Article
Dermatology
Takeshi Namiki, Moe Makiguchi, Shogo Wada, Hind Al-Busani, Makiko Nishida, Tsukasa Ugajin, Keiko Miura, Kota Yokoyama, Naoko Okiyama
Summary: This article presents a case of squamous cell carcinoma (SCC) arising from extensive pyoderma, which was successfully diagnosed using thallium-201 scintigraphy. Thallium-201 scintigraphy was found to be useful for the diagnosis of SCC by excluding false-positive signals detected by other imaging technologies.
JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemical Research Methods
Alex Rigby, George Firth, Charlotte Rivas, Truc Pham, Jana Kim, Andreas Phanopoulos, Luke Wharton, Aidan Ingham, Lily Li, Michelle Ma, Chris Orvig, Philip J. Blower, Samantha Y. A. Terry, Vincenzo Abbate
Summary: Auger electron therapy utilizes low-energy electrons emitted during radioactive decay to achieve cytotoxicity. However, suitable bifunctional chelators to incorporate Tl3+ into bioconjugates have not been developed. In this study, several multidentate N- and O-donor chelators were synthesized and shown to form stable complexes with (201)T1, exhibiting improved serum stability. By conjugating H(4)pypa to prostate-specific membrane antigen, tumor imaging was achieved in vivo, although tumor targeting efficacy needs improvement.
BIOCONJUGATE CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Joon Hyuk Choi, Jae Y. Ro
Summary: Soft tissue tumors are rare mesenchymal tumors with diverse differentiation. They are challenging to diagnose due to the variety of tumor types and histological overlap. Advances in molecular genetic techniques and the development of immunohistochemical markers have improved our understanding of the molecular pathogenesis of soft tissue tumors. This review provides updated information on recent molecular findings and novel immunohistochemical markers in selected soft tissue tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Article
Oncology
Matthew F. Gong, William T. Li, Sumail Bhogal, Brittany Royes, Tanya Heim, Maria Silvaggio, Marcus Malek, Rajeev Dhupar, Stella J. Lee, Richard L. McGough, Kurt R. Weiss
Summary: Soft tissue sarcomas (STS) are rare malignant tumors associated with poor outcomes and high local recurrence rates. Indocyanine green (ICG) has shown efficacy for intraoperative margin assessment in breast and gastrointestinal cancers. This study presents an ongoing clinical study implementing ICG intraoperative margin assessment in patients with STS. ICG margins matched permanent pathology margins in 56% of patients, with 22% sensitivity and 89% specificity. Larger sample sizes are needed to further evaluate the optimal dosage, timing, and impact on different histological subtypes of STS.
Article
Biotechnology & Applied Microbiology
Kang-Wen Xiao, Zhi-Qiang Yang, Xin Yan, Zhi-Bo Liu, Min Yang, Liang-Yu Guo, Lin Cai
Summary: By analyzing the characteristics and patterns of m6A modification in soft tissue sarcoma (STS), this study identified two different modification patterns and found that m6A cluster A had better clinical outcomes and lower immune/stromal scores compared to m6A cluster B. Additionally, the m6Ascore effectively predicted the characteristics and prognosis of STS, as well as the outcome of PD-1/PD-L1 blockade immunotherapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mareomi Hamada, Yuji Shigematsu, Shigeru Nakata, Taishi Kuwahara, Shuntaro Ikeda, Kiyotaka Ohshima, Akiyoshi Ogimoto
Summary: This study evaluated changes in left ventricular remodelling in patients with HCM using thallium-201 myocardial scintigraphy. The apex was the most common lesion site, and patients with LVHF had higher ES and MCC values.
Article
Oncology
Do Weon Lee, Han-Soo Kim, Ilkyu Han
Summary: The study found that actual 5-year survival in stage III soft tissue sarcoma patients is associated with tumor size, histological grade, and ASA score. Nevertheless, the majority of long-term survivors still exhibit factors of poor prognosis.
