Article
Medicine, Research & Experimental
Ni Su, Cassandra Villicana, Carl Zhang, Jeehee Lee, Sauradeep Sinha, Andrew Yang, Fan Yang
Summary: Mineral particle-coated scaffolds combined with aspirin have a synergistic effect in promoting endogenous bone regeneration and reducing bone resorption. The optimized formulation shows promising potential for repairing critical-sized cranial bone defects.
Article
Surgery
Alaa Abdelqader Altaweel, Adeeb Safwan Lababidy, Mohamed Abd-Ellatif El-Patal, Shadia Abdelhameed Elsayed, Mohamed Shams Eldin, Jamal Dabbas, Marwa Hassan Abd-El Meneim, Mohamed Yaser Kharma
Summary: Bifocal transport distraction osteogenesis improves the success rate of alveolar cleft treatment, especially for wide or previously failed cases. This technique is associated with minimal complications when careful planning and patient cooperation are combined, and can be recommended when other modalities for alveolar cleft treatment have failed. Patients also tolerate the device well.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Cell & Tissue Engineering
Ziqian Wu, Xudong Wang, Jingcun Shi, Anand Gupta, Yuhan Zhang, Bingqing Zhang, Yang Cao, Lei Wang
Summary: Through RNA sequencing and bioinformatics analysis, we identified differentially expressed genes related to innervation of bone grafts and their functional modules and signaling pathways. Additionally, we demonstrated that CGRP regulates the differentiation of BMMSCs through p38 MAPK and Wnt6/beta-catenin pathways. These findings have important implications for maintaining bone mass after bone grafting and the structural and functional integration of the graft.
STEM CELLS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Sachio Tsuchida, Tomohiro Nakayama
Summary: The periodontal ligament is a connective tissue located between the bone and the cementum of the tooth, maintaining the healthy foundation supporting the teeth. Periodontal diseases lead to the absorption of the alveolar bone around the teeth, causing shrinkage and various dental problems. Recently, advancements in implant therapy and bone augmentation methods have greatly expanded the treatment options and chances of restoring teeth to their original healthy state. Furthermore, the potential application of induced pluripotent stem cell (iPS) technology offers hope for regenerating periodontal tissues. This review focuses on the alveolar bone and provides insights into clinical practice, techniques, and the latest research developments.
Article
Chemistry, Physical
Sarun Chancharoen, Peerapong Santiwong, Dutmanee Seriwatanachai, Anak Khantachawana, Rochaya Chintavalakorn
Summary: The new design of an alveolar distractor with NiTi open-coil springs can generate light and continuous forces to overcome the resistance from porcine attached gingiva, showing potential for further development in dental applications.
Review
Biochemistry & Molecular Biology
Revatyambigai Subramaniam, Ubashini Vijakumaran, Lohashenpahan Shanmuganantha, Jia-Xian Law, Ekram Alias, Min-Hwei Ng
Summary: This paper discusses the role and mechanism of human miR21 in regulating bones, as well as the feasibility of using exogenous miR21 to promote osteogenesis. It emphasizes the research on miR21 in promoting bone synthesis. From the literature review, it is clear that miR21 plays a dual role in bone metabolism by regulating both bone formation and bone resorption. There is substantial evidence to support the exploration of exogenous miR21 in bone regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yanshi Liu, Feiyu Cai, Kai Liu, Jialin Liu, Xiaoxu Zhang, Aihemaitijiang Yusufu
Summary: The CDC technique has been found to improve bone regeneration during distraction osteogenesis, with better outcomes achieved by increasing the amplitude and slowing down the rate of the technique. The mechanism may involve the activation of the HIF pathway and enhancement of the osteogenic-angiogenic coupling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pediatrics
Tao Han, Yi Ji, Jie Cui, Liangliang Kong, Lijun Shi, Jianbin Chen, Weimin Shen
Summary: This study reports the use of allogenic acellular bone matrix and mandibular distraction osteogenesis in severe Pierre Robin sequence cases. The results suggest that bilateral mandibular distraction osteogenesis combined with placing allogenic acellular bone are safe and effective treatment options for severe Pierre Robin sequence.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biotechnology & Applied Microbiology
Shahrokh Hatefi, Milad Sh Etemadi, Javad Alizargar, Venous Behdadipour, Khaled Abou-El-Hossein
Summary: The application of Distraction Osteogenesis (DO) techniques in reconstruction surgeries is advantageous with fewer side effects. However, the development of automatic devices for controlled continuous force still requires further research. A two-axis continuous distractor is proposed for mandibular reconstruction, meeting the current requirements.
