Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients with Stable Coronary Artery Disease

Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer

(2011) Patrick M. Dansette et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers

(2010) Kathleen Butler et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies

(2010) Paul A. Gurbel et al.   CIRCULATION

In Vitro Evaluation of Potential Drug-Drug Interactions with Ticagrelor: Cytochrome P450 Reaction Phenotyping, Inhibition, Induction, and Differential Kinetics

(2010) D. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects

(2010) R. Teng et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y12 receptor antagonist, in healthy subjects

(2010) Renli Teng et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Determination of ticagrelor and two metabolites in plasma samples by liquid chromatography and mass spectrometry

(2010) Henrik Sillén et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Ticagrelor: The First Reversibly Binding Oral P2Y12Receptor Antagonist

(2009) Steen Husted et al.   Cardiovascular Therapeutics

Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease

(2009) Paul A. Gurbel et al.   CIRCULATION

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis

(2009) Bengt C. Fellström et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transitioning patients from cangrelor to clopidogrel: Pharmacodynamic evidence of a competitive effect

(2007) Steven R. Steinhubl et al.   THROMBOSIS RESEARCH