Article
Immunology
Tomoki Nakamura, Kunihiro Asanuma, Tomohito Hagi, Akihiro Sudo
Summary: High-sensitivity modified Glasgow prognostic score (HS-mGPS) and mGPS were compared in predicting oncological outcomes in patients with soft tissue sarcomas (STSs) who underwent primary surgical tumour resection. The study found that patients with HS-mGPS and mGPS scores of 1 or 2 had a poorer survival rate, and tumor size and mGPS score were significant prognostic factors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Clinical Neurology
Swaminathan Ganesh, Ramanan Rajagopal, Shalini Nair, Mathew Joseph
Summary: A 15-year observational study on pregnant women with TBI admitted to a level 1 trauma center showed that pregnant TBI patients have better long-term outcomes than their similar-aged counterparts. However, radiologic severity of injury does not seem to predict outcome in this cohort.
WORLD NEUROSURGERY
(2022)
Article
Engineering, Biomedical
Stefan Trnka, Premysl Stejskal, Jakub Jablonsky, David Krahulik, Daniel Pohlodek, Lumir Hrabalek
Summary: This study investigated the prognostic potential of S100B protein in patients with traumatic brain injury. The levels and changes of S100B protein 72 hours after injury were found to be significantly associated with the clinical condition 1 month after injury. A higher level of S100B protein was observed in polytrauma patients compared to isolated TBI patients. S100B protein showed no correlation with hypertension, diabetes mellitus, BMI, or season.
BIOMEDICAL PAPERS-OLOMOUC
(2023)
Article
Infectious Diseases
Sigurdur Arnason, Kesia Molewijk, Anna J. Henningsson, Ivar Tjernberg, Barbro H. Skogman
Summary: This study evaluated NSE and S100B in serum as prognostic biomarkers for clinical outcomes in pediatric LNB patients. The results showed that there were no significant differences in NSE and S100B concentrations between LNB patients and controls, and these biomarkers concentrations were not associated with clinical recovery at the 2-month follow-up.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Geriatrics & Gerontology
T. Mori, H. Wakabayashi, M. Kishima, M. Itoda, I Fujishima, K. Kunieda, T. Ohno, T. Shigematsu, F. Oshimas, N. Ogawa, S. Nishioka, R. Momosaki, A. Shimizu, Y. Saito, M. Yamada, S. Ogawa
Summary: This study found that inflammation may affect the outcome of patients with sarcopenic dysphagia, suggesting that inflammation could be an important risk factor in evaluating these patients.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Pediatrics
Danielle S. Wendling-Keim, Anja Hefele, Oliver Muensterer, Markus Lehner
Summary: The study examined the value of trauma scores in pediatric polytrauma patients, with ISS and NACA scores being more accurate predictors of operative interventions and outcomes compared to PTS and GCS.
FRONTIERS IN PEDIATRICS
(2021)
Article
Oncology
Yusuke Noda, Taku Naiki, Yosuke Sugiyama, Takashi Nagai, Aya Naiki-Ito, Tatsuya Kawai, Shuzo Hamamoto, Toshiki Etani, Keitaro Iida, Nami Tomiyama, Maria Aoki, Nobuhiko Shimizu, Yoshinobu Moritoki, Hidetoshi Akita, Ryosuke Ando, Noriyasu Kawai, Takahiro Yasui
Summary: This study evaluated the oncological outcomes of patients with bladder cancer after RP-LRC and assessed the impact of mGPS on patient outcomes. The results showed that >= cT3 stage, worse clinical N stage, and poor mGPS status were significant prognostic factors for short-term disease-free survival and cancer-specific survival.
Article
Medicine, Research & Experimental
Tao Yuan, Hongyu He, Yuepeng Liu, Jianwei Wang, Xin Kang, Guanghui Fu, Fangfang Xie, Aimin Li, Jun Chen, Wenxue Wang
Summary: This study demonstrates the relationship between blood glucose levels and the Glasgow Outcome Score (GOS) in traumatic brain injury (TBI) patients. Blood glucose levels that are too high or too low are associated with a poor prognosis.
