Article
Dentistry, Oral Surgery & Medicine
Stefan Krennmair, Lukas Postl, Uwe Yacine Schwarze, Michael Malek, Michal Stimmelmayr, Gerald Krennmair
Summary: This study compared new bone formation, graft stability, and clinical implant outcome between maxillary sinus grafting using DPBM and DBBM. The results showed that both materials had similar effects on new bone formation and graft stability, with good implant retention.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Biology
Mone Zaidi, Se-Min Kim, Mehr Mathew, Funda Korkmaz, Farhath Sultana, Sari Miyashita, Anisa Azatovna Gumerova, Tal Frolinger, Ofer Moldavski, Orly Barak, Anusha Pallapati, Satish Rojekar, John Caminis, Yelena Ginzburg, Vitaly Ryu, Terry F. Davies, Daria Lizneva, Clifford J. Rosen, Tony Yuen
Summary: Significant advances have been made in understanding skeletal homeostasis and the mechanisms of bone disease over the past decade. Identifying disease-causing mutations and modeling human bone disease in rodents have highlighted the integrative nature of skeletal physiology. Bone cells communicate and regulate each other's fate through various signaling pathways, and developmental pathways like BMP, NOTCH, and WNT play important roles in postnatal bone remodeling. The skeleton communicates with neighboring organs as well as vital organs, and has effects on energy homeostasis and other physiological processes. This article discusses the mechanisms controlling bone remodeling, communication between bone cells and other cell lineages, crosstalk between bone and vital organs, and potential treatments for bone diseases.
Article
Engineering, Biomedical
E. Andres Sastre, Y. Nossin, I Jansen, N. Kops, C. Intini, J. Witte-Bouma, B. van Rietbergen, S. Hofmann, Y. Ridwan, J. P. Gleeson, F. J. O'Brien, E. B. Wolvius, G. J. V. M. van Osch, E. Farrell
Summary: The study introduces a refined murine subcutaneous model for semi-orthotopic bone formation, allowing testing of up to four grafts per mouse, one order of magnitude greater in volume than currently possible. This model enables evaluation of bone healing potential of different grafts and assessment of ossification promotion and prevention.
Article
Dentistry, Oral Surgery & Medicine
Rodrigo dos Santos Pereira, Joao Paulo Bonardi, Felippe Ricardo Frossard Ouverney, Annelise Backer Campos, Geraldo Luiz Griza, Roberta Okamoto, Eduardo Hochuli-Vieira
Summary: This study evaluated the effectiveness of 5 different bone substitutes for maxillary sinus bone augmentation. After 6 months of bone healing, all groups demonstrated suitable lamellar bone formation for receiving dental implants.
JOURNAL OF APPLIED ORAL SCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Tiago Borges, Javier Montero, Bruno Leitao, Miguel Pereira, Pablo Galindo-Moreno
Summary: This study found that in posterior mandibular edentulous areas, the installation of 2 mm prosthetic abutments in areas with limited keratinized mucosa presents as a favorable treatment option in terms of peri-implant marginal bone maintenance.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Review
Environmental Sciences
Margherita Tumedei, Eitan Mijiritsky, Carlos Fernando Mourao, Adriano Piattelli, Marco Degidi, Carlo Mangano, Giovanna Iezzi
Summary: This retrospective review evaluates the histological and biological aspects of bone substitute biomaterials studied over three decades. The evaluation of 52 articles provides a better understanding of the properties and applications of these biomaterials.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Physical
Ping Qi Lim, Sue Huey Lim, Maria Sherilyn, Tulio Fernandez-Medina, Saso Ivanovski, Sepanta Hosseinpour
Summary: This study aims to identify and rectify potential clinical risks of a 3D-printed patient-specific scaffold for large-volume alveolar bone regeneration through risk assessment. The survey showed a positive perception of clinicians towards this novel scaffold. The clinical risk assessment revealed two failure modes that should be prioritized for risk mitigation.
