Article
Pediatrics
Hong Zhao, Yan Han, Ke-Rong Peng, You-You Luo, Jin-Dan Yu, You-Hong Fang, Jie Chen, Jin-Gan Lou
Summary: This study aimed to compare the use of nasogastric (NG) feeding with nasojejunal (NJ) feeding in treating pediatric patients with acute pancreatitis. Results showed that the NG tube feeding group had significantly shorter tube feeding time and length of hospital stay compared to the NJ group, with no significant differences in other outcomes between the two groups.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Jiajia Lin, Cheng Lv, Cuili Wu, He Zhang, Zirui Liu, Lu Ke, Gang Li, Zhihui Tong, Jianfeng Tu, Weiqin Li
Summary: This study investigated the incidence and risk factors of gastric feeding intolerance in moderately-severe to severe acute pancreatitis patients. The findings showed that respiratory failure was an independent risk factor for gastric feeding intolerance. The energy intake significantly increased after switching to nasojejunal feeding.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Ioannis Pothoulakis, Haq Nawaz, Pedram Paragomi, Kwonho Jeong, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh Kumar Goenka, Aiste Gulla, Vikesh K. Singh, Jose A. Gonzalez, Miguel Ferreira, Sorin T. Barbu, Tyler Stevens, Silvia C. Gutierrez, Narcis O. Zarnescu, Gabriele Capurso, Jeffrey Easler, Konstantinos Triantafyllou, Mario Pelaez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Bechien U. Wu, Gregory A. Cote, Kaleab Abebe, Gong Tang, Ali Lahooti, Anna E. Phillips, Georgios Papachristou
Summary: Oral feeding intolerance occurs in 13% of acute pancreatitis patients and is independently associated with systemic inflammatory response syndrome at 48 hours and a non-biliary etiology.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thibaut Zver, Paul Calame, Stephane Koch, Sebastien Aubry, Lucine Vuitton, Eric Delabrousse
Summary: This study aimed to evaluate abdominal CT features of acute biliary pancreatitis and to predict the biliary origin of a first episode of AP using a combination of CT and clinical data. The findings showed that age, alanine aminotransferase level, gallbladder gallstone, choledochal ring sign, liver spontaneous attenuation, and duodenal thickening were independently associated with ABP. The nomogram combining clinical and CT features demonstrated good diagnostic performance for early diagnosis of ABP.
Article
Gastroenterology & Hepatology
Ingrid Kvale Nordaas, Erling Tjora, Georg Dimcevski, Ingfrid S. Haldorsen, Soren Schou Olesen, Asbjorn Mohr Drewes, Kristina Zviniene, Giedrius Barauskas, Berivan Kyed Bayram, Peter Norregaard, Anders Borch, Camilla Nojgaard, Annette Bojer Jensen, Svetlana S. Kardasheva, Alexey Okhlobystin, Truls Hauge, Anne Waage, Jens Brondum Frokjaer, Trond Engjom
Summary: This study found independent associations between distinct structural changes on pancreatic imaging and clinical complications in patients with chronic pancreatitis. Structural changes included pancreatic atrophy, severe calcifications, and continuous organ involvement. These findings provide insights for monitoring pancreatic function and nutritional status.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Nursing
Jia Wang, Yahong Chen, Hui Xue, Zhiming Chen, Qiuchen Wang, Mingyue Zhu, Jiannan Yao, Hua Yuan, Xiuying Zhang
Summary: Abdominal massage can reduce the incidence of feeding intolerance and gastrointestinal symptoms in patients receiving enteral nutrition.
Article
Pediatrics
Wolfgang J. Schnedl, Michael Schenk, Simon Michaelis, Dietmar Enko, Harald Mangge
Summary: Functional abdominal pain disorders (FAPDs) are common chronic pain disorders in children, and they may be associated with food intolerance/malabsorption. In this study, all 51 children with investigated FAPDs were diagnosed with food intolerance/malabsorption, and various combinations of symptoms were observed.
