Article
Multidisciplinary Sciences
Fatima Regina Nunes de Sousa, Vanessa Costa de Sousa Ferreira, Conceicao da Silva Martins, Hugo Victor Dantas, Frederico Barbosa de Sousa, Virginia Claudia Carneiro Girao-Carmona, Paula Goes, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao
Summary: The study evaluated the effect of Zoledronic acid on orthodontic tooth movement and root and bone resorption, finding that it can reduce tooth movement and exhibit anti-resorptive effects.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Review
Immunology
Weidong Zhang, Ling Gao, Wenhao Ren, Shaoming Li, Jingjing Zheng, Shasha Li, Chunmiao Jiang, Shuying Yang, Keqian Zhi
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug effect, with hypotheses involving reduced bone remodeling, infection, inflammation, and bisphosphonates-induced immune dysfunction. Treatment with bisphosphonates disrupts mucosal and osteo immune homeostasis, impairing the body's ability to resist infection and repair from injury, contributing to the development of MRONJ.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hironobu Hata, Kenji Imamachi, Michihiro Ueda, Masashi Matsuzaka, Hiroaki Hiraga, Toshihisa Osanai, Toru Harabayashi, Katsuya Fujimoto, Satoshi Oizumi, Masato Takahashi, Kazuhito Yoshikawa, Jun Sato, Yutaka Yamazaki, Yoshimasa Kitagawa
Summary: The study aimed to clarify the incidence of MRONJ and the corresponding survival rate of patients treated with zoledronic acid for different types of cancer. The results showed that patients with shorter survival times did not develop MRONJ, and dentists need to be aware of prognosis-related factors to predict MRONJ risk for effective dental management planning.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Raiza Querrer, Nathalia Ferrare, Nilce Melo, Cristine Miron Stefani, Paula Elaine Diniz dos Reis, Carla Ruffeil Moreira Mesquita, Gabriel Alvares Borges, Andre Ferreira Leite, Paulo Tadeu Figueiredo
Summary: Bisphosphonate-related ONJ and denosumab-related ONJ exhibit differences in imaging characteristics, with the former showing bone sequestra increase, cortical bone lysis, and bone density increase, while the latter showing larger bone sequestra, more frequent periosteal reactions, and mandibular canal enhancement.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Endocrinology & Metabolism
Maaya Inoue, Chihaya Matsumoto, Kazunori Nakajima, Shinichiro Kuroshima, Takashi Sawase
Summary: This study found that combination therapy of alendronate and dexamethasone had a negative impact on wound healing around implants in rat maxillae, possibly due to the continuous accumulation of M1 macrophages.
Article
Multidisciplinary Sciences
Cindy J. J. M. van de Ven, Nicole E. C. Bakker, Dennis P. Link, Edwin J. W. Geven, Jan A. Gossen
Summary: Testosterone and alendronate have been found to synergistically stimulate bone regeneration when combined in a novel ultrasonic spray coating for sustained release. In vitro assays showed sustained release of the compounds without a burst release, leading to significantly improved bone regeneration in rat and rabbit models. Coated implants enabled with local sustained delivery of these compounds may provide a promising system for improving osseo-integration and healing of bone defects and fractures.
Review
Dentistry, Oral Surgery & Medicine
Lucio Henrique Ives Martins, Delaine Cristina Ferreira, Marcus Tolentino Silva, Rogerio Heladio Lopes Motta, Reginaldo Tavares Franquez, Cristiane de Cassia Bergamaschi
Summary: The objective of this study was to determine the frequency of osteonecrosis of the jaw in bisphosphonate users undergoing dental procedures. The results showed a higher frequency of osteonecrosis in intravenous bisphosphonate users compared to oral users. There was no significant association between longer treatment duration and increased frequency of osteonecrosis.
Review
Pharmacology & Pharmacy
M. Dioguardi, M. DI Cosola, C. Copelli, S. Cantore, C. Quarta, G. Nitsch, D. Sovereto, F. Spirito, G. A. Caloro, A. P. Cazzolla, R. Aiuto, E. Cascardi, A. greco Lucchina, L. LO Muzio, A. Ballini, F. Mastrangelo
Summary: Bisphosphonates, commonly used anti-resorptive medications, inhibit osteoclast activity by disrupting the macrophage colony-stimulating factor pathway. Oral surgery in patients undergoing bisphosphonate therapy carries a high risk of developing osteonecrosis of the jaws.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Samili Albuquerque Gurgel, Edilson Martins Rodrigues Neto, Ana Cristina de Mello Fiallos, Camila Costa Dias, Analice Mendes Barreto Fernandes, Joao Hildo de Carvalho Furtado Junior, Celiane Mary Tapety Carneiro, Monica do Amaral Silva, Guilherme Antonio Lopes de Oliveira, Emmanuel Arraes de Alencar Junior, Carlos Ricardo de Queiroz Martiniano
Summary: BF medication poses risks in dental implant surgery, as it can enhance mechanical stability but also increase the risk of osteonecrosis of the jaw. Patients undergoing oral treatment must be cautious and choose the appropriate method of BF administration to prevent complications.
