Article
Chemistry, Physical
Sergej Zankovic, Michael Seidenstuecker, Wolf C. Prall, Johannes Loos, Franziska Maderer, Mike Oberle, Sergio H. Latorre, Pia Schilling, Bianca Riedel, Anke Bernstein
Summary: An ex vivo organ model using human bone was developed to evaluate the initial osseointegration behavior of implant materials, showing that cells can remain viable for up to 28 days in the model. The geometry of test substrates influences the number of cells grown onto the substrate, offering an alternative for in vitro tests and animal models for testing implant materials.
Article
Cell Biology
Hai Xin, Sara Romanazzo, Eva Tomaskovic-Crook, Timothy C. Mitchell, Jui Chien Hung, Steven G. Wise, Kai Cheng, D. S. Abdullah Al Maruf, Murray J. Stokan, Timothy G. H. Manzie, Krishnan Parthasarathi, Veronica K. Y. Cheung, Ruta Gupta, Mark Ly, Carlo Pulitano, Innes K. Wise, Jeremy M. Crook, Jonathan R. Clark
Summary: We have developed an ex vivo perfusion bioreactor system to preserve surgically resected periosteal flaps, demonstrating long-term cell viability and metabolism. This proof-of-concept study paves the way for innovative bone engineering approaches using autotransplanted periosteum to enhance in vivo bone repair.
Article
Engineering, Biomedical
Yinbo Xiao, ChanelleA. S. McGuinness, W. Sebastian Doherty-Boyd, Manuel Salmeron-Sanchez, Hannah Donnelly, Matthew J. Dalby
Summary: Hematopoietic stem cells play a fundamental role in the generation of blood and immune cells. Although the signaling mechanisms in their bone marrow niche microenvironment have been increasingly understood, the ability to recreate these mechanisms in vitro for clinical purposes is still lacking. Recent studies have used engineering techniques to establish ex vivo bone marrow niche models, showing promising potential for research and clinical applications.
Article
Multidisciplinary Sciences
Hendricus Nijland, Jinwen Zhu, Thomas C. Kwee, Ding-Jun Hao, Paul C. Jutte
Summary: Bone metastases are becoming more common in cancer patients, and microwave ablation is commonly used for treatment. This study found that in the metaphysis of long bones, MWA may decrease mechanical strength up to 50% after six weeks, but it remains sufficient for patients to engage in direct mobilization.
Article
Dentistry, Oral Surgery & Medicine
Joao Marcus de Carvalho e Silva Fuglsig, Lars Schropp, Brian Hansen, Ann Wenzel, Rubens Spin-Neto
Summary: This study compared the measurements of height, width, and area in alveolar bone sites using magnetic resonance imaging (MRI) and cone beam CT (CBCT). The results showed that bone height measurements were similar using both CBCT and MRI, while ZTE-MRI resulted in smaller estimates for bone width and area.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Engineering, Biomedical
Joana Fontes, Victor Zacharias Martin, Marta Resende, Bruno Colaco, Pedro de Sousa Gomes, Jose Manuel Amarante
Summary: This study investigated the stability of orthodontic mini-implants under immediate orthodontic functional load, with or without splinting, and examined the histomorphometric parameters of the adjacent bone tissue in an in vivo experimental model. Mini-implants were placed in rabbits' proximal tibia and loaded with a 150g force. The study found that splinting reduced the tipping of mini-implants to levels similar to unloaded implants, and immediate loading increased bone formation at the peri-implant region. This study highlights the importance of splinting in minimizing displacement while promoting bone formation in orthodontic treatment with mini-implants.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Acoustics
Molly Smallcomb, Julianna C. Simon
Summary: Histotripsy can fractionate most soft tissues, but healthy tendons have shown resistance. However, pre-heating tendons and using dual-frequency histotripsy may successfully fractionate tendons. This study evaluated the efficacy of single- and dual-frequency histotripsy in healthy and tendinopathic bovine tendons, and found that dual-frequency histotripsy can achieve complete fractionation in tendinopathic tendons.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Engineering, Biomedical
Thomas S. Rau, Samuel John, Marcel Kluge, Felix Repp, M. Geraldine Zuniga, Jan Stieghorst, Max E. Timm, Max Froehlich, Omid Majdani, Thomas Lenarz
Summary: This article describes a new micro-stereotactic targeting system designed for cochlear implant surgery and its evaluation in an ex vivo study. The system demonstrated successful performance of minimally invasive posterior tympanotomy in all specimens.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Minh Khai Le Thieu, Amin Homayouni, Lena Ringsby Haeren, Hanna Tiainen, Anders Verket, Jan Eirik Ellingsen, Hans Jacob Ronold, Johan Caspar Wohlfahrt, Antonio Gonzalez Cantalapiedra, Fernando Maria Guzon Munoz, Maria Permuy Mendana, Stale Petter Lyngstadaas, Havard Jostein Haugen
Summary: This study evaluated bone healing with the use of a synthetic TiO2 block scaffold in peri-implant defects with fenestrations. The results showed less bone formation in defects with buccal fenestrations when TiO2 scaffold was used compared to sham sites.
