Review
Physiology
Gustavo Jose Justo da Silva, Raffaele Altara, George W. Booz, Alessandro Cataliotti
Summary: Atrial natriuretic peptide is a crucial cardiac hormone that helps maintain heart function through potent natriuretic, diuretic, and vasodilating actions. Its main effects involve promoting the function of different tissues and organs in the body, and it shows potential in cardiorenal protective actions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Nina A. Dzhoyashvili, Seethalakshmi R. Iyer, Horng H. Chen, John C. Burnett
Summary: In this study, the researchers investigated the cardiorenal and neurohumoral actions of MANP in a genetic model of hypertension in rats. They found that MANP potentiated the blood pressure-lowering effects of furosemide, inhibited the renin-angiotensin-aldosterone system, and preserved renal function. These findings are highly relevant to the clinical treatment of hypertension and heart failure.
Review
Biochemistry & Molecular Biology
Giovanna Gallo, Speranza Rubattu, Camillo Autore, Massimo Volpe
Summary: Natriuretic peptides (NPs) are important in regulating heart function and have beneficial effects in cardiovascular diseases. They serve as biomarkers for diagnosis and prognosis, and can guide treatment strategies for improved outcomes. Therapies based on the properties and regulation of NPs are being developed for heart failure, hypertension, and other cardiovascular conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Giuseppe Vergaro, Alberto Aimo, Claudio Rapezzi, Vincenzo Castiglione, Iacopo Fabiani, Angela Pucci, Gabriele Buda, Claudio Passino, Josep Lupon, Antoni Bayes-Genis, Michele Emdin, Eugene Braunwald
Summary: Cardiac amyloidosis is an important cause of heart failure, manifested by increased wall thickness and diastolic dysfunction of the left ventricle. Atrial involvement in amyloidosis can lead to an increased risk of atrial fibrillation and thromboembolic events, even in the absence of systemic disease and ventricular involvement.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Tristan W. Dorey, Martin Mackasey, Hailey J. Jansen, Megan D. McRae, Loryn J. Bohne, Yingjie Liu, Darrell D. Belke, Logan Atkinson, Robert A. Rose
Summary: NPR-B receptor plays an essential physiological role in maintaining normal heart rate and sinoatrial node function by modulating ion channel function in sinoatrial node myocytes via a cGMP/PDE3/cAMP signaling mechanism.
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Carlos M. Ferrario, Seethalakshmi R. Iyer, John C. Burnett, Sarfaraz Ahmad, Kendra N. Wright, Jessica L. VonCannon, Amit Saha, Leanne Groban
Summary: The study identified the presence of Ang (1-12) in the blood of both normotensive subjects and patients with hypertension, regardless of age or sex, suggesting its role as a potential source for Ang II production in the blood. Higher plasma Ang (1-12) concentrations in hypertensive patients were correlated with certain indicators.
Review
Biology
Tomoko Ichiki, Atsushi Jinno, Yoshihisa Tsuji
Summary: This review discusses the role of natriuretic peptides and their receptors in cardiovascular protection and bone growth. The natriuretic peptide system is useful in the treatment of conditions such as heart failure, hypertension, and dwarfism. Optimization of therapeutics for each disease state requires consideration of drug metabolism, delivery systems, and target receptors.
