Article
Medicine, General & Internal
Ming-Hsuan Su, Hua-Hsi Wu, Hsin-Yi Huang, Na-Rong Lee, Wen-Hsun Chang, Shih-Chieh Lin, Yi-Jen Chen, Peng-Hui Wang
Summary: This study compared the efficacy of paclitaxel-platinum and ifosfamide-platinum regimens in the management of advanced uterine carcinosarcoma patients. The results showed a significantly longer progression-free survival in the paclitaxel-platinum group compared to the ifosfamide-platinum group, although there was no significant difference in overall survival. Further research is needed to determine the optimal treatment regimen for this highly lethal disease.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2022)
Article
Oncology
Bryan S. Squires, Thomas J. Quinn, Sirisha R. Nandalur, M. Saada Jawad
Summary: In patients with stage I-III UCS treated with surgery and CHT, receiving RT is associated with improved overall survival. Further prospective studies are needed to fully understand the benefit of RT in UCS.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Jiajia Li, Shaohai Wang, Xiufa Tang, Lin Que, Wenzhe Han, Bo Yu
Summary: This paper presents a case of primary maxillary sinus carcinosarcoma (CS) and its treatment. CS is an extremely rare malignant tumor characterized by biphasic histologic components, lack of standardized treatment, high recurrence rate, and poor prognosis.
Article
Oncology
Henry M. Kuerer, Benjamin D. Smith, Savitri Krishnamurthy, Wei T. Yang, Vicente Valero, Yu Shen, Heather Lin, Anthony Lucci, Judy C. Boughey, Richard L. White, Emilia J. Diego, Gaiane M. Rauch
Summary: This study aims to evaluate whether radiotherapy alone can replace breast surgery in early-stage triple-negative breast cancer or HER2-positive breast cancer patients who have achieved pathological complete response through image-guided vacuum-assisted core biopsy.
Article
Medicine, General & Internal
Mariano Provencio, Ernest Nadal, Jose L. Gonzalez-Larriba, Alex Martinez-Marti, Reyes Bernabe, Joaquim Bosch-Barrera, Joaquin Casal-Rubio, Virginia Calvo, Amelia Insa, Santiago Ponce, Noemi Reguart, Javier de Castro, Joaquin Mosquera, Manuel Cobo, Andres Aguilar, Guillermo Lopez Vivanco, Carlos Camps, Rafael Lopez-Castro, Teresa Moran, Isidoro Barneto, Delvys Rodriguez-Abreu, Roberto Serna-Blasco, Raquel Benitez, Carlos Aguado de la Rosa, Ramon Palmero, Florentino Hernando-Trancho, Javier Martin-Lopez, Alberto Cruz-Bermudez, Bartomeu Massuti, Atocha Romero
Summary: This study evaluated the efficacy of the neoadjuvant nivolumab plus chemotherapy regimen on operable stage III non-small-cell lung cancer (NSCLC) patients. The results showed that patients receiving the combination therapy had a higher rate of pathological complete response and longer survival, indicating the effectiveness of this treatment approach in this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Materials Science, Biomaterials
Qi Xu, Jiarui Wu, Yiming Feng, Han Hu, Zhimin Mo, Zushun Xu, Hewei Li, Shengli Yang
Summary: Sonodynamic therapy is a non-invasive treatment that utilizes ultrasound and a sound sensitizer to generate reactive oxygen species and kill tumor cells. In this study, raspberry-like AgBiS2@PVP nanoparticles with suitable properties for SDT and CDT were successfully synthesized. In vivo and in vitro experiments showed that the combination of SDT and CDT had a stronger inhibitory effect on tumor cells compared to single treatments.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Oncology
Kerri Beckmann, Sudarshan Selva-Nayagam, Ian Olver, Caroline Miller, Elizabeth S. Buckley, Kate Powell, Dianne Buranyi-Trevarton, Raghu Gowda, David Roder, Martin K. Oehler
Summary: Analysis of multi-institutional clinical registry data from South Australia suggests that UCS patients benefit from nodal excision, chemotherapy, and multimodal therapy in terms of reducing disease-specific and all-cause mortality, particularly in late-stage disease. However, caution is warranted in interpreting the results due to potential indication bias and limited statistical power, underscoring the need for further prospective research.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Pathology
Atsushi Kihara, Yusuke Amano, Noriyoshi Fukushima, Hiroyuki Fujiwara, Toshiro Niki
Summary: The present study investigated the expression of H3K27 trimethylation and found that the deficiency of H3K27me3 may be one of the causes of certain types of endometrial carcinomas and uterine mesenchymal tumors. The study also found differences in the dimethylation of H3K27 in different tumor components and its potential association with the normal function of the SWI/SNF complex.
