Article
Chemistry, Medicinal
Kirandeep Samby, Dominique Besson, Anirban Dutta, Buddhadev Patra, Angelique Doy, Paul Glossop, James Mills, Gavin Whitlock, Rob Hooft van Huijsduijnen, Alessandra Monaco, Graeme Bilbe, Charles Mowbray, Benjamin Perry, Anna Adam, Timothy N. C. Wells, Paul A. Willis
Summary: The Covid-19 pandemic has highlighted the importance of investing in the search for new medicines to address emerging health threats. Researchers have assembled the Pandemic Response Box, a collection of 400 compounds, to facilitate drug discovery in emerging infectious diseases.
ACS INFECTIOUS DISEASES
(2022)
Article
Microbiology
Anne-Grete Maertson, Jan-Willem C. Alffenaar, Roger J. Brueggemann, William Hope
Summary: Invasive fungal infections are a common cause of death in immunocompromised patients, and current strategies for antifungal therapy do not cater to individual patient's needs. More research is needed to maximize the effectiveness of antifungal therapy at an individual level.
Article
Critical Care Medicine
Kiran Shekel, Mohd H. Abdul-Aziz, Vesa Cheng, Fay Burrows, Hergen Buscher, Young-Jae Cho, Amanda Corley, Arne Diehl, Eileen Gilder, Stephan M. Jakob, Hyung-Sook Kim, Bianca J. Levkovich, Sung Yoon Lim, Shay McGuinness, Rachael Parke, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C. Wallis, Susan A. Welch, David Zacharias, John F. Fraser, Jason A. Roberts
Summary: This study aimed to describe the pharmacokinetics of antimicrobials in critically ill patients receiving ECMO and evaluate the effectiveness and safety of current dosing regimens. The study found that there were large variations in antimicrobial concentrations in ECMO patients, leading to poor target attainment rates. Understanding these issues is crucial for the development of appropriate dosing regimens.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Infectious Diseases
Jing Zhou, Li Jiang, Zhi-Ling Zhang, Zhao-Rui Wang, Yan-Xiu Zhang, Xu Lin, Bo-Hao Tang, Bu-Fan Yao, Zi-Xuan Guo, Jing-Jing Yang, John Van den Anker, Yue-E Wu, Wei Zhao
Summary: This study aims to describe the pharmacokinetic characteristics of mezlocillin in neonates and young infants, and propose the optimal dosing regimen based on the population pharmacokinetic model of mezlocillin. The results showed that a two-compartment model with first-order elimination can be used to describe the population pharmacokinetics of mezlocillin, and postmenstrual age, current weight, and serum creatinine concentration are the most important covariates.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Li Xue, Qi Hui, Jin Fei, Yao Bu-Fan, Wu Yue-E, Qi Yu-Jie, Kou Chen, Wu Xi-Rong, Luo Xiao-Jing, Shen Yan-Hua, Zheng Xu, Wang Yong-Hong, Xu Fang, Jiao Wei-Wei, Li Jie-Qiong, Xiao Jing, Dong Yi-Ning, Du Bin, Shi Hai-Yan, Xu Bao-Ping, Shen A-Dong, Zhao Wei
Summary: By conducting a population pharmacokinetic study and recommending a model-based dosage regimen, this study aimed to optimize sepsis therapy in neonates and young infants using ceftazidime. Through Monte Carlo simulation, evidence-based dosage regimens were proposed based on developmental pharmacokinetic-pharmacodynamic analysis, covering the entire range of this vulnerable population.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pediatrics
Yue-E Wu, Chen Kou, Xue Li, Bo-Hao Tang, Bu-Fan Yao, Guo-Xiang Hao, Yi Zheng, John van den Anker, Dian-Ping You, A-Dong Shen, Wei Zhao
Summary: This study aimed to optimize the dosing regimens of meropenem for late-onset sepsis (LOS) in Chinese newborns. By conducting a population pharmacokinetic-pharmacodynamic analysis based on domestic common pathogens and their susceptibility patterns, an evidence-based dosing regimen was proposed, providing guidance for clinical treatment.
