Review
Immunology
Damon J. Disabato, Christina M. Marion, Katherine A. Mifflin, Anthony N. Alfredo, Kyleigh A. Rodgers, Kristina A. Kigerl, Phillip G. Popovich, Dana M. Mctigue
Summary: Spinal cord injury not only affects motor function, but also has systemic consequences on immune and metabolic functions. Therefore, studying the detrimental aspects of spinal cord injury is crucial for improving patients' lifespan and quality of life.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Maria Cecilia Cercato, Concetta Elisa Onesti, Sabrina Vari, Gabriella Maggi, Wioletta Faltyn, Serena Ceddia, Irene Terrenato, Virginia Scarinci, Francesca Servoli, Cristina Cenci, Roberto Biagini, Virginia Ferraresi
Summary: This study aimed to evaluate the feasibility and usefulness of a digital narrative diary in the care pathway of patients with bone sarcoma and limb soft tissue sarcoma. The results showed that the diary provided benefits for both patients and healthcare professionals, including increased awareness, improved communication, and deeper knowledge of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Alberto Romano, Silvia Triarico, Emanuele Rinninella, Luigi Natale, Maria Gabriella Brizi, Marco Cintoni, Pauline Raoul, Palma Maurizi, Giorgio Attina, Stefano Mastrangelo, Antonio Gasbarrini, Maria Cristina Mele, Antonio Ruggiero
Summary: In this study, nutritional and sarcopenia status were assessed in pediatric patients with bone and soft tissue sarcomas. It was found that over half of the patients experienced sarcopenia at diagnosis, and there was a significant decrease in prognostic nutritional index (PNI) and total psoas muscle area (tPMA) after 12 months of treatment. Furthermore, a decrease in PNI was associated with poor overall survival (OS) in these patients.
Review
Biochemistry & Molecular Biology
Minjia Zhu, Zeqing Zhao, Hockin H. K. Xu, Zixiang Dai, Kan Yu, Le Xiao, Abraham Schneider, Michael D. D. Weir, Thomas W. W. Oates, Yuxing Bai, Ke Zhang
Summary: Bone tissue engineering is a promising approach for reconstructing bone defects, and metformin can enhance osteogenesis and angiogenesis. Vascular networks are crucial for bone tissue engineering, and metformin can also enhance vascular differentiation. This review article summarizes the effects of metformin on stem cells and bone tissue engineering, as well as its applications in bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Zahra Gholamnezhad, Bahare Safarian, Ali Esparham, Mohammad Mirzaei, Mahla Esmaeilzadeh, Mohammad Hossein Boskabady
Summary: Recent studies have shown that proper exercise can significantly restrict inflammatory responses by regulating the immune system. This review discusses the mechanisms of the protective effects of exercise in LPS-induced lung injury. The results suggest that aerobic exercise can alleviate LPS-induced lung injury by suppressing oxidative stress and reducing the ratio of pro-inflammatory to anti-inflammatory cytokines.
Article
Microbiology
Bao-Zhu Li, Hua Wang, Xian-Bao Li, Qian-Ru Zhang, Rong-Gui Huang, Hong Wu, Yi-Yu Wang, Kai-Di Li, Xiu-Jie Chu, Nv-Wei Cao, Hao-Yue Zhou, Xin-Yu Fang, Rui-Xue Leng, Yin-Guang Fan, Jin-Hui Tao, Zong-Wen Shuai, Dong-Qing Ye
Summary: This study presents a pilot analysis of fungal microbiota in patients with systemic lupus erythematosus (SLE), showing significant differences in diversity and composition compared to other diseases and healthy controls. The composition of fungal and bacterial microbiota is imbalanced in SLE patients, and there is a complex relationship network between them.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Emergency Medicine
Kai-Hsiang Wu, Po-Han Wu, Chih-Yao Chang, Yen-Ting Kuo, Kuang-Yu Hsiao, Cheng-Ting Hsiao, Shang-Kai Hung, Chia-Peng Chang
Summary: This study evaluates the characteristics of infectious fluid in soft tissue infection and suggests that biochemical tests and Gram stain smear can be useful in distinguishing necrotizing soft tissue infection (NSTI) from cellulitis.