Review
Biochemistry & Molecular Biology
Sachio Tsuchida, Tomohiro Nakayama
Summary: The periodontal ligament is a connective tissue located between the bone and the cementum of the tooth, maintaining the healthy foundation supporting the teeth. Periodontal diseases lead to the absorption of the alveolar bone around the teeth, causing shrinkage and various dental problems. Recently, advancements in implant therapy and bone augmentation methods have greatly expanded the treatment options and chances of restoring teeth to their original healthy state. Furthermore, the potential application of induced pluripotent stem cell (iPS) technology offers hope for regenerating periodontal tissues. This review focuses on the alveolar bone and provides insights into clinical practice, techniques, and the latest research developments.
Review
Engineering, Biomedical
Angela Maria Paiva Magri, Julia Risso Parisi, Ana Laura Martins de Andrade, Ana Claudia Muniz Renno
Summary: Bone fractures can usually heal on their own, but in critical situations, the use of ceramic biomaterials and PBM in combination can enhance bone regeneration. Studies have shown that 75% of experiments demonstrate positive effects from the association of ceramic biomaterials and PBM in stimulating bone regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Editorial Material
Multidisciplinary Sciences
Joshua Bloomekatz, Neil C. Chi
Summary: A combination of computational modelling and experimental techniques in live zebrafish embryos reveals the mechanism of how the heart initiates organized and rhythmic beating.
Article
Pharmacology & Pharmacy
Rehana K. Leak, James B. Schreiber
Summary: This two-part series discusses how to test hypotheses on molecular mechanisms underlying biological phenomena, using preclinical drug testing as an example. Students will learn the limitations of descriptive and mechanistic studies and develop the skills to design their own mechanistic studies and interpret the outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Engineering, Biomedical
Guanyin Zhu, Tianxu Zhang, Miao Chen, Ke Yao, Xinqi Huang, Bo Zhang, Yazhen Li, Jun Liu, Yunbing Wang, Zhihe Zhao
Summary: Bone-tissue defects are a global issue, with autologous and allogeneic bone grafting failing to achieve ideal therapeutic effects. This has led researchers to explore novel bone-regeneration methods, with the development of BTE scaffolds at the forefront. By delving into bone physiology and healing mechanisms, biomimicking and bioinspired BTE scaffolds are making progress.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Physical
Joao Paulo Bonardi, Rodrigo dos Santos Pereira, Carlos F. Mourao, Bruno Coelho Mendes, Adam Lowenstein, Pietro Montemezzi, Flavio Giubilato, Roberta Okamoto, Eduardo Hochuli-Vieira
Summary: The aim of this study was to compare two different forms of biphasic calcium phosphate (BCP) - granules and paste - in human maxillary sinus bone reconstruction. The results showed that both BCP granules and paste had suitable bone formation and high osteocalcin immunolabeling, indicating good bone calcification for dental implant placement.
Review
Chemistry, Physical
Shahnavaz Khijmatgar, Massimo Del Fabbro, Margherita Tumedei, Tiziano Testori, Niccolo Cenzato, Gianluca Martino Tartaglia
Summary: This study used network meta-analysis (NMA) to determine the influence of residual bone height (RBH) on new bone formation after lateral sinus augmentation, and found that there is no consistently superior grafting biomaterial for new bone formation.
Review
Biotechnology & Applied Microbiology
Ali Mahnavi, Mina Shahriari-Khalaji, Bahareh Hosseinpour, Mostafa Ahangarian, Amir Aidun, Simona Bungau, Syed Shams ul Hassan
Summary: Different biomaterials and methods have been used in tissue engineering for repairing damaged bones. However, the weakness in cellular activity or osteoconductivity sometimes limits their optimal use. To address this issue, surface modification techniques, such as polydopamine coating, have been employed. Polydopamine not only covers the weakness of scaffolds but also enhances their osteoconductivity. The hydrophilic layer created by polydopamine allows bone cells to anchor and adhere well to the surfaces, while the catechol and amine groups make the surfaces chemically active, resulting in increased osteoconductivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Moritz Hertel, Andrea-Maria Schmidt-Westhausen, Stephanie Wendy, Max Heiland, Susanne Nahles, Robert Preissner, Saskia Preissner
Summary: This study investigated the occurrence of OLL/OLP after COVID-19 vaccination. The results showed a significantly higher risk of developing OLL/OLP, especially with mRNA vaccines. However, these lesions tend to resolve spontaneously, so there should be no limitation on the use of COVID-19 vaccines in the general population.
