Article
Neurosciences
Andrew E. Silva, Katelyn Tsang, Syeda Javeria Hasan, Benjamin Thompson
Summary: The study found that TMS-induced phosphenes locations do not perfectly match eye position, with significant individual differences in reliability. Careful control of eye movements is necessary during phosphenes localization studies, and individual differences in the reported position of phosphenes must be taken into consideration.
Article
Neurosciences
Ted Maldonado, Trevor Bryan Jackson, Jessica A. Bernard
Summary: This study investigated the impact of transcranial direct current stimulation on cerebellar and cortical activation. The findings showed that anodal stimulation worsened task performance and increased cortical activation in parietal and frontal regions.
HUMAN BRAIN MAPPING
(2023)
Review
Neurosciences
Gustavo V. Ponce, Jana Klaus, Dennis J. L. G. Schutter
Summary: This article provides a brief historical account of cerebellar neurostimulation and discusses current challenges and future direction in this field of research. From the early research on electric stimulation of the cerebellum to the use of non-invasive techniques in the 21st century, significant advancements have been made in understanding cerebellar functioning through neurostimulation.
Article
Clinical Neurology
Gaia Bonassi, Elisa Pelosin, Giovanna Lagravinese, Ambra Bisio, Giorgio Grasselli, Marco Bove, Laura Avanzino
Summary: The study showed that when peripheral electrical stimulation was delivered 25 and 35 ms earlier to the ipsilateral cerebellum in healthy subjects, there was a significantly weaker cerebellar brain inhibition (CBI). This suggests that somatosensory inputs may modulate the inhibitory effect of the cerebellum on the primary motor cortex.
CLINICAL NEUROPHYSIOLOGY
(2021)
Editorial Material
Neurosciences
Po-Yu Fong, Danny Spampinato, Kevin Michell, Marco Mancuso, Katlyn Brown, Jaime Ibanez, Alessandro Di Santo, Anna Latorre, Kailash Bhatia, John C. Rothwell, Lorenzo Rocchi
Summary: This commentary article compares the differences between their recently published paper on cerebellar transcranial magnetic stimulation (TMS) induced electroencephalographic responses and Gassmann et al.'s previous work on the same topic. The authors agree that the differences mainly stem from the use of different magnetic stimulation coils but raise two unanswered questions: (1) which method is most likely to achieve optimal activation of cerebellar output, and (2) to what extent are the evoked cerebellar responses contaminated by concomitant sensory input? They emphasize the importance of careful experimental design and combining electrophysiological and behavioral data for obtaining reliable TMS-EEG data.
Review
Neurosciences
Lin He, Qi-Fan Guo, Yu Hu, Hui-Xin Tan, Yi Chen, Chen-Han Wang, Tian-Yu Zhou, Qiang Gao
Summary: Non-invasive cerebellar stimulation (NICS) is a promising technique for rehabilitating brain functions in neurological or psychiatric diseases. This study used bibliometric analysis to examine the current status, hot spots, and trends of NICS research.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Dania Abuleil, Daphne McCulloch, Benjamin Thompson
Summary: Neuromodulation of the primary visual cortex using anodal transcranial direct current stimulation (a-tDCS) can alter visual perception and enhance neuroplasticity, but the mechanisms behind these effects remain unknown. Contrary to expectations, a-tDCS had no effect on visual cortex inhibition, while continuous theta-burst transcranial magnetic stimulation (cTBS) increased mixed percept duration during rivalry.
Article
Clinical Neurology
Yuting Shi, Guangdong Zou, Zhao Chen, Linlin Wan, Linliu Peng, Huirong Peng, Lu Shen, Kun Xia, Rong Qiu, Beisha Tang, Hong Jiang
Summary: This study compared the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) and intermittent Theta Burst Stimulation (iTBS) in SCA3 patients. The results showed that both 1 Hz rTMS and iTBS were effective in improving the symptoms of ataxia in SCA3 patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Yue Lv, Mengran Wang, Juan Yang, Jin Shi, Tingting Xuan, Junmei Zhang, Dandan Du, Jiang Cheng, Haining Li
Summary: The main aim of this study was to evaluate the antitremor effect of 1-Hz cerebellar rTMS and compare it to the use of propranolol in ET patients. The results showed that both cerebellar rTMS and propranolol could be effective treatment options for patients with ET, but it is not clear which method is more effective.
