Article
Pediatrics
Marika Paalanne, Minna Honkila, Niko Paalanne, Suvi Mattila, Tytti Pokka, Marjo Renko, Terhi Tapiainen
Summary: This study investigated the social burden of nasopharyngeal detection of different respiratory viruses and the co-detection of viral and bacterial pathogens. It was found that co-detection of any respiratory virus and Streptococcus pneumoniae or Haemophilus influenzae in the nasopharynx was associated with longer parental absence from work compared to the detection of viruses alone.
Article
Biology
Nik Mohd Noor Nik Zuraina, Habsah Hasan, Suharni Mohamad, Siti Suraiya
Summary: This study conducted a diagnostic screening of bacterial respiratory tract infections (RTIs) among Malaysian Hajj pilgrims using a newly developed PCR assay. The results showed that H. influenzae was the predominant bacterium in the pilgrims' sputum samples. The multiplex PCR assay demonstrated advantages of simplicity, speed, and reliability compared to sputum culture, particularly during the Hajj pilgrimage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Microbiology
Brianna Atto, Dale Kunde, David A. Gell, Stephen Tristram
Summary: The study suggests that carrying Haemophilus haemolyticus (Hh) strains producing the novel haemophilin protein can reduce the prevalence and density of Nontypeable Haemophilus influenzae (NTHi) colonisation in the oropharynx. Adults and elderly individuals carrying Hh-hpl(+) are less likely to have NTHi colonization, with high densities of Hh-hpl(+) correlating with lower NTHi carriage.
Article
Infectious Diseases
Chunjiang Zhao, Shuo Yang, Feifei Zhang, Zhanwei Wang, Yawei Zhang, Xiaojuan Wang, Henan Li, Hongbin Chen, Hui Wang
Summary: The study summarized the antimicrobial resistance trends in common respiratory tract pathogens isolated from patients with community acquired respiratory tract infections (CARTIs) in China over a 10-year period. The results showed an increase in resistance and decrease in sensitivity to 13-lactam drugs among the studied pathogens. However, certain antimicrobial agents such as moxifloxacin and levofloxacin maintained low resistance rates and better susceptibility.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Marlena Kiedrowska, Weronika Jasmina Forys, Agnieszka Golebiewska, Izabela Wasko, Patrycja Ronkiewicz, Alicja Kuch, Izabela Wrobel-Pawelczyk, Michal Wroczynski, Waleria Hryniewicz, Anna Skoczynska
Summary: This study characterized antibiotic resistance in Haemophilus influenzae strains isolated from patients with lower respiratory tract infections in Poland. The results showed resistance to multiple antibiotics, including third-generation cephalosporins, which is a cause for concern.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Grigorios Chatziparasidis, Ahmad Kantar, Keith Grimwood
Summary: The respiratory tract antimicrobial defense system protects the lungs from microorganisms through various defense mechanisms. Nontypeable Haemophilus influenzae (NTHi), a potential pathogen, uses multiple strategies to colonize the lower airways and establish persistent infections. NTHi impairs mucociliary clearance, evades host defenses, and forms biofilms, causing chronic infections and inflammation. Understanding the molecular pathogenesis of NTHi is important for developing effective therapies and vaccines, considering its genetic heterogeneity. Currently, there are no vaccine candidates ready for large clinical trials.
PEDIATRIC PULMONOLOGY
(2023)
Article
Clinical Neurology
Maria J. Gutierrez, Gustavo Nino, Jeremy S. Landeo-Gutierrez, Miriam R. Weiss, Diego A. Preciado, Xiumei Hong, Xiaobin Wang
Summary: The study found that early life lower respiratory tract infections independently increase the risk of pediatric obstructive sleep apnea, especially those that occur during the first two years of life. Children with severe lower respiratory tract infections in early life have a significantly higher risk of developing OSA during the first 5 years of life.
Article
Clinical Neurology
Maria J. Gutierrez, Gustavo Nino, Jeremy S. Landeo-Gutierrez, Miriam R. Weiss, Diego A. Preciado, Xiumei Hong, Xiaobin Wang
Summary: The study suggests that early lower respiratory tract infections in children increase the risk of obstructive sleep apnea independently, especially when occurring in the first 2 years of life. Additionally, severe respiratory syncytial virus bronchiolitis during infancy may also contribute to a higher risk of developing OSA in children by the age of 5 years.