Article
Cardiac & Cardiovascular Systems
Antoni Bayes-Genis, Kieran F. Docherty, Mark C. Petrie, James L. Januzzi, Christian Mueller, Lisa Andreson, Biykem Bozkurt, Javed Butler, Ovidiu Chioncel, John G. F. Cleland, Ruxandra Christodorescu, Stefano Del Prato, Finn Gustafsson, Carolyn S. P. Lam, Brenda Moura, Rodica Pop-Busui, Petar Seferovic, Maurizio Volterrani, Muthiah Vaduganathan, Marco Metra, Giuseppe Rosano
Summary: Diagnosing heart failure is often difficult due to non-specific symptoms. This document explores the use of NT-proBNP as a biomarker for diagnosing heart failure in different clinical scenarios. Validated cut-points are provided for ruling in or ruling out acute and de novo heart failure. The concept of 'heart stress' is introduced, and a simple acronym FIND-HF is proposed for early diagnosis of heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Carolyn S. P. Lam, Amina Rakisheva, Andrew J. S. Coats, Trisha Greenhalgh, Marco Metra, Mark C. Petrie, Giuseppe M. C. Rosano
Summary: A significant number of patients with heart failure face delays in diagnosis due to the non-specific symptoms. Diagnostic tools like measurement of natriuretic peptide concentrations are crucial but often underutilized. This clinical consensus statement aims to provide a diagnostic framework for non-cardiology physicians in the community to recognize and investigate patients with possible heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Hiroyuki Tsutsui, Nancy M. Albert, Andrew J. S. Coats, Stefan D. Anker, Antoni Bayes-Genis, Javed Butler, Ovidiu Chioncel, Christopher R. Defilippi, Mark H. Drazner, G. Michael Felker, Gerasimos Filippatos, Mona Fiuzat, Tomomi Ide, James L. Januzzi, Koichiro Kinugawa, Koichiro Kuwahara, Yuya Matsue, Robert J. Mentz, Marco Metra, Ambarish Pandey, Giuseppe Rosano, Yoshihiko Saito, Yasushi Sakata, Naoki Sato, Petar M. Seferovic, John Teerlink, Kazuhiro Yamamoto, Michihiro Yoshimura
Summary: Natriuretic peptides, such as B-type natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP), are widely used for diagnosing heart failure and have an important role in risk stratification. The development of angiotensin receptor neprilysin inhibitors (ARNIs) has increased the importance of natriuretic peptides as therapeutic agents.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Vibhu Parcha, Nirav Patel, Orlando M. Gutierrez, Peng Li, Karen L. Gamble, Kiran Musunuru, Kenneth B. Margulies, Thomas P. Cappola, Thomas J. Wang, Garima Arora, Pankaj Arora
Summary: This clinical trial investigated the diurnal rhythmicity of natriuretic peptides in healthy lean and obese individuals, revealing a misalignment of the NP-BP diurnal rhythm in the obese population.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Abdulaziz Joury, Hector Ventura, Selim R. Krim
Summary: Early detection and risk stratification are crucial for patients with heart failure (HF). Various biomarkers have been investigated for their diagnostic, prognostic, and therapeutic roles in HF, including markers of myocardial stretch, neurohormonal activation, inflammation and oxidative stress, as well as cardiac hypertrophy, fibrosis, and remodeling. This paper summarizes the current evidence supporting the use of selected biomarkers in HF management, discusses potential factors limiting their use in clinical practice, and highlights the challenges of adopting a multi-biomarker strategy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Peripheral Vascular Disease
Hitoshi Nakagawa, Takuya Kumazawa, Kenji Onoue, Yasuki Nakada, Tomoya Nakano, Satomi Ishihara, Naoto Minamino, Hiroshi Hosoda, Nobuhisa Iwata, Tomoya Ueda, Ayako Seno, Taku Nishida, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: The study showed that overexpression of NEP in cardiomyocytes leads to increased degradation of natriuretic peptides in the heart, resulting in an exaggerated hypertrophic and fibrotic response to pressure overload.
Review
Peripheral Vascular Disease
Koichi Yamamoto, Hiromi Rakugi
Summary: ARNIs are a new class of cardiovascular agents with dual action on major regulators of the cardiovascular system; a specific ARNI has been established as a first-line therapy for patients with heart failure; ARNIs may be superior to conventional RAS blockers in lowering blood pressure in patients with hypertension.
HYPERTENSION RESEARCH
(2021)
Article
Medical Laboratory Technology
Giuseppe Pinto, Barbara Colombo, Adriano Autieri, Luca Foppoli, Roberto Spoladore, Valentina Ardizzone, Alberto Margonato, Angelo Corti, Gabriele Fragasso
Summary: In patients with chronic systolic heart failure, vasostatin-1 and chromogranin A may serve as prognostic markers for cardiovascular events, providing complementary information to NT-proBNP and age, distinct from the association with left ventricular ejection fraction.
CLINICA CHIMICA ACTA
(2022)