BRAIN AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Akiyoshi Matsugi, Satoru Nishishita, Kyota Bando, Yutaka Kikuchi, Keigo Tsujimoto, Yuto Tanabe, Naoki Yoshida, Hiroaki Tanaka, Shinya Douchi, Takeru Honda, Masato Odagaki, Hideki Nakano, Yohei Okada, Nobuhiko Mori, Koichi Hosomi
Summary: This study aimed to investigate abnormalities in inhibitory cortical excitability and motor control during ballistic-targeting movements in individuals with degenerative cerebellar ataxia (DCA). The results indicated that individuals with DCA showed longer cortical silent period (cSP), suggesting excessive activity in the inhibitory cortical circuit. However, this increase in inhibitory activity did not contribute to the control of ballistic-targeting movements and did not correlate with the severity of ataxia. These findings contribute to our understanding of motor control abnormalities in people with DCA and provide potential evidence for further research in this area.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Milan Pantovic, Daniel E. Lidstone, Lidio Lima de Albuquerque, Erik W. Wilkins, Irwin A. Munoz, Daniel G. Aynlender, Desiree Morris, Janet S. Dufek, Brach Poston
Summary: This study found that multi-day c-tDCS does not improve motor learning in a complex overhand throwing task or increase primary motor cortex (M1) excitability.
BIOENGINEERING-BASEL
(2023)
Review
Clinical Neurology
Lianjun Yin, Xiaoyu Wang, Lianghua Chen, Dandan Liu, Haihong Li, Zhaoxing Liu, Yong Huang, Junqi Chen
Summary: This meta-analysis aimed to summarize the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) for treating cerebellar ataxia (CA). The results showed that rTMS significantly improved various measures of ataxia in CA patients compared to sham stimulation. However, the findings should be interpreted with caution due to the limitations of the small sample size and inconsistent approach and target of rTMS treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jinzhu Rao, Fang Li, Lida Zhong, Jing Wang, Yang Peng, Huiyu Liu, Pu Wang, Jianwen Xu
Summary: This study found that intermittent theta burst stimulation with bilateral cerebellar transcranial magnetic stimulation can effectively improve swallowing function in patients with dysphagia after stroke. The stimulation of bilateral cerebellar hemisphere provides a more efficient treatment. Additionally, 100% resting motor threshold bilateral cerebellar iTBS is a relatively safe treatment.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Review
Clinical Neurology
Ying Wang, Di Zhang, Ju Wang, Jiang Ma, Li Lu, Song Jin
Summary: This study investigated the effectiveness of transcranial magnetic stimulation in improving cerebellar ataxia. The results showed that TMS had a significant effect on patients with cerebellar ataxia. It is recommended to conduct future large-scale and high-quality research.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Francesca Ginatempo, Nicoletta Manzo, Danny A. Spampinato, Nicola Loi, Francesca Burgio, John C. Rothwell, Franca Deriu
Summary: This study investigated the effects of peripheral nerve and cerebellum paired associative stimulation (cPAS) on plasticity in the cerebellum and cortex. The results showed that cPAS25 had the ability to induce plasticity effects in the cerebellar cortex, resulting in a reduction in cerebellum-brain inhibition (CBI).
Article
Neurosciences
Fulvia Palesi, Roberta Maria Lorenzi, Claudia Casellato, Petra Ritter, Viktor Jirsa, Claudia A. M. Gandini Wheeler-Kingshott, Egidio D'Angelo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Mathematical & Computational Biology
Gloria Castellazzi, Maria Giovanna Cuzzoni, Matteo Cotta Ramusino, Daniele Martinelli, Federica Denaro, Antonio Ricciardi, Paolo Vitali, Nicoletta Anzalone, Sara Bernini, Fulvia Palesi, Elena Sinforiani, Alfredo Costa, Giuseppe Micieli, Egidio D'Angelo, Giovanni Magenes, Claudia A. M. Gandini Wheeler-Kingshott
FRONTIERS IN NEUROINFORMATICS
(2020)
Article
Neurosciences
F. Locatelli, T. Soda, I Montagna, S. Tritto, L. Botta, F. Prestori, E. D'Angelo
Summary: Research has found that excitatory synapses on Golgi cells in the cerebellum exhibit a unique voltage dependence in long-term plasticity, with activation of T-type and L-type Ca2+ channels playing important roles in inducing LTP and LTD. Additionally, there is an inverted relationship between plasticity at mossy fiber-Golgi cell synapses and mossy fiber-granule cell synapses in terms of voltage dependence.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Martina Francesca Rizza, Francesca Locatelli, Stefano Masoli, Diana Sanchez-Ponce, Alberto Munoz, Francesca Prestori, Egidio D'Angelo
