Review
Peripheral Vascular Disease
Tatsuya Maruhashi, Yukihito Higashi
Summary: Blood-pressure-lowering therapy with antihypertensive drugs can reduce the risk of cardiovascular morbidity and mortality in patients with hypertension, but may impair endothelial function and worsen prognosis. Lifestyle modifications and nonpharmacological interventions are recommended for both untreated and treated individuals to improve endothelial function and reduce cardiovascular risk.
HYPERTENSION RESEARCH
(2022)
Review
Hematology
Simon Kraler, Peter Libby, Paul C. Evans, Alexander Akhmedov, Martin O. Schmiady, Michael Reinehr, Giovanni G. Camici, Thomas F. Luscher
Summary: Atherosclerotic cardiovascular disease has become a global epidemic, with the internal mammary artery's unique biological properties providing resilience against atherosclerotic plaque formation. Shifting the perspective from risk to resilience may help decipher the mechanisms of atheroresistance and identify new therapeutic targets.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Physiology
H. Jonathan Groot, Ryan M. Broxterman, Jayson R. Gifford, Ryan S. Garten, Matthew J. Rossman, Catherine L. Jarrett, Oh Sung Kwon, Jay R. Hydren, Russell S. Richardson
Summary: This study investigated the reliability of the passive leg movement test in assessing vascular function in men and compared it to the commonly used flow-mediated vasodilation method. The results showed that the passive leg movement test is a reliable method for evaluating vascular function in men, comparable to previous studies in women and flow-mediated vasodilation. These findings support the usefulness of the passive leg movement test as a clinical measurement of vascular function and cardiovascular disease risk.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
P. Totoson, C. Santini, A. Prigent-Tessier, C. Marie, C. Demougeot
Summary: This study found that endothelial BDNF can act as an autocrine regulator of vascular tone in the rat middle cerebral artery, and that a TrkB receptor agonist can induce artery relaxation. The results show that the TrkB agonist can induce vascular relaxation by promoting phosphorylation of the TrkB receptors, and that removal of endothelium or inhibition of NO and EDHF production will prevent this effect.
VASCULAR PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Naoto Fujii, Randeep Rakwal, Junko Shibato, Yoko Tanabe, Glen P. Kenny, Tatsuro Amano, Toby Mundel, Tze-Huan Lei, Koichi Watanabe, Narihiko Kondo, Takeshi Nishiyasu
Summary: This study found that activation of GAL3 receptors contributes to sweating but limits cutaneous vasodilation induced by heating, while GAL2 receptors do not contribute. Activation of GAL1 receptors attenuates both sweating and cutaneous vasodilation during heating.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Yuji Takaeko, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yiming Han, Yoshiki Aibara, Farina Mohamad Yusoff, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, Yukiko Nakano, Yukihito Higashi
Summary: In patients with cardiovascular risk factors, VE may represent atherosclerotic structural alterations of the vascular wall but not vascular function. The accuracy of oscillometric measurement of brachial artery diameter is acceptable.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Thaysa Ghiarone, Jorge A. Castorena-Gonzalez, Christopher A. Foote, Francisco I. Ramirez-Perez, Larissa Ferreira-Santos, Francisco J. Cabral-Amador, Roger de la Torre, Rama R. Ganga, Andrew A. Wheeler, Camila Manrique-Acevedo, Jaume Padilla, Luis A. Martinez-Lemus
Summary: This study investigates the involvement of ADAM17 in causing impaired insulin-induced vasodilation in type 2 diabetes (T2D). It provides evidence that ADAM17 activity is increased in the vasculature of T2D patients and supports the notion that ADAM17-mediated shedding of endothelial IRa ectodomains is a novel mechanism causing vascular insulin resistance. Targeting ADAM17 activity may be a potential therapeutic strategy to correct vascular insulin resistance in T2D.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Donald M. Lloyd-Jones, Cora E. Lewis, Pamela J. Schreiner, James M. Shikany, Stephen Sidney, Jared P. Reis
Summary: The CARDIA study began in 1985-1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 from 4 US communities. Over 35 years, CARDIA has contributed fundamentally to our understanding of cardiovascular health and disease, as well as associations between neighborhood environment, lifestyle behaviors, and biological risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kelly A. Stockelman, Anthony R. Bain, Caitlin A. Dow, Kyle J. Diehl, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Summary: Insufficient sleep is associated with endothelial dysfunction and increased cardiovascular risk, while regular aerobic exercise can improve endothelial function and reduce cardiovascular risk. In this study, aerobic exercise training was found to enhance endothelium-dependent vasodilation and reduce ET-1-mediated vasoconstriction in adults with habitual insufficient nightly sleep, regardless of changes in sleep duration. Regular aerobic exercise can potentially mitigate the cardiovascular risk associated with insufficient sleep-related endothelial dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Hematology
Maria J. Iglesias, Larissa D. Kruse, Laura Sanchez-Rivera, Linnea Enge, Philip Dusart, Mun-Gwan Hong, Mathias Uhlen, Thomas Renne, Jochen M. Schwenk, Goran Bergstrom, Jacob Odeberg, Lynn M. Butler
Summary: This study identified 216 proteins associated with cardiovascular disease risk factor exposure, and showed a relationship between individual cardiovascular disease risk and corresponding biomarker profiles. The findings indicate that EC proteins in plasma could reflect vascular health status.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
A. Parker Ruhl, Neal Jeffries, Yu Yang, Orlando M. Gutierrez, Paul Muntner, Rakhi P. Naik, Lydia H. Pecker, Bryan T. Mott, Neil A. Zakai, Monika M. Safford, Leslie A. Lange, Cheryl A. Winkler, Marguerite R. Irvin, Mary Cushman, Hans C. Ackerman
Summary: Increased HBA copy number is not associated with the risk of hypertension among Black American adults.
Article
Cardiac & Cardiovascular Systems
Sander Craps, Jore Van Wauwe, Sofie De Moudt, Dorien De Munck, Arthur J. A. Leloup, Bram Boeckx, Tim Vervliet, Wouter Dheedene, Nathan Criem, Carla Geeroms, Elizabeth A. Jones, An Zwijsen, Diether Lambrechts, Paul Fransen, Manu Beerens, Aernout Luttun
Summary: Prdm16 plays a critical role in arterial flow recovery by maintaining endothelial function, making it a potential target for therapeutic strategies in peripheral artery disease patients ineligible for revascularization.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anna Bartakova, Marie Novakova
Summary: Cardiovascular diseases are a major cause of death globally, often involving endothelial dysfunction. Plants contain biologically active substances that can affect the endothelium, potentially contributing to the development of cardiovascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Lauren A. Biwer, Brigett V. Carvajal, Qing Lu, Joshua J. Man, Iris Z. Jaffe
Summary: The study showed that deletion of endothelial MR in obese female animals can improve vascular dilation, and endothelial ER alpha plays a positive role in increasing nitric oxide to rescue vasodilation. MR and ER alpha may compete for striatin binding within endothelial cells to regulate NO.
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)