Article
Public, Environmental & Occupational Health
Zhimin Hao, Yangli Yu
Summary: The purpose of this study was to investigate the outcomes of adjuvant treatments for non-endometrioid endometrial carcinomas (NEEC). The results showed that combined chemotherapy and radiotherapy (CRT) had more beneficial effects than any single treatment mode. Chemotherapy and brachytherapy were found to improve survival in early stage serous carcinoma patients, while late stage patients may benefit from chemotherapy plus external beam radiotherapy (EBRT) or brachytherapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofeng Jiang, Hengyu Zhao, Oliver Lester Saldanha, Sven Nebelung, Christiane Kuhl, Iakovos Amygdalos, Sven Arke Lang, Xiaojian Wu, Xiaochun Meng, Daniel Truhn, Jakob Nikolas Kather, Jia Ke
Summary: A deep learning model based on preoperative MRI scans was developed and validated to predict survival in patients with rectal cancer.
Review
Biotechnology & Applied Microbiology
Lihan Zhang, Xing Li, Guangxing Yue, Lihao Guo, Yanhui Hu, Qingli Cui, Jia Wang, Jingwen Tang, Huaimin Liu
Summary: With the increasing incidence of esophageal cancer, there is a need for new methods to improve diagnosis and treatment. Nanomaterials, which have advantages such as high drug capacity and specific targeting capability, show great potential in cancer therapy. However, their application in esophageal cancer is still lacking systematic review and analysis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ioannis M. Koukourakis, Kalliopi Platoni, Vassilis Kouloulias, Stella Arelaki, Anna Zygogianni
Summary: Under normal conditions, stem cells differentiate into mature organ/tissue-specific cells at a steady pace. However, their growth can be accelerated during tissue healing or in certain diseases. It is believed that the proliferation and growth of cancer cells are sustained by a vital cellular compartment resembling stem cells in normal tissues, known as cancer stem cells (CSCs). Mutations in prostate stem cells can lead to the formation of prostate cancer. Prostate CSCs (PCSCs) have been identified and characterized, expressing specific surface markers and over-activating signaling pathways. They are associated with radiotherapy and chemotherapy resistance, aggressive cancer behavior, and higher relapse rates. Developing treatment strategies to target PCSCs in tumors can improve the effectiveness of cytotoxic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Maurizio Muscaritoli, Jann Arends, Patrick Bachmann, Vickie Baracos, Nicole Barthelemy, Hartmut Bertz, Federico Bozzetti, Elisabeth Hutterer, Elizabeth Isenring, Stein Kaasa, Zeljko Krznaric, Barry Laird, Maria Larsson, Alessandro Laviano, Stefan Muhlebach, Line Oldervoll, Paula Ravasco, Tora S. Solheim, Florian Strasser, Marian de van der Schueren, Jean-Charles Preiser, Stephan C. Bischoff
Summary: This practical guideline is based on the current scientific ESPEN guidelines on nutrition in cancer patients, providing 43 recommendations for the nutritional and metabolic management of patients with neoplastic diseases. It offers guidance to health care providers involved in the management of cancer patients to offer optimal nutritional care.
