Article
Biochemistry & Molecular Biology
Eugenio Velasco-Ortega, Ivan Ortiz-Garcia, Alvaro Jimenez-Guerra, Enrique Nunez-Marquez, Jesus Moreno-Munoz, Jose Luis Rondon-Romero, Daniel Cabanillas-Balsera, Javier Gil, Fernando Munoz-Guzon, Loreto Monsalve-Guil
Summary: The study evaluated two different types of sandblasted-etched surface implants and found that both surfaces demonstrated a favorable bone response, confirming the relevance of surface characteristics in implant osseointegration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kristian Kniha, Benita Hermanns-Sachweh, Stephan Christian Moehlhenrich, Florian Peters, Marius Heitzer, Philipp Winnand, Frank Hoelzle, Ali Modabber
Summary: This study evaluated the osseointegration of zirconia and titanium implants in the rat maxilla under systemic antiresorptive therapy. After 4 weeks of medication administration, histopathological samples were evaluated for implant osteointegration parameters.
Review
Multidisciplinary Sciences
Martina Jolic, Sonali Sharma, Anders Palmquist, Furqan A. Shah
Summary: The success of metal implants in rehabilitation is due to osseointegration, the direct connection between living bone and the implant. Removal torque measurement can assess the extent of biomechanical anchorage between the implant and bone. Various pharmacological agents have been evaluated for their impact on osseointegration, with some substances showing positive effects on removal torque and others showing adverse effects. Factors such as bone quality play a role in the biomechanical anchorage of metal implants, and questions regarding drug metabolism, dosage, and treatment interruption remain unanswered.
Article
Dentistry, Oral Surgery & Medicine
Nicolas Rousseau, Ines Msolli, Patrick Chabrand, Arnaud Destainville, Olivier Richart, Jean-Louis Milan
Summary: This study evaluated the local effects and osseointegration of dental implants with surface micro/nanofeatures compared to untreated implants through various analyses after implantation in sheep femoral condyles for 4 and 13 weeks. The results showed that the surface-treated implants promoted faster bone healing and higher bone-to-implant contact in the coronal region compared to untreated implants.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yohei Jinno, Michele Stocchero, Silvia Galli, Marco Toia, Jonas P. Becktor
Summary: In rabbits, the effect of surface hydrophilicity on the biomechanical aspects of osseointegration of dental implants in the tibia and femur was not significant.
JOURNAL OF ORAL IMPLANTOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yifan Zhang, Karan Gulati, Ze Li, Ping Di, Yan Liu
Summary: Titanium and its alloys are ideal materials for dental implants, but long-term success may be hindered by implant-related infections and inadequate osseointegration. Recent development in nanotechnology has focused on nanoscale modifications and application of nanomaterials for improving dental implant performance.
Article
Multidisciplinary Sciences
Kristian Kniha, Benita Hermanns-Sachweh, Faruk Al-Sibai, Reinhold Kneer, Stephan Christian Moehlhenrich, Marius Heitzer, Frank Hoelzle, Ali Modabber
Summary: The purpose of this rat study was to investigate the feasibility of temperature thresholds affecting bone contact at the surface of implants in vivo. The results showed that thermal necrosis should be used for implant removal in subsequent in vivo studies. The study found that temperatures ranging from 48°C to 50°C led to a decrease in the BIC ratio, with significant differences observed between the 50°C group and the control group. However, there were no significant variations within the cold temperatures.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Baixuan Yang, Ainara Irastorza-Landa, Peter Heuberger, Heidi-Lynn Ploeg
Summary: This study proposed an analytical model to improve the understanding of the main factors influencing dental implant insertion torque. The model differentiated between different implant types and effectively represented the effects of various factors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Ran Yan, Jinhua Li, Qianju Wu, Xiangkai Zhang, Longwei Hu, Yuwei Deng, Ruixue Jiang, Jin Wen, Xinquan Jiang
Summary: The deteriorated bone quality in osteoporosis poses challenges for successful implants, emphasizing the need for early osseointegration and long-term antibacterial properties. This study explores the angiogenic effects of bioactive strontium ions and their potential role in promoting osteogenesis. By screening different doses of strontium ions, researchers developed a bioactive titanium surface augmented with zinc and strontium, which exhibited enhanced osteogenic differentiation and antimicrobial properties. The modified titanium implant surfaces showed improved bone formation and bone-implant contact, suggesting the potential of zinc- and strontium-augmented surfaces for osseointegration in osteoporosis.
FRONTIERS IN CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Zixuan Wang, Baosheng Li, Qing Cai, Xiaoyu Li, Zhaoyi Yin, Birong Li, Zhen Li, Weiyan Meng
Summary: Dental implantation has become the preferred protocol for restoring dentition defects. However, biological complications such as insufficient bone volume and poor osseointegration can lead to implant failure. This review summarizes recent modifications to dental implant surfaces, specifically focusing on antibacterial-osteogenic properties. The effects of these modifications on biological performance and potential clinical applications are discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Hao-Zhen Lyu, Jae Hyup Lee
Summary: This study aimed to compare the correlation of Bone-to-Implant Contact ratio (BIC) between 2D micro-CT (μCT) and histomorphometry, and found that integrating bone information of several 2D μCT slices at different sites is a feasible method for assessing implant osseointegration.