BIOENGINEERING-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Marc Quirynen, Pierre Lahoud, Wim Teughels, Simone Cortellini, Rutger Dhondt, Reinhilde Jacobs, Andy Temmerman
Summary: Alveolar ridge resorption is a common complication after tooth extraction, requiring lateral bone augmentation. This study investigated the hypothesis that individual phenotypic dimensions may play a role in the degree of resorption.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Engineering, Multidisciplinary
Shuai Bu, Meilin Yu, Qin Chen, Dong Chen, Pengfei Xia, Guifei Li, Kunxi Zhang, Shifeng Yan, Haimiao Wu, Jingbo Yin
Summary: Injectable microcarriers with osteogenic and angiogenic properties were fabricated for the repair of alveolar bone defects. The ICA@nCP/nHA-g-PBLG composite microcarriers showed enhanced proliferation of bone marrow mesenchymal stem cells and demonstrated promising potential for the restoration of alveolar bone defects.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Hye-Jung Ihn, Yi-Seul Kim, Soomin Lim, Jong-Sup Bae, Jae-Chang Jung, Yeo-Hyang Kim, Jin-Woo Park, Zhao Wang, Jeong-Tae Koh, Yong-Chul Bae, Moon-Chang Baek, Eui-Kyun Park
Summary: PF-3845 significantly suppressed osteoclast differentiation and decreased the induction of nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) and the expression of osteoclast-specific markers. Actin ring formation and osteoclastic bone resorption were also reduced by PF-3845, and the anti-osteoclastogenic and anti-resorptive activities were mediated by the suppression of phosphorylation of rapidly accelerated fibrosarcoma (RAF), mitogen-activated protein kinase (MEK), extracellular signal-regulated kinase (ERK), and nuclear factor kappa B (NF-kappa B) inhibitor (I kappa B alpha).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Agriculture, Dairy & Animal Science
Mario Garcia-Gonzalez, Fernando Munoz, Antonio Gonzalez-Cantalapiedra, Monica Lopez-Pena, Nikola Saulacic
Summary: Periosteal distraction osteogenesis (PDO) is a promising new technique for bone regeneration that has shown better results in animal models such as rabbits and rats compared to minipigs. The quality of studies has improved since the implementation of ARRIVE guidelines in 2010, but there is still room for enhancing transparency, comparability, and reproducibility in future research.
Article
Multidisciplinary Sciences
Chenyi Shao, Yi Liu, Jiaci Li, Ziyun Liu, Yuxia Zhao, Yaqing Jing, Zhe Lv, Ting Fu, Zihan Wang, Guang Li
Summary: Osteogenesis imperfecta (OI), a congenital bone dysplasia, is mainly caused by defective production or assembly of type I collagen. Studies have found that increased osteoclasts and excessive bone resorption exist in collagen-related OI, which is associated with inflammation. Transcriptomic analysis of bone marrow cells from OI mouse models revealed dysregulated genes and pathways related to interferon response, IL17 signaling, tumor necrosis factor signaling, and osteoclast differentiation. These findings contribute to understanding the mechanism of enhanced bone absorption in OI and provide evidence for potential anti-inflammatory therapies.
Article
Cell & Tissue Engineering
Y. Li, Y. Yang, M. Wang, X. Zhang, S. Bai, X. Lu, Y. Li, E. I. Waldorff, N. Zhang, W. Y. W. Lee, G. Li
Summary: The study compared a new, high slew rate (HSR) PEMF signal with different treatment durations with the standard FDA-approved signal, finding that HSR signal significantly enhances bone formation and could shorten daily treatment duration.
BONE & JOINT RESEARCH
(2021)