JOURNAL OF YOUNG PHARMACISTS
(2021)
Article
Medicine, General & Internal
Funda Goker, Emma Grecchi, Massimo Del Fabbro, Salvatore Longoni, Luigi Vito Stefanelli, Francesco Grecchi
Summary: The oral rehabilitation of MRONJ patients is challenging. This case study describes the successful use of zygomatic implants as an alternative for a patient with a large maxillary defect. After three years of follow-up, the patient showed healing and healthy tissues around the implants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Toxicology
Bhumrapee Srivichit, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Bisphosphonates are commonly used in the treatment of bone and joint diseases, but long-term use can lead to osteonecrosis. Osteonecrosis is characterized by cell death and impaired cell functions, with medication-related osteonecrosis of the jaw being the most concerning condition. In addition to surgical treatment, non-surgical interventions have been explored to mitigate bisphosphonate-induced osteonecrosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Gabor Kammerhofer, Daniel Vegh, Dorottya Banyai, Adam Vegh, Arpad Joob-Fancsaly, Peter Hermann, Zoltan Geczi, Tamas Hegedus, Kata Sara Somogyi, Bulcsu Bencze, Zita Biczo, Donat Huba Juhasz, Peter Zaborszky, Marta Ujpal, Mihaly Tamas Vaszilko, Zsolt Nemeth
Summary: This study aimed to evaluate the association between hyperglycemia and medication-related osteonecrosis of the jaw (MRONJ). The results showed a significant association between hyperglycemia and MRONJ, suggesting that hyperglycemia may lead to vascular anomaly and immune dysfunction, resulting in necrosis after tooth extraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Filip Michalak, Sylwia Hnitecka, Marzena Dominiak, Kinga Grzech-Lesniak
Summary: Medications that inhibit bone resorption are commonly prescribed by orthopedists, hematologists, or oncologists, with dental professionals often overlooking their impact on oral health. While primarily affecting older individuals due to oncological issues or postmenopausal consequences, anyone can be at risk. Careful interviews and analysis of patient history and disease should always be conducted before taking any action with these medications.
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Leire Virto, David Simoes-Martins, Maria Carmen Sanchez, Ana Encinas, Mariano Sanz, David Herrera
Summary: The study demonstrated that the new brushing solution concept has antibacterial and antibiofilm effects against peri-implant pathogens, especially impacting F. nucleatum and A. actinomycetemcomitans.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Minh Khai Le Thieu, Sabine Stoetzel, Maryam Rahmati, Thaqif El Khassawna, Anders Verket, Javier Sanz-Esporrin, Mariano Sanz, Jan Eirik Ellingsen, Havard Jostein Haugen
Summary: The study evaluated osteogenic markers and alveolar ridge profile changes in noncontained bone defects treated with guided bone regeneration using a nonresorbable TiO2 block. Results indicated contact osteogenesis with TiO2 block or DBBM particulates, and potential for bone formation beyond 12 weeks. Alveolar profile data showed sustained lateral bone augmentation with TiO2 block and collagen membrane compared to other treatment options.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Georgios N. Antonoglou, Mario Romandini, Jukka H. Meurman, Markku Surakka, Sok-Ja Janket, Mariano Sanz
Summary: This study investigated the association between periodontitis and edentulism with cardiovascular disease (CVD) and all-cause mortality. The results demonstrated a strong link between edentulism and CVD and all-cause mortality, while periodontitis showed no significant association.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Andrea Alonso-Espanol, Enrique Bravo, Honorato Ribeiro-Vidal, Leire Virto, David Herrera, Bettina Alonso, Mariano Sanz
Summary: This study evaluated the antimicrobial activity of curcumin and xanthohumol using a multi-species biofilm model. The results showed that both curcumin and xanthohumol exhibited antimicrobial activity against six different bacterial species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
David Martin-Hernandez, Maria Martinez, Javier Robledo-Montana, Marina Munoz-Lopez, Leire Virto, Nagore Ambrosio, Maria Jose Marin, Eduardo Montero, David Herrera, Mariano Sanz, Juan C. Leza, Elena Figuero, Borja Garcia-Bueno
Summary: This study investigated the potential mechanisms underlying the association between periodontitis and depression. Using a rat model, the study found that neuroinflammation (microglia, blood-brain barrier permeability, and sphingosine-1-phosphate pathways) may play a role in this association. The findings showed that the combined effects of periodontitis and chronic mild stress increased neuroinflammation and disrupted the blood-brain barrier. The study also identified differential regulation of enzymes and receptors in the sphingosine-1-phosphate pathway. These findings contribute to our understanding of the relationship between periodontitis and depression.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Carolina Encalada Abad, Ignacio Sanz-Sanchez, Victor Serrano, Javier Sanz Esporrin, Ignacio Sanz-Martin, Mariano Sanz
Summary: This study aimed to evaluate the efficacy of leukocyte and platelet-rich fibrin (L-PRF) for alveolar ridge preservation (ARP) compared with spontaneous healing. The results showed that L-PRF did not minimize bone resorption after tooth extraction in non-molar sites or reduce the need for bone regeneration when placing implants. Furthermore, its use did not improve patient-reported outcome measures (PROM's).
