Article
Dentistry, Oral Surgery & Medicine
Rafiqul Islam, Yu Toida, Fei Chen, Toru Tanaka, Satoshi Inoue, Tetsuya Kitamura, Yasuhiro Yoshida, Abu Faem Mohammad Almas Chowdhury, Hany Mohamed Aly Ahmed, Hidehiko Sano
Summary: The study demonstrated that MTAPPL exhibited favorable pulpal responses and induction of mineralized tissue formation as a potential application for direct pulp capping.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Cell Biology
Milos Papic, Suzana Zivanovic, Tamara Vucicevic, Miona Vuletic, Mirjana V. Papic, Nevena Milivojevic, Ana Miric, Marina Miletic Kovacevic, Marko Zivanovic, Milan Stamenkovic, Vladimir Zivkovic, Slobodanka Mitrovic, Vladimir Jakovljevic, Biljana Ljujic, Milica Popovic
Summary: The study aimed to evaluate the dental pulp responses to rhEPO and/or MTA in pulp capping of inflamed dental pulp in vivo. Pulp capping with rhEPO or MTA + rhEPO resulted in lower inflammation and higher mineralization scores compared to untreated control. Capping with rhEPO or MTA + rhEPO resulted in a favorable effect that was similar or even superior to that of MTA.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chawan Manaspon, Chavin Jongwannasiri, Sujin Chumprasert, Noppadol Sa-Ard-Iam, Rangsini Mahanonda, Prasit Pavasant, Thantrira Porntaveetus, Thanaphum Osathanon
Summary: The study found that ProRoot(R) MTA and Biodentine(TM) have favorable in vitro biocompatibility and bioactive properties on human dental pulp stem cells, suggesting their superior regenerative potential compared with DyCal(R) and TheraCal(TM).
Article
Polymer Science
Mijoo Kim, Marc Hayashi, Bo Yu, Thomas K. Lee, Reuben H. Kim, Deuk-Won Jo
Summary: This study evaluated the mechanical, physical, and biological effects of fucoidan combined with conventional MTA for direct pulp capping. Fucoidan was found to reduce setting time, improve cell migration, and enhance osteogenic ability.
Article
Chemistry, Multidisciplinary
Jayanandan Muruganandhan, Govindarajan Sujatha, Saravanan Poorni, Manali Ramakrishnan Srinivasan, Nezar Boreak, Ahmed Al-Kahtani, Mohammed Mashyakhy, Hitesh Chohan, Shilpa Bhandi, A. Thirumal Raj, Alessio Zanza, Luca Testarelli, Shankargouda Patil
Summary: The study compared four pulp-capping agents and found MTA and ERRM to be more effective than other materials in promoting complete dentinal bridge formation and favorable pulpal response. There were no significant differences between MTA and ERRM.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sabrina Elise Moecke, Ana Gabriele de Cassia Santos Silva, Adrielle Caroline Moreira Andrade, Alessandra Buhler Borges, Carlos Rocha Gomes Torres
Summary: This study evaluated the effects of varnishes containing different concentrations of S-PRG filler or sodium fluoride on enamel caries remineralization. The results showed that the varnish containing 40% S-PRG filler was the most effective, followed by the one containing 5% sodium fluoride.
JOURNAL OF DENTISTRY
(2022)
Review
Chemistry, Physical
Ermin Nie, Jiali Yu, Rui Jiang, Xiangzhen Liu, Xiang Li, Rafiqul Islam, Mohammad Khursheed Alam
Summary: This systematic review evaluated the dentin regeneration efficacy of direct pulp capping biomaterials, concluding that MTA and Biodentine can induce dentin regeneration. The results suggest that MTA and its variants have better efficacy in the DPC procedure for dentin regeneration.
