Article
Cardiac & Cardiovascular Systems
Mariel E. Turner, Ismail Bouhout, Christopher J. Petit, David Kalfa
Summary: The field of congenital interventional cardiology has grown significantly in recent years, with percutaneous device closure becoming a mainstay of treatment for many septal defects. This review discusses the current state, patient selection, procedural approach, and outcomes of transcatheter closure of atrial septal defects (ASDs) and ventricular septal defects (VSDs) in children and adults, as well as potential areas for future evolution and innovation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dongchen Fan, Shuchao Pang, Jing Chen, Jiping Shan, Qianjin Cheng, Bo Yan
Summary: The study found five heterozygous regulatory variants in ASD patients, which significantly affected the transcriptional activity of the GATA4 gene promoter. Two of the variants notably impacted transcription factor binding sites. This suggests that GATA4 gene regulatory variants may contribute to ASD susceptibility by reducing GATA4 levels.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Valtteri Muroke, Mikko Jalanko, Jari Haukka, Juha Sinisalo
Summary: This study aimed to evaluate the long-term mortality and cause-specific mortality of patients with atrial septal defect (ASD) in a nationwide cohort. The results showed that patients with ASD had higher overall mortality, with increased cause-specific mortality in congenital malformations, stroke, and heart diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Anne-Sif Lund Schram, Anna Sellmer, Camilla Nyboe, Martin Sillesen, Vibeke Elisabeth Hjortdal
Summary: Patients with adult atrial septal defects have altered inflammatory activity, which may contribute to the development of morbidities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Victor Waldmann, Francis Bessiere, Kevin Gardey, Sebastien Hascoet, Roland Henaine, Laurence Iserin, Magalie Ladouceur, Damien Bonnet, Eloi Marijon, Alice Maltret, Nicolas Combes, Natasja de Groot
Summary: This study aimed to investigate the main mechanisms of atrial tachyarrhythmias in patients with atrioventricular septal defect (AVSD) and analyse the outcomes after catheter ablation. The study found that most circuits involved the cavo-annular isthmus, but complex mechanisms were frequently encountered in patients who underwent repeated procedures. The acute success rate was excellent, but recurrences were common during follow-up.
Article
Medicine, General & Internal
V. Muroke, M. Jalanko, J. Haukka, J. Hartikainen, A. Tahvanainen, H. Ukkonen, K. Ylitalo, J. Pihkala, J. Sinisalo
Summary: This nationwide cohort evaluated the long-term outcome of transcatheter-closed ASDs. The study found that patients who underwent transcatheter closure of ASD are at higher risk of new-onset atrial fibrillation and migraine, as well as comorbidities such as ischemic heart disease, ventricular fibrillation/tachycardia, and AV conduction disorder. Major complications after the closure, including erosion and device embolization, are rare.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Connor P. Callahan, Anusha Jegatheeswaran, David J. Barron, S. Adil Husain, Stephanie Fuller, David M. Overman, Brian W. McCrindle
Summary: This study aimed to determine factors associated with mortality after biventricular repair of atrioventricular septal defect (AVSD). The results showed that atrial fenestration placed during repair was associated with reduced long-term survival, challenging the routine practice of fenestration.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Xiu-Yun Yin, Huan-Xin Chen, Zhuo Chen, Qin Yang, Jun Han, Guo-Wei He
Summary: Four variants in the promoter region of the ISL1 gene were identified in ASD patients only, with three of them significantly decreasing transcriptional activities. These variants may affect binding sites of transcription factors, potentially influencing the development of ASD.
JOURNAL OF GENE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jana Rubackova Popelova, Marketa Tomkova, Jakub Tomek, Renata Zivna
Summary: ASD closure appears to be associated with improved long-term survival independently of age, PH, and other clinical variables.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Boning Li, Zhaofeng Xie, Qunsong Wang, Xianmiao Chen, Qingsong Liu, Wei Wang, Yang Shen, Jianxiong Liu, Anning Li, Yifan Li, Gui Zhang, Jianxiong Liu, Deyuan Zhang, Cong Liu, Shushui Wang, Yumei Xie, Zhiwei Zhang, Jiandong Ding
Summary: The successful application of fully biodegradable PLLA ASD occluder in clinical practice demonstrated its excellent degradation behavior and safety in animal models and actual patients.
