Article
Infectious Diseases
Alice Casenaz, Lionel Piroth, Ludovic Labattut, Thibault Sixt, Arnaud Magallon, Adrien Guilloteau, Catherine Neuwirth, Lucie Amoureux
Summary: This study described the microorganisms responsible for prosthetic joint infections (PJIs) and their antimicrobial susceptibilities. The results showed that Staphylococci, Gram-negative bacilli (GNB), and streptococci were the most commonly found bacteria in PJIs. Different categories of infections required different antibiotics. The study highlights the importance of understanding local epidemiology for optimizing empirical antimicrobial treatments (EATs).
JOURNAL OF INFECTION
(2022)
Article
Infectious Diseases
Llanos Salar-Vidal, John Jairo Aguilera-Correa, Holger Bruggemann, Yvonne Achermann, Jaime Esteban
Summary: This study characterized Cutibacterium acnes strains isolated from prosthetic joint infections (PJIs) and evaluated their biofilm formation ability and antibiotic susceptibility. The results showed that C. acnes strains can produce biofilms and are susceptible to commonly used antibiotics, with rifampin being the most effective in eradicating biofilm-embedded strains.
Article
Medicine, General & Internal
Sylvain Goutelle, Anne Conrad, Cecile Pouderoux, Evelyne Braun, Frederic Laurent, Marie-Claude Gagnieu, Sabine Cohen, Jerome Guitton, Florent Valour, Tristan Ferry
Summary: Suppressive parenteral antibiotic therapy with beta-lactams may be necessary for Gram-negative bone and joint infections. Subcutaneous administration in outpatient settings, guided by therapeutic drug monitoring and PK/PD principles, can effectively control infections without promoting resistance, supporting further clinical evaluations.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Narayan Pant, Socorro Miranda-Hernandez, Catherine Rush, Jeffrey Warner, Damon P. Eisen
Summary: This study explores the application of savirin as an adjunct therapy to prevent prosthetic joint infections caused by biofilm-associated Staphylococcus aureus. The results show that savirin has inhibitory effects on planktonic and biofilm growth of S. aureus in vitro, and it can enhance the inhibitory activity of antibiotics. Savirin also down-regulates the expression of key biofilm-related genes in S. aureus, and it significantly reduces bacterial counts on joint implants and peri-prosthetic tissues in a mouse model.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Andres Ruiz-Sancho, Maria Nunez-Nunez, Laura Castelo-Corral, Francisco Javier Martinez-Marcos, Nagore Lois-Martinez, Mohd Hafiz Abdul-Aziz, David Vinuesa-Garcia
Summary: Suppressive antibiotic therapy (SAT) is a strategy used to alleviate infection symptoms when other treatment options are not feasible. This study examined the clinical experience of dalbavancin used as SAT in patients with prosthetic joint or vascular infections. The results showed that dalbavancin was effective in reducing infection progression and had a high clinical success rate of 75%. Adverse events were reported in two patients, but overall, dalbavancin was well-tolerated. The cost savings due to avoided hospital days were also significant.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Henk Scheper, Julia M. Wubbolts, Joanne A. M. Verhagen, Adriette W. de Visser, Robert J. P. van der Wal, Leo G. Visser, Mark G. J. de Boer, Peter H. Nibbering
Summary: Prosthetic joint infection is a severe complication of arthroplasty, often caused by biofilm formation. Current treatment strategies are often ineffective, prompting the need for innovative anti-biofilm and anti-persister agents. A study developed an in vitro model for PJI using various surfaces exposed to antibiotics, with SAAP-148 showing high effectiveness against persister bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Narayan Pant, Socorro Miranda-Hernandez, Catherine Rush, Jeffrey Warner, Damon P. Eisen
Summary: The study demonstrates that Ticagrelor shows antibacterial and antibiofilm activity against Staphylococcus aureus in vitro, with a strain-specific downregulation effect on biofilm-related genes. In an animal model, Ticagrelor combined with antibiotics significantly reduces bacterial concentrations on implants and decreases bacterial dissemination to surrounding tissues.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
James B. Doub, Vincent Y. Ng, Myounghee Lee, Andrew Chi, Alina Lee, Silvia Wurstle, Benjamin Chan
Summary: Prosthetic joint infections are a serious complication of joint replacement surgery, and novel therapeutics like bacteriophage therapy show promise in treating these infections. Personalized bacteriophage therapy may help in treating recalcitrant infections, but further research and clinical trials are needed to validate its efficacy.