Article
Chemistry, Multidisciplinary
AlAnoud Almeshari, Rita Khounganian, Wael Mahdi, Fahd Aljarbou, Shilpa Bhandi, Sara Alsubait
Summary: The study evaluated the effects of using iloprost, MTA, and MTA-iloprost as pulp capping materials on pulpal inflammation and tertiary dentin formation in rat molars. Results showed similar pulpal responses in all groups, suggesting that mixing MTA with iloprost might not have significant clinical benefits.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rafiqul Islam, Md Refat Readul Islam, Toru Tanaka, Mohammad Khursheed Alam, Hany Mohamed Aly Ahmed, Hidehiko Sano
Summary: The aim of direct pulp capping (DPC) is to promote pulp healing and mineralized tissue barrier formation by placing a dental biomaterial directly over the exposed pulp. Successful application of this approach avoids the need for further and more extensive treatment. This review focuses on the DPC procedure, the materials used, and their mechanisms of action to promote pulpal healing.
JAPANESE DENTAL SCIENCE REVIEW
(2023)
Article
Chemistry, Physical
Maiko Yamada, Motohiko Nagayama, Yuka Miyamoto, Satoshi Kawano, Yoshiaki Takitani, Masashi Tanaka, Michiko Ehara, Juna Nakao, Takanaga Ochiai, Yoshihiro Shibukawa, Takakazu Yoshida
Summary: MTA can promote early differentiation of IPMSCs into odontoblasts, while MTA combined with PRP can stimulate calcified granule and dentin bridge formation through calcium mineral deposition. This combination is an effective method for activating endogenous dental pulp stem cells into odontoblasts in the early stages of pulp regeneration.
Article
Polymer Science
Soumya Sheela, Fatma Mousa AlGhalban, Khalil Abdelrazek Khalil, Tahar Laoui, Vellore Kannan Gopinath
Summary: This study developed potential dental pulp capping material by coating mineral trioxide aggregate/hydroxyapatite (MTA/HA) on polycaprolactone (PCL) electrospun membranes. The fabricated membranes were characterized and tested for biocompatibility and cell adhesion, spreading, and migration. The results showed that the PCLMTA membrane exhibited better cell adhesion, spreading, and migration.
Article
Materials Science, Biomaterials
Zhengmao Li, Kunke Xie, Shuang Yang, Ting Yu, Yin Xiao, Yinghong Zhou
Summary: Using Zn-doped bioactive glass micro-nano spheres for dental pulp capping can effectively control infection and inflammation, promote tissue regeneration, and facilitate mineralized dentin formation of dental pulp cells. The method demonstrated excellent dentin regenerative properties in rat experiments.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Nidambur Vasudev Ballal, Sheetal Rao, Nirmala Rao, Arun Urala, Jun-Sang Yoo, Nadin Al-Haj Husain, Mutlu Oezcan
Summary: Results of the study showed a significant difference in hard tissue bridge formation with ProRoot MTA, while RetroMTA performed better in terms of continuity, morphology, and inflammatory reaction. Although RetroMTA healed pulpal tissue faster, it seemed to be more of a reparative process compared to ProRoot MTA.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Amirah Alnour, Ghassan Almohammad, Anas Abdo, Kinda Layous
Summary: This study aimed to compare the histopathological response of dental pulp after direct pulp capping using two different materials, exogenous nitric oxide (NOC-18) and Mineral Trioxide Aggregate (MTA), in dogs' teeth. The results showed that the active status of the odontoblasts layer was significantly higher in the NOC-18 group compared to the MTA group after one month. However, there was no significant difference between the two groups in terms of dentine bridge formation after three months.