Review
Pharmacology & Pharmacy
Tomoki Nakamura, Akihiro Sudo
Summary: Trabectedin is a safe and effective therapeutic option for patients with advanced STS. While it may be effective as first-line treatment in selected patients, doxorubicin remains the preferred choice for locally advanced or metastatic STS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Zhehong Li, Honghong Zheng, Lirui Liu, Zhen Fen, Haiying Cao, Jilong Yang, Junqiang Wei
Summary: This study developed an inflammatory score and risk stratification model for soft tissue sarcoma (STS) based on analysis of inflammatory response genes, which can evaluate prognosis, tumor microenvironment status, immunotherapy, and chemotherapy efficacy. The findings suggest potential value in assessing prognosis and immune status of multiple malignancies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Zhen-Dong Huang, Lu-Lu Lin, Zi-Zhen Liu, Chao Hu, Hui-Yun Gu, Ren-Xiong Wei
Summary: The study revealed different m6A modification patterns in soft tissue sarcoma (STS) patients, impacting prognosis, immune cell infiltration, metabolic pathways, etc. Patients with lower m6Ascores were found to have increased antitumor immune responses and sensitivity to immunotherapy and chemotherapy, highlighting the potential of evaluating m6A modification patterns for guiding more effective treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Dario Callegaro, Chandrajit P. Raut, Emily Z. Keung, Teresa Kim, Cecile Le Pechoux, Javier Martin-Broto, Alessandro Gronchi, Carol Swallow, Rebecca Gladdy
Summary: The COVID-19 pandemic has greatly impacted cancer patients' access to surgery, but surgical oncologists can adapt their decision-making by revisiting treatment options.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Teppei Takeshima, Noboru Mimura, Shun Aoki, Tomoki Saito, Jurii Karibe, Kimitsugu Usui, Shinnosuke Kuroda, Mitsuru Komeya, Yasushi Yumura
Summary: This study aims to assess spermatogenesis in male patients diagnosed with malignant bone and soft tissue tumors before and after chemotherapy. Recovery of spermatogenesis was observed in many cases, and assisted reproduction using cryopreserved sperm was a viable option for achieving parenthood.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Minchao Lv, Feixiong He, Jinku Guo, Zhenxin Zheng, Wei Wang, Jun Xie
Summary: This study identified the key genes associated with M1-like macrophage infiltration in soft tissue sarcomas (STS) cells. The LCK gene was found to be positively related to the level of M1-like macrophage infiltration and positively regulated the expression of genes involved in macrophage polarization and chemotaxis.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Tom Wei-Wu Chen, Ruru Chun-Ju Chiang, Alex Le Cesne, Yu-Chun Hsieh, Antoine Italiano, Ya-Wen Yang, Nicolas Penel, Wen-Chung Lee, Emmanuelle Bompas, Thibaud Valentin, Philippe Anract, Nelly Firmin, Florence Duffaud, Ann-Lii Cheng, Francoise Ducimetiere, K. Arnold Chan, Jean-Yves Blay
Summary: The study found significant differences in the incidence and clinical characteristics of soft tissue sarcoma (STS) among different geographic and ethnic populations, suggesting that geographic and ethnic factors may play a crucial role in the pathogenesis of STS.
Article
Neurosciences
Taro Yamauchi, Ashish Jaiswal, Masato Tanaka, Yoshihiro Fujiwara, Yoshiaki Oda, Shinya Arataki, Haruo Misawa
Summary: The case describes a patient undergoing a new minimally invasive L5 corpectomy technique with successful outcomes at 1-year follow-up. The new technique is effective in reducing surgical invasiveness and improving surgical success rates.
Article
Medicine, General & Internal
Masakazu Nagamatsu, Sameer Ruparel, Masato Tanaka, Yoshihiro Fujiwara, Koji Uotani, Shinya Arataki, Taro Yamauchi, Yoshiyuki Takeshita, Rika Takamoto, Shinsuke Moriue
Summary: The study evaluated 3D lumbosacral vascular anatomy using a non-enhanced MRI and CT medical image fusion technique, finding it to be very useful for OLIF51, especially for patients in whom the use of contrast medium is contraindicated.