Article
Pharmacology & Pharmacy
Sarah Tubiana, Jeanne Sibiude, Philippe Herlemont, Jerome Drouin, Olivier Picone, Xavier Duval, Alain Weill, Mahmoud Zureik, Rosemary Dray-Spira
Summary: This study investigated the trends in anti-infective use during pregnancy from 2010 to 2019 using the French national health data system. The study found a decrease in the use of antibacterials and an increase in the use of antiviral agents. The study also suggested room for improvement in influenza vaccination.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Infectious Diseases
Julie Gorham, Fabio S. Taccone, Maya Hites
Summary: Obesity is associated with increased risks of comorbidities, postoperative infections, and nosocomial infections. The pharmacokinetics and pharmacodynamics of antibiotics are affected by obesity, leading to increased risks of antibiotic therapy failure and toxicity. Precision dosing of antibiotics using therapeutic drug monitoring may improve the management of critically ill obese patients with infections.
Article
Microbiology
Rene Welte, Herbert Oberacher, Tiziana Gasperetti, Hartwig Pfisterer, Andrea Griesmacher, Tobias Santner, Cornelia Lass-Floerl, Caroline Hoertnagl, Sandra Leitner-Rupprich, Maria Aigner, Ingo Lorenz, Stefan Schmid, Michael Edlinger, Philipp Eller, Daniel Dankl, Michael Joannidis, Romuald Bellmann
Summary: This study evaluated the pharmacokinetics and antifungal activity of echinocandins in critically ill adults with suspected or proven invasive candidiasis. The findings showed that echinocandin concentrations in ascites fluid were lower than in plasma, and therapeutic doses did not consistently eradicate Candida albicans or Candida glabrata growth.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Oncology
Shelby Barnett, Guy Makin, Deborah A. Tweddle, Caroline Osborne, Gareth J. Veal
Summary: This study aims to optimize the doses of carboplatin in infants by utilizing real world clinical pharmacology data. The results show that optimizing the weight-based doses to 6 mg/kg and 9 mg/kg per day can effectively achieve the target AUC values, thereby reducing drug exposure variability.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Peter Ertl, Eva Altmann, Sophie Racine, Odile Decoret
Summary: Boronic acids are crucial for synthesizing bioactive molecules and exploring structure-activity relationships. With over ten thousand commercially available options, medicinal chemists face the challenge of selecting the most informative ones for new target molecule synthesis. This article identifies frequently used boronic acids and their properties through mining large databases, and proposes a diverse set of boronic acids for efficient library design. In addition, a web tool called the Boronic Acid Navigator is provided to assist chemists in making their own selections.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Ajinath Kale, Vishwadeep Shelke, Neha Dagar, Hans-Joachim Anders, Anil Bhanudas Gaikwad
Summary: Antiviral drugs, such as Remdesivir and Molnupiravir, can reduce the risk of severe and fatal COVID-19. However, most clinical trials exclude patients with impaired kidney function, which is a prevalent risk factor for severe COVID-19. It is a challenge to select appropriate therapies for COVID-19 patients with impaired kidney function.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Infectious Diseases
Elio Castagnola, Giuliana Cangemi, Alessio Mesini, Carlo Castellani, Antonietta Martelli, Dario Cattaneo, Francesca Mattioli
Summary: Cystic fibrosis can lead to severe bacterial respiratory infections and pathological changes affecting drug absorption, distribution, metabolism, and elimination. It is crucial to be aware of pharmacokinetic derangements in cystic fibrosis patients to optimize antibiotic therapy. Recent evidence shows that many cystic fibrosis patients treated with conventional dosing schemes have subtherapeutic antibiotic concentrations, increasing the risk of treatment failure and the emergence of resistant pathogens.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Microbiology
Praneeth Jarugula, Ayse Akcan-Arikan, Flor Munoz-Rivas, Brady S. Moffett, Vijay Ivaturi, Danielle Rios
Summary: This study aimed to determine the optimal vancomycin starting dose regimens in infants <= 180 days of age to achieve the highest probability of target attainment with AUC(24) of >= 400. It also examined the relationship between serum creatinine and vancomycin clearance in neonates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pediatrics
Manal Abouelkheir, Abdullah Almohaizeie, Abdulrahman Almutairi, Sara Almuhisen, Saeed Alqahtani, Abdullah Alsultan
Summary: This study evaluated the use of a population pharmacokinetic model-based approach for optimizing vancomycin initial dosing in neonates. The results showed that the model-based method had a higher probability of achieving the recommended therapeutic target compared to empirical dosing based on other references.