BIOMATERIALS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Francesca Ferrara, Mascia Benedusi, Franco Cervellati, Maddalena Sguizzato, Leda Montesi, Agnese Bondi, Markus Drechsler, Walter Pula, Giuseppe Valacchi, Elisabetta Esposito
Summary: In this study, transethosomes were explored as potential delivery systems for dimethyl fumarate. Formulative studies were conducted to investigate the effects of various compositions on the morphology and drug entrapment capacity of vesicles. Results showed that certain formulations were able to effectively improve wound healing and control drug release, indicating their potential application in wound treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Henning Staedt, Diana Heimes, Karl M. Lehmann, Peter Ottl, Monika Bjelopavlovic, Wilfried Wagner, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The study found that primary stability of dental implants increases with increasing length and the presence of screw threads at the apical end in both hard and soft bone. Undersized drilling preparation in soft bone significantly improves primary stability.
Article
Biochemistry & Molecular Biology
Elisabetta Esposito, Laura Calderan, Andrea Galvan, Enrica Cappellozza, Markus Drechsler, Paolo Mariani, Alessia Pepe, Maddalena Sguizzato, Enrico Vigato, Edoardo Dalla Pozza, Manuela Malatesta
Summary: This study investigated the transdermal fate of ethosomes and transethosomes on human skin. The results showed that the vesicle penetration capability was influenced by their physical-chemical features, with different vesicles reaching different levels of the skin. This offers potential for tailored transdermal drug delivery based on specific cutaneous pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Franciska Oberdiek, Carlos Ivan Vargas, Patrick Rider, Milijana Batinic, Oliver Goerke, Milena Radenkovic, Stevo Najman, Jose Manuel Baena, Ole Jung, Mike Barbeck
Summary: The study evaluated a composite material of PCL and BCP fabricated via fused deposition modeling in terms of its ex vivo and in vivo properties. Results showed no significant differences in mechanical properties between PCL and PCL + BCP, with good biocompatibility observed for both scaffolds. Additionally, all materials demonstrated osteoconductive properties, with the BCP group showing the highest new bone formation in the calvaria model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Salim Ghandour, Konstantinos Pazarlis, Susanne Lewin, Per Isaksson, Peter Forsth, Cecilia Persson
Summary: This study developed a biomechanical model to study the effectiveness of Percutaneous Cement Discoplasty (PCD) in treating degenerative disc disease. The model showed that PCD treatment restored spinal segment stiffness after injury, and it accurately represented the clinical vacuum phenomena. The model can be used to test more complex loading scenarios, new materials, and surgical techniques in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Hematology
Monica T. Hinds, Azzdine Y. Ammi, Jennifer Johnson, Sanjiv Kaul
Summary: This study examined the effects of ultrasound and microbubbles on thrombosis in an ex vivo physiological model using juvenile baboons. Results showed that high peak rarefactional acoustic pressure amplitudes at 1.05 and 2.20 MHz significantly reduced platelet accumulation on the thrombogenic device.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Frank R. Kloss, Peer W. Kaemmerer, Anita Kloss-Brandstaetter
