Article
Clinical Neurology
F. S. Kleinstueck, T. F. Fekete, M. Loibl, D. Jeszenszky, D. Haschtmann, F. Porchet, A. F. Mannion
Summary: A study investigated the outcomes of isolated C1-C2 fusion in a large series of patients, showing extremely good results with high satisfaction rates among patients. Despite the complexity of the procedure, outcomes exceeded those typically reported for simpler procedures, suggesting a need for further evaluation and consideration of the approach.
EUROPEAN SPINE JOURNAL
(2021)
Article
Multidisciplinary Sciences
Jae-Won Shin, Kyung-Soo Suk, Hak-Sun Kim, Jae-Ho Yang, Hwan-Mo Lee, Sung-Hwan Moon, Byung-Ho Lee, Jin-Oh Park, Sang-Jun Park, Sub-ri Park, Sun-kyu Kim, Jane F. Garcia
Summary: This retrospective study evaluated radiographic and clinical outcomes and changes of retro-odontoid mass (R-OM) after upper cervical spine surgery. The study concluded that stabilization through fusion surgery is essential for treating R-OM, resulting in improved clinical and radiographic outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Giovanni Cagnotto, Lennart T. H. Jacobsson, Emil Rydell, Anna Eberhard, Michele Compagno, Carl Turesson
Summary: In early rheumatoid arthritis patients, male sex is associated with better clinical outcomes in the absence of anti-citrullinated peptide antibody, but not in the presence of the antibody. Poor outcomes in females with early seronegative RA suggest this group represents a difficult-to-treat population.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Drazen Bedekovic, Damir Kirner, Ivica Bosnjak, Aleksandar Kibel, Sandra Saric, Srdan Novak, Visnja Prus
Summary: Rheumatoid arthritis (RA) increases the risk of cardiovascular diseases (CVDs), mainly due to arterial hypertension (HT). However, this study found no difference in HT prevalence between RA and osteoarthritis (OA) groups, but the RA group had a higher incidence of CVDs. RA patients with long-term remission had a slightly lower HT prevalence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Mingyue Cheng, Yan Zhao, Yazhou Cui, Chaofang Zhong, Yuguo Zha, Shufeng Li, Guangxiang Cao, Mian Li, Lei Zhang, Kang Ning, Jinxiang Han
Summary: This study investigated the role of microbial dysbiosis and metabolic disorders in different stages of rheumatoid arthritis (RA). The findings suggest that microbial dysbiosis and metabolic disorders exhibit distinct patterns and play stage-specific roles in RA. This provides new insights for prognosis and therapy of RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Lotte van Ouwerkerk, Maarten Boers, Paul Emery, Pascal H. P. de Jong, Robert B. M. Landewe, Willem Lems, Josef S. Smolen, Patrick Verschueren, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: This study investigated whether patients with rheumatoid arthritis (RA) can discontinue glucocorticoids (GC) after GC 'bridging' in the initial treatment step and identified factors that may affect this. The probability of using GC decreased over time after bridging therapy ended, while the probability of continuous GC use increased. In oral GC bridging studies, the probabilities of later and continuous GC use and the cumulative GC doses were higher compared to studies that included parenteral GC bridging.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Iona J. MacDonald, Chien-Chung Huang, Shan-Chi Liu, Yen-You Lin, Chih-Hsin Tang
Summary: The CCN family of matricellular proteins play essential roles in processes like angiogenesis, wound healing, and inflammation, particularly in the inflammatory pathologies of rheumatoid arthritis and osteoarthritis. Several proteins within the CCN family are thought to be potential therapeutic targets for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Theoharris Frangos, Wolfgang Maret
Summary: Zinc and cadmium play crucial roles in osteoarthritis and rheumatoid arthritis, affecting the immune system, inflammation, and metabolism. The mutations in proteins involved in zinc homeostasis and cadmium exposure through inhalation may contribute to joint destruction.
Article
Clinical Neurology
Ryoko Niwa, Keisuke Takai, Makoto Taniguchi
Summary: This study compared nonrheumatoid and rheumatoid pseudotumor patients, finding significant clinical and radiological differences between the two groups. The main etiology for nonrheumatoid pseudotumors was subaxial cervical degeneration and ossified lesions. Good outcomes were observed following posterior fixation, with pseudotumor regression within 12 months after surgery.
Article
Medicine, General & Internal
Yumi Tsuchida, Yasuo Nagafuchi, Tomoko Uehara, Hisato Suzuki, Mamiko Yamada, Masanori Kono, Hiroaki Hatano, Hirofumi Shoda, Keishi Fujio, Kenjiro Kosaki
Summary: We report a patient with RA who has compound heterozygous variants in the COL11A2 gene. Autoantibodies against type XI collagen are detected in the sera of RA patients, suggesting a potential involvement of type XI collagen in the pathogenesis of RA. The hearing loss and osteoarthritis in this patient may be attributed to the compound heterozygous variants in the COL11A2 gene, and the conformational changes induced by these variants may have altered the immunogenicity of type XI collagen, leading to the development of RA.
