Article
Psychology, Multidisciplinary
Hanna Kedzierska, Karolina Rataj, Anna Balas, Zuzanna Cal, Chloe Castle, Magdalena Wrembel
Summary: The research found that in multilingual participants, MMN responses are sensitive to the differences between L1, L2, and L3/Ln, suggesting that foreign language status has an impact on early auditory processing.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Changcheng Sun, Zhuoyue Zhao, Longlong Cheng, Rong Tian, Wenchang Zhao, Jingang Du, Ying Zhang, Chunfang Wang
Summary: This study investigated the effects of transcranial direct current stimulation (tDCS) on children with Autism Spectrum Disorder (ASD). The results showed that combining anodal tDCS with conventional rehabilitation treatment can enhance the behavioral improvement in children with ASD. Additionally, the changes in evoked EEG signals were observed and found to correlate with the behavioral abilities of the children.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychiatry
Suguru Nakajima, Yuko Higuchi, Takahiro Tateno, Daiki Sasabayashi, Yuko Mizukami, Shimako Nishiyama, Tsutomu Takahashi, Michio Suzuki
Summary: The study found that the amplitude of duration mismatch negativity (dMMN) in first-episode schizophrenia patients may be a useful biomarker for predicting symptomatic remission and improvement of cognitive and social functions.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Bernd Feige, Chiara Baglioni, Philipp Boehm, Anna Heinrich, Samuel Trumm, Fee Benz, Christoph Nissen, Katharina Domschke, Lukas Frase, Dieter Riemann
Summary: The study found a reduced P2 amplitude in insomnia patients during phasic REM sleep, which was correlated with sleep misperception. Independent component analysis showed that frontal negativity played a key role in this group difference.
Article
Neurosciences
Muzhen Guan, Xufeng Liu, Li Guo, Ruiguo Zhang, Qingrong Tan, Huaihai Wang, Huaning Wang
Summary: The study investigated the combined effects of occipital repetitive transcranial magnetic stimulation (rTMS) and escitalopram oxalate tablets on pre-attentive processing in medication-naive patients with first-episode depression. The results showed that this combined treatment significantly improved symptoms and pre-attentive processing, providing a scientific basis for rTMS therapy in clinical depression patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Giulia M. Giordano, Luigi Giuliani, Andrea Perrottelli, Paola Bucci, Giorgio Di Lorenzo, Alberto Siracusano, Francesco Brando, Pasquale Pezzella, Michele Fabrazzo, Mario Altamura, Antonello Bellomo, Giammarco Cascino, Anna Comparelli, Palmiero Monteleone, Maurizio Pompili, Silvana Galderisi, Mario Maj
Summary: Impairment in functioning over time is a key aspect of subjects with schizophrenia. MMN and P3a, indices of early attention processing often impaired in schizophrenia, may represent optimal electrophysiological candidate biomarkers. Our results suggest that MMN amplitude reduction might serve as a biomarker for poor functioning in schizophrenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Nina Coy, Maria Bader, Erich Schroeger, Sabine Grimm
Summary: The study revealed that participants could use relative pitch to detect new melodic patterns even in the absence of absolute pitch sensitivity. Event-related potentials (ERPs) showed the importance of relative pitch in information extraction, with an increase in behavioral reaction time. The data indicated that ERP indicators MMN and P3a were elicited even with only relative pitch information available, suggesting an impact on higher-level processing.
Article
Audiology & Speech-Language Pathology
Yana Criel, Edward Baert, Jean-Pierre Kalala Okito, Giorgio Hallaert, Dirk Van Roost, Luc De Baerdemaeker, Wouter Degreve, Marijke Miatton, Patrick Santens, Pieter Van Mierlo, Miet De Letter
Summary: The present study aimed to investigate the pre- to postoperative evolution of neural phoneme perception processes in glioma patients and assess if event-related potentials (ERPs) reflecting phoneme perception can provide added value to the diagnostic approach in individuals undergoing awake surgery. Pre- and postoperative behavioural language assessment and electrophysiological investigation of phoneme perception were performed in five individuals undergoing an awake craniotomy for glioma resection. The results showed aberrant phoneme categorization processing preoperatively, but postoperative normalization of electrophysiological measures was observed, indicating a high potential for postsurgical plasticity.
Article
Clinical Neurology
Serkan Aksu, Atilla Uslu, Pinar Iscen, Emine Elif Tulay, Huzeyfe Barham, Ahmet Zihni Soyata, Asli Demirtas-Tatlidede, Gulsen Babacan Yildiz, Basar Bilgic, Hasmet Hanagasi, Adam J. Woods, Sacit Karamursel, Fatma Aytul Uyar
Summary: This study investigates the effects of transcranial direct current stimulation on cognitive functions in individuals with Parkinson's disease-mild cognitive impairment, and provides evidence of its efficacy and neural mechanisms.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Narges Moein, Reza Rostami, Reyhane Mohamadi, Reza Zomorrodi, Michael Nitsche, Amir Ostadi, Mohsen Shabani
Summary: This study investigates the correlation between stuttering severity and ERP measures, and finds differences not only between stutterers and fluent speakers, but also among different levels of stuttering severity.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Guzide Atalik, Suha Yagcioglu, Oznur Yigit, Erol Belgin, Eser Sendesen, Meral Didem Turkyilmaz
Summary: This study aimed to evaluate the reliability of MMN responses obtained through a 5-stimulus version of the MMN paradigm using a test-retest study. It also aimed to determine a reliable MMN recording number by comparing the MMN responses obtained under conditions of ten and four recordings while shortening the recording time.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Vasco Ribeiro Ferreira, Ana Rita Pereira, Joana Vieira, Frederico Pereira, Rui Marques, Guilherme Campos, Adriana Sampaio, Alberto Crego
Summary: Clinical auditory alarms in hospital environments need to be designed to convey priority without compromising other features. This study found that the Medium Priority pulse of the updated IEC60601-1-8 standard is more easily detected and attended at the neural level compared to the High Priority pulse. Behavioral experiments also showed shorter reaction times for the Medium Priority pulse. The study highlights the need for intervention in hospital soundscapes and auditory alarm design settings.