CLINICAL NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Chiara de Waure, Carlotta Bertola, Gaia Baccarini, Manuela Chiavarini, Cesare Mancuso
Summary: This systematic review aims to collate the results of studies on the therapeutic effect of curcumin in cancer patients. It was found that curcumin as an adjuvant therapy may have some positive effects in certain cancer patients, but overall clinical evidence is not strong enough to support its therapeutic use in cancer.
Review
Immunology
Huiling Wang, Yufei Xu, Fengli Zuo, Junzhi Liu, Jiqiao Yang
Summary: This article provides a systematic summary and analysis of immunotherapy-based combination therapies for esophageal cancer (EC), highlighting the clinical advantages and various treatment options, particularly the use of PD-1 monoclonal antibodies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Emily A. Slopnick, Graham C. Chapman, Kasey Roberts, David D. Sheyn, Sherif El-Nashar, Sangeeta T. Mahajan
Summary: A study was conducted to assess the national utilization of apical suspension procedures for the surgical treatment of complete pelvic organ prolapse (POP). The results showed that apical suspension procedures were performed in 46.7% of patients, with a higher rate in post-hysterectomy cases. Colpocleisis was more common in older age groups, post-hysterectomy cases, and those with higher comorbidity indexes.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Obstetrics & Gynecology
Sonia Carlson, Sadhvi Batra, Megan Billow, Sherif A. El-Nashar, Graham Chapman
Summary: A study compared complications in patients undergoing laparoscopic vs open surgery for acute pelvic inflammatory disease (PID) and found that laparoscopy was associated with lower complication rates in a well-matched cohort of patients.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
David Sheyn, Nicole M. Martin, Lucas Walden, Kasey M. Roberts, Sherif El-Nashar, Adonis K. Hijaz, Jeffrey W. Prescott
Summary: This study revealed measurable volumetric differences in brain structures between responders (R) and nonresponders (NR) to anticholinergic (AC) therapy for overactive bladder (OAB). Nonresponders exhibited lower volumes of specific brain regions compared to responders, and there were correlations between brain structure volumes and symptom severity.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2021)
Article
Obstetrics & Gynecology
Emily A. Slopnick, Kasey Roberts, David D. Sheyn, Graham C. Chapman, Sherif El-Nashar, Sangeeta T. Mahajan
Summary: The study found that total hysterectomy is more common than subtotal hysterectomy during concurrent sacrocolpopexy, and the overall risk of complications is low with similar rates between the two types of hysterectomy.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2021)
Review
Obstetrics & Gynecology
Olivia Thornton, Emily Daggett, Lyba Zia, Anna Quian, Emma Close, Leena Khaitan, Sherif A. El-Nashar, Maria Shaker
Summary: Through reviewing the medical records of bariatric surgery patients, the study found that over half of the patients did not use contraception after surgery, leading to a 6% pregnancy rate within 18 months postoperatively.