Summary: This study aimed to identify potential risk factors for complications related to alveolar ridge augmentation using bone blocks. The study found that complications were more frequent with autogenous bone blocks compared to allogeneic bone blocks, but these complications were minor and did not affect the success of dental rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lena Katharina Mueller-Heupt, Nadine Wiesmann-Imilowski, Sofia Schroeder, Jonathan Gross, Pablo Cores Ziskoven, Philipp Bani, Peer Wolfgang Kaemmerer, Eik Schiegnitz, Anja Eckelt, John Eckelt, Ulrike Ritz, Till Opatz, Bilal Al-Nawas, Christopher Synatschke, James Deschner
Summary: Periodontitis is a chronic inflammatory disease that leads to tooth loss and significantly impacts global health. A hyaluronic acid-based dispersion with controlled oxygen delivery shows potential as a treatment for periodontitis. In vitro and in vivo studies demonstrate the biocompatibility, antimicrobial activity against Porphyromonas gingivalis, and angiogenesis enhancement of the developed oxygen-releasing dispersion. This suggests the potential of oxygen-releasing biomaterials for periodontal tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Anja Kriegel, Eva Langendorf, Valentina Kottmann, Peer W. Kaemmerer, Franz Paul Armbruster, Nadine Wiesmann-Imilowski, Andreas Baranowski, Erol Gercek, Philipp Drees, Pol Maria Rommens, Ulrike Ritz
Summary: Bone fracture healing is a complex process involving early immune reactions, bone formation, and angiogenesis. This study focuses on the effects of bone sialoprotein (BSP) immobilized in a collagen type I gel on angiogenesis. In vitro analyses and a yolk sac membrane assay demonstrate that BSP induces angiogenesis and that collagen type I is the optimal carrier for BSP. This suggests that BSP could be a promising molecule for bone tissue regeneration.
Article
Oncology
Peer W. Kaemmerer, Silke Tribius, Lena Cohrs, Gabriel Engler, Tobias Ettl, Kolja Freier, Bernhard Frerich, Shahram Ghanaati, Martin Gosau, Dominik Haim, Stefan Hartmann, Max Heiland, Manuel Herbst, Sebastian Hoefert, Juergen Hoffmann, Frank Hoelzle, Hans-Peter Howaldt, Kilian Kreutzer, Henry Leonhardt, Rainer Lutz, Maximilian Moergel, Ali Modabber, Andreas Neff, Sebastian Pietzka, Andrea Rau, Torsten E. Reichert, Ralf Smeets, Christoph Sproll, Daniel Steller, Joerg Wiltfang, Klaus-Dietrich Wolff, Kai Kronfeld, Bilal Al-Nawas
Summary: This is the first prospective study using a multicentric approach to investigate the effectiveness of adjuvant radiotherapy in patients with early squamous cell carcinoma of the oral cavity and oropharynx. The study found that adjuvant radiotherapy does not seem to influence overall survival, but it positively affects time to progression. However, irradiated patients report a significantly decreased quality of life up to three years after therapy.
Article
Oncology
Sebastian Blatt, Peer W. Kaemmerer, Maximilian Krueger, Rambabu Surabattula, Daniel G. E. Thiem, Simon T. Dillon, Bilal Al-Nawas, Towia A. Libermann, Detlef Schuppan
Summary: Oral cancer is a life-threatening disease and specific protein biomarkers in the blood can help with early tumor detection and individualized therapy. This exploratory study used advanced technology to analyze serum proteome and identified novel biomarkers for oral cancer. The study showed significant differences in serum protein levels between oral cancer patients and controls, as well as before and after curative surgery.
Article
Biochemistry & Molecular Biology
Nadja Engel, Michael Dau, Vivien Engel, Denise Franz, Fabian Klemmstein, Christiane Thanisch, Juergen F. Kolb, Marcus Frank, Armin Springer, Ruediger Koehling, Rainer Bader, Bernhard Frerich, Nadine Wiesmann, Diana Heimes, Peer W. Kaemmerer
Summary: By combining electrical stimulation of a commercial titanium implant with real-time impedance sensing, osteogenesis progress can be monitored and electrical stimulation can be adjusted accordingly for individual fracture healing.