Review
Biochemistry & Molecular Biology
Yuan Zhang, Freda E. -C. Jen, Kate L. Fox, Jennifer L. Edwards, Michael P. Jennings
Summary: Phosphorylcholine (ChoP) is present in all life forms, including bacteria. Recent research has shown that ChoP modification and phase variation play a role in bacterial pathogenesis. However, the mechanisms of ChoP synthesis in some bacteria are still unclear. This review examines the recent developments in ChoP-modified proteins and glycolipids, as well as ChoP biosynthetic pathways, and discusses the role of ChoP in bacterial pathobiology and immune response modulation.
TRENDS IN MICROBIOLOGY
(2023)
Article
Microbiology
Timothy F. Murphy, Charmaine Kirkham, Adonis D'Mello, Sanjay Sethi, Melinda M. Pettigrew, Herve Tettelin
Summary: Chronic obstructive pulmonary disease (COPD) is a common and debilitating disorder that is the third leading cause of death worldwide. This study analyzed the persistence of nontypeable Haemophilus influenzae (NTHi) in COPD airways and found that the NTHi genome undergoes inversion during persistence, resulting in changes in expression of key virulence factors. It was also discovered that the adhesins HMW1 and HMW2 play a critical role in NTHi adherence and invasion of respiratory epithelial cells. These findings provide important insights into the mechanisms of NTHi persistence in COPD airways and may inform the development of novel interventions.
Review
Microbiology
M. P. E. Slack, A. W. Cripps, K. Grimwood, G. A. Mackenzie, G. M. Ulanova
Summary: Hib used to be a common cause of bacterial infections in children, but with the widespread use of vaccines, its incidence has decreased. However, other capsulated serotypes are now causing more invasive infections in various regions. Surveillance and prevention efforts need to be strengthened to address this emerging trend.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Review
Microbiology
Bryn Short, Stephen Carson, Anna-Claire Devlin, James A. Reihill, Anne Crilly, William MacKay, Gordon Ramage, Craig Williams, Fionnuala T. Lundy, Lorcan P. McGarvey, Keith D. Thornbury, S. Lorraine Martin
Summary: Haemophilus influenzae is a common cause of bacterial infection in the lungs of COPD patients, leading to acute exacerbations. Its ability to adhere to host epithelial cells, form biofilms, and persist through immune evasion and antibiotic tolerance plays a crucial role in the pathogenesis of COPD.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Immunology
Benoit Lemarie, Ghilas Boussaid, Elyanne Gault, Helene Prigent, Sebastien Beaune, Frederique Moreau, Jennifer Dumoulin, Marion Pepin, Segolene Greffe, Pierre De Truchis, Benjamin Davido
Summary: In our study conducted in a hospital setting, regardless of the type of viral respiratory tract infection, there is a high risk of superinfection (56%), highlighting the need for improved vaccination coverage among high-risk patients. Influenza virus is associated with a poorer prognosis compared to paramyxoviruses, underscoring the importance of broad and large-scale vaccination efforts among individuals at risk of viral respiratory tract infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Anna Carrera-Salinas, Aida Gonzalez-Diaz, Rachel L. Ehrlich, Damaris Berbel, Fe Tubau, Xavier Pomares, Junkal Garmendia, M. Angeles Dominguez, Carmen Ardanuy, Daniel Huertas, Alicia Marin, Conchita Monton, Joshua Chang Mell, Salud Santos, Sara Marti
Summary: The immunomodulatory properties of azithromycin reduce the frequency of exacerbations and improve the quality of life of COPD patients. However, long-term administration may alter the respiratory microbiota, such as Haemophilus influenzae, an opportunistic respiratory colonizing bacteria that play an important role in exacerbations. This study contributes to a better understanding of COPD progression by characterizing the clinical evolution of H. influenzae in a cohort of patients with prolonged azithromycin treatment. The emergence of macrolide resistance during the first months, combined with the role of Haemophilus parainfluenzae as a reservoir and source of resistance dissemination, is a cause for concern that may lead to therapeutic failure. Furthermore, genetic variations in cell wall and inorganic ion metabolism coding genes likely favor bacterial adaptation to host selective pressures. Therefore, the bacterial pathoadaptive evolution in these severe COPD patients raise our awareness of the possible spread of macrolide resistance and selection of host-adapted clones.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Malini Shariff, Elizabeth Ramengmawi
Summary: This study aimed to investigate anaerobes causing respiratory tract infections and their antibiotic susceptibility. The results showed variable resistance of many anaerobic bacteria to most classes of antibiotics.