Article
Pathology
Ebtesam O. Abo El-Mal, Ashraf M. Abu-Seida, Salma H. El Ashry
Summary: The study compared the effects of Hesperidin, Mineral Trioxide Aggregate (MTA)-Angelus, and calcium hydroxide for direct pulp capping. Hesperidin was found to induce mild inflammation and promote good dentine bridge formation, making it a promising material for pulp capping.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Takahiko Sakai, Hefei Li, Tomohiro Abe, Satoshi Yamaguchi, Satoshi Imazato
Summary: This study aimed to investigate fracture initiation criteria of resin composites (RCs) at the micro-scale and evaluate the impact of filler shapes on RCs' flexural properties. Experimental RCs with irregular-shaped silica fillers were compared to models with sphere-shaped fillers, showing that irregular-shaped fillers led to significantly greater elastic modulus values and flexural strength. Ultimately, optimizing filler shapes can improve the mechanical strength of RCs.
Article
Dentistry, Oral Surgery & Medicine
Satoshi Yamaguchi, Oguzcan Karaer, Chunwoo Lee, Takahiko Sakai, Satoshi Imazato
Summary: The study evaluated the optical properties of supra-nano spherical fillers with different diameters and the color matching ability of resin composites. Results showed that both 150-nm and 260-nm nano fillers had uniform spherical shape and produced structural colors close to blue and yellow. The experimental RC could reflect base RC colors via the matrix resin, suggesting its ability to enhance color matching effects.
Article
Dentistry, Oral Surgery & Medicine
Keita Sugiyama, Jiro Miura, Masato Shimizu, Aoi Takashima, Yusuke Matsuda, Hiroki Kayashima, Motoki Okamoto, Tadashi Nagashima, Tsutomu Araki
Summary: The study demonstrates that glycated collagen containing AGEs enhances calcification of RDPCs without affecting cell proliferation or differentiation. This form of calcification may lead to cytotoxicity, with glycated collagen exhibiting negative polarity that facilitates the formation of calcium phosphate crystals.
Article
Dentistry, Oral Surgery & Medicine
Naoya Saeki, Chizuko Inui-Yamamoto, Moe Kuraki, Shousaku Itoh, Toshihiro Inubushi, Motoki Okamoto, Shigehisa Akiyama, Satoshi Wakisaka, Makoto Abe
Summary: SAMP8 mice exhibited reduced development of the disto-lingual cusp in the lower second molar compared to SAMR1 mice. Aged SAMP8 mice also showed severe wear of the entoconid in the lower second molar. These findings suggest that SAMP8 mice may serve as a potential model for studying genetic causes of distal reduction of molar cusp size.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Manahil Ali, Motoki Okamoto, Masakatsu Watanabe, Hailing Huang, Sayako Matsumoto, Shungo Komichi, Yusuke Takahashi, Mikako Hayashi
Summary: This study evaluated the biological performance of lithium-modified surface pre-reacted glass fillers (S-PRG/Li-100 mM) compared to mineral trioxide aggregate (MTA) and S-PRG without additives. The results showed that S-PRG/Li-100 mM exhibited similar biocompatibility to MTA and S-PRG, promoted apatite formation, and had better sealing capability and antibacterial activity than MTA.
Article
Pharmacology & Pharmacy
Motoki Okamoto, Sayako Matsumoto, Kiichi Moriyama, Hailing Huang, Masakatsu Watanabe, Jiro Miura, Keita Sugiyama, Yujiro Hirose, Manabu Mizuhira, Nanako Kuriki, Julian G. Leprince, Yusuke Takahashi, Shigetada Kawabata, Mikako Hayashi
Summary: This study evaluated the biological effects of different types of root canal sealers on surrounding tissues. The results showed that all sealers were in contact with the surrounding tissue and had unique immune and inflammatory modulatory effects. Calcium and phosphorus accumulation was observed only in the bio-glass-containing sealer. These findings can guide future research and comparisons with new generations of materials.
