Article
Radiology, Nuclear Medicine & Medical Imaging
Julian Schreck, Kai Roman Laukamp, Julius Henning Niehoff, Arwed Elias Michael, Jan Boriesosdick, Matthias Michael Woeltjen, Jan Robert Kroeger, Robert P. P. Reimer, Jan-Peter Grunz, Jan Borggrefe, Simon Lennartz
Summary: This study investigated the effectiveness of photon-counting CT (PCCT)-derived virtual monoenergetic images (VMI) in reducing artifacts in patients with unilateral total hip replacements (THR). The results demonstrated that VMI (110keV) significantly reduced hypo- and hyperdense artifacts and achieved the best performance in bone and bladder assessment.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Article
Oncology
Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Masanori Saito, Jun Sugaya, Katsuhiro Hayashi, Hiroyuki Kawashima, Tomoaki Torigoe, Tomoki Nakamura, Hiroya Kondo, Toru Wakamatsu, Munenori Watanuki, Munehisa Kito, Satoshi Tsukushi, Akihito Nagano, Hidetatsu Outani, Shunichi Toki, Shunji Nishimura, Hiroshi Kobayashi, Itsuo Watanabe, Yusuke Demizu, Ryohei Sasaki, Takumi Fukumoto, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Summary: This study retrospectively analyzed the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS) in Japan. Osteosarcoma showed significantly worse overall survival (OS) and progression-free survival (PFS) compared to other sarcomas in the pelvis and retroperitoneum. Larger primary tumor size was the only poor prognostic factor associated with local control (LC).
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Review
Oncology
Zhenyi Chen, Huayi Huang, Siyuan He, Yi Wang, Lin Cai, Yuanlong Xie
Summary: Fluorescence imaging technology can assist surgeons in judging tumor boundaries and improving the accuracy of surgical resection. This technology is simple, safe, and does not require additional time during surgery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Catherine Sarre-Lazcano, Sinziana Dumitra, Marco Fiore
Summary: Pelvic soft tissue sarcomas (PSTS) are a rare and heterogeneous group of tumors that differ from retroperitoneal sarcomas (RPS). Adequate imaging and preoperative biopsy are crucial for differential diagnosis and treatment planning. Surgical approach and multidisciplinary teamwork are essential due to anatomic constraints and potential complications. Early referral to specialized centers is recommended for optimal resection and improved survival. International consensus on PSTS treatment is needed, similar to recent efforts for RPS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bernd M. Erber, Paul Reidler, Sophia S. Goller, Jens Ricke, Hans R. Durr, Alexander Klein, Lars Lindner, Dorit Di Gioia, Tobias Geith, Andrea Baur-Melnyk, Marco Armbruster
Summary: This study evaluated the diagnostic accuracy of quantitative DCE-MRI and DWI in the detection of local recurrence of soft-tissue sarcomas in the limbs. The results showed that rPF was significantly higher in cases of local recurrence, while rMTT was slightly lower. rPF demonstrated higher accuracy and specificity, allowing for differentiation between local recurrence and benign postoperative changes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Orthopedics
Alexander L. Lazarides, Eliana B. Saltzman, Julia D. Visgauss, Suhail K. Mithani, William C. Eward, Brian E. Brigman
Summary: The study assessed the feasibility of intraoperative indocyanine green fluorescent angiography (ICGA) for predicting wound complications in soft tissue sarcoma patients receiving preoperative radiation therapy. The results showed that ICGA had a certain level of accuracy and sensitivity in predicting wound complications.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Miao, Shu-Tao Ma, Xu Jiang, Huan-Huan Zhang, Yan-Mei Wang, Meng Li
Summary: Radiomics features extracted from CECT imaging can be used to predict the efficacy of epirubicin combined with ifosfamide in patients with pulmonary metastases from soft tissue sarcoma.
BMC MEDICAL IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Mauro Loi, Giulia Salvatore, Michele Aquilano, Daniela Greto, Cinzia Talamonti, Viola Salvestrini, Maria Elena Melica, Marianna Valzano, Giulio Francolini, Mariangela Sottili, Costanza Santini, Carlotta Becherini, Domenico Andrea Campanacci, Monica Mangoni, Lorenzo Livi
Summary: Trabectedin sensitizes STS cells to radiation therapy by reducing cell survival rate, inhibiting invasiveness, altering cell cycle distribution, and increasing γ-H2AX foci formation. However, it does not have a synergistic effect on DNA damage repair, neoangiogenesis, and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Gijsbert M. Kalisvaart, Willem Grootjans, Judith V. M. G. Bovee, Hans Gelderblom, Jos A. van der Hage, Michiel A. J. van de Sande, Floris H. P. van Velden, Johan L. Bloem, Lioe-Fee de Geus-Oei
Summary: SUVmax and SUVpeak were identified as independent prognostic factors for overall survival in patients with metastases from soft tissue sarcoma, indicating their potential value in treatment decision making. The study suggests that these PET features can assist in predicting patients' survival outcomes and may warrant further investigation in the clinical setting.
Article
Oncology
Do Weon Lee, Han-Soo Kim, Ilkyu Han
Summary: The study found that actual 5-year survival in stage III soft tissue sarcoma patients is associated with tumor size, histological grade, and ASA score. Nevertheless, the majority of long-term survivors still exhibit factors of poor prognosis.
Review
Pharmacology & Pharmacy
Tomoki Nakamura, Akihiro Sudo
Summary: Trabectedin is a safe and effective therapeutic option for patients with advanced STS. While it may be effective as first-line treatment in selected patients, doxorubicin remains the preferred choice for locally advanced or metastatic STS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paulo Roberto Costa, Alessandra Tomal, Jullianna Cristina de Oliveira Castro, Isabella Paziam Fernandes Nunes, Denise Yanikian Nersissian, Marcio Valente Yamada Sawamura, Hilton Leao Filho, Choonsik Lee
Summary: This study evaluates the correlations between DRL quantities and organ doses in non-contrast chest and abdomen-pelvis CT examinations in adult patients. By stratifying DRL quantities into patient size ranges and analyzing their correlations with organ doses, it is found that organ doses in the imaged area are higher than those in peripheral, distributed, and outside regions, except for peripheral doses associated with chest examinations. Different levels of statistical significance between organ doses and DRL quantities are presented.
INSIGHTS INTO IMAGING
(2023)
Article
Oncology
Linus Lee, Alexander Kazmer, Matthew W. Colman, Steven Gitelis, Marta Batus, Alan T. Blank
Summary: This study investigated the use of PET-CT in patients with bone and soft tissue sarcoma. The results showed that additional workups and changes in the clinical course were not uncommon, indicating the potential clinical value of PET-CT in sarcoma care.
JOURNAL OF SURGICAL ONCOLOGY
(2022)