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Article
Orthopedics
Weilong Diwu, Gang Hu, Minghao Zhou, Long Bi, Ming Yan, Hongbo Wei, Junjun Fan
Summary: Intermittent pneumatic soft-tissue compression can accelerate new bone formation of bone defects, and the optimal intensity is 8-10 kPa for repairing the rabbit radial bone defect.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Cell Biology
Anoushka Ashok Kumar Samat, Jolijn van der Geest, Sebastiaan J. Vastert, Jorg van Loosdregt, Femke van Wijk
Summary: The article summarizes the role of tissue-resident memory T cells (T-RM) in chronic inflammatory diseases, highlighting the presence of T-RM in both non-lymphoid tissue and circulation, and their potential significance in disease progression and treatment.
Article
Pediatrics
Scott A. Holmes, Joud Mar'i, Jordan Lemme, Anne Margarette Maallo, Alyssa Lebel, Laura Simons, Michael J. O'Brien, David Zurakowski, Rami Burnstein, David Borsook
Summary: A mild Traumatic Brain Injury (mTBI) causes changes in blood flow and white matter in the brain, suggesting a physiological basis for chronic symptoms. Post-traumatic headache (PTH) often persists beyond the acute period and it is unclear if inflammation contributes to its clinical trajectory.
Article
Chemistry, Multidisciplinary
Crystal S. Shin, Fernando J. Cabrera, Richard Lee, John Kim, Remya Ammassam Veettil, Mahira Zaheer, Aparna Adumbumkulath, Kirti Mhatre, Pulickel M. Ajayan, Steven A. Curley, Bradford G. Scott, Ghanashyam Acharya
Summary: The development of an inflammation modulating biomaterial scaffold for soft tissue repair has shown promising results in inhibiting visceral adhesions formation and minimizing postsurgical complications. In vivo evaluation in a rat ventral hernia model confirmed that the bioscaffold acts as an inflammation trap, capturing proinflammatory cytokines and modulating local inflammation effectively without the need for exogenous anti-inflammatory agents.
ADVANCED MATERIALS
(2021)
Article
Infectious Diseases
Georgios S. Chatzopoulos, Alejandro Cisneros, Miguel Sanchez, Larry F. Wolff
Summary: The study found a significant association between periodontal disease and systemic inflammatory conditions, with conditions like hypertension, arthritis, and diabetes affecting the severity of bone loss, while diabetes and lupus were linked to the extent of missing teeth.
Article
Oncology
Valentina Fausti, Alessandro De Vita, Silvia Vanni, Virginia Ghini, Lorena Gurrieri, Nada Riva, Roberto Casadei, Marco Maraldi, Giorgio Ercolani, Davide Cavaliere, Carlo Alberto Pacilio, Federica Pieri, Flavia Foca, Alberto Bongiovanni, Nicoletta Ranallo, Sebastiano Calpona, Giovanni Luca Frassineti, Toni Ibrahim, Laura Mercatali
Summary: High NLR, PLR, and SII are associated with worse PFS in second-line STS patients. Trabectedin-treated patients have a better PFS when LMR is low, while patients treated with other regimens have a worse PFS when LMR is low. Patients showing a high LMR seem to have high levels of M2 intratumoral macrophages.
Article
Biochemistry & Molecular Biology
Meagan J. Makarczyk, Sophie Hines, Haruyo Yagi, Zhong Alan Li, Alyssa M. Aguglia, Justin Zbikowski, Anne-Marie Padget, Qi Gao, Bruce A. Bunnell, Stuart B. Goodman, Hang Lin
Summary: Osteoarthritis (OA) is a common joint disease that causes pain and disability. The miniJoint model, which mimics the nature of OA in humans, was used to explore the potential of co-treatment with anti-inflammation and chondroinducing agents. The study demonstrated that the combined treatment with BMP-7 and NF-kappa B ODNs reduced inflammation and promoted glycosaminoglycan formation in cartilage, indicating the potential for developing disease-modifying OA drugs.