BIOMATERIALS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Jeong Min Kwak, Jungho Kim, Chung-Sung Lee, Il-Soo Park, Min Lee, Dal-Hee Min, In-Sung Luke Yeo
Summary: Graphene oxide has promoting effects on bone marrow stromal cells and human gingival fibroblasts, significantly enhancing osseointegration on titanium surfaces. Physicochemical modification of titanium surfaces with SLA treatment and GO coating stimulates osteogenic activities of mesenchymal stem cells, improving biocompatibility with connective tissue cells and enhancing bone healing at the bone-implant interface.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alessandra Julie Schuster, Joao Luiz Bittencourt de Abreu, Natalia Marcumini Pola, Lukasz Witek, Paulo G. Coelho, Fernanda Faot
Summary: This study evaluated peri-implant bone formation of titanium implants using an in vivo rat model with and without uncontrolled diabetes mellitus. The results showed that the hydrophilic surface was able to counteract the adverse effects of diabetes at early osseointegration periods, but the metabolic systemic impairment caused by diabetes overcame the surface treatment effect after 28 days, leading to impaired osseointegration in both hydrophilic and hydrophobic implants.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Orthopedics
Klemens Vertesich, Branden R. Sosa, Yingzhen Niu, Gang Ji, Vincentius Suhardi, Kathleen Turajane, Sehwan Mun, Ren Xu, Reinhard Windhager, Kyung Hyun Park-Min, Matthew B. Greenblatt, Mathias P. Bostrom, Xu Yang
Summary: The study investigated the short-term effects of postoperative systemic alendronate on osseointegration using a mouse implant model. Results showed that alendronate treatment enhanced osseointegration, increasing bone mass and maximum pullout load, while decreasing peri-implant osteoclasts. This data supports the postoperative clinical use of bisphosphonates, especially in patients with high risks of aseptic loosening.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Multidisciplinary
Ehsan Anbarzadeh, Bijan Mohammadi
Summary: This study investigated the best sandblasting conditions for dental implant fixtures by examining 18 different sandblasting conditions. The parameters included particle size, blasting pressure, and blasting angle. Surface treatment was performed using the SLA + Anodizing method, and AFM testing was conducted to compare surface roughness. State No. 4, prepared using the SLA + Anodizing method with a surface roughness of 1.989 μm, showed the best sandblasting conditions with high cell viability and accelerated bone formation.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Cell & Tissue Engineering
Jennifer L. Bain, Paul P. Bonvallet, Ramzi V. Abou-Arraj, Peter Schupbach, Michael S. Reddy, Susan L. Bellis
TISSUE ENGINEERING PART A
(2015)
Article
Dentistry, Oral Surgery & Medicine
France Lambert, Miljana Bacevic, Pierre Layrolle, Peter Schupbach, Pierre Drion, Eric Rompen
CLINICAL ORAL IMPLANTS RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
Michael K. McGuire, E. Todd Scheyer, Peter Schupbach
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Orthopedics
N. Martinez-Carranza, L. Ryd, K. Hultenby, H. Hedlund, H. Nurmi-Sandh, A. S. Lagerstedt, P. Schupbach, H. E. Berg
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Orthopedics
Nicolas L. Martinez-Carranza, Kjell Hultenby, Anne Sofie Lagerstedt, Peter Schupbach, Hans E. Berg
Article
Dentistry, Oral Surgery & Medicine
Marc L. Nevins, Laureen Langer, Peter Schupbach
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Cristiano Susin, Jaebum Lee, Tiago Fiorini, Ki-Tae Koo, Peter Schuepbach, Patricia D. M. Angst, Amanda Finger Stadler, Ulf M. E. Wikesjo
JOURNAL OF CLINICAL PERIODONTOLOGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Daniel Baeumer, Otto Zuhr, Stephan Rebele, David Schneider, Peter Schupbach, Markus Huerzeler
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2015)
Article
Dentistry, Oral Surgery & Medicine
Brent A. Wenzel, Inaki Gamborena, Jaebum Lee, Tiago Fiorini, Peter Schuepbach, Ulf M. E. Wikesjoe, Cristiano Susin
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2016)
Article
Dentistry, Oral Surgery & Medicine
Jaebum Lee, Tiago Fiorini, Inaki Gamborena, Brent A. Wenzel, Peter Schuepbach, Ulf M. E. Wikesjoe, Cristiano Susin
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2016)
Article
Dentistry, Oral Surgery & Medicine
Cristiano Susin, Amanda Finger Stadler, Tiago Fiorini, Mariana de Sousa Rabelo, Umberto D. Ramos, Peter Schupbach
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Daniele Cardaropoli, Myron Nevins, Peter Schupbach
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2019)
Article
Chemistry, Physical
Bruno De Carvalho, Eric Rompen, Geoffrey Lecloux, Peter Schupbach, Emilie Dory, Jean-Francois Art, France Lambert
Article
Dentistry, Oral Surgery & Medicine
Roland Glauser, Peter Schupbach
Summary: This study histologically examined early bone formation around transmucosal implants using a miniature pig model. The results showed that both rough zirconia and surface-modified titanium implants achieved good osseointegration at 4 and 8 weeks after placement. These findings are important for improving material selection and implant design for better bone healing.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2022)
Article
Materials Science, Biomaterials
Peter Schupbach, Roland Glauser, Sebastian Bauer
INTERNATIONAL JOURNAL OF BIOMATERIALS
(2019)