Article
Infectious Diseases
Nina Breinholt Staerke, Janne Tegder Martinsen, Torben Tranborg Jensen, Ulla Moller Weinreich, Ole Hilberg, Dorte Bek Folkvardsen, Christian Wejse, Andreas Floe
Summary: The prevalence of TB is high among socially marginalized citizens in Denmark. The long-term outcome of preventive treatment for LTBI in these patients is limited. However, while the completion of preventive treatment did not significantly reduce the incidence of TB, no TB cases were observed within the first 2 years following the completion of treatment.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Morten Borg, Sara Witting Christensen Wen, Torben Frostrup Hansen, Anders Jakobsen, Rikke Fredslund Andersen, Ole Hilberg, Ulla Moller Weinreich, Line Nederby
Summary: This study examined the relationship between NK cell activity and lung cancer in a high-risk cohort. The results showed significantly lower NK cell activity in patients with late-stage lung cancer compared to controls, suggesting a potential correlation between NK cell activity and advanced lung cancer.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Oncology
M. Borg, O. Hilberg, M. B. Andersen, U. M. Weinreich, T. R. Rasmussen
Summary: The number of CT thorax examinations and the incidence of lung cancer in Denmark have both been increasing. The study found that the majority of early-stage lung cancers were incidental findings. It highlights the importance of using follow-up algorithms for incidental findings and managing CT follow-up of pulmonary infiltrates according to guidelines.
Article
Public, Environmental & Occupational Health
P. A. Jacobsen, K. Kragholm, M. P. Andersen, F. L. Lindgren, K. B. Ringgren, C. Torp-Pedersen, U. M. Weinreich
Summary: This study examines the impact of voluntary early retirement (VER) on mortality, finding that individuals who choose VER at the age of 60 have a higher mortality rate in the subsequent three years, while no similar trend is observed among those who choose VER at the age of 62. Furthermore, individuals with COPD and heart failure are more likely to opt for early retirement.
Article
Medicine, Research & Experimental
Josefin Eklof, Imane Achir Alispahic, Pradeesh Sivapalan, Torgny Wilcke, Niels Seersholm, Karin Armbruster, Jakob Lyngby Kjaergaard, Mohamad Isam Saeed, Thyge Lynghoj Nielsen, Andrea Browatzki, Rikke Holmen Overgaard, Camilla Sund Fenlev, Zitta Barella Harboe, Helle Frost Andreassen, Therese Sophie Lapperre, Lars Pedersen, Stine Johnsen, Charlotte Suppli Ulrik, Julie Janner, Mia Moberg, Maria Heidemann, Ulla Moller Weinreich, Roxana Vijdea, Hans Linde, Ingrid Titlestad, Sofie Lock Johansson, Flemming Schonning Rosenvinge, Christian Ostergaard, Khaled Saoud Ali Ghathian, Lise Gundersen, Christina Wellendorph Christensen, Jette Bangsborg, Torben Tranborg Jensen, Vibeke Muff Sorensen, Thilde Ellingsgaard, Raluca Datcu, John Eugenio Coia, Uffe Bodtger, Jens Ulrik Staehr Jensen
Summary: This study aims to investigate whether targeted antibiotic treatment against P. aeruginosa can reduce exacerbations and mortality in patients with chronic obstructive pulmonary disease (COPD), non-CF bronchiectasis, and asthma. The ongoing trial involves 150 patients randomly assigned to receive either no antibiotic treatment or anti-pseudomonal antibiotic treatment for 14 days, with primary outcomes focusing on time to exacerbation requiring prednisolone and/or antibiotics, and days alive without exacerbation. The results will provide insights into optimizing therapeutic approaches for patients with chronic, non-CF pulmonary disease and P. aeruginosa infection.
Article
Respiratory System
Peter Ascanius Jacobsen, Kristian Kragholm, Christian Torp-Pedersen, Ulla Moller Weinreich
Summary: This study investigates disability retirement in COPD patients 3 years after the first-ever AECOPD. The study utilizes nationwide Danish registry data to analyze the socio-demographics, comorbidities, and inhaled medication use of COPD patients. The hazard ratio of disability retirement during the 3-year follow-up period is calculated. Higher age, living alone, comorbidities, specific treatments, and low educational level are associated with an increased risk of disability retirement.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Oncology
Morten Borg, Line Nederby, Sara Witting Christensen Wen, Torben Frostrup Hansen, Anders Jakobsen, Rikke Fredslund Andersen, Ulla Moller Weinreich, Ole Hilberg
Summary: This study assessed the diagnostic properties of a biomarker panel consisting of CYFRA 21-1, CEA, and CA125 for lung cancer detection. The results showed that the biomarkers had high sensitivity and specificity for detecting lung cancer, but their ability to detect early-stage lung cancer was low.