Review
Medicine, General & Internal
Hongyun Fan, Chunchun Yang, Zhiying Duan, Xiaohui Huo, Yang Yang
Summary: This study analyzed the factors of enteral nutrition intolerance in patients with SAP through meta-analysis, providing a basis for protecting enteral nutrition in patients.
Article
Multidisciplinary Sciences
Vanda Ho, Gordon Goh, Xuan Rong Tang, Kay Choong See
Summary: Thirst, a distressing feeling often overlooked by healthcare professionals, is a major source of patient distress among NGT + NBM and NBM patients. The majority of patients in these populations experience thirst, with significant distress associated with it. Active identification and treatment of thirst are suggested to achieve person-centered care.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Cecile Frugier, Francois Graham, Kathryn Samaan, Louis Paradis, Anne Des Roches, Philippe Begin
Summary: Inhaled salbutamol has shown significant efficacy in relieving abdominal pain caused by IgE-mediated allergic reactions, leading to faster symptom improvement in patients. This retrospective study provides hypothesis generating evidence for further investigation in a double-blind randomized controlled trial.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Gastroenterology & Hepatology
Javier Aguilera-Lizarraga
Summary: Abdominal pain, a common symptom worldwide, often occurs after food ingestion. Current treatment strategies mainly focus on excluding culprit food(s) from the diet. However, this approach has limitations, as patients may recognize multiple food items and not all offending foods can be identified. Newly identified mechanisms involving neuroimmune interactions and intestinal microbiota communication are important for developing new therapeutic strategies.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Editorial Material
Surgery
Zi-Ping Cai, Fa-Chao Fan, Wei Liu
Summary: IgG4-related disease is a systemic autoimmune disease that results in fibro-inflammation and affects multiple organs, including the pancreas, retroperitoneum, and lymph nodes.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Environmental Sciences
Takuma Okumura, Koji Hara, Ayako Nakane, Chizuru Namiki, Kazuharu Nakagawa, Kohei Yamaguchi, Kanako Yoshimi, Mizue Toyoshima, Yoshiyuki Sasaki, Haruka Tohara
Summary: This study identified predictive factors for the removal of nasogastric tubes and oral intake recovery in oral cancer patients post-surgery, with upper esophageal sphincter opening being the most significant factor. After oral cancer surgery, videofluoroscopic swallowing studies should be conducted to assess safe eating methods and predict recovery of oral intake and NGT removal.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Surgery
Lijuan Zeng, Weiting Zhang, Jiali Fang, Luhao Liu, Min Jin, Xuanying Deng, Lixin Huang, Jiali Li, Wanyi Zhang
Summary: This study compared the differences between early oral feeding and traditional oral feeding in patients undergoing simultaneous pancreas-kidney transplantation. The results showed that early oral feeding is not only safe and feasible, but also reduces the incidence of gastrointestinal bleeding and pulmonary infections.
Review
Psychiatry
Fengya Zhu, Shao Yin, Xinyun Zhu, Deya Che, Zimeng Li, Yue Zhong, Hui Yan, Daohui Gan, Lanying Yang, Xiaohan Wu, Liuying Li
Summary: Acupuncture combined with routine treatment has significant efficacy in relieving abdominal pain and distension in patients with acute pancreatitis, as evidenced by increased total effectiveness rate, reduced pain intensity as measured by VAS scores, and other positive outcomes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Xinmin Yang, Ruwen Zhang, Tao Jin, Ping Zhu, Linbo Yao, Lan Li, Wenhao Cai, Rajarshi Mukherjee, Dan Du, Xianghui Fu, Jing Xue, Reynaldo Martina, Tingting Liu, Sayali Pendharkar, Anthony R. Phillips, Vikesh K. Singh, Robert Sutton, John A. Windsor, Lihui Deng, Qing Xia, Wei Huang
Summary: This study identified optimal blood glucose levels to define stress hyperglycemia in non-diabetic and diabetic acute pancreatitis patients and found a significant relationship between stress hyperglycemia and adverse clinical outcomes.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Peter S. Russell, Jiwon Hong, Natalie L. Trevaskis, John A. Windsor, Niels D. Martin, Anthony R. J. Phillips
Summary: The lymphatic system is often overlooked as a potential drug target and a source of adverse effects from cardiovascular drugs. This study aimed to identify drugs that directly affect lymphatic contractions and drugs in clinical use that have positive or negative effects on lymphatic function. The findings suggest that certain drugs can either enhance or inhibit lymphatic contractile function.
