Article
Engineering, Biomedical
Agneta Vezenkova, Janis Locs
Summary: With the increase in global population, the demand for bone substitutes is growing. Calcium phosphate cements (CPCs) have the potential for various applications in bone regeneration due to their ability to self-set and resorb. However, finding an osteoinductive material that is suitable for injection remains a challenge.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Dorien Van Hede, Bingbing Liang, Sandy Anania, Mojtaba Barzegari, Bruno Verlee, Gregory Nolens, Justine Pirson, Liesbet Geris, France Lambert
Summary: Utilizing a simulation approach to optimize the internal design of calcium phosphate-based scaffolds for bone regeneration showed promising results. The gyroid experimental internal architecture demonstrated high potential for intra-oral bone regeneration applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Chia-Jen Wu, Kang-Fan Liu, Chung-Ming Liu, Wen-Chien Lan, Shu-Fen Chu, Yung-Kang Shen, Bai-Hung Huang, Jonathan Huang, Yung-Chieh Cho, Keng-Liang Ou, Pei -Wen Peng
Summary: This study successfully developed a highly pure and crystalline beta-tricalcium phosphate (b-TCP) bone graft substitute using the propagated Scleractinian coral. The coral-derived b-TCP with interconnected microporosity exhibited favorable biocompatibility and proper resorbed properties, showing promise as a bone graft substitute for bone defect repair in dental and orthopedic fields.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Engineering, Biomedical
Yanyan Zhou, Zihe Hu, Wenjing Jin, Haiyan Wu, Minghao Zuo, Changyu Shao, Yanhua Lan, Yang Shi, Ruikang Tang, Zhuo Chen, Zhijian Xie, Jue Shi
Summary: Inspired by bionic mineralization theory, researchers have developed an organic-inorganic composite scaffold with orderly arranged hydroxyapatite nanorods along collagen fibrils. This scaffold can promote intrafibrillar mineralization and regulate the immune microenvironment simultaneously. To enhance bone regeneration, a scaffold containing ultra-small particle size calcium phosphate nanocluster (UsCCP) is prepared, which promotes both mineralization and M2-type polarization of macrophages for an immune microenvironment with osteogenic and angiogenic potential.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Polymer Science
Jothi Varghese, Anjale Rajagopal, Shashikiran Shanmugasundaram
Summary: Periodontal infections are chronic inflammatory diseases that can lead to destruction of periodontal tissues. Treatment involves the use of biomaterials for tissue restoration. Bone replacement grafts have been extensively studied for their osteogenic potential. Synthetic substitutes for bone replacement are more practical for clinical use compared to autogenic biomaterials.
Article
Engineering, Biomedical
Yanan Zhao, Honglei Kang, Xiaopei Wu, Pengzhen Zhuang, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: A drug carrier system composed of gelatin-coated hollow mesoporous silica nanoparticles loaded with pro-osteogenic parathyroid (PTH) and anti-osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). It enhances osteoporotic bone regeneration in ovariectomized rats by promoting osteogenic differentiation, inhibiting osteoclastogenesis, and accelerating vascularization. The MCPC/HMSNs@ALN-PTH/GM demonstrates a synergistic effect on osteogenesis, osteoclastogenesis, and angiogenesis, holding potential for other biomaterials design and clinical management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ho-Kyung Lim, Ik-Jae Kwon, Sung-Woon On, Seok-Jin Hong, Byoung-Eun Yang, Soung-Min Kim, Jong-Ho Lee, Soo-Hwan Byun
Summary: The study investigated the bone regeneration capacity of BCP powder, BCP block, and BCP collagen with different concentrations of rhBMP-2 in an animal model. Results showed that increasing rhBMP-2 concentration did not significantly enhance osteogenesis, while collagen-added material may help mediate rapid bone formation in initial stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Matej Tomas, Matej Karl, Marija Candrlic, Marko Matijevic, Martina Juzbasic, Olga Cvijanovic Peloza, Ana Terezija Jerbic Radetic, Davor Kuis, Bruno Vidakovic, Zrinka Ivanisevic, Zeljka Peric Kacarevic