Article
Obstetrics & Gynecology
Ghanshyam S. Yadav, Graham C. Chapman, Rubin Raju, Sherif A. El-Nashar, John A. Occhino
Summary: The study compared perioperative outcomes of different reconstructive approaches for apical prolapse surgery in women aged 80 years or older and found that abdominal sacrocolpopexy had higher perioperative morbidity compared to vaginal colpopexy and minimally invasive sacrocolpopexy. Vaginal colpopexy was overall the safest approach in this elderly population.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Obstetrics & Gynecology
Graham C. Chapman, Emily A. Slopnick, Kasey Roberts, David Sheyn, Sherif A. El-Nashar, Jeffrey M. Mangel, Adonis K. Hijaz
Summary: In elderly patients aged 80 years or older, there was no difference in overall complication rates between reconstructive surgery and obliterative surgery. However, propensity score matching revealed that patients who underwent reconstructive surgery had a higher risk of severe complications.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2021)
Article
Obstetrics & Gynecology
Graham C. Chapman, David Sheyn, Emily A. Slopnick, Kasey Roberts, Sherif A. El-Nashar, Joseph W. Henderson, Jeffrey Mangel, Adonis K. Hijaz, Robert R. Pollard, Sangeeta T. Mahajan
Summary: The study found that tamsulosin reduced the risk of postoperative urinary retention in women undergoing surgery for pelvic organ prolapse without an increased rate of urinary tract infection. Additionally, it improved urinary symptoms compared to placebo.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Anood Alfahmy, Amr Mahran, Britt Conroy, Rosemary R. Brewka, Mostafa Ibrahim, David Sheyn, Sherif A. El-Nashar, Adonis Hijaz
Summary: The study compared outcomes of abdominal sacrocolpopexy and vaginal pelvic support (with either uterosacral ligament suspension or sacrospinous ligament fixation) combined with hysterectomy for treating apical prolapse. Results showed comparable anatomical outcomes between the two methods, but differences were found in total vaginal length and POP-Q Ba scores.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Obstetrics & Gynecology
Sadhvi Batra, Sarah A. Kennedy, Frank Tu, Sherif A. El-Nashar, John Nakayama
Summary: The COVID-19 pandemic has led to changes in gynecology practice patterns, with most institutions increasing social-distancing efforts and encouraging the use of personal protective equipment. Elective surgeries were cancelled, telemedicine was utilized, and patients were found to delay needed care according to a survey of gynecologists.
JOURNAL OF GYNECOLOGIC SURGERY
(2022)
Article
Obstetrics & Gynecology
John M. Nakayama, David Sheyn, Amr Mahran, Sherif A. El-Nashar
Summary: The study found that gynecologic procedures accounted for 6.8% of all surgical procedures from 2010 to 2015 and remained stable during the study period. The top 10% of procedures made up around 70% of all procedures, while the top 40% constituted approximately 97% of all procedures. Additionally, there was a significant trend towards an increase in total laparoscopic hysterectomy (TLH) and a decrease in total vaginal hysterectomy (TVH) and abdominal hysterectomy, potentially reflecting a shift in surgical practices.
JOURNAL OF GYNECOLOGIC SURGERY
(2021)
Article
Obstetrics & Gynecology
John Nakayama, Karen Ashby, Susan Wherley, Christa Dominick, Gi-Ming Wang, Curtis Tatsuoka, Sherif El-Nashar, Steven Waggoner
Summary: The study aimed to assess the effectiveness of antislip surfaces in reducing intraoperative patient displacement in the Trendelenburg position. Pink pad was found to significantly reduce movement and facilitate faster positioning compared to gel pad, with less postoperative back pain. Obesity was identified as a major predictor of movement, and pink pad was associated with significantly less postoperative erythema compared to the beanbag.
JOURNAL OF GYNECOLOGIC SURGERY
(2022)
Review
Obstetrics & Gynecology
Nina Rivera, Allison B. Reid, Maria Phillis, Sherif A. El-Nashar
Summary: The aim of this study was to estimate the incidence and time to diagnosis of postmolar gestational trophoblastic neoplasia (GTN) following uterine evacuation and normalization of human chorionic gonadotropin (hCG). The study found that the overall incidence of postmolar GTN after hCG normalization was low, and when it did occur, it often presented well beyond the recommended surveillance time periods.
JOURNAL OF GYNECOLOGIC SURGERY
(2022)
Letter
Obstetrics & Gynecology
Julia Cook, Megha Gupta, John Nakayama, Sherif El-Nashar, Joshua Kesterson, Stephen Wagner
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Meeting Abstract
Urology & Nephrology
Anood Alfahmy, Amr Mahran, Britt Conroy, Rosemary Brewka, David Sheyn, Sherif El-Nashar, Adonis Hijaz, Anood Alfahmy
NEUROUROLOGY AND URODYNAMICS
(2021)