CARDIOVASCULAR RESEARCH
(2022)
Review
Surgery
Bathiya Ratnayake, Sayali A. Pendharkar, Saxon Connor, Jonathan Koea, Diana Sarfati, Elizabeth Dennett, Sanjay Pandanaboyana, John A. Windsor
Summary: Contemporary literature confirms a strong relationship between patient volume and clinical outcomes for pancreatic cancer resection, with high-volume centers showing lower mortality, morbidity, failure-to-rescue, and positive resection margin rates.
Editorial Material
Surgery
John A. Windsor
Review
Surgery
Navamayooran Thavanesan, Sophie White, Shiela Lee, Bathiya Ratnayake, Kofi W. Oppong, Manu K. Nayar, Linda Sharp, Asbjorn Mohr Drewes, Gabriele Capurso, Enrique De-Madaria, Ajith K. Siriwardena, John A. Windsor, Sanjay Pandanaboyana
Summary: This article presents a systematic review and meta-analysis comparing the efficacy of different analgesic modalities in acute pancreatitis (AP). The results suggest that epidural analgesia is most effective within the first 24 hours, while NSAIDs can be an effective alternative to opiates during the first day.
WORLD JOURNAL OF SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Sara Moazzam, Lomani A. O'Hagan, Alys R. Clarke, Maxim Itkin, Anthony R. J. Phillips, John A. Windsor, S. Ali Mirjalili
Summary: The cisterna chyli is an important lymphatic structure that receives lymph drainage from various parts of the body, and plays a key role in interventional procedures. However, its anatomy shows significant variation, making accurate detection and assessment challenging.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cell Biology
Armen A. Gharibans, Stefan Calder, Chris Varghese, Stephen Waite, Gabriel Schamberg, Charlotte Daker, Peng Du, Saeed Alighaleh, Daniel Carson, Jonathan Woodhead, Gianrico Farrugia, John A. Windsor, Christopher N. Andrews, Greg O'Grady
Summary: Chronic nausea and vomiting syndromes (NVSs) are prevalent and debilitating disorders. A medical device enabling noninvasive body surface gastric mapping (BSGM) was developed and applied to evaluate NVS pathophysiology. The study found that patients with NVS have impaired meal responses and can be divided into two distinct subgroups based on gastric motor abnormalities and psychological comorbidities.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Surgery
Daniel Joh, Mathew Morreau, Angela Lee, Sayali Pendharkar, Bruce Stokes, Roger Warren, Anthony Hickey, Anthony J. Phillips, John A. Windsor
Summary: Acute Mesenteric Ischaemic (AMI) is a rare and serious condition, and current treatments have limitations. This systematic review of experimental studies suggests that intraluminal oxygen delivery may be an effective treatment for AMI, but further research is needed to determine the optimal timing and formulation before clinical translation.