Article
Cardiac & Cardiovascular Systems
Lingqun Ye, You Yu, Zhen-Ao Zhao, Dandan Zhao, Xuan Ni, Yong Wang, Xing Fang, Miao Yu, Yongming Wang, Jun-Ming Tang, Ying Chen, Zhenya Shen, Wei Lei, Shijun Hu
Summary: This study used human-induced pluripotent stem cells to investigate the molecular mechanisms of congenital heart disease, specifically atrial septal defect. The GATA4 gene mutation was found to impair cell proliferation in cardiomyocytes, and this defect could be restored by gene correction and overexpression of the FGF16 gene. These findings provide insights into heart development and potential treatment strategies for congenital heart disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Michele D'Alto, Andrew Constantine, Massimo Chessa, Giuseppe Santoro, Gianpiero Gaio, Mario Giordano, Emanuele Romeo, Paola Argiento, Julie Wacker, Angelo Fabio D'Aiello, Berardo Sarubbi, Maria Giovanna Russo, Robert Naeije, Paolo Golino, Konstantinos Dimopoulos
Summary: In adults with ASD without overt LV disease, even small rises in PVR may have significant implications on cardiovascular haemodynamics. Fluid challenge may provide additional information to balloon occlusion in this setting.
Review
Cardiac & Cardiovascular Systems
Gillian Hardman, Joseph Zacharias
Summary: Progress in the development and use of minimally invasive techniques in cardiac surgery has been slower compared to other surgical specialties. Among cardiac diseases, congenital heart disease (CHD) patients are significant, with atrial septal defect (ASD) being a common diagnosis. ASD management involves a range of minimally invasive approaches, such as transcatheter device closure, mini-sternotomy, thoracotomy, video-assisted, endoscopic, and robotic approaches. This article discusses the pathophysiology, diagnosis, management, and intervention indications of ASD, with a focus on the evidence supporting minimally invasive and minimal-access surgical ASD closure in both adult and pediatric patients, as well as areas for further research.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Haisong Bu, Guowen Sun, Yun Zhu, Yifeng Yang, Zhiping Tan, Tianli Zhao, Shijun Hu
Summary: Through whole-exome sequencing and bioinformatics strategies, we identified a novel mutation in the GATA4 gene associated with ASD in a Chinese family for the first time.
BMC CARDIOVASCULAR DISORDERS
(2021)
Review
Cardiac & Cardiovascular Systems
Margarita Brida, Massimo Chessa, David Celermajer, Wei Li, Tal Geva, Paul Khairy, Massimo Griselli, Helmut Baumgartner, Michael A. Gatzoulis
Summary: Atrial septal defects (ASDs) are the most common congenital heart defect diagnosed in adulthood, presenting significant challenges in terms of diagnosis and treatment. This review aims to provide clinicians with the latest evidence and optimize diagnostics, treatment options, and long-term care for patients with ASDs.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Theo M. M. H. de By, Christiaan F. J. Antonides, Martin Schweiger, Joanna Sliwka, Ben Davies, Felix Berger, Michael Hubler, Mustafa Ozbaran, Bohdan Maruszewski, Carlo Pace Napoleone, Daniel Zimpfer, Eugen Sandica, Herwig Antretter, Bart Meyns, Oliver Miera
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Alexandra Toste, Andreas Perrot, Cemil Oezcelik, Nuno Cardim
REVISTA PORTUGUESA DE CARDIOLOGIA
(2020)
Article
Cardiac & Cardiovascular Systems
Kilian Runte, Kay Brosien, Charlotte Schubert, Johannes Nordmeyer, Peter Kramer, Stephan Schubert, Felix Berger, Anja Hennemuth, Titus Kuehne, Marcus Kelm, Leonid Goubergrits
Summary: A reduced-order model was developed to accurately predict dobutamine-induced hemodynamic changes with equivalent accuracy to heart catheterization; the method is easy to use and offers a promising alternative to conventional stress testing in clinical routine.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Philippe Chouvarine, Joachim Photiadis, Robert Cesnjevar, Jens Scheewe, Ulrike M. M. Bauer, Thomas Pickardt, Hans-Heiner Kramer, Sven Dittrich, Felix Berger, Georg Hansmann
Summary: The study identified changes in both coding and noncoding RNA expression in human right ventricular hypertrophy (RVH), and predicted that some microRNAs regulate the expression of RVH-related genes through noncoding RNAs. These genes are mainly involved in regulating glucose and lipid metabolism, cell surface interactions, apoptosis, extracellular matrix composition, and other biological processes.
Article
Cardiac & Cardiovascular Systems
Marie Schafstedde, Sarah Nordmeyer, Anastasia Schleiger, Johannes Nordmeyer, Felix Berger, Peter Kramer, Stanislav Ovroutski
Summary: The prevalence of cyanosis remains significant in long-term follow-up after Fontan operation, and is associated with increased late mortality. Cyanosis is one of the strongest predictors for late mortality.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Vinzenz Boos, Felix Berger, Mi-Young Cho, Joachim Photiadis, Christoph Buehrer, Constanze Pfitzer
Summary: This study aimed to investigate the morbidity, long-term mortality, and neurodevelopmental outcomes in very low birthweight infants who underwent cardiac surgery for severe congenital heart defect within 1 year after birth. The findings revealed that survival rates decreased with increasing STAT mortality category of the surgical procedure, and the type of cardiac malformation may affect early- and long-term outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cell Biology
Jana Luecht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong
Summary: The study investigated the role of CIRBP in cooling-induced cellular protection and sterile inflammation, as well as the potential impact of microglia in cerebral I/R injury. The results showed that cooling had a protective effect on cell viability and influenced the expression of cold shock proteins and release of DAMPs.