Article
Dentistry, Oral Surgery & Medicine
Anders Esberg, Catrine Isehed, Anders Holmlund, Susanne Lindquist, Pernilla Lundberg
Summary: This study followed patients undergoing surgical treatment for periodontitis over time and found that changes in treatment outcomes, such as relapse with increased BOP and PPD, were associated with alterations in serum levels of specific proteins like PD-L1 and Cystatin D. These findings suggest that these proteins may play a role in the pathogenesis of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Surgery
Y. Kalbas, Y. Kumabe, R. M. Sellei, H. C. Pape
Summary: Acute compartment syndrome of the extremities is a surgical emergency that requires rapid diagnosis and immediate surgical treatment to prevent potential disastrous consequences. A basic understanding of this condition is crucial for trauma surgeons, as timely treatment relies on rapid diagnosis and evaluation of indications.
Article
Emergency Medicine
Claudio Canal, Alexander Kaserer, Laurent Sebastien Morax, Franziska Ziegenhain, Hans-Christoph Pape, Valentin Neuhaus
Summary: The purpose of this study was to investigate the impact of anesthesia type (regional vs. general anesthesia) on in-hospital complications in ankle fractures. The findings revealed that the type of anesthesia was not an independent predictor of complications.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Emergency Medicine
Klaus Wendt, Christoph Nau, Marko Jug, Hans Christoph Pape, Richard Kdolsky, Sam Thomas, Frank Bloemers, Radko Komadina
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Orthopedics
Felix Karl-Ludwig Klingebiel, Morgan Hasegawa, Oliver A. Strahle, Yannik Kalbas, Michel Teuben, Sascha Halvachizadeh, Yohei Kumabe, Hans-Christoph A. Pape, Roman Pfeifer
Summary: The purpose of this study was to identify key factors and quantify the surgical load for different types of fracture fixation in multiple anatomic regions. The results showed that intraoperative blood loss and soft tissue damage were the most significant factors, and surgeries in distal anatomical regions had lower surgical load.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Till Berk, Ivan Zderic, Peter Schwarzenberg, Tatjana Pastor, Felix Lesche, Sascha Halvachizadeh, R. Geoff Richards, Boyko Gueorguiev, Hans-Christoph Pape
Summary: The aim of this biomechanical study was to compare the stability of retrograde placed cannulated compression headless screw (CCHS) fixation with conventional fully and partially threaded screws for superior pubic ramus fractures (SPRF). The study found that CCHS fixation provided superior stability and could be a better alternative for retrograde SPRF screw fixation.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Felix Karl-Ludwig Klingebiel, Morgan Hasegawa, Joshua A. Parry, Zsolt Balogh, Ramesh Kumar Sen, Yannik Kalbas, Michel Teuben, Sascha Halvachizadeh, Hans-Christoph A. Pape, Roman Pfeifer, SICOT Trauma Research Grou
Summary: This study aims to assess practice variation in the management of unstable pelvic injuries globally. The Young-Burgess and Tile/AO classification systems are commonly used. Initial non-invasive stabilization and temporary external fixation are commonly utilized, while specific hemorrhage control techniques such as pelvic packing and angioembolization are rarely used.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Emergency Medicine
Till Berk, Ivan Zderic, Peter Varga, Peter Schwarzenberg, Karlyn Berk, Niklas Grueneweller, Tatjana Pastor, Sascha Halvachizadeh, Geoff Richards, Boyko Gueorguiev, Hans-Christoph Pape
Summary: The semi-rigid technique shows promising results for the treatment of unstable pubic symphysis injuries, but further studies with larger sample sizes are needed.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Editorial Material
Critical Care Medicine
Guido A. Wannera, Sandro M. Heiningb, Vladislav Raykovc, Hans-Christoph Papeb
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Surgery
Katharina Schmelzer, Franziska Ziegenhain, Claudio Canal, Hans-Christoph Pape, Valentin Neuhaus
Summary: This study analyzed concomitant injuries in unilateral and bilateral rib fractures and pulmonary contusions and evaluated the differences in complication rates between the two. The results revealed that patients with bilateral chest trauma had a higher incidence of complications and mortality rate. Therefore, these significant risk factors should be considered in treatment and resource management.