Article
Immunology
Kathleen Gallo, Andrean Goede, Cameron Mura, Renata Abel, Barbara Moahamed, Saskia Preissner, Susanne Nahles, Max Heiland, Philip E. Bourne, Robert Preissner, Michael Mallach
Summary: This study analyzed real-world data and found that COVID-19 vaccines may have some adverse reactions, especially an increased risk of cerebral venous sinus thrombosis after receiving the Johnson & Johnson vaccine. Additionally, the Pfizer/BioNTech vaccine may increase the risk of Guillain-Barre syndrome and myocarditis/pericarditis in young men. However, it is necessary to confirm these findings through prospective clinical trials, and it should be noted that the benefits of COVID-19 vaccination outweigh the potential complications.
Article
Oncology
Marlene Heym, Max Heiland, Robert Preissner, Christopher Huebel, Susanne Nahles, Andrea Maria Schmidt-Westhausen, Saskia Preissner, Moritz Hertel
Summary: This study investigated the association between psycho-emotional stress and chronic soft tissue injuries caused by bruxism and oral squamous cell carcinoma. The findings suggest that psycho-emotional stress and chronic mucosal injuries may play a role in carcinogenesis. However, further research is needed to validate these results.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Claudius Steffen, Katharina Duda, Dag Wulsten, Jan O. O. Voss, Steffen Koerdt, Susanne Nahles, Max Heiland, Sara Checa, Carsten Rendenbach
Summary: This study evaluates a new bite force measuring device and its feasibility in patients after mandibular resection. The device shows high accuracy and reproducibility, providing new opportunities for quantifying perioperative oral function after reconstructive surgery of the mandible.
Article
Dentistry, Oral Surgery & Medicine
Florian Kernen, Dominik Braendle, Oliver Wagendorf, Mario Recca, Juergen Mehrhof, Kirstin Vach, Susanne Nahles, Katja Nelson, Tabea Fluegge
Summary: This study evaluated the accuracy of an intraoral scan aid for scanning multiple implants in the edentulous arch. By comparing the scans of 87 implants in 22 patients, it was found that the scan aid significantly improved scanning accuracy and success rate.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Genetics & Heredity
Maxime N. N. Gottschalk, Max Heiland, Susanne Nahles, Robert Preissner, William A. A. Petri, Stephanie Wendy, Saskia Preissner
Summary: Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disease. Recent studies have shown an association between AOSD and SARS-CoV-2 infection and/or COVID-19 vaccination.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Oncology
Jonas Wuester, Max Heiland, Susanne Nahles, Robert Preissner, Saskia Preissner
Summary: Statins are commonly prescribed to lower cholesterol levels and have been found to have beneficial effects on cancer prevention and treatment. In this study, the effect of statin medication on head and neck cancer patients was investigated. The results showed that patients who received statins had significantly higher five-year survival rates and a lower risk of death compared to those who did not receive statins. However, further clinical research is needed to confirm these findings.
Article
Infectious Diseases
Florian Gaertner, Saskia Preissner, William Arthur Petri, Olubunmi Atolani, Max Heiland, Susanne Nahles, Robert Preissner, Moritz Hertel
Summary: By retrospectively comparing the recent outbreak of monkeypox with historical outbreaks, it was found that the risk of hospital admission, ventilation, and pneumonitis was relatively low in the recent outbreak. However, some patients still required hospitalization and experienced severe complications.