Article
Medicine, General & Internal
Ying Tan, Masato Tanaka, Sumeet Sonawane, Koji Uotani, Yoshiaki Oda, Yoshihiro Fujiwara, Shinya Arataki, Taro Yamauchi, Tomoyuki Takigawa, Yasuo Ito
Summary: Simultaneous single-position O-arm-navigated OLIF can reduce surgical time, blood loss, and time to ambulation after surgery. It also achieves good indirect decompression with comparable fusion rates and lower complication rates compared to MI-PLIF/TLIF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Tomoyoshi Sakaguchi, Masato Tanaka, Hardik Suthar, Yoshihiro Fujiwara, Koji Uotani, Shinya Arataki, Taro Yamauchi, Atsushi Sugyo, Kazuhiko Takamatsu, Yosuke Yasuda, Masami Nakagawa, Nana Takahashi
Summary: Adult spinal deformity (ASD) is common in older adults, affecting more than 30% of the population. This study aimed to determine the recovery time of gait and spinal balance ability after ASD surgery. The results showed that gait ability and dynamic spinal balance improved at 12 months after surgery, while static spinal balance remained the same as preoperative levels.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Masakazu Nagamatsu, Praful Maste, Masato Tanaka, Yoshihiro Fujiwara, Shinya Arataki, Taro Yamauchi, Yoshiyuki Takeshita, Rika Takamoto, Tsukasa Torigoe, Masato Tanaki, Ryosuke Tanaka, Shinsuke Moriue
Summary: This study visualized the morphology of lumbar herniated discs and Kambin's triangle using 3D CT/MRI fusion images. The measurements of the safe usage of transforaminal endoscopic approach and 3D lumbar nerve root sleeve angulation were evaluated. The results showed that the 3DNRA became smaller from L2 to S1, and the herniated discs were clearly visualized in the fusion image. The study concludes that this new imaging technique is important for the safety of endoscopic lumbar disc surgery.
Review
Medicine, General & Internal
Sameer Ruparel, Masato Tanaka, Rahul Mehta, Taro Yamauchi, Yoshiaki Oda, Sumeet Sonawane, Ram Chaddha
Summary: Tuberculosis of the spine, the most common form of bone and joint tuberculosis, has seen significant changes in treatment principles over time. The development of various diagnostic tests, effective anti-tubercular therapy, and associated research have revolutionized treatment. The advent of minimally invasive spine surgery is rapidly changing the approach to treating spinal tuberculosis.
Article
Medicine, General & Internal
Taro Yamauchi, Sagar Sharma, Sarath Chandra, Masato Tanaka, Yoshihiro Fujiwara, Shinya Arataki, Ayush Sharma, Yusuke Yokoyama, Toshinori Oomori, Akihiro Kanamaru, Shin Masuda, Noriyuki Shimizu, Kenta Torigoe, Osamu Honda
Summary: This study evaluates the role of lumbar magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis of sacral insufficiency fractures (SIF). The results show that lumbar MRI has higher sensitivity and can detect more complex fracture patterns compared to CT. MRI can be useful for early detection of SIF, recognition of concomitant pathologies, and adequate treatment for patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Masato Tanaka, Dhvanit Desai, Yoshihiro Fujiwara, Shinya Arataki, Kajetan Latka, Naveen Sake, Wang Liang, Yuya Kodama, Yoshiaki Miyamoto, Taro Yamauchi
Summary: This study assessed the lumbar sagittal alignment of patients positioned prone over an adjustable hinged carbon fiber operating table in three different positions: neutral, 20 degrees convex, and 20 degrees concave bending. The lumbar lordosis was measured on radiographs, and it showed divergent results in all three table positions. The efficacy of table bending was found to be 46.5% in convex and 34.0% in concave bending.