Summary: The study examined the healing ability of alveolar bone defects during augmentation with two different biomaterials: injectable biphasic calcium phosphate (BCP) and anorganic bovine bone (ABB). Histological and immunohistochemical analyses showed comparable results for both materials in terms of newly formed bone, residual biomaterial, and soft tissue, indicating that BCP is equally suitable and successful for alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Janice Lay Tin Tan, Masaya Shimabukuro, Mamiko Kobayashi, Ryo Kishida, Masakazu Kawashita, Kunio Ishikawa
Summary: In this study, ant-nest type porous (ANP) scaffolds consisting of CO(3)Ap were fabricated using calcium carbonate powder or slurry and two types of polyurethane foam. The ANP structures displayed a clear structural advantage in bone regeneration, owing to the promotion of cell and tissue migration throughout the scaffolds. ANP-structured CO(3)Ap scaffolds, especially those with highest porosity, interconnectivity, and smallest strut thickness, showed mechanical strength comparable to cancellous bone and resulted in cancellous bone-like bone tissue regeneration at 12 weeks of healing.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Materials Science, Multidisciplinary
Chunxia Gao, Hualei Fan, Jing Chen, Deyang Zheng, Peizhi Zhu, Jiadeng Zhu
Summary: In this study, novel beta-tricalcium and hydroxyapatite (beta-TCP/HA) biphasic calcium phosphate (BCP) microspheres with different surface topographies were successfully prepared by adjusting phosphoric acid concentrations and pH values. The in vitro cytocompatibility and drug delivery potential of the microspheres were evaluated, demonstrating their promising applications.
Article
Nanoscience & Nanotechnology
Jingwen Wu, Peilei Wang, Yijia Yin, Jie Liang, Yujiang Fan, Xingdong Zhang, Xianglong Han, Yong Sun
Summary: A porous cationic biopolymeric scaffold with microenvironment self-regulating ability was synthesized, which promoted periodontal bone regeneration and eliminated infection.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Ceramics
Yun-Hee Lee, Ji-Won Lee, Seo-Young Yang, Hyun Lee, Young Hag Koh, Hyoun-Ee Kim
Summary: This study introduces a novel type of biphasic calcium phosphate (BCP) gyroid scaffolds with unique structure and microporous walls, produced using PMMA microspheres as porogen for ceramic manufacturing technique. By controlling the PMMA content, the microporosity of the BCP walls and the overall porosity of the scaffolds were adjusted, resulting in high overall porosity while maintaining reasonable compressive strength.
CERAMICS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Joviniano Martins de Oliveira Junior, Pedro Giorgetti Montagner, Rafael Coutinho Carrijo, Elizabeth Ferreira Martinez
Summary: The study demonstrated the promising application of biphasic calcium phosphate bioceramics in repairing critical defects in rat calvaria, with no significant differences in inflammatory response and bone formation observed between different particle sizes of BCP.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Eri Uchikawa, Michiko Yoshizawa, Xianqi Li, Nahomi Matsumura, Ni Li, Kai Chen, Hideaki Kagami
Summary: This study investigated a tissue engineering approach of using a scaffold or cells in tooth transplantation to accelerate bone formation and periodontal tissue regeneration. The results showed that the approach significantly increased bone volume and promoted periodontal tissue regeneration in a mouse model.
Article
Biochemistry & Molecular Biology
Jean-Claude Imber, Andrea Roccuzzo, Alexandra Staehli, Nikola Saulacic, James Deschner, Anton Sculean, Dieter Daniel Bosshardt
Summary: The study demonstrates a positive effect of VCMX on angiogenesis and suggests an equally high cell turnover in the regenerated and pristine PDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)