Article
Neurosciences
Elizabeth S. Norton, Sara D. Beach, Marianna D. Eddy, Sean McWeeny, Ola Ozernov-Palchik, Nadine Gaab, John D. E. Gabrieli
Summary: The amplitude of MMN may be related to phonological representations and the ability to manipulate them, while MMN laterality may reflect differences in brain processes that support the automaticity needed for reading.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Kelin M. Brace, Elyse S. Sussman
Summary: The study investigated how the brain maintains rhythmic predictions in the presence of multiple perceptual interpretations from the same sound source. Results showed that the brain can track multiple predictions about complexities in sound streams and automatically detect deviations with respect to these predictions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Ekaterina Yukhnovich, Kai Alter, William Sedley
Summary: We attempted to replicate a potential tinnitus biomarker called the Intensity Mismatch Asymmetry in humans based on the Sensory Precision Integrative Model of Tinnitus. The design included improvements such as tighter matching of participants for gender and using a control stimulus frequency to investigate differences specific to tinnitus. However, no significant group differences were found, though there were differences in response amplitude and deviant direction effects between tinnitus and control groups at different frequencies.
Article
Psychology, Clinical
Zuzana Forejtova, Tereza Serranova, Tomas Sieger, Matej Slovak, Lucia Novakova, Gabriela Vechetova, Evzen Ruzicka, Mark J. Edwards
Summary: The study explored the relationships between various symptoms in FND patients and found significant correlations between self-reported and objective measures of motor and non-motor symptoms, as well as HRQoL. Despite attempting to identify subgroups within the cohort, cluster analysis showed a homogenous patient sample, supporting the idea of a unified pathophysiology for these symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Clinical Neurology
Anne-Catherine M. L. Huys, Patrick Haggard, Kailash P. Bhatia, Mark J. Edwards
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Engineering, Biomedical
Zhongxi Li, Angel Peterchev, John C. Rothwell, Stefan M. Goetz
Summary: This paper presents a detection method that extracts motor-evoked potentials (MEPs) hidden below noise floor, in order to estimate excitatory activations of the corticospinal pathways below conventional detection level. The method utilizes a self-learning matched-filter approach to improve robustness against noise and extends the dynamic range. Results show that the proposed method significantly increases the signal-to-noise ratio compared to conventional peak-to-peak measure.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Gabriela Vechetova, Tomas Nikolai, Matej Slovak, Zuzana Forejtova, Marek Vranka, Eva Strakova, Tiago Teodoro, Evzen Ruzicka, Mark J. Edwards, Tereza Serranova
Summary: This study found both subjective and objective cognitive impairments in patients with mFND, characterized primarily by attentional impairment including slow processing speed and high intra-individual variability in cognitive performance.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Anne-Catherine M. L. Huys, Patrick Haggard, Kailash P. Bhatia, Mark J. Edwards
Summary: This study aimed to test whether patients with functional tremor exaggerate their symptom perception and reporting. The results showed that compared to patients with organic tremor and healthy controls, patients with functional tremor did not perceive or report their tremor to be exaggerated.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Mirta Fiorio, Miriam Braga, Angela Marotta, Bernardo Villa-Sanchez, Mark J. Edwards, Michele Tinazzi, Diletta Barbiani
Summary: Functional neurological disorder (FND) refers to neurological symptoms that cannot be explained by structural neurological causes. The Bayesian predictive coding model suggests that perception relies on top-down cortical predictions to infer sensory information. This model may also apply to placebo and nocebo effects. The relationship between FND and placebo and nocebo effects extends beyond diagnosis and treatment, and shared cognitive, personality, and neuroanatomical factors may be involved. This new perspective offers potential insights into the pathogenesis of FND and the identification of therapeutic targets.
NATURE REVIEWS NEUROLOGY
(2022)
Review
Clinical Neurology
Andrea Quattrone, Anna Latorre, Francesca Magrinelli, Eoin Mulroy, Roopa Rajan, Ray Jen Neo, Aldo Quattrone, John C. Rothwell, Kailash P. Bhatia
Summary: In this review, we discuss the clinical and pathophysiological aspects of various motor phenomena in patients with movement disorders. These phenomena, including mirror movements and dystonic overflow, share some similarities but also differ in terms of the body part involved, the type of movement, and the underlying neurological condition. We aim to improve the clinical recognition and standardize the terminology of these fascinating clinical signs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Medicine, Research & Experimental
Louise Marston, Marie Le Novere, Federico Ricciardi, Irwin Nazareth, Alan Carson, Mark Edwards, Laura H. Goldstein, Jonathan Marsden, Hayley Noble, Markus Reuber, Jon Stone, Rachael M. Hunter, Glenn Nielsen
Summary: Functional motor disorder (FMD) is a common neurological condition that causes symptoms such as weakness and tremor. The Physio4FMD trial aims to evaluate the effectiveness and cost effectiveness of specialist physiotherapy for FMD. The trial was impacted by the COVID-19 pandemic, leading to disruptions in the treatment of participants. The analysis plans have been adjusted to account for these disruptions and maintain the integrity of the trial while providing meaningful results.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Letter
Clinical Neurology
Duncan Austin, John Rothwell
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Clinical Neurology
Anna Latorre, Daniele Belvisi, John C. Rothwell, Kailash P. Bhatia, Lorenzo Rocchi
Summary: Cortical myoclