Article
Oncology
Mingming Zhang, Xiaoru Hu, Ye Kang, Wanfeng Xu, Xianghong Yang
Summary: The study found that fasting blood glucose levels are not significantly associated with overall survival of patients with pancreatic cancer, with only CA199 > 1000 being independently correlated with survival. The median survival in the normal glucose group was 20.5 months, while in the high blood glucose group it was 14.2 months, with no significant difference between the two groups.
Article
Endocrinology & Metabolism
Yingting Zuo, Xinsheng Han, Xue Tian, Shuohua Chen, Shouling Wu, Anxin Wang
Summary: The study revealed that individuals without traditional ASCVD risk factors are at increased risk of developing CVD with higher levels of abnormal fasting plasma glucose, underlining the importance of prevention strategies targeting elevated FPG levels in addition to other traditional ASCVD risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Jianing Bi, Lulu Song, Lulin Wang, Mingyang Wu, Shouhua Chen, Youjie Wang, Shouling Wu, Yaohua Tian
Summary: Higher fasting blood glucose variability is associated with an increased lifetime risk of cardiovascular disease, especially in men. Focusing on FBG variability may serve as a valuable clinical tool in reducing the lifetime risk of CVD.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chaiwat Washirasaksiri, Weerachai Srivanichakorn, Nutsakol Borrisut, Tullaya Sitasuwan, Rungsima Tinmanee, Chayanis Kositamongkol, Pinyapat Ariyakunaphan, Chonticha Auesomwang, Naruemit Sayabovorn, Thanet Chaisathaphol, Pochamana Phisalprapa
Summary: The incidences of diabetes and diabetic retinopathy in high-risk individuals in Thailand increase significantly with higher degrees of dysglycemia. Individuals with FPG 110-125 mg/dl and HbA1c 6.0%-6.4% are more likely to develop type 2 diabetes and diabetic retinopathy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Marcus Lind, Henrik Imberg, Ruth L. Coleman, Olle Nerman, Rury R. Holman
Summary: The glycemic legacy effects in type 2 diabetes are largely explained by historical HbA(1c) values having a greater impact than recent values on clinical outcomes. Early detection and intensive glucose control from the time of diagnosis are essential to maximize reduction of long-term glycemic complications.
Article
Cardiac & Cardiovascular Systems
Catarina Djupsjo, Jeanette Kuhl, Tomas Andersson, Magnus Lundback, Martin J. Holzmann, Thomas Nystrom
Summary: This study found that patients with disturbed blood glucose levels at emergency department admission have a higher mortality risk compared to patients with normal glucose tolerance. Patients with hyperglycemia have almost a two-fold increase in long-term mortality risk and more than a doubled risk for cardiovascular events compared to patients with normal glucose tolerance.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Galarregui, Santiago Navas-Carretero, Carlos J. Gonzalez-Navarro, J. Alfredo Martinez, M. Angeles Zulet, Itziar Abete
Summary: This study showed that consuming a high protein product significantly lowered peak and Delta blood glucose concentrations compared to a high carbohydrate product. Insulin response did not show significant differences between the two foods. Fasting glucose was positively correlated with glucose iAUC only for the high protein product.
Article
Cardiac & Cardiovascular Systems
Viktor Lind, Niklas Hammar, Pia Lundman, Leif Friberg, Mats Talback, Goran Walldius, Anna Norhammar
Summary: Dysglycaemia, even at prediabetes levels, is associated with an increased risk of developing atrial fibrillation and heart failure. The study found that individuals with diagnosed diabetes had the highest risk. However, the associations were somewhat weakened when BMI data was taken into account, with only diagnosed diabetes remaining statistically significant for atrial fibrillation.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Medicine, General & Internal
Guoyi Yang, Shiu Lun Au Yeung, Catherine Mary Schooling
Summary: This study investigated the relationship between hemoglobin A1c (HbA1c) and glucose levels, and found that hemoglobin and iron were inversely associated with HbA1c. Fasting glucose showed a stronger association with HbA1c and diabetes in women compared to men. HbA1c in men underestimated fasting glucose, possibly due to erythrocyte properties.
Article
Biotechnology & Applied Microbiology
Zhaonian Wang, Hexiang Peng, Wenjing Gao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Biqi Wang, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Liming Cong, Hua Wang, Xianping Wu, Yu Liu, Liming Li
Summary: The study suggests significant associations between DNA methylation and type 2 diabetes, fasting plasma glucose, and HbA1c in twins, with the cg19690313 site on the TXNIP gene showing correlations with both fasting plasma glucose and HbA1c levels.
Article
Medical Laboratory Technology
Andrea Valle, Javier Rodriguez, Felix Camina, Miguel A. Martinez-Olmos, Juan B. Ortola, Santiago Rodriguez-Segade
Summary: This study examines the glycaemic status and the impact of at-admission HbA1c levels on the outcome of COVID-19 hospitalized patients. The results show that in participants with known diabetes, blood glucose and HbA1c levels are not associated with mortality, while in participants without known diabetes, blood glucose is positively associated with mortality, and HbA1c is slightly inversely associated with mortality.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Matteo Tosato, Giulia Savera, Francesco Landi, Emanuele Marzetti
Summary: The study aimed to investigate the relationship between protein intake and blood pressure, glucose levels, and blood cholesterol in a large sample of Italian older adults. The findings showed that high protein intake was negatively associated with diastolic blood pressure and positively associated with total blood cholesterol levels in a large cohort of Italian older adults.
Article
Medicine, General & Internal
Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
Summary: This study examined the relationship between glycemic control and cardiovascular disease risk in patients with type 2 diabetes. The results suggest that controlling glucose levels during early diabetes may be more important than reducing glycemic variability.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
N. M. J. Hanssen, J. L. J. M. Scheijen, A. J. H. M. Houben, M. van de Waarenburg, T. T. J. M. Berendschot, C. A. B. Webers, K. D. Reesink, M. M. J. van Greevenbroek, C. van der Kallen, N. C. Schaper, M. T. Schram, R. M. A. Henry, C. D. A. Stehouwer, C. G. Schalkwijk
Summary: Plasma MGO levels, both fasting and post-OGTT, were found to be associated with microvascular diseases such as albuminuria, decreased eGFR, and retinopathy, but not with prior cardiovascular disease. Therapeutic strategies focusing on reducing MGO levels may help prevent microvascular diseases.
DIABETES & METABOLISM
(2021)
Article
Peripheral Vascular Disease
Alparslan Kilic, Onur Baydar
Summary: The study found a strong correlation between HbA(1c) levels and the severity of coronary artery disease in non-diabetic patients with NSTEMI, as measured by the SSII score. Additionally, HbA(1c) level and hypertension were identified as independent risk factors for high SSII scores.