Article
Public, Environmental & Occupational Health
Desheng Zhao, Jian Cheng, Ping Bao, Yanwu Zhang, Fengjuan Liang, Hao Wang, Xu Wang, Shiyuan Fang, Hong Su
Summary: This study found a significant association between temperature decrease and RA admission, with females and patients aged 41-65 years being more vulnerable to the effect. However, no significant association between temperature and OA admission was observed.
Article
Engineering, Electrical & Electronic
Ahmad Mobed, Sanam Dolati, Seyed Kazem Shakouri, Bina Eftekharsadat, Behzad Izadseresht
Summary: OA and RA are two most frequent types of degenerative joint diseases in adults, with common symptoms but differences in pathological manifestations. Biomarker detection can identify disease development at early stages, benefiting patients with prompt diagnosis.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Review
Rheumatology
Christopher McMaster, Alix Bird, David F. L. Liew, Russell R. Buchanan, Claire E. Owen, Wendy W. Chapman, Douglas E. Pires
Summary: Deep learning has become the leading method in machine learning and has great potential for applications in rheumatology, particularly for handling unstructured data such as images and text. It is important for rheumatologists to understand the methods and limitations of deep learning algorithms and contribute to the development of relevant clinical applications.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Angel Y. S. Wong, Brian MacKenna, Caroline E. Morton, Anna Schultze, Alex J. Walker, Krishnan Bhaskaran, Jeremy P. Brown, Christopher T. Rentsch, Elizabeth Williamson, Henry Drysdale, Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J. Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen McDonald, Laurie Tomlinson, Rohini Mathur, Kevin Wing, Harriet Forbes, Rosalind M. Eggo, John Parry, Frank Hester, Sam Harper, Stephen J. W. Evans, Liam Smeeth, Ian J. Douglas, Ben Goldacre
Summary: Two cohort studies were conducted to assess the association between routinely prescribed NSAIDs and COVID-19 related deaths, finding no evidence of a harmful effect. Therefore, the risks of COVID-19 do not need to influence decisions about the routine therapeutic use of NSAIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Djedjiga Ait Eldjoudi, Alfonso Cordero Barreal, Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Yousof Farrag, Mariam Farrag, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, Jesus Pino, Oreste Gualillo
Summary: White adipose tissue is a specialized tissue involved in lipid synthesis and storage. It serves as an active organ that secretes hormones and cytokines called adipokines, with leptin being a key molecule. Leptin not only regulates energy balance and food intake, but also plays roles in reproduction, glucose metabolism, hematopoiesis, and immune system interactions. It is involved in innate and adaptive immunity and contributes to the pathogenesis of chronic inflammation and immune-related diseases like osteoarthritis and rheumatoid arthritis. This review summarizes recent findings on the involvement of leptin in immunity and inflammatory responses in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Matevz Topolovec, David Vozlic, Nejc Plohl, Rok Vengust, Miha Vodicar, Anne Frances Mannion
BMC MUSCULOSKELETAL DISORDERS
(2020)
Article
Clinical Neurology
A. F. Mannion, M. Loibl, J. Bago, A. Vila-Casademunt, S. Richner-Wunderlin, T. F. Fekete, D. Haschtmann, D. Jeszenszky, F. Pellise, A. Alanay, I. Obeid, F. S. Perez-Grueso, F. S. Kleinstuck
EUROPEAN SPINE JOURNAL
(2020)
Article
Clinical Neurology
AlShaymaa Abdeldaiem, Emad S. B. Saweeres, Abd-Elhafiz Abd-Elsalam Shehab-Eldien, Anne F. Mannion, Aliaa Rehan Youssef
EUROPEAN SPINE JOURNAL
(2020)
Article
Clinical Neurology
Anne F. Mannion, Francine Mariaux, Raluca Reitmeir, Tamas F. Fekete, Daniel Haschtmann, Markus Loibl, Dezsoe Jeszenszky, Frank S. Kleinstueck, Francois Porchet, Achim Elfering
EUROPEAN SPINE JOURNAL
(2020)
Article
Clinical Neurology
Anne F. Mannion, Francine Mariaux, Valerie Pittet, Felix Steiger, Martin Aepli, Tamas F. Fekete, Dezso Jeszenszky, Dave O'Riordan, Francois Porchet
Summary: Treatment failures in spine surgery are often due to poor patient selection and inappropriate treatment. This study retrospectively analyzed outcome data from a group of patients operated in a Spine Centre and found a relationship between appropriateness of surgery and improvements in COMI score after surgery. Further prospective studies with a control group of non-operated patients are needed to confirm these findings.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
F. S. Kleinstueck, T. F. Fekete, M. Loibl, D. Jeszenszky, D. Haschtmann, F. Porchet, A. F. Mannion
Summary: A study investigated the outcomes of isolated C1-C2 fusion in a large series of patients, showing extremely good results with high satisfaction rates among patients. Despite the complexity of the procedure, outcomes exceeded those typically reported for simpler procedures, suggesting a need for further evaluation and consideration of the approach.