Article
Medicine, General & Internal
Gabriel Stefan, Simona Stancu, Adrian Zugravu, Cristina Capusa
Summary: This study found that the inflammation-based mGPS score is associated with renal function decline in CKD patients, which could be useful in improving risk stratification of CKD patients.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Critical Care Medicine
Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl, Eric Peter Thelin
Summary: This study conducted a multiplex screening of brain enriched and inflammatory proteins in blood and cerebrospinal fluid (CSF) to investigate their role in BBB disruption, neuroinflammation, and long-term functional outcome in TBI patients. The research found that TBI patients showed upregulation of structural CNS and neuroinflammatory pathways in both CSF and serum, with proteins correlating with BBB integrity and identifying potential independent predictors of clinical outcome. The findings provide substantial support for the idea that neuroinflammatory markers, like complement activation, can predict BBB disruption and long-term outcomes in severe TBI.
Article
Clinical Neurology
Shivender Sobti, Manuranjan Goyari, Raghavendra Harpanahalli, Laxmi Narayan Gupta, Ajay Choudhary, Anil Taneja
Summary: This study indicates that pediatric extradural hematoma is a rare but potentially life-threatening condition, commonly caused by falls. Prompt diagnosis and intervention are crucial in reducing mortality and morbidity rates.
JOURNAL OF PEDIATRIC NEUROSCIENCES
(2021)
Article
Hematology
Gabriel Stefan, Adrian Zugravu, Simona Stancu
Summary: This retrospective study found a significant association between the Glasgow Prognostic Score (GPS) at hemodialysis (HD) initiation and overall/cardiovascular mortality. The study included 264 patients starting HD between 2014 and 2015 at a single center, with a median follow-up of 6.8 years. Patients with a higher GPS were more likely to have emergent HD initiation and higher eGFR at initiation. The findings highlight the potential of GPS as a prognostic tool for identifying high-risk patients in HD.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Medicine, General & Internal
Muhammad Pervez Khan, Muhammad Anwar
Summary: This study revealed a significant relationship between the volume of extradural hematoma and both clinical and functional outcomes, with prognosis worsening as the size of the hematoma increases.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)
Article
Veterinary Sciences
Carly W. Gregory, Akaterina M. Davros, Darren M. Cockrell, Kelly E. Hall
Summary: This study aimed to evaluate the outcome of cats with different trauma types (blunt, penetrating, both) and investigate the associations between trauma type, injury severity, and clinicians' choices in diagnostics and interventions. The results showed that cats with penetrating trauma had the best survival, lower injury severity scores, and higher Glasgow Coma Scale scores.
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2023)
Article
Emergency Medicine
Seyed Mohsen Hosseini Shirazi, Zahra Parsian, Haniyeh Ebrahimi Bakhtavar, Farzad Rahmanil
Summary: This study demonstrates the significant value of assessing NT-pro BNP serum levels in predicting the mortality rate of patients with head trauma.
Letter
Cardiac & Cardiovascular Systems
Ann-Kathrin Kahle, Christiane Jungen, Katharina Scherschel, Fares-Alexander Alken, Christian Meyer
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ruben Schleberger, Jana M. Schwarzl, Julia Moser, Moritz Nies, Alexandra Hoeller, Paula Muenkler, Leon Dinshaw, Christiane Jungen, Marc D. Lemoine, Philippe Maury, Frederic Sacher, Claire A. Martin, Tom Wong, Heidi L. Estner, Pierre Jais, Stephan Willems, Christian Eickholt, Christian Meyer
Summary: This study compares the outcomes of ultra-high-density mapping and conventional point-by-point mapping in patients undergoing ventricular tachycardia ablation. The results show that ablation guided by ultra-high-density mapping is associated with better long-term outcomes compared to conventional mapping. Complication rates and other procedural parameters are similar in both groups.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Heiss, Ana Rodriguez-Mateos, Mariam Bapir, Simon S. Skene, Helmut Sies, Malte Kelm
Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M. Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Soren Zoga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stephane N. Hatem, Karl Georg Haeusler, Jeff S. Healey, Hein Heidbuchel, Gerhard Hindricks, F. D. Richard Hobbs, Thomas Huebner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y. H. Lip, Maja Lisa Lochen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L. Merino, Ralf Meyer, Lluis Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S. Potpara, George Psaroudakis, Helmut Purerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rudiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. van Gelder, Burcu Vardar, Elena Pala, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, Andre Ziegler, Matthias Daniel Zink, Paulus Kirchhof
Summary: This article summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference, which was held in Hamburg in October 2021 and attended by 83 international experts. The consensus paper highlights new evidence-based approaches to improve care for patients with atrial fibrillation (AF), including population-based screening, evolving management strategies, atrial cardiomyopathy characterization, cognitive function assessment, and the role of artificial intelligence (AI).
