Journal
CLINICAL NUCLEAR MEDICINE
Volume 33, Issue 4, Pages 271-272Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0b013e3181662bbf
Keywords
F-18FDG and PET/CT; fat necrosis; false-positive B-cell lymphoma
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F-18 fluoro-2-deoxyglucose positron emission tomography combined with computed tomography (FDG and PET/CT) is increasingly becoming the standard in staging and restaging patients with a range of malignancies including B-cell lymphoma. However, there are well-known pitfalls in PET/CT with FDG imaging, which comprise infection, inflammation, physiological variants, and benign pathologic conditions. Fat necrosis is the result of death of adipose tissue from disease, injury, or pathologic conditions. We describe a case of false positive PET/CT and FDG scan in a patient with fat necrosis mimicking B-cell lymphoma after 6 cycles of rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment. In interpreting PET/CT and FDG images with inconsistency in lesion response, fat necrosis should be considered in the differential diagnosis.
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