PEDIATRICS AND NEONATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Anil R. Maharaj, Huali Wu, Kanecia O. Zimmerman, Julie Autmizguine, Rohit Kalra, Amira Al-Uzri, Catherine M. T. Sherwin, Stuart L. Goldstein, Kevin Watt, Jinson Erinjeri, Elizabeth H. Payne, Michael Cohen-Wolkowiez, Christoph P. Hornik
Summary: The study aimed to evaluate the population pharmacokinetics of olanzapine in children and develop a model-informed pediatric dosing scheme. The analysis of opportunistically collected plasma samples revealed body weight and postmenstrual age as influential factors on apparent clearance of olanzapine in children.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cameron L. McGlone, Lea Christian, Benjamin Schmeusser, Langni Liu, Charles E. Chalfant, Daniel J. Stephensen, Catherine M. Sherwin, Christine M. Rapp, Zafer Sattouf, Craig A. Rohan, Connor Morris, Yanfang Chen, Jeffrey B. Travers
Summary: Recent studies have shown that UVB radiation can generate subcellular microvesicle particles (MVP) both locally and systemically. The ability of UVB to generate MVP is dependent on reactive oxygen species (ROS), and antioxidant vitamins like vitamin C and vitamin E can diminish UVB-induced skin MVPs.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Shahrzad Habibi Ghahfarrokhi, Abdollah Mohammadian-Hafshejani, Catherine M. T. Sherwin, Saeid Heidari-Soureshjani
Summary: This study investigated the relationship between serum 25-hydroxyvitamin D (25OHD) levels and the occurrence of hip fractures in the elderly. The results suggest that low serum vitamin D levels are associated with an increased odds of hip fracture.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Review
Obstetrics & Gynecology
Farnoosh Farahbod, Parham Talebi-Boroujeni, Catherine M. T. Sherwin, Saeid Heidari-Soureshjani
Summary: Phosphodiesterase type 5 (PDE5) inhibitors affect endometrial thickness through various mechanisms and have a positive impact on pregnancy outcomes. However, their effects may be influenced by various factors and further research is needed.
JOURNAL OF ENDOMETRIOSIS AND PELVIC PAIN DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Abdallah Derbalah, Stephen Duffull, Catherine M. Sherwin, Kathleen Job, Hesham Al-Sallami
Summary: Current enoxaparin dosing guidelines in children may not be appropriate for obese children. This study aimed to characterize the pharmacokinetics of enoxaparin in obese children and propose a more suitable dosing regimen.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pediatrics
Candice D. Fike, Charul Avachat, Angela K. Birnbaum, Judy L. Aschner, Catherine M. Sherwin
Summary: This study investigated the pharmacokinetics (PK) of enterally administered l-citrulline in neonates at risk of developing bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) and proposed a model-informed dosing strategy. The results showed that oral l-citrulline can achieve steady-state concentrations, indicating its potential as a treatment for reducing BPD-PH in premature neonates.
Review
Medicine, Research & Experimental
Karamali Kasiri, Catherine M. T. Sherwin, Sahar Rostamian, Saeid Heidari-Soureshjani
Summary: This systematic review and meta-analysis investigated the properties and risk factors associated with using gastric acid suppressants in patients with esophageal adenocarcinoma (EAC). The results found that gastric acid suppressants do not have a protective role in EAC and are not risk factors. Further studies are needed to understand the development of EAC.