Article
Immunology
Diana Fernandez-Rodriguez, Claudia Adriana Colin-Castro, Melissa Hernandez-Duran, Luis Esau Lopez-jacome, Rafael Franco-Cendejas
Summary: This study found a relatively high proportion of Staphylococcus epidermidis small colony variants in prosthetic joint infections, which were associated with difficulties in achieving remission. Small colony variants showed higher resistance rates to trimethoprim/sulfamethoxazole and lower resistance rates to levofloxacin.
MICROBES AND INFECTION
(2021)
Article
Infectious Diseases
Yannick Herry, Olivier Lesens, Gaelle Bourgeois, Mylene Maillet, Romain Bricca, Celine Cazorla, Judith Karsenty, Tomasz Chroboczek, Anissa Bouaziz, Julien Saison, Marie-Elodie Langlois, Celine Dupieux-Chabert, Tristan Ferry, Florent Valour
Summary: This study describes the management and outcome of Staphylococcus lugdunensis prosthetic joint infection (PJI). Surgical management plays a pivotal role in the treatment of this difficult-to-treat infection.
JOURNAL OF INFECTION
(2022)
Review
Immunology
Nicolas Cortes-Penfield, Martin Krsak, Laura Damioli, Michael Henry, Jessica Seidelman, Angela Hewlett, Laura Certain
Summary: This narrative review synthesizes the literature on the role of suppressive antibiotic therapy (SAT) to prevent treatment failure after debridement, antibiotics, and implant retention (DAIR) for prosthetic joint infection. It aims to answer three key questions: (1) the identification of patients at highest risk for treatment failure after DAIR, (2) the effectiveness of SAT in reducing treatment failure rate after DAIR, and (3) the rates of treatment failure and adverse events in patients receiving SAT. The review proposes risk-benefit stratification criteria for selecting patients for SAT following DAIR.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Christos Koutserimpas, Ifigeneia Chamakioti, Stylianos Zervakis, Konstantinos Raptis, Kalliopi Alpantaki, Diamantis P. Kofteridis, Georgia Vrioni, George Samonis
Summary: Non-Candida fungal prosthetic joint infections pose a clinical challenge that requires a multidisciplinary approach. The combination of two-stage revision arthroplasty and prolonged antifungal treatment has been shown to be the standard of care in the reviewed cases.
Article
Health Care Sciences & Services
Jasmin S. Gruener, Raymund E. Horch, Alexander Geierlehner, Wibke Mueller-Seubert, Aijia Cai, Andreas Arkudas, Ingo Ludolph
Summary: In this retrospective cohort study, the effectiveness of negative pressure wound treatment with instillation and dwell time (NPWTi-d) on peri-prosthetic breast infections was investigated. The results showed that NPWTi-d decreased bacterial burden and contributed to the healing process. The study suggests that NPWTi-d may have a positive impact on secondary reimplantation of breast prostheses.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Infectious Diseases
Raquel Bandeira da Silva, Mauro Jose Salles
Summary: This study identified independent risk factors associated with multidrug-resistant GNB prosthetic joint infection, including revision arthroplasty, postoperative hematoma, previous orthopaedic infection, and early infection. Extensively drug-resistant GNB and comorbidities were independently associated with higher treatment failure rates in MDR-GNB PJI.
Article
Microbiology
Erlangga Yusuf, Charlotte Roschka, Jaime Esteban, Annibale Raglio, Anna Tisler, Philippe Willems, Tobias Siegfried Kramer
Summary: This study provides an overview of common practices in microbiology diagnosis tests of Prosthetic joint infections (PJI) in Europe. The study found that there is some uniformity in sample processing and result reporting. However, variations in diagnostic tests need to be considered when interpreting and comparing clinical microbiology results.
FRONTIERS IN MICROBIOLOGY
(2022)