Article
Orthopedics
Janic Fischer, JoEllen Welter, Nils Horn, Simon Graber, Hans-Christoph Pape, Laurenz Jaberg, Florian Hess
Summary: The purpose of this study was to evaluate patient outcomes after reverse shoulder arthroplasty for complex proximal humerus fractures and to explore the clinical implications of greater tuberosity malunions. The study included 56 patients who underwent reverse shoulder arthroplasty. The results showed that patients with complete tuberosity healing had better clinical outcomes compared to those with tuberosity malunions.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Medicine, General & Internal
Till Berk, Ivan Zderic, Jan Caspar, Peter Schwarzenberg, Torsten Pastor, Sascha Halvachizadeh, Biser Makelov, Geoff Richards, Hans-Christoph Pape, Boyko Gueorguiev
Summary: The aim of this biomechanical feasibility study was to develop and test a novel intramedullary splinting implant for the treatment of pubic ramus fractures and evaluate its biomechanical viability compared to established fixation methods. The results showed that the novel ramus intramedullary splint can be used as an alternative option and has the potential to decrease the rate of implant failures due to its minimally invasive implantation procedure.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, Research & Experimental
Henrik Teuber, Sascha Halvachizadeh, Melvin Muthirakalayil, Luxu Yin, Harry Eisenkrein, Frank Hildebrand, Philipp Kobbe, Kai Sprengel, Ladislav Mica, Hatem Alkadhi, Hans-Christoph Pape, Roman Pfeifer
Summary: This study investigated the influence of ankylosing spondylitis (AS) on radiologic parameters used to detect traumatic and degenerative instability of the cervical spine. A retrospective analysis of AS patients and controls was performed, and no significant clinical or morphologic differences were found in the evaluated cervical radiologic parameters between the two groups. CT imaging may be diagnostically appropriate for assessing cervical pathologies in patients with AS.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Selim Safali, Till Berk, Biser Makelov, Mehmet Ali Acar, Boyko Gueorguiev, Hans-Christoph Pape
Summary: With the advancements in software and 3D printing, personalized 3D printed orthopedic implants have gained popularity for treating complicated surgical cases. This study presents the design, modeling, and production stages of four different personalized 3D printed prostheses and their successful application in clinical cases. Based on computed tomography scanning, the personalized prostheses were designed, produced, and used within a short period of time after injury or admission. Early term follow-ups showed excellent results, indicating the potential benefits of personalized 3D printed prostheses in treating patients with appropriate indications.
MEDICINA-LITHUANIA
(2023)
Article
Orthopedics
Thomas Rauer, Eva Friedl, Jamison G. G. Gamble, Boris A. A. Zelle, Hans-Christoph Pape, Roman Pfeifer
Summary: The main objective of this study is to examine the relationship between chronic pain and limping with lower extremity and pelvic fracture location in multiple injured patients. The study found that the combination and location of fractures are critical factors in determining long-term outcome.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Clinical Neurology
Jakob Hax, Michel Teuben, Sascha Halvachizadeh, Till Berk, Julian Scherer, Kai Oliver Jensen, Rolf Lefering, Hans-Christoph Pape, Kai Sprengel
Summary: This retrospective database analysis aimed to evaluate the impact of spinal injury localization, severity, and concurrent injury patterns on the timing of surgery and subsequent outcome in polytraumatized patients. The results showed that polytrauma patients frequently sustain multiple spinal injuries, and the severity of concomitant injuries and spinal injury localization play a role in the timing of surgical intervention and the outcome.
GLOBAL SPINE JOURNAL
(2023)