ANZ JOURNAL OF SURGERY
(2023)
Letter
Gastroenterology & Hepatology
Lin Gao, Xiaojia Xiao, Lu Ke, Jiwon Hong, Lisa Brown, Anthony Phillips, John A. Windsor
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Tiago Bouca-Machado, Stefan A. W. Bouwense, Martin Brand, Ihsan Ekin Demir, Jens Brondum Frokjaer, Pramod Garg, Peter Hegyi, J. -Matthias Lohr, Enrique de-Madaria, Soren Schou Olesen, Sanjay Pandanaboyana, Jan Bech Pedersen, Vinciane Rebours, Andrea Sheel, Vikesh Singh, Martin Smith, John A. Windsor, Dhiraj Yadav, Asbjorn Mohr Drewes
Summary: Acute on chronic pancreatitis (ACP) is a common condition, but there are significant gaps in our knowledge about it. Through a systematic review and expert consensus, a new definition of ACP was reached. Despite the poor evidence base, this position statement provides a foundation for the management of ACP.
Article
Gastroenterology & Hepatology
Linqian Li, Xiaoying Zhang, Guilan Cheng, Dingxi Wang, Shiyu Liu, Lan Li, Na Shi, Tao Jin, Ziqi Lin, Lihui Deng, Wei Huang, John A. Windsor, Guixiang Li, Qing Xia
Summary: This study aimed to optimize the technique for measuring intra-bladder pressure in patients with predicted severe acute pancreatitis. The results showed that measuring intra-bladder pressure at the iliac crest with a head of bed elevation of 15 degrees and instilling 25 mL of normal saline can be appropriate for monitoring intra-abdominal pressure in predicted severe acute pancreatitis patients. A bed elevation of 30 degrees significantly increased intra-bladder pressure.
Review
Gastroenterology & Hepatology
Dhya Al-Leswas, Nesta Baxter, Wei B. Lim, Francis Robertson, Bathiya Ratnayake, Jayanta Samanta, Gabriele Capurso, Enrique de-Madaria, Asbjorn M. Drewes, John Windsor, Sanjay Pandanaboyana
Summary: This systematic review and meta-analysis found that epidural anesthesia (EA) is safe and effective in managing pain in acute pancreatitis (AP). EA can reduce pain severity, improve pancreatic perfusion, and decrease mortality in AP patients. The use of EA is associated with lower need for ventilatory support.
Article
Gastroenterology & Hepatology
Wenjian Mao, Kang Li, Jing Zhou, Miao Chen, Bo Ye, Gang Li, Vikesh Singh, James Buxbaum, Xiaoyun Fu, Zhihui Tong, Yuxiu Liu, John Windsor, Weiqin Li, Lu Ke, CAPCTG
Summary: This study aimed to assess the performance of the Pancreatitis Activity Scoring System (PASS) and its modifications in predicting infected pancreatic necrosis (IPN) in patients with acute necrotizing pancreatitis. The mPASS-4 model had the best predictive performance and simplified the original PASS, increasing the likelihood of clinical implementation.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Johanes K. Kasim, Jiwon Hong, Anthony J. R. Hickey, Anthony R. J. Phillips, John A. Windsor, Paul W. R. Harris, Margaret A. Brimble, Iman Kavianinia
Summary: Pancreatic ductal adenocarcinoma is a debilitating disease with no effective treatments. Trichoderin A, a natural product, shows promise as an anticancer agent. It selectively kills pancreatic cancer cells under glucose deprivation, which is significant given the nutrient-deprived nature of the disease.
Article
Gastroenterology & Hepatology
Phil A. Hart, Dana K. Andersen, Erica Lyons, Gregory A. Cote, Zobeida Cruz-Monserrate, Robert H. Dworkin, B. Joseph Elmunzer, Evan L. Fogel, Christopher E. Forsmark, Ian Gilron, Megan Golden, Aysegul Gozu, Lindsay McNair, Stephen J. Pandol, Emily R. Perito, Anna Evans Phillips, Jennifer A. Rabbitts, David C. Whitcomb, John A. Windsor, Dhiraj Yadav, Tonya M. Palermo
Summary: Recurrent acute pancreatitis and chronic pancreatitis are high-morbidity diseases with no current therapies for reversing or delaying disease progression. Clinical trials are needed to address this important gap. A conference sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases discussed the current gaps and opportunities in patient-focused trials for pancreatitis.