Article
Orthopedics
Ittai Shichman, Spencer A. Ward, Laura Lu, Simon Garceau, Nicolas S. Piuzzi, Thorsten M. Seyler, Ran Schwarzkopf
Summary: This study investigated the characteristics and risk factors associated with treatment failure in patients with recurrent infection following 2-stage revision for chronic prosthetic joint infection (PJI). The results showed that 31.1% of the patients achieved infection control after a failed 2-stage revision. The most common pathogen identified for both index and recurrent PJI was coagulase-negative Staphylococci, and a certain proportion of recurrent infections persisted.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Medicine, General & Internal
Michael Fuchs, Andrej Trampuz, Stephanie Kirschbaum, Tobias Winkler, F. Andrea Sass
Summary: The study revealed that local sPecam-1 levels are correlated to the infection status of the implant, showing potential as a biomarker for PJI with high predictive power. Further research is needed to uncover the underlying mechanism of sPecam-1's natural function in infection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Timothy C. Keating, Jonathan Guntin, William E. Harkin, Matthew T. Weintraub, Vasili Karas, Richard A. Berger
Summary: This study evaluated the incidence of iatrogenic periprosthetic joint infection (PJI) following diagnostic knee aspiration within 6 months of primary total knee arthroplasty (TKA). The results showed that the rate of iatrogenic PJI was extremely low (0%).
JOURNAL OF ARTHROPLASTY
(2023)
Article
Medicine, General & Internal
Nike Walter, Markus Rupp, Katja Hierl, Matthias Koch, Maximilian Kerschbaum, Michael Worlicek, Volker Alt
Summary: Patients with knee periprosthetic joint infection (PJI) still experience significantly lower quality of life even years after successful treatment, particularly in terms of mental health. Future clinical studies should focus on patient-related outcomes to improve the quality of life for these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Christopher N. Carender, David E. DeMik, Natalie A. Glass, Nicolas O. Noiseux, Timothy S. Brown, Nicholas A. Bedard
Summary: In patients with BMI >= 40 kg/m(2), extended oral antibiotic prophylaxis after primary THA and TICS did not reduce rates of wound complications or early PJI.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Christoph Theil, Rouven F. Riegel, Georg Gosheger, Jan Schwarze, Tom Schmidt-Braekling, Burkhard Moellenbeck
Summary: The prevalence of AKIN in patients undergoing two-stage exchange is 33%, with older age, higher baseline creatinine level, and fungal infections identified as potential risk factors. Particularly in patients with chronic renal dysfunction, attention and optimized treatment should be provided to prevent AKIN.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Elizabeth B. Gausden, Mark W. Pagnano, Kevin Perry, Gina A. Suh, Daniel J. Berry, Matthew P. Abdel
Summary: Synchronous periprosthetic joint infections (PJIs) are a serious complication with high mortality rates. Patients with synchronous PJIs have a high 30-day mortality rate of 18% and a quarter of them require unplanned reoperation within the first year. Rheumatoid arthritis and liver disease are associated with increased risk of mortality.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Orthopedics
Mark F. Zhu, Katy Kim, Alana Cavadino, Brendan Coleman, Jacob T. Munro, Simon W. Young
Summary: This study reviewed 230 patients treated with DAIR for primary total knee arthroplasty (TICS) PJIs and found an overall success rate of 53.9%. DAIR was more successful in early PJIs compared to late PJIs, and infections caused by Staphylococcus aureus and gram-negative bacteria were risk factors for DAIR failure. The age of implant was identified as an important predictor of DAIR outcomes.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Infectious Diseases
Lars-Rene Tuecking, Julia Silligmann, Peter Savov, Mohamed Omar, Henning Windhagen, Max Ettinger
Summary: This study compared single- and two-stage revision surgeries for periprosthetic joint infection in knee arthroplasty. The results showed no significant difference in implant survival rates and revision rates between the two groups, but a tendency towards higher reinfection rates in single-stage surgery. Difficult-to-treat organisms and implant types were found to be associated with higher reinfection rates.
Review
Medicine, General & Internal
Robin Patel
Summary: Arthroplasty-associated infection, or periprosthetic joint infection, is a rare disease that is different from native bone or joint infection. The infection involves interactions between microorganisms, the implant, and the host immune system. Even a small amount of microorganisms can cause infection, as bacteria (and sometimes fungi) adhere to and form biofilms on the arthroplasty surfaces that are resistant to antimicrobial agents and the immune system.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Orthopedics
Christoph Theil, Burkhard Moellenbeck, Jan Puetzler, Sebastian Klingebiel, Jan Schwarze, Georg Gosheger
Summary: In patients with chronic periprosthetic joint infection and massive femoral bone loss, the placement of a total femoral spacer can effectively control the infection. However, the reinfection rate and subsequent amputation rate after second-stage megaprosthetic total femoral arthroplasty is around 50%.
JOURNAL OF ARTHROPLASTY
(2023)
Review
Medicine, General & Internal
Christos Koutserimpas, Symeon Naoum, Vasileios Giovanoulis, Konstantinos Raptis, Kalliopi Alpantaki, Konstantinos Dretakis, Georgia Vrioni, George Samonis
Summary: Fungal hip prosthetic joint infections (PJIs) are rare but severe infections. This review analyzed all published cases of fungal hip PJIs to provide comprehensive information on demographics, causative fungi, treatment options, and infection outcomes.
Review
Orthopedics
Shiyu Liao, Zhize Yang, Xiao Li, Jintian Chen, Jian-guo Liu
Summary: This study aimed to analyze the impact of different doses of vancomycin powder on periprosthetic joint infection (PJI) following total joint arthroplasty (TJA). The results showed that in primary total knee arthroplasty (TKA), both 1 g and 2 g of vancomycin powder were effective in preventing PJI, while in primary total hip arthroplasty (THA), 1 g of vancomycin powder had a better effect and the effect of 2 g was unclear. Vancomycin powder was also effective in reducing the incidence of PJI in revision TKA and revision THA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, General & Internal
Dominik Szymski, Nike Walter, Volker Alt, Markus Rupp
Summary: This study analyzed the frequency of comorbidities in FRI and PJI patients in Germany in 2019, and evaluated comorbidities as a risk factor for PJI and FRI. The results showed that patients with diabetes mellitus, arterial hypertension, and heart failure have an increased risk for PJI and FRI compared to the general population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Rui Xiang Toh, Zhen Ning Yeo, Ming Han Lincoln Liow, Seng-Jin Yeo, Ngai-Nung Lo, Jerry Yongqiang Chen
Summary: This study retrospectively analyzed 106 cases of DAIR treatment and found a success rate of 69.8%. Failure was associated with earlier time to mortality, methicillin-susceptible Staphylococcus aureus PJI, and higher preoperative ESR. The study suggests that repeat DAIRs, elevated ESR, and S aureus PJI are associated with treatment failure, recommending 2-stage revision.
JOURNAL OF ARTHROPLASTY
(2021)