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Enrique Bravo, Benjamin Serrano, Honorato Ribeiro-Vidal, Leire Virto, Ignacio Sanz Sanchez, David Herrera, Mariano Sanz
Summary: The study aims to evaluate biofilm formation on hybrid titanium implants with moderately rough and turned surface topographies. A dynamic in vitro multispecies biofilm model was used to assess biofilm formation on the tested implant surfaces. The study found that the moderately rough implant surfaces had significantly higher bacterial biomass and total bacterial counts compared to the turned surface area of HS implants. These findings highlight the importance of implant surface topography in influencing in vitro biofilm formation.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leire Virto, Veronica Odeh, Enrique Garcia-Quismondo, David Herrera, Jesus Palma, Faleh Tamimi, Mariano Sanz
Summary: The objective of this study was to investigate the effect of electrochemical treatment on biofilms developed on titanium dental implants. The study found that electrochemical treatment had an impact on the structure and bacterial composition of the biofilms. The reduction in bacterial counts, especially for Fusobacterium nucleatum, demonstrated a bactericidal effect of the treatment.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Margarita Iniesta, Cristina Chamorro, Nagore Ambrosio, Maria Jose Marin, Mariano Sanz, David Herrera
Summary: The aim of this study was to characterize the subgingival microbiome in subjects with different periodontal health statuses. Subgingival samples were collected from Spanish subjects and analyzed using high-throughput sequencing technologies. Significant differences were found in the subgingival microbiome among periodontal health, gingivitis and different stages of periodontitis, suggesting distinct microbial profiles.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
David Herrera, Tord Berglundh, Frank Schwarz, Iain Chapple, Soren Jepsen, Anton Sculean, Moritz Kebschull, Panos N. Papapanou, Maurizio S. Tonetti, Mariano Sanz
Summary: This study aims to develop clinical practice guidelines for the prevention and treatment of peri-implant diseases, emphasizing the need for interdisciplinary approaches and interventions at different stages. The guidelines provide recommendations for maintaining healthy peri-implant tissues and managing peri-implant diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Maurizio S. S. Tonetti, Lisa Heitz-Mayfield, Panos N. N. Papapanou, Mariano Sanz
Summary: Consensus on a valid and comprehensive set of outcomes for implant dentistry interventions is necessary for improving clinical guidelines and policy. The Implant Dentistry Core Outcome Set and Measurements (ID-COSM) initiative has identified four core outcome domain areas and several mandatory outcomes for trials. This innovative approach combines input from scientific evidence, patients, and industry representatives.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Medicine, General & Internal
Aniela Brodzikowska, Bartlomiej Gorski, Marcin Szerszen, Mariano Sanz
Summary: This study compared the clinical and radiographic outcomes of two biomaterials in the treatment of periodontal intra-bony defects. It was found that both frozen radiation-sterilized allogenic bone grafts (FRSABG) and deproteinized bovine bone mineral (DBBM) combined with a bioabsorbable collagen membrane yielded successful clinical benefits, but FRSABG significantly enhanced pocket depth reduction and defect fill.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lucas Menezes dos Anjos, Aurelio de Oliveira Rocha, Gabriel Leonardo Magrin, Pedro Vitali Kammer, Cesar Augusto Magalhaes Benfatti, Julio Cesar Matias de Souza, Mariano Sanz, Bruno Alexandre Pacheco de Castro Henriques
Summary: This bibliometric study analyzed the characteristics of the 100 most cited articles on bone grafts in dentistry and found scientific progress on bone grafts in dentistry. The most prominent trend was the use of xenogeneic grafts for horizontal and/or vertical ridge augmentation.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuki Ichioka, Leire Virto, Paula Nuevo, Juan Daniel Gamonal, Jan Derks, Lena Larsson, Mariano Sanz, Tord Berglundh
Summary: The aim of this study was to evaluate the cleaning efficacy of two mechanical and two chemical protocols in the decontamination of implant surfaces. Results showed that air-polishing and rotating titanium brush were more effective in removing biofilm compared to other methods. The use of chemical agents did not provide significant overall benefit, and complete biofilm removal was not achieved with any treatment method.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Erika B. S. Carvalho, Mario Romandini, Sofya Sadilina, Adriana C. P. Sant'Ana, Mariano Sanz
Summary: This study aimed to answer the question: In systemically healthy human subjects, what are the differences in terms of bacterial presence/count between peri-implantitis and peri-implant health/mucositis? The results showed that peri-implantitis is associated with the presence of S. epidermidis and specific periodontopathogens (P. gingivalis, T. forsythia, T. denticola, F. nucleatum, and P. intermedia), while it is not associated with certain other bacteria (A. actinomycetemcomitans, S. aureus, and C. rectus).
CLINICAL ORAL IMPLANTS RESEARCH
(2023)