Summary: The study reveals that cerebellar stellate cells exhibit intrinsic pacemaking and characteristic responses, acting as delay-high-pass filters by inhibiting Purkinje cell responses to parallel fiber stimulation. Reciprocal inhibitory connections between stellate cells maintained control over Purkinje cell discharge only at very high frequencies. These findings predict a new role for stellate cells in providing molecular layer with filtering properties and regulating Purkinje cell gain.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jonathan Mapelli, Daniela Gandolfi, Enrico Giuliani, Stefano Casali, Luigi Congi, Alberto Barbieri, Egidio D'Angelo, Albertino Bigiani
Summary: The general anesthetic sevoflurane alters neurotransmission by increasing GABAergic inhibition and decreasing glutamatergic NMDA activity, leading to changes in neuronal communication without silencing neural circuits. The drug also affects the intrinsic excitability of cerebellar granule cells by promoting action potential generation through modulation of ion currents.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Rin Kuriyama, Claudia Casellato, Egidio D'Angelo, Tadashi Yamazaki
Summary: This study focuses on large-scale simulation of detailed computational models of neuronal microcircuits using a scaffolding approach, which involves replacing simulation modules to improve computational speed. The research demonstrates that the scaffolding method can accelerate real-time simulation significantly, reducing computational time without affecting experimental results.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Adnan A. S. Alahmadi, Matteo Pardini, Rebecca S. Samson, Egidio D'Angelo, Karl J. Friston, Ahmed T. Toosy, Claudia A. M. Gandini Wheeler-Kingshott
Summary: This study demonstrates the selective impact of multiple sclerosis (MS) on regional BOLD responses to different levels of grip forces in the brain's motor areas BA 4a and BA 4p. MS patients show greater alterations in BA 4p compared to healthy volunteers, especially those with more severe disability. Polynomial analysis beyond the main effect of movement is crucial for uncovering these differences between MS patients and healthy individuals.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Mathematical & Computational Biology
Giordana Florimbi, Emanuele Torti, Stefano Masoli, Egidio D'Angelo, Francesco Leporati
Summary: In this work, authors described the development of a novel Granular layEr Simulator implemented on a multi-GPU system capable of reconstructing the cerebellar granular layer in a 3D space and reproducing its neuronal activity. The simulation was validated by reproducing typical behaviors well-documented in the literature. The use of GPU technology demonstrated significant speedups in large network simulations.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Neurosciences
Fulvia Palesi, Matteo Ferrante, Marta Gaviraghi, Anastasia Misiti, Giovanni Savini, Alessandro Lascialfari, Egidio D'Angelo, Claudia A. M. Gandini Wheeler-Kingshott
Summary: This study identified the topography of human dentate nuclei using multimodal MRI approaches, defining motor and higher-order function regions. Results showed that over half of the dentate nuclei volume is involved in non-motor functions, with connectivity-based and microstructure-based atlases providing complementary information.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Petrut A. Bogdan, Beatrice Marcinno, Claudia Casellato, Stefano Casali, Andrew G. D. Rowley, Michael Hopkins, Francesco Leporati, Egidio D'Angelo, Oliver Rhodes
Summary: This work presents the first simulation of a large-scale, bio-physically constrained cerebellum model performed on neuromorphic hardware, validating the results on SpiNNaker against a baseline simulation with NEST. The study investigates acceleration strategies for real-time simulation on SpiNNaker, aiming to pave the way for exploration of cerebellum-inspired controllers and extended duration simulations on neuro-robotic applications.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Kurt G. Schilling, Francois Rheault, Laurent Petit, Colin B. Hansen, Vishwesh Nath, Fang-Cheng Yeh, Gabriel Girard, Muhamed Barakovic, Jonathan Rafael-Patino, Thomas Yu, Elda Fischi-Gomez, Marco Pizzolato, Mario Ocampo-Pineda, Simona Schiavi, Erick J. Canales-Rodriguez, Alessandro Daducci, Cristina Granziera, Giorgio Innocenti, Jean-Philippe Thiran, Laura Mancini, Stephen Wastling, Sirio Cocozza, Maria Petracca, Giuseppe Pontillo, Matteo Mancini, Sjoerd B. Vos, Vejay N. Vakharia, John S. Duncan, Helena Melero, Lidia Manzanedo, Emilio Sanz-Morales, Angel Pena-Melian, Fernando Calamante, Arnaud Attye, Ryan P. Cabeen, Laura Korobova, Arthur W. Toga, Anupa Ambili Vijayakumari, Drew Parker, Ragini Verma, Ahmed Radwan, Stefan Sunaert, Louise Emsell, Alberto De Luca, Alexander Leemans, Claude J. Bajada, Hamied Haroon, Hojjatollah Azadbakht, Maxime