Article
Neurosciences
Katharina Apelt-Glitz, Fares-Alexander Alken, Christiane Jungen, Katharina Scherschel, Nikolaj Kloecker, Christian Meyer
Summary: This study investigated the effects of different testing methods (hyperoxic cardiac chemoreflex sensitivity testing, cold face test, and cold pressor test) on heart rate dynamics, hemodynamics, and respiratory rate. The results showed that changes in heart rate characteristics during the deactivation of peripheral chemoreceptors were related to a decrease in respiratory rate. This highlights the importance of assessing respiratory rate when evaluating adaptations of cardiorespiratory chemoreceptor control.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2022)
Review
Medicine, General & Internal
Cathrin Caroline Braun, Matthias Daniel Zink, Sophie Gozdowsky, Julie Martha Hoffmann, Nadine Hochhausen, Anna Bettina Roehl, Stefan Kurt Beckers, Felix Kork
Summary: The T-peak-T-end interval is associated with all-cause mortality, and patients with a prolonged interval have a higher risk of death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Neurosciences
Juliane Bremer, Johannes Friemann, Saskia von Stillfried, Peter Boor, Joachim Weis
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Patricia Franzka, Svenja Caren Schueler, Takfarinas Kentache, Robert Storm, Andrea Bock, Istvan Katona, Joachim Weis, Katrin Buder, Christoph Kaether, Christian A. Hubner
Summary: Proteins of the secretory pathway undergo glycosylation in the ER and Golgi apparatus. Mutations in GMPPA can cause AAMR syndrome with various symptoms. Loss of GMPPA leads to Golgi fragmentation, altered protein abundance, reduced furin activity, and increased retention of alpha-DG.
Article
Chemistry, Analytical
Markus Lueken, Michael Gramlich, Steffen Leonhardt, Nikolaus Marx, Matthias D. Zink
Summary: Atrial fibrillation (AF) is a common cardiac disorder that often goes undetected due to its asymptomatic and paroxysmal nature. Large-scale screenings can help identify silent AF early and prevent complications. This study presents a machine learning-based algorithm for assessing the signal quality of hand-held diagnostic ECG devices to improve accuracy in detecting AF.
Review
Hematology
William McIntyre
Summary: Atrial fibrillation is a common cause of stroke. Timely diagnosis and treatment with oral anticoagulation can prevent many AF-related strokes. However, the impact of population-based ECG screening on stroke is uncertain as current RCTs lack sufficient power.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Kabita Pradhan, Paul Niehues, Balram Neupane, Carole Maleck, Ahmad Sharif-Yakan, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich
Summary: In this study, miR-21-5p was validated as a biomarker for the extent of left atrial fibrosis in AF patients. Furthermore, it was found that cardiomyocytes release miR-21-5p under tachyarrhythmic conditions, which stimulates fibroblasts to induce collagen production in a paracrine mode.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Vincent Menger, Michael Frick, Ahmad Sharif-Yakan, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich
Summary: This study compared the efficacy and safety of two cryoballoon ablation systems for atrial fibrillation and investigated the influence of pulmonary vein anatomy. The POLARx system had shorter procedural time and lower balloon temperature, while the AFAP system performance varied with the anatomy. There was no significant correlation between PV anatomy and clinical outcome. Both systems had comparable outcomes and safety profiles.
JOURNAL OF ARRHYTHMIA
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Tobias Zeus, Artur Lichtenberg, Malte Kelm
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maximilian Spieker, Malte Kelm, Verena Veulemans
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Wern Yew Ding, Marco Proietti, Giuseppe Boriani, Laurent Fauchier, Carina Blomstrom-Lundqvist, Francisco Marin, Tatjana S. Potpara, Gregory Y. H. Lip
Summary: The 4S-AF classification scheme, consisting of four domains, including stroke risk, symptom severity, AF burden, and substrate, improves mortality rates in AF patients through treatment decisions. Implementing this scheme is feasible and associated with a significant decrease in all-cause mortality.