APPLIED SCIENCES-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Yuya Kodama, Shin Masuda, Toshinori Ohmori, Akihiro Kanamaru, Masato Tanaka, Tomoyoshi Sakaguchi, Masami Nakagawa
Summary: Damage to the fascia can have negative impacts on sports performance and contribute to musculoskeletal disorders. This article reviews the molecular response of the fascia to mechanical properties and other physiological challenges, explores imaging techniques for studying the fascial system, and discusses therapeutic interventions in sports medicine.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Masato Tanaka, Sumeet Sonawane, Umesh Meena, Zhichao Lu, Yoshihiro Fujiwara, Takuya Taoka, Koji Uotani, Yoshiaki Oda, Tomoyoshi Sakaguchi, Shinya Arataki
Summary: This study compared symptomatic and radiological outcomes between OLIF51 and TLIF51 in ASD patients. The results showed similar clinical outcomes in both groups, but OLIF51 had significantly shorter surgical time and better improvement in L5-S1 lordosis and disc height compared to TLIF51.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Kajetan Latka, Waldemar Kolodziej, Kornel Pawlak, Tomasz Sobolewski, Rafal Rajski, Jacek Chowaniec, Tomasz Olbrycht, Masato Tanaka, Dariusz Latka
Summary: This report describes the surgical methodology and potential effectiveness of endoscopic separation surgery (ESS) in patients with metastatic spine disease. The concept aims to reduce invasiveness and speed up the wound healing process, allowing faster application of radiotherapy. Fully endoscopic spine surgery (FESS) followed by percutaneous screw fixation (PSF) was performed on three patients, resulting in disqualification for further treatment in one case and satisfactory outcomes in the remaining two patients who were referred for additional radiotherapy.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Masato Tanaka, Naveen Sake, Dae-Geun Kim, Shinya Arataki, Dhvanit Desai, Yoshihiro Fujiwara, Taro Yamauchi
Summary: This study presents a novel C-arm-free technique guided by navigation for C1 lateral mass screw insertion. It provides a practical and safe method for the treatment of atlantoaxial subluxation in patients with rheumatoid arthritis and upper cervical trauma, avoiding the risk of fluoroscopic radiation.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Tomoyoshi Sakaguchi, Masato Tanaka, Naveen Sake, Kajetan Latka, Yoshihiro Fujiwara, Shinya Arataki, Taro Yamauchi, Kazuhiko Takamatsu, Yosuke Yasuda, Masami Nakagawa, Nana Takahashi, Tomoya Kishimoto
Summary: This study investigated the factors affecting gait, postural balance, and activities of daily living (ADL) in patients who underwent adult spinal deformity (ASD) surgery. The results showed that the timed up and go test (TUG) was a significant factor, with a cut-off value of 9.7 seconds for ADL satisfaction.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Masato Tanaka, Tsang-Tung Chan, Haruo Misawa, Koji Uotani, Shinaya Arataki, Tomoyuki Takigawa, Tetsuro Mazaki, Yoshihisa Sugimoto
Summary: This study presented retrospective case series of long-term surgical results for severe thoracolumbar kyphosis in achondroplastic patients. The surgical treatment involved posterior vertebral column resection (p-VCR) with a cage and segmental instrumentation. The study found that p-VCR was effective in treating thoracolumbar kyphosis in patients with achondroplasia, but complications such as rod breakage and surgical site infection were common.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Masato Tanaka, Mahendra Singh, Yoshihiro Fujiwara, Koji Uotani, Yoshiaki Oda, Shinya Arataki, Taro Yamauchi, Tomoyuki Takigawa, Yasuo Ito
Summary: By retrospectively comparing navigational and conventional minimally invasive corpectomy techniques, the clinical outcomes were found to be similar, but the radiographic outcomes of lateral cage mal-position and postoperative cage sinking were significantly lower in the navigation group.
MEDICINA-LITHUANIA
(2022)