Chamberland, Sila Genc, Chantal M. W. Tax, Ping-Hong Yeh, Rujirutana Srikanchana, Colin D. Mcknight, Joseph Yuan-Mou Yang, Jian Chen, Claire E. Kelly, Chun-Hung Yeh, Jerome Cochereau, Jerome J. Maller, Thomas Welton, Fabien Almairac, Kiran K. Seunarine, Chris A. Clark, Fan Zhang, Nikos Makris, Alexandra Golby, Yogesh Rathi, Lauren J. O'Donnell, Yihao Xia, Dogu Baran Aydogan, Yonggang Shi, Francisco Guerreiro Fernandes, Mathijs Raemaekers, Shaun Warrington, Stijn Michielse, Alonso Ramirez-Manzanares, Luis Concha, Ramon Aranda, Mariano Rivera Meraz, Garikoitz Lerma-Usabiaga, Lucas Roitman, Lucius S. Fekonja, Navona Calarco, Michael Joseph, Hajer Nakua, Aristotle N. Voineskos, Philippe Karan, Gabrielle Grenier, Jon Haitz Legarreta, Nagesh Adluru, Veena A. Nair, Vivek Prabhakaran, Andrew L. Alexander, Koji Kamagata, Yuya Saito, Wataru Uchida, Christina Andica, Masahiro Abe, Roza G. Bayrak, Claudia A. M. Gandini Wheeler-Kingshott, Egidio D'Angelo, Fulvia Palesi, Giovanni Savini, Nicolo Rolandi, Pamela Guevara, Josselin Houenou, Narciso Lopez-Lopez, Jean-Francois Mangin, Cyril Poupon, Claudio Roman, Andrea Vazquez, Chiara Maffei, Mavilde Arantes, Jose Paulo Andrade, Susana Maria Silva, Vince D. Calhoun, Eduardo Caverzasi, Simone Sacco, Michael Lauricella, Franco Pestilli, Daniel Bullock, Yang Zhan, Edith Brignoni-Perez, Catherine Lebel, Jess E. Reynolds, Igor Nestrasil, Rene Labounek, Christophe Lenglet, Amy Paulson, Stefania Aulicka, Sarah R. Heilbronner, Katja Heuer, Bramsh Qamar Chandio, Javier Guaje, Wei Tang, Eleftherios Garyfallidis, Rajikha Raja, Adam W. Anderson, Bennett A. Landman, Maxime Descoteaux
Summary: White matter bundle segmentation using diffusion MRI fiber tractography is a popular method for identifying white matter fiber pathways in human brains, but there is significant variability in segmentation protocols and techniques. A study evaluated the variability among protocols for bundle segmentation and found that even with the same underlying data, the variability across protocols was greater than other sources of variability, indicating a need to reduce heterogeneity for reproducible research and routine clinical use of tractography bundle dissection.
Article
Public, Environmental & Occupational Health
Daniela Gandolfi, Giuseppe Pagnoni, Tommaso Filippini, Alessia Goffi, Marco Vinceti, Egidio D'Angelo, Jonathan Mapelli
Summary: The COVID-19 pandemic has led to a debate on the hidden factors driving the outbreak dynamics, with various computational models proposed to inform social and healthcare strategies. The dynamic causal modeling (DCM) framework has shown reliability in predicting and analyzing the factors governing the pandemic diffusion, particularly in northern Italy. This modeling tool has the potential to identify containment and control strategies against further waves of infection by understanding the mechanisms of the spread of SARS-CoV-2.
FRONTIERS IN PUBLIC HEALTH
(2021)
Proceedings Paper
Computer Science, Artificial Intelligence
Marta Gaviraghi, Giovanni Savini, Gloria Castellazzi, Fulvia Palesi, Nicolo Rolandi, Simone Sacco, Anna Pichiecchio, Valeria Mariani, Elena Tartara, Laura Tassi, Paolo Vitali, Egidio D'Angelo, Claudia A. M. Gandini Wheeler-Kingshott
Summary: This study developed a fully automated segmentation method for dentate nuclei (DNs) and tested it on healthy subjects and patients with Temporal Lobe Epilepsy (TLE). Results showed that using Convolutional Neural Network (CNN) yielded better segmentation results, showcasing its potential for accurate extraction of DNs from different resolution DWI data.
COMPUTATIONAL DIFFUSION MRI
(2021)
Proceedings Paper
Computer Science, Theory & Methods
Alessandra Trapani, Alberto Antonietti, Giovanni Naldi, Egidio D'Angelo, Alessandra Pedrocchi
Summary: The study found that a single active source of NO has a local effect on individual synapses, while multiple closely-located sources act more like a volume transmitter, influencing even inactive synapses within the area. In the cerebellum's input layer, NO produced by granule cells enhances pre-synaptic currents in mossy fiber - granule cell synapses, leading to long-term effects.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)
Proceedings Paper
Computer Science, Theory & Methods
Massimo Grillo, Alice Geminiani, Alberto Antonietti, Egidio D'Angelo, Alessandra Pedrocchi
Summary: The cerebellum plays a crucial role in motor control and learning, with the Deep Cerebellar Nuclei serving as the core of processing. By advancing spiking neural network models of the cerebellar nuclei, including nucleocortical pathways, more accurate simulations of cerebellum-driven tasks can be achieved to investigate signal integration between sensorimotor inputs and internal feedback.
2021 10TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2021)