Article
Emergency Medicine
Vibe Maria Laden Nielsen, Tim Alex Lindskou, Ulla Moller Weinreich, Michael Skaerbaek Jespersen, Erika Frischknecht Christensen, Henrik Boggild
Summary: During the early weeks of the COVID-19 outbreak, paramedics in North Denmark were authorized to assess suspected patients at home and decide if they needed to be transported to a hospital. This study aimed to describe the patients assessed at home and their outcomes. The majority of non-conveyed patients did not visit a hospital within three days after the assessment.
BMC EMERGENCY MEDICINE
(2023)
Article
Respiratory System
Ulla Moller Weinreich, Kasper Svendsen Juhl, Malene Soby Christophersen, Svend Gundestrup, Munsoor Ali Hanifa, Kristine Jensen, Frank Dyekjaer Andersen, Ole Hilberg, Line Hust Storgaard
Summary: Long-term High Flow Nasal Cannula (LT-HFNC) has emerged as a home treatment for patients with chronic lung diseases. This paper summarizes the physiological effects and clinical knowledge of LT-HFNC in patients with chronic obstructive lung disease, interstitial lung disease, and bronchiectasis. The Danish Respiratory Society's National guideline for treatment of stable disease, which supports evidence-based decision making and practical issues, is described in this paper.
EUROPEAN CLINICAL RESPIRATORY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mia Solholt Godthaab Brath, Marina Sahakyan, Esben Bolvig Mark, Jens Brondum Frokjaer, Henrik Hojgaard Rasmussen, Lasse Riis ostergaard, Ulla Moller Weinreich
Summary: This study aimed to investigate the correlation between skeletal muscle area (SMA), skeletal muscle index (SMI), and skeletal muscle density (SMD) at contrast-enhanced thoracic CT in patients without chronic disease. The results suggest that any thoracic level can be used to assess skeletal muscle mass, with T5 being most favorable for measuring SMA, T11 for SMI, and T10 for SMD.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2023)
Article
Cardiac & Cardiovascular Systems
Marie Dam Lauridsen, Jan Brink Valentin, Jarl Emanuel Strange, Peter A. Jacobsen, Lars Kober, Soren Paaske Johnsen, Ulla Weinreich, Emil Fosbol
Summary: Severe chronic obstructive pulmonary disease (COPD) is associated with higher 1-year mortality after tran-scatheter aortic valve replacement (TAVR). Among COPD patients, those with a higher risk of exacerbation have a significantly increased mortality rate compared to those with a lower risk. The use of guideline recommended COPD medication and home oxygen therapy can help reduce mortality in COPD patients undergoing TAVR.
AMERICAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Suzana Tanni, Fernando Wehrmeister, Robson Prudente, Felipe Damatto, Carlos Breda Neto, Leiliane Oliveira, Luana Pagan, Mariana Gatto, Leticia Vieira, Liana Coelho, Diane Rezende, Luiz Machado, Gustavo Mota, Marina Gaiato, Felipe Santaella, Elisangela Campos, Estefania Franco, Matheus Callegari, Marina Politi Okoshi, Ulla Weinreich
Summary: This study evaluated the effects of inhaling hypertonic NaCl particles on the duration of COVID-19-induced acute symptoms. The results showed that inhaling hypertonic NaCl particles may reduce the duration of COVID-19-induced coughing, and no serious adverse events occurred.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Respiratory System
Kiki Waeijen-Smit, Peter A. Jacobsen, Sarah Houben-Wilke, Sami O. Simons, Frits M. E. Franssen, Martijn A. Spruit, Christian T. Pedersen, Kristian H. Kragholm, Ulla M. Weinreich
Summary: This study aimed to determine the 5-year all-cause hospital admission trajectories of patients with COPD following their first ever exacerbation-related hospitalisation. The results showed that nonrespiratory causes contribute significantly to hospital admissions in COPD patients, highlighting the importance of targeting these causes for preventive interventions.
Meeting Abstract
Respiratory System
M. S. G. Brath, E. B. Mark, J. B. Frokjaer, P. Veiss-Pedersen, L. R. Ostergaard, H. H. Rasmussen, U. M. Weinreich
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
M. S. G. Brath, S. Dyrman Alsted, P. Veiss-Pedersen, R. Brath Christensen, U. Moller Weinreich
EUROPEAN RESPIRATORY JOURNAL
(2022)