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
(2023)
Article
Dermatology
Oladayo A. Oyebanji, Chad Brewer, Sharlo Bayless, Benjamin Schmeusser, Danielle A. Corbin, Courtney E. W. Sulentic, Catherine M. T. Sherwin, Yanfang Chen, Christine M. Rapp, Elizabeth E. Cates, Yuhan Long, Jeffrey B. Travers, Craig A. Rohan
Summary: Topical photodynamic therapy (PDT) has been shown to be immunosuppressive through unknown mechanisms, possibly limiting its effectiveness. This study found that PDT can generate the immunosuppressive lipid mediator platelet-activating factor (PAF) and subcellular microvesicle particles (MVPs), which are involved in PDT-induced immunosuppression. The immunosuppression caused by PDT was shown to be dependent on the MVP-generating enzyme acid sphingomyelinase. Additional experiments in mice and human patients confirmed these findings. These results provide a potential target, MVP, to improve the effectiveness of PDT.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Charul Avachat, Jessica M. Barry, Xintian Lyu, Catherine M. Sherwin, Angela K. Birnbaum
Summary: The management of seizures during pregnancy is crucial due to the potential risks of altered drug exposure and neurodevelopmental outcomes. While newer anti-seizure medications have more favorable pharmacokinetics, therapeutic monitoring of drug concentrations is still necessary for pregnant patients.
Article
Pharmacology & Pharmacy
Sissel Haslund-Krog, Jessica M. Barry, Angela K. Birnbaum, Kim Dalhoff, Tine Brink Henriksen, Catherine M. T. Sherwin, Charul Avachat, Susanne Poulsen, Ulla Christensen, Rory P. Remmel, Diana Wilkins, John N. van den Anker, Helle Holst
Summary: This study aimed to investigate the pharmacokinetics and safety of prolonged paracetamol use for neonatal pain. The results showed that there was no evidence of liver injury or changes in metabolism in neonates receiving prolonged paracetamol administration.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tan Zhang, Cornelis Smit, Catherine M. T. Sherwin, Catherijne A. J. Knibbe, Elke H. J. Krekels
Summary: This study investigates the pharmacokinetic differences of vancomycin in overweight and obese adolescents and adults, finding significant differences in vancomycin clearance rate between these populations, suggesting that dosing of vancomycin cannot be directly extrapolated between obese adolescents and adults.
CLINICAL PHARMACOKINETICS
(2023)
Review
Pharmacology & Pharmacy
Razieh Mohammadi-Dashtaki, Saeid Heidari-Soureshjani, Catherine Mary Turner Sherwin
Summary: This study investigated the pain-relieving effects of aromatherapy with medicinal plants on patients with cardiovascular diseases. The results showed that inhalation aromatherapy significantly reduced pain severity in CVD patients after 5 minutes and 15-30 minutes of intervention. Therefore, inhalation aromatherapy can be used as a complementary medicine for pain reduction in CVD patients.
CURRENT DRUG THERAPY
(2023)
Review
Oncology
Khatereh Anbari, Mehdi Mohammadian Amiri, Saeid Heidari-Soureshjani, Catherine M. T. Sherwin, Karamali Kasiri
Summary: This study provides scientific evidence through systematic review and meta-analysis that statins can reduce the risk of mortality in patients with pancreatic cancer, especially in case-control studies and studies with good quality scores. However, no significant relation was observed in randomized clinical trials, highlighting the need for cautious interpretation of the results.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Lubov V. Krepkova, Alexandra N. Babenko, Svetlana V. Lemyaseva, Olga L. Saybel, Catherine M. Sherwin, Elena Y. Enioutina
Summary: This study investigated the effects of a novel chicory extract on liver enzymes and metabolism in rats with acute liver injury or hyperlipidemia. The results showed that the chicory extract effectively improved acute liver injury and hyperlipidemia. This study suggests that chicory extract may have potential applications in the treatment of liver injuries and related diseases.
Review
Rheumatology
Shahin Asgari Savadjani, Catherine M. T. Sherwin, Saeid Heidari-Soureshjani, Mohammad Darvishi, Mehdi Mohammadian Amiri
Summary: Vitamin D supplementation can improve symptoms in patients with carpal tunnel syndrome (CTS), and low serum levels of 25(OH)D may aggravate the symptoms and be a risk factor for its occurrence. However, more observational studies and clinical trials are needed.
CURRENT RHEUMATOLOGY REVIEWS
(2023)