Article
Health Care Sciences & Services
Soenke Percy Frey, Berrin Yorumazel, Stefanie Hoelscher-Doht, Lars Eden, Norbert Schuetze, Rainer Heribert Meffert, Hendrik Jansen
Summary: The study found that local application of CYR61 can significantly promote the recovery of muscle strength and angiogenesis, while moderately reducing the formation of scar tissue.
TECHNOLOGY AND HEALTH CARE
(2021)
Article
Cell Biology
Cory M. Dungan, Kevin A. Murach, Christopher J. Zdunek, Zuo Jian Tang, Georgia L. Nolt, Camille R. Brightwell, Zachary Hettinger, Davis A. Englund, Zheng Liu, Christopher S. Fry, Antonio Filareto, Michael Franti, Charlotte A. Peterson
Summary: The study found that clearance of senescent cells benefits skeletal muscle regeneration and improves muscle function in old mice. However, clearance of senescent cells has a suppressive effect on regeneration in young mice.
Article
Nutrition & Dietetics
Shamsa Jabeen, Javed Iqbal Qazi
Summary: This study investigated the effects of probiotic supplementation on the regeneration of extensor digitorum longus (EDL) muscle after transplantation in mice. The results showed that the supplemented mice had better muscle fiber regeneration, suggesting the importance of understanding the underlying mechanism of probiotics in regulating muscle fiber regeneration.
Article
Cardiac & Cardiovascular Systems
Gengfu Dong, Chatick Moparthy, Trace Thome, Kyoungrae Kim, Feng Yue, Terence E. Ryan
Summary: Using a rodent model of PAD, this study demonstrates that treatment of the ischemic limb with insulin-like growth factor (IGF)-1 significantly increases muscle size and strength without improving limb hemodynamics. Interestingly, the effect size of IGF1 therapy was larger in female mice than in male mice, highlighting the need to carefully examine sex-dependent effects in experimental PAD therapies.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Biology
Anirban Roy, Meiricris Tomaz da Silva, Raksha Bhat, Kyle R. Bohnert, Takao Iwawaki, Ashok Kumar
Summary: IRE1 alpha, along with its downstream target XBP1, play a crucial role in regulating skeletal muscle regeneration by promoting proliferation of satellite cells. The ablation of IRE1 alpha diminishes Notch signaling and canonical NF-kappa B pathway, leading to reduced satellite cell abundance and impaired muscle regeneration in both normal and Duchenne muscular dystrophy models.
Article
Engineering, Biomedical
Xiu-Zhen Zhang, Yan-Lin Jiang, Jun-Gen Hu, Long-Mei Zhao, Qiu-Zhu Chen, Yan Liang, Yi Zhang, Xiong-Xin Lei, Rui Wang, Yi Lei, Qing-Yi Zhang, Jesse Li-Ling, Hui-Qi Xie
Summary: The study successfully repaired full-thickness bladder defects using procyanidins (PC) crosslinked small intestine submucosa (SIS) biomaterial scaffold, reducing complications and enhancing bladder functions.
BIOACTIVE MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Rauchelle E. Richey, Holden W. Hemingway, Amy M. Moore, Albert H. Olivencia-Yurvati, Steven A. Romero
Summary: This work was funded by the National Institute on Aging Grant R01 AG059314 (to S.A.R.) and University of North Texas Health Science Center laboratory startup funds.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Estelle M. D'Cunha, Jowan G. Penn-Barwell, John McMaster, Charles A. Fries
Summary: Performance against the British Orthopaedic Association Standards for Orthopaedics and Trauma 4 (BOAST 4) has shown further improvements in outcomes and changes in service delivery. Compliance with BOAST 4 guidelines and the introduction of the fix and flap technique have resulted in improved management of open lower-limb fractures.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Geriatrics & Gerontology
Georgia L. Nolt, Alexander R. Keeble, Yuan Wen, Aubrey C. Strong, Nicholas T. Thomas, Taylor R. Valentino, Camille R. Brightwell, Kevin A. Murach, Sini Patrizia, Harald Weinstabl, Andreas Gollner, John J. Mccarthy, Christopher S. Fry, Michael Franti, Antonio Filareto, Charlotte A. Peterson, Cory M. Dungan
Summary: The aim of this study was to determine if a novel pharmaceutical agent (BI01) improves muscle regeneration and hypertrophy in old mice by upregulating p53. The results showed that BI01 effectively reduced senescent cell burden in old mice and enhanced muscle regeneration and hypertrophy.
Article
Biochemistry & Molecular Biology
Eun Ju Lee, Sibhghatulla Shaikh, Mohammad Hassan Baig, So-Young Park, Jeong Ho Lim, Syed Sayeed Ahmad, Shahid Ali, Khurshid Ahmad, Inho Choi
Summary: This study reports the potential of novel peptides MIF1 and MIF2 derived from MSTN in enhancing myogenesis and reducing adipogenesis. Modified MIF1 and MIF2 showed better cell proliferation and differentiation compared to non-modified peptides. Pretreatment of mice with (Ac)-MIF1 or (Ac)-MIF2-(NH2) promoted muscle regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Juquan Song, Imran H. Chowdhury, Subhadip Choudhuri, Amina E. I. Ayadi, Lizette E. Rios, Steven E. Wolf, Joseph C. Wenke, Nisha J. Garg
Summary: Burn injury leads to muscle wasting, and this study found that high mobility group box 1 (HMGB1) plays an important role in the hyper-inflammatory response and subsequent muscle impairment after burn. Neutralizing HMGB1 with antibodies reduced burn wound size and preserved muscle weight, while also decreasing cell death and autophagy markers. Furthermore, the antibodies inhibited inflammatory activation of bone marrow and T cells, and reduced inflammatory infiltrate in muscle tissues. Neutralization of HMGB1-dependent proteolytic and inflammatory responses may have beneficial effects in preventing muscle loss after severe burn injury.