EUROPEAN SPINE JOURNAL
(2021)
Letter
Clinical Neurology
Anne F. Mannion, Tamas F. Fekete, Francois Porchet
Correction
Clinical Neurology
A. F. Mannion, A. Elfering, T. F. Fekete, I. J. Harding, M. Monticone, P. Obid, T. Niemeyer, U. Liljenqvist, A. Boss, L. Zimmermann, A. Vila-Casademunt, F. J. Sanchez Perez-Grueso, J. Pizones, F. Pellise, S. Richner-Wunderlin, F. S. Kleinstuck, I. Obeid, L. Boissiere, A. Alanay, J. Bago
Article
Clinical Neurology
A. F. Mannion, A. Elfering, T. F. Fekete, I. J. Harding, M. Monticone, P. Obid, T. Niemeyer, U. Liljenqvist, A. Boss, L. Zimmermann, A. Vila-Casademunt, F. J. Sanchez Perez-Grueso, J. Pizones, F. Pellise, S. Richner-Wunderlin, F. S. Kleinstuck, I. Obeid, L. Boissiere, A. Alanay, J. Bago
Summary: The study aimed to validate the shorter version of the SRS questionnaire in adolescents with spinal deformity and compare its equivalence across different language versions. The results showed that the 16-item version exhibited better model fit across all language versions, but further improvements are needed in terms of equivalence across languages.
Article
Clinical Neurology
Alexandra Grob, Markus Loibl, Amir Jamaludin, Sebastian Winklhofer, Jeremy C. T. Fairbank, Tamas Fekete, Francois Porchet, Anne F. Mannion
Summary: This study evaluated the reliability of a computer vision-based system, SpineNet, in automated analysis of degenerative features in lumbar MRI scans. The results showed moderate to substantial agreement compared to expert radiologists. This system has important applications in analyzing large cohorts of MRI scans.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
D. Mueller, D. Haschtmann, T. F. Fekete, F. Kleinstueck, R. Reitmeir, M. Loibl, D. O'Riordan, F. Porchet, D. Jeszenszky, A. F. Mannion
Summary: This study developed a model to predict the outcome of spine surgery patients using a comprehensive set of data. The study found that factors affecting the outcome include preoperative scores, age, BMI, etc.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Po-Chien Wu, Jui-Chen Hsu, Anne F. Mannion, Christopher Wu, Ching-Yu Lee, Tsung-Jen Huang, Yen-Kuang Lin, Meng-Huang Wu
Summary: The study aimed to adapt the Core Outcome Measures Index (COMI) for Traditional Chinese-speaking patients with low back pain and investigate its psychometric properties. The findings indicate that the Traditional Chinese COMI is a practical and reliable tool for assessing patients with back problems in Traditional Chinese-speaking population.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
A. F. Mannion, A. Elfering, T. F. Fekete, J. Pizones, F. Pellise, A. M. Pearson, J. D. Lurie, F. Porchet, E. Aghayev, A. Vila-Casademunt, F. Mariaux, S. Richner-Wunderlin, F. S. Kleinstuck, M. Loibl, F. S. Perez-Grueso, I Obeid, A. Alanay, R. Vengust, D. Jeszenszky, D. Haschtmann
Summary: This study aimed to create a mapping function between the Oswestry Disability Index (ODI) and the Core Outcome Measures Index (COMI) in order to interpret the scores of one instrument in terms of the other. The results showed that the predictions at the group level were very good, but caution should be taken when using individual values for treatment decisions. The ability to convert scores via the developed mapping function can facilitate collaboration and data combining in meta-analyses.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Anne F. Mannion, Tamas F. Fekete, Dave O'Riordan, Markus Loibl, Frank S. Kleinstuck, Francois Porchet, Raluca Reitmeir, Dezso Jeszenszky, Daniel Haschtmann
Summary: This study evaluated the attrition in a long-established, single-centre spine registry and analyzed its implications on the research results. The findings showed that non-responders had worse early outcomes, indicating that failure to address loss to follow-up may lead to overly optimistic results.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Steven P. Baltic, Keith W. Lyons, Francine Mariaux, Anne F. Mannion, Paul M. Werth, Tamas Fekete, Francois Porchet, Christopher Kepler, Kevin J. McGuire, Jon D. Lurie, Adam M. Pearson
Summary: The study aimed to determine if outcomes vary with different surgical techniques across the CARDS categories. The results showed that outcomes for uninstrumented and instrumented surgical techniques were similar across the CARDS categories. Surgeons likely took factors included in CARDS into account during surgical technique selection.