Article
Biochemistry & Molecular Biology
Stephane Durual, Leandra Schaub, Mustapha Mekki, Daniel Manoil, Carla P. Martinelli-Klay, Irena Sailer, Susanne S. Scherrer, Laurine Marger
Summary: The study demonstrated that saline treatment could improve the handling of DBBM-C and accelerate bone regeneration, resulting in higher quality tissue in vivo.
Article
Dentistry, Oral Surgery & Medicine
Kyeong-Won Paeng, Jae-Kook Cha, Daniel S. Thoma, Ronald E. Jung, Ui-Won Jung, Goran Benic
Summary: The aim of this study was to investigate the additional effects of collagen membrane and synthetic bone substitute on lateral bone augmentation of chronic peri-implant defect. The results suggest that the use of collagen membrane and/or synthetic bone substitute did not provide additional benefits for lateral bone augmentation.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jae-Kook Cha, Rafael Pla, Fabio Vignoletti, Ui-Won Jung, Javier Sanz-Esporrin, Mariano Sanz
Summary: The study investigated the immunohistochemical characteristics of a highly porous synthetic bone substitute and a cross-linked collagen membrane for guided bone regeneration. Results showed that combining biphasic calcium phosphate with a crosslinked collagen membrane resulted in extended osteogenic potential compared to deproteinized bovine bone mineral and a native collagen membrane. There was no significant difference in the angiogenic potential between the different groups.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Engineering, Biomedical
E. Andres Sastre, Y. Nossin, I Jansen, N. Kops, C. Intini, J. Witte-Bouma, B. van Rietbergen, S. Hofmann, Y. Ridwan, J. P. Gleeson, F. J. O'Brien, E. B. Wolvius, G. J. V. M. van Osch, E. Farrell
Summary: The study introduces a refined murine subcutaneous model for semi-orthotopic bone formation, allowing testing of up to four grafts per mouse, one order of magnitude greater in volume than currently possible. This model enables evaluation of bone healing potential of different grafts and assessment of ossification promotion and prevention.
Article
Dentistry, Oral Surgery & Medicine
Minh Khai Le Thieu, Havard Jostein Haugen, Javier Sanz-Esporrin, Mariano Sanz, Stale Petter Lyngstadaas, Anders Verket
Summary: In chronic non-contained bone defects treated with GBR, TiO2 blocks demonstrated the largest lateral volume augmentation but less new bone formation, while DBBM particles showed more mineralized bone in the grafted area but in smaller amounts. Empty controls had the most new lateral bone formation outward from the defect margins.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Chemistry, Physical
Ji Hoon Jun, Kyung Chul Oh, Kyu-Hyung Park, Narae Jung, Jiayi Li, Hong Seok Moon
Summary: The study evaluated the effects of UV treatment and simvastatin immersion on osseointegration of titanium dental implants in rabbit tibias with or without xenogenic bone graft materials. Both treatments increased bone-to-implant contact, but their combination did not show a synergistic effect on bone area.
Review
Chemistry, Physical
Maria Pia Ferraz
Summary: This review summarizes the various materials used for bone defect replacement or repair in dentistry and oral and maxillofacial surgeries. Factors such as tissue viability, size, shape, and defect volume influence the choice of material. Autologous bone is the gold standard for bone grafting but has limitations. Alternatives include allografts, xenografts, and synthetic materials. Calcium-phosphate-based ceramics, especially hydroxyapatite, are commonly used due to their similarity to natural bone. This review aims to provide a comprehensive analysis of grafting materials in dentistry and discusses their properties, advantages, and challenges.
Article
Dentistry, Oral Surgery & Medicine
Amanda de Carvalho Silva Leocadio, Matusalem Silva, Guilherme Jose Pimentel Lopes Oliveira, Elcio Marcantonio Jr
Summary: The study found that the addition of BM and the type of implant surface did not have a significant impact on osseointegration in areas grafted with sintered deproteinized bovine bone at high temperatures. There were no differences observed in the quantity of mineralized tissues around the implants or the bone-implant contact between the different groups assessed.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Minh Khai Le Thieu, Sabine Stoetzel, Maryam Rahmati, Thaqif El Khassawna, Anders Verket, Javier Sanz-Esporrin, Mariano Sanz, Jan Eirik Ellingsen, Havard Jostein Haugen
Summary: The study evaluated osteogenic markers and alveolar ridge profile changes in noncontained bone defects treated with guided bone regeneration using a nonresorbable TiO2 block. Results indicated contact osteogenesis with TiO2 block or DBBM particulates, and potential for bone formation beyond 12 weeks. Alveolar profile data showed sustained lateral bone augmentation with TiO2 block and collagen membrane compared to other treatment options.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Engineering, Biomedical
Yuhei Miyauchi, Takayuki Izutani, Yuki Teranishi, Takahisa Iida, Yasushi Nakajima, Samuel Porfirio Xavier, Shunsuke Baba
Summary: This study compared the healing of collagenated and non-collagenated xenografts used for maxillary sinus floor elevation. The results showed that the collagenated xenograft underwent higher resorption and resulted in greater new bone formation. The region adjacent to the bone wall was found to have the highest new bone content, which is clinically relevant as it is where the implant will be installed.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Review
Immunology
Ayumi Morimura, Shigeto Hamaguchi, Yukihiro Akeda, Kazunori Tomono
Summary: Research on Streptococcus pneumoniae has shown that it is a commensal in the human upper respiratory tract as well as a pathogen causing various diseases. The lack of tractable animal models has hindered the full understanding of its transmission mechanism, but recent studies and novel animal models have helped shed light on this aspect.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Polymer Science
Carlos Humberto Valencia-Llano, Diego Lopez-Tenorio, Carlos David Grande-Tovar
Summary: This study compared the biological response of two commercial xenografts and a commercial collagen membrane, demonstrating their biocompatibility and potential through a series of tests.
Review
Endocrinology & Metabolism
Merle Stein, Florent Elefteriou, Bjorn Busse, Imke A. K. Fiedler, Ronald Young Kwon, Eric Farrell, Mubashir Ahmad, Anita Ignatius, Liam Grover, Liesbet Geris, Jan Tuckermann
Summary: Major achievements in bone research have relied on animal models and in vitro systems. However, the ethical debate surrounding animal experimentation and advancements in in vitro and in silico techniques have challenged their use. This review provides an overview of the strengths and limitations of animal models, as well as in vitro and in silico technologies, in skeletal research. The authors propose that a combination of the right animal model and state-of-the-art technology is essential for advancing bone research.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Immunology
Thamil Vaani Komarasamy, Nur Amelia Azreen Adnan, William James, Vinod R. M. T. Balasubramaniam
Summary: This review provides a comprehensive overview of the role and mechanisms of Zika virus in the brain, including the study of target cells, cellular and molecular mechanisms. By analyzing the modulation of different host factors and the role of immune response and inflammatory process, a comprehensive understanding of Zika virus-induced neuroimmunopathogenesis is achieved.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Friedrich Barsch, Andreas Mamilos, Volker H. Schmitt, Maximilian Babel, Lina Winter, Willi Wagner, Hinrich Winther, Christian Ottomann, Tanja Niedermair, Stephan Schreml, Helmut Hierlemann, Christoph Brochhausen
Summary: Synthetic macroporous biomaterials are widely used in skin tissue engineering to mimic native dermis functions. However, they often face limitations due to unfavorable foreign body responses. This study compared the foreign body responses of two different 3D matrix designs and found that the matrix design significantly affected the responses.