Alexios S. Antonopoulos, Panagiotis Theofilis, Marios Sagris, Martha Bounta, Georgia Konisti, Nikolaos Galiatsatos, Anna Xanthaki, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Oxidative stress is critical in atherosclerosis and biomarkers can help in early diagnosis and better prognosis of coronary artery disease. Current biomarkers include oxidized low-density lipoprotein, myeloperoxidase, and lipid peroxidation biomarkers. These biomarkers are associated with the presence and extent of atherosclerosis and elevated in patients with acute coronary syndromes, possibly predicting clinical outcomes.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Min Jung Kwon, Jeong Yong Lee, Eo Jin Kim, Eun Ju Ko, Chang Soo Ryu, Hye Jung Cho, Hak Hoon Jun, Jong Woo Kim, Nam Keun Kim
Summary: This study elucidated the multifunctional aspects of MUC4 through genetic polymorphism analysis. The findings showed that MUC4 rs1104760 A>G polymorphism decreased the risk of CRC, while MUC4 rs2688513 A>G was associated with an increased mortality rate of CRC. Additionally, MUC4 rs1104760 A>G showed a significant synergistic effect with LDL-C level, indicating its potential as a biomarker for CRC patients. This study provides important insights for the prevention of CRC.
Letter
Dermatology
Anupam Mitra, Jesus I. Luna, Alina I. Marusina, Alexander Merleev, Smriti Kundu-Raychaudhuri, David Fiorentino, Siba P. Raychaudhuri, Emanual Maverakis
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2015)
Review
Chemistry, Medicinal
Khiem A. Tran, Michelle Y. Cheng, Anupam Mitra, Hiromi Ogawa, Vivian Y. Shi, Laura P. Olney, April M. Kloxin, Emanual Maverakis
DRUG DESIGN DEVELOPMENT AND THERAPY
(2016)
Article
Biochemical Research Methods
Dayoung Park, Narine Arabyan, Cynthia C. Williams, Ting Song, Anupam Mitra, Bart C. Weimer, Emanual Maverakis, Carlito B. Lebrilla
MOLECULAR & CELLULAR PROTEOMICS
(2016)
Article
Immunology
Noa Safra, Peta L. Hitchens, Emanual Maverakis, Anupam Mitra, Courtney Korff, Eric Johnson, Amir Kol, Michael J. Bannasch, Niels C. Pedersen, Danika L. Bannasch
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2016)
Letter
Dermatology
Itzel Bustos-Villalobos, Jennifer Williams Bergstrom, Nathan E. Haigh, Jesus I. Luna, Anupam Mitra, Alina I. Marusina, Alexander A. Merleev, Elizabeth A. Wang, Andrea Sukhov, Hawa Sultani, Ruiwu Liu, Gaurav Bhardwaj, Wenchang Guo, Hsing-Jien Kung, Kit S. Lam, Emanual Maverakis
JOURNAL OF DERMATOLOGICAL SCIENCE
(2017)
Correction
Allergy
David Siegel, Sridevi Devaraj, Anupam Mitra, Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Ishwarlal Jialal
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2018)
Article
Immunology
Elizabeth A. Wang, Andrea Steel, Guillaume Luxardi, Anupam Mitra, Forum Patel, Michelle Y. Cheng, Reason Wilken, Jason Kao, Kristopher de Ga, Hawa Sultani, Alexander A. Merleev, Alina I. Marusina, Alain Brassard, Maxwell A. Fung, Thomas Konia, Michiko Shimoda, Emanual Maverakis
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Rheumatology
Smriti Kundu-Raychaudhuri, Anupam Mitra, Ananya Datta-Mitra, Abhijit J. Chaudhari, Siba P. Raychaudhuri
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2016)
Review
Cardiac & Cardiovascular Systems
Anupam Mitra, Raktim Kumar Ghosh, Dhrubajyoti Bandyopadhyay, Gopal Chandra Ghosh, Ankur Kalra, Carl J. Lavie
CURRENT PROBLEMS IN CARDIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Smriti K. Raychaudhuri, Christine Abria, Anupam Mitra, Siba P. Raychaudhuri
Article
Dermatology
Maria Fernanda Ortega-Springall, Sarah Yang, Anupam Mitra, Maxwell A. A. Fung
Summary: In this study, the presence of the Free Sign was found in most cases of morphea, indicating its potential role as a clue to evolving sclerosis. The Free Sign may also be seen in other sclerosing disorders. However, it is important to consider technical artifact as a possible cause of false-positive Free Sign.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Meeting Abstract
Medicine, General & Internal
A. Dubrovsky, K. A. Olson, E. Vali Betts, J. P. Graff, A. D. Jones, G. Gao, A. Datta Mitra, A. Mitra, H. H. Rashidi
JOURNAL OF INVESTIGATIVE MEDICINE
(2019)
Letter
Psychiatry
Anupam Mitra, Samidha Tripathi, Gargi Bhattacharya, Pradipta Majumder
INDIAN JOURNAL OF PSYCHIATRY
(2018)
Article
Immunology
A. Mitra, S. Kundu-Raychaudhuri, C. Abria, A. Rona, A. J. Chaudhari, S. P. Raychaudhuri
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2017)
Meeting Abstract
Rheumatology
Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Anupam Mitra, Abhijit Chaudhari
ARTHRITIS & RHEUMATOLOGY
(2016)