SCIENTIFIC REPORTS
(2023)
Review
Nutrition & Dietetics
Luana Toniolo, Monica Concato, Emiliana Giacomello
Summary: Resveratrol, a natural polyphenol, has been utilized in Chinese traditional medicine and is thought to contribute to the French Paradox. Recent studies suggest that resveratrol could mimic the effects of calorie restriction by modulating skeletal muscle metabolism. Although animal studies show potential benefits of resveratrol on skeletal muscle structure and function, clinical trials have not provided clear information. This may be due to the heterogeneity in response to resveratrol in humans and the complexity of skeletal muscle physiology.
Article
Biotechnology & Applied Microbiology
Qi Zheng, Cuiyun Zhu, Jing Jing, Yinghui Ling, Shuaiqi Qin, Jiao Wang, Lisha Zha, Ya Liu, Fugui Fang
Summary: This study observed structural changes in skeletal muscle and obtained circRNA expression profiles at different stages in hind leg muscles of fetus, child, and adult rabbits. The study identified differentially expressed circRNAs and genes, and found circRNAs with potential coding or miRNA sponge capability. These findings provide insights into the functional transitions in mammalian muscle development.
Article
Biochemistry & Molecular Biology
Jaime Gutierrez, David Gonzalez, Rodrigo Escalona-Rivano, Chiaki Takahashi, Enrique Brandan
Summary: RECK plays a role as a potential myogenic repressor during muscle formation and regeneration, with transient up-regulation accelerating muscle regeneration. RECK-deficient mice show reduced fibrosis in a model of chronic muscle damage, suggesting RECK as a potential target for treating muscle-wasting diseases.
Article
Orthopedics
Martin C. Jordan, Vanessa Schmitt, Hendrik Jansen, Rainer H. Meffert, Stefanie Hoelscher-Doht
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2015)
Article
Orthopedics
Martin C. Jordan, Stefanie Hoelscher-Doht, Kai Fehske, Fabian Gilbert, Hendrik Jansen, Rainer H. Meffert
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2015)
Article
Clinical Neurology
Timo Michael Heintel, Stefan Dannigkeit, Annabel Fenwick, Martin Cornelius Jordan, Hendrik Jansen, Fabian Gilbert, Rainer Meffert
EUROPEAN SPINE JOURNAL
(2017)
Article
Orthopedics
Sebastian P. Boelch, Martin C. Jordan, Rainer H. Meffert, Hendrik Jansen
INTERNATIONAL ORTHOPAEDICS
(2017)
Article
Biophysics
Martin C. Jordan, Sebastian Boelch, Hendrik Jansen, Rainer H. Meffert, Stefanie Hoelscher-Doht
JOURNAL OF BIOMECHANICS
(2016)
Article
Anatomy & Morphology
H. Jansen, R. H. Meffert, F. Birkenfeld, W. Petersen, T. Pufe
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2012)
Article
Orthopedics
Hendrik Jansen, Soenke P. Frey, Christine Ziegler, Rainer H. Meffert, Stefanie Doht
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2013)
Article
Orthopedics
Hendrik Jansen, Annabel Fenwick, Stefanie Doht, Soenke Frey, Rainer Meffert
INTERNATIONAL ORTHOPAEDICS
(2013)
Article
Orthopedics
Soenke Percy Frey, Stefanie Doht, Lars Eden, Stefan Dannigkeit, Norbert Schuetze, Rainer H. Meffert, Hendrik Jansen
INTERNATIONAL ORTHOPAEDICS
(2012)
Article
Orthopedics
Stefanie Doht, Hendrik Jansen, Rainer Meffert, Soenke Frey
INTERNATIONAL ORTHOPAEDICS
(2012)
Article
Orthopedics
Stefanie Doht, Teresa Lehnert, Soenke Frey, Kai Fehske, Hendrik Jansen, Torsten Blunk, Rainer Heribert Meffert
INTERNATIONAL ORTHOPAEDICS
(2012)
Article
Orthopedics
Hendrik Jansen, Stefanie Doht, Soenke P. Frey, Rainer H. Meffert
JOURNAL OF ORTHOPAEDIC SCIENCE
(2013)
Article
Orthopedics
Hendrik Jansen, Soenke P. Frey, Stefanie Doht, Kai Fehske, Rainer H. Meffert
JOURNAL OF ORTHOPAEDIC SCIENCE
(2013)
Article
Multidisciplinary Sciences
Soenke Percy Frey, Hendrik Jansen, Stefanie Doht, Luis Filgueira, Rene Zellweger
SCIENTIFIC WORLD JOURNAL
(2013)