Review
Dentistry, Oral Surgery & Medicine
Peer W. Kaemmerer, Shengchi Fan, Carlos Aparicio, Edmond Bedrossian, Ruben Davo, Dean Morton, Gerry M. M. Raghoebar, Sepehr Zarrine, Bilal Al-Nawas
Summary: This study assessed the outcome and complications of zygomatic implant placement using the original surgical technique (OST) and an Anatomy-Guided approach (AGA) in patients with severely atrophic maxillae. Based on the systematic review, placing ZI with OST and AGA is associated with a high implant survival rate and a higher risk of surgical complications, including sinusitis and soft tissue infection around the implant, during a minimum of 6 months follow-up.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vinay V. Kumar, Sainath Venkat, P. C. Jacob, Gaurav Khemeria
Summary: This 10-year follow-up report discusses the interdisciplinary comprehensive management of an aneurysmal bone cyst in the maxilla of a 24-year-old patient. The treatment involved resection and reconstruction using a vascularized deep circumflex iliac artery-based composite free flap, implant placement, and soft tissue management using denture-guided epithelial regeneration. The patient was followed up for 10 years, with definitive management achieved through implant-supported cast partial dentures.
JOURNAL OF MAXILLOFACIAL & ORAL SURGERY
(2023)
Article
Surgery
Diana Heimes, Peer W. Kaemmerer
Summary: Secondary chronic osteomyelitis (SCO) is a progressive jawbone destruction caused by bacterial infection. Antibiotics are the first-line treatment, but surgery may not provide a cure. Bisphosphonates have shown promising results in SCO patients, similar to their success in primary nonbacterial osteomyelitis.
JOURNAL OF SURGICAL CASE REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Diana Heimes, Andreas Pabst, Philipp Becker, Amely Hartmann, Frank Kloss, Jochen Tunkel, Ralf Smeets, Peer W. Kaemmerer
Summary: This study analyzed and compared morbidity-related parameters after alveolar ridge augmentation using autogenous and allogeneic bone blocks from patients' perspective. The results showed that the rate of nerve irritations was twice as high in the autologous group, and swelling was significantly higher in patients with autologous bone blocks. However, the overall satisfaction of patients in both groups was very high, with over 8/10 points.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Matthias W. Gielisch, Fabia Siegberg, Daniel G. E. Thiem, Sebastian Blatt, Diana Heimes, Peer W. Kaemmerer
Summary: This study investigated the impact of three different osteosynthesis plate systems on failure rates and complications after mandibular resections. The results suggest that RP3 should be preferred over RP1 and RP2 due to lower failure rates and complications.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Review
Medicine, General & Internal
Shengchi Fan, Gustavo Saenz-Ravello, Leonardo Diaz, Yiqun Wu, Ruben Davo, Feng Wang, Marko Magic, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The study aimed to evaluate the accuracy of different approaches for zygomatic implant (ZI) placement in patients with severe maxillary problems. The results showed that dynamic computer-aided surgery (d-CAIS) and modified static computer-aided surgery (s-CAIS) had clinically acceptable outcomes, while the conventional s-CAIS had the highest deviation values. Surgeons should be aware of potential deviations and complications regardless of the selected approach.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Daniel Stephan, Sebastian Blatt, Julian Riedel, Katja Mohnke, Robert Ruemmler, Alexander Ziebart, Bilal Al-Nawas, Peer W. Kaemmerer, Daniel G. E. Thiem
Summary: This study aimed to investigate the impact of ischemia on intra-flap metabolism and electrolyte concentrations during transplantation surgery using a novel animal model. The results showed that even a short ischemic period could induce anaerobic glycolysis and electrolyte displacement, leading to acidosis and tissue damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Diana Heimes, Nicolas Alexander Mark, Robert Kuchen, Andreas Pabst, Philipp Becker, Solomiya Kyyak, Daniel G. E. Thiem, Ralf Schulze, Peer W. Kaemmerer
Summary: The study aimed to evaluate the skills of dental students in choosing the correct stage, diagnostics, and treatment option for MRONJ based on clinical and radiographic imaging. The results showed a lack of knowledge among students in staging, diagnostics, and treatment of MRONJ, although CBCT imaging positively affected decision-making. Further teaching in this disease's context and X-ray diagnostics is needed.
MEDICINA-LITHUANIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jochen Tunkel, Frederik Hoffmann, Yannik Schmelcher, Anita Kloss-Brandstaetter, Peer W. Kaemmerer
Summary: Compared to the autogenous technique, allogeneic shell augmentation has a shorter surgical time and a similar rate of intra- and postoperative complications as autogenous bone. Together with its promising clinical results, this technique can be recommended.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)