BMC INFECTIOUS DISEASES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Robert Gaudin, Jan Dirk Raguse, Sophie Krause, Jennifer Mumm, Yvonne Motzkus, Iman Ghanad, Susanne Nahles, Christian Doll, Ahmad Sedaghat, Carsten Rendenbach, Max Heiland, Daniel Troeltzsch
Summary: Facial prostheses can improve mental wellbeing and quality of life among patients with facial defects. Multiple factors such as type of facial defect, location of residence, and education level can potentially influence the quality of life of affected patients.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Claudius Steffen, Ana Prates Soares, Thelma Heintzelmann, Heilwig Fischer, Jan Oliver Voss, Susanne Nahles, Jonas Wuester, Steffen Koerdt, Max Heiland, Carsten Rendenbach
Summary: The impact of bone origin at the intersegmental gap on osseous union in mandibular reconstruction was evaluated in this study. The results showed that the bone interface did not significantly influence the change in bone volume at the intersegmental gap. Radiotherapy, time between CBCT scans, and wound healing disorders were identified as independent risk factors for osseous non-union. Preliminary analysis of the intersegmental bone microstructure did not reveal morphological differences.
HEAD & FACE MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Jonas Wuester, Bernhard Hesse, Rene Rothweiler, Emely Bortel, Christian Gross, Shima Bakhtiyari, Andrew King, Elodie Boller, Javier Gerber, Carsten Rendenbach, Tobias Fretwurst, Saskia Preissner, Max Heiland, Katja Nelson, Susanne Nahles
Summary: By comparing bone samples from the jaw and fibula, this study found that they have similar vascular network and distribution of vascular porosity, which may contribute to the high regeneration potential of fibula graft when connected to the jaw bone. These findings are important for improving the performance of autologous bone grafts and the design of 3D scaffolds.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Oliver Wagendorf, Susanne Nahles, Kirstin Vach, Florian Kernen, Stefan Zachow, Max Heiland, Tabea Fluegge
Summary: This study investigated the influence of teeth and dental restorations on the gray value distributions of the facial skeleton in cone-beam computed tomography (CBCT). Gray value selection procedures were performed on 20 maxillae and 20 mandibles, including partially and fully edentulous cases, using manual and automated threshold selection. The study found that teeth and dental restorations affected the gray values and segmentation results in CBCT, highlighting the importance of accurate bone segmentation for surgical protocols.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jonas Wuester, Claudia Sachse, Christian Sachse, Carsten Rendenbach, Oliver Wagendorf, Kirstin Vach, Saskia Preissner, Max Heiland, Katja Nelson, Susanne Nahles
Summary: This study evaluated the influence of vestibuloplasty on the clinical success and survival rate of dental implants in head and neck tumor patients. The results showed that patients who underwent vestibuloplasty had a significantly higher survival rate and success rate of dental implants, and lower peri-implant bone resorption rate after 5 years.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Tabea Fluegge, Christian Gross, Ute Ludwig, Johanna Schmitz, Susanne Nahles, Max Heiland, Katja Nelson
Summary: MRI is increasingly used in various dental specialities, such as orthodontics, endodontics, prosthodontics, periodontics, oral surgery, pediatric dentistry, and operative dentistry. It is used for cephalometry, detection of dental pulp inflammation, characterization of periodontal pathologies, caries detection, and dental implant planning, among others.
DENTOMAXILLOFACIAL RADIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Norbert Neckel, Daniel Troeltzsch, Dario Zocholl, Steffen Koerdt, Yvonne Motzkus, Andrej Trampuz, Jan-Dirk Raguse, Max Heiland, Susanne Nahles
Summary: The purpose of this study was to compare different assessment methods for peri-implant inflammation, evaluate potential risk factors, and establish a comprehensive algorithm for clinical staging, treatment, and evaluation of success in periorbital implants. The results showed that probing depth and skin reaction to be valuable quick assessment tools, which can be complemented with sulcus fluid flow rate for improved accuracy. Patient-specific factors did not have a significant impact on peri-implant inflammation.
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2023)