MEDIATORS OF INFLAMMATION
(2021)
Article
Cardiac & Cardiovascular Systems
Clara Stammnitz, Doerte Huscher, Ulrike M. M. Bauer, Aleksandra Urban, Johannes Nordmeyer, Stephan Schubert, Joachim Photiadis, Felix Berger, Sabine Klaassen
Summary: This study aimed to identify specific long-term risk factors for infective endocarditis (IE) in patients with congenital heart disease after pulmonary valve replacements. The study found that bovine jugular vein valves had the highest risk of IE, while Edwards Sapien and mechanical valves were used less frequently and remained without IE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sven C. Weber, Friederike Danne, Moritz Kieslich, Annemarie Krauss, Felix Berger, Hannes Sallmon
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Marie Schafstedde, Johannes Nordmeyer, Felix Berger, Christoph Knosalla, Philipp Mertins, Matthias Ziehm, Marie-Luise Kirchner, Vera Regitz-Zagrosek, Titus Kuehne, Milena Kraus, Sarah Nordmeyer
Summary: Animal studies have shown the important role of dihydrotestosterone (DHT) in pressure overload-induced myocardial hypertrophy and dysfunction. This study aimed to evaluate the relationship between DHT levels and myocardial hypertrophy and protein expression in patients with severe aortic valve stenosis (AS). The findings suggest that DHT may be a target for preventing or attenuating adverse myocardial remodeling in patients with AS.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Marvin Steitz, Sabra Zouhair, Mahamuda Badhon Khan, Alexander Breitenstein-Attach, Katharina Fritsch, Sugat Ratna Tuladhar, Dag Wulsten, Willem-Frederik Wolkers, Xiaolin Sun, Yimeng Hao, Jasper Emeis, Hans-E. Lange, Felix Berger, Boris Schmitt
Summary: A novel alternative crosslinking method was investigated for collagen-based biomaterials, showing improved thermal and enzymatic stability compared to glutaraldehyde, while maintaining similar biomechanical properties. The study suggests potential for the novel crosslinking agent in intraoperative processing of biomaterials, with further long-term studies required for assessing longevity and calcification.
BIOENGINEERING-BASEL
(2023)
Article
Cardiac & Cardiovascular Systems
Dietmar Boethig, Murat Avsar, Ulrike M. M. Bauer, Samir Sarikouch, Philipp Beerbaum, Felix Berger, Robert Cesnjevar, Ingo Daehnert, Sven Dittrich, Peter Ewert, Axel Haverich, Juergen Hoerer, Martin Kostelka, Joachim Photiadis, Eugen Sandica, Stephan Schubert, Aleksandra Urban, Dmitry Bobylev, Alexander Horke
Summary: This study evaluated the performance and durability of pulmonary valve replacement procedures in Germany, including both transcatheter and surgical valve replacements. The results showed that transcatheter valves had equivalent performance to surgical valves and extended durability. Different types of valves had different levels of durability, with homografts performing the best and Matrix P-valves performing the worst. The interval between procedures shortened significantly in most age groups below 40 years.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Anastasia Schleiger, Peter Kramer, Madeleine Salzmann, Friederike Danne, Stephan Schubert, Christian Bassir, Tobias Muller, Frank Tacke, Hans-Peter Muller, Felix Berger, Joachim Photiadis, Stanislav Ovroutski
Summary: In this study, a scoring system for Fontan-associated liver disease (FALD) severity was proposed and found to be applicable for evaluating Fontan failure. The FALD score significantly correlated with impaired Fontan hemodynamics and showed high diagnostic accuracy in detecting Fontan failure.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Vinzenz Boos, Christoph Buhrer, Joachim Photiadis, Felix Berger
Summary: Newborns with dextro-transposition of the great arteries (d-TGA) are at risk of severe acidosis and encephalopathy shortly after birth, with systemic hypothermia potentially delaying corrective surgery and improving postoperative survival rates.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Health Care Sciences & Services
Charlotte Schubert, Gareth Archer, Jo M. Zelis, Sarah Nordmeyer, Kilian Runte, Anja Hennemuth, Felix Berger, Volkmar Falk, Pim A. L. Tonino, Rod Hose, Herman ter Horst, Titus Kuehne, Marcus Kelm
NPJ DIGITAL MEDICINE
(2020)