Article
Dentistry, Oral Surgery & Medicine
M. Watanabe, M. Okamoto, S. Komichi, H. Huang, S. Matsumoto, K. Moriyama, J. Ohshima, S. Abe, M. Morita, M. Ali, K. Takebe, I. Kozaki, A. Fujimoto, K. Kanie, R. Kato, K. Uto, M. Ebara, A. Yamawaki-Ogata, Y. Narita, Y. Takahashi, M. Hayashi
Summary: This study investigates the effects of functional peptides derived from the S100A8 protein on dental pulp tissue. It found that one of the peptides can promote tertiary dentin formation and inhibit inflammatory responses. These findings provide important insights for the development of next-generation biological vital pulp therapies.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Huang, M. Okamoto, M. Watanabe, S. Matsumoto, K. Moriyama, S. Komichi, M. Ali, S. Matayoshi, R. Nomura, K. Nakano, Y. Takahashi, M. Hayashi
Summary: In this study, a caries-induced pulpitis model was established to evaluate the inflammatory changes in reversible pulpitis induced by caries infection. It was found that M2 macrophages were predominant in moderate caries-stimulated pulp, while M1 macrophages were predominant in severe caries-stimulated pulp. After pulp capping, M2 macrophages played an important role in the early stages of wound healing in reversible pulpitis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Environmental Sciences
Natsumi Fujiwara, Shohei Yamashita, Motoki Okamoto, Marion A. Cooley, Kazumi Ozaki, Eric T. Everett, Maiko Suzuki
Summary: In this study, it was found that perfluorooctanoic acid (PFOA) negatively affects tooth enamel development through cell death mechanisms involving necrosis/necroptosis and apoptosis, mediated by the ROS-MAPK/ERK signaling pathway. PFOA also suppressed cell proliferation and viability. This research provides initial evidence that PFOA could potentially contribute to cryptogenic enamel malformation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuzo Kawanishi, Hazuki Maezono, Tsuyoshi Shimaoka, Takumi Kitatani, Katsuaki Naito, Maki Sotozono, Kittipit Klanliang, Yusuke Takahashi, Mikako Hayashi
Summary: Objective of this study was to compare the effects of using sodium hypochlorite and two different concentrations of ethylenediaminetetraacetic acid (EDTA) solution on removal of the smear layer and decalcification of the root canal dentin in an experimental root canal model and an immersion model. Results showed that the experimental design affected the residual smear layer and decalcification of the root canal dentin. EDTA and NaOCl irrigation did not cause erosion in the root canal dentin in the root canal model.
INTERNATIONAL JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Motoki Okamoto, Yoko Asahi, Henry Fergus Duncan, Nanako Kuriki, Yusuke Takahashi, Mikako Hayashi
Summary: The treatment of large external cervical resorption lesions can be difficult and result in non-restorable teeth. Intentional replantation is a potential option depending on the location and extent of the resorption. This case report presents a successful management of a large resorption lesion with intentional replantation and tooth rotation. The patient, a female, had an extensive palatal resorption on the maxillary lateral incisor that was not amenable to nonsurgical treatment, and a deliberate replantation with rotation was planned and performed.
CASE REPORTS IN DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yusuke Takahashi, Shotaro Abe, Motoki Okamoto, Tomomi Tsujimoto, Shumei Murakami, Mikako Hayashi
Summary: Autologous tooth transplantation is an effective method for replacing missing teeth, especially when there is a suitable donor tooth. It can be performed immediately after extraction or delayed when the recipient site has a large bone defect. This case report illustrates the success of delayed tooth transplantation by monitoring bone formation at the recipient site using CT images.
FRONTIERS IN DENTAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Yoshio Yahata, Keisuke Handa, Naoto Ohkura, Motoki Okamoto, Jun Ohshima, Shusaku Itoh, Nobuyuki Kawashima, Toshinori Tanaka, Nobuya Sato, Yuichiro Noiri, Mikako Hayashi, Takashi Okiji, Masahiro Saito
Summary: This randomized multicenter trial evaluated the effects of concentrated growth factor (CGF) on bone healing in combination with root-end microsurgery. The results showed that CGF in conjunction with root-end microsurgery accelerated lesion reduction, indicating it as a promising treatment option.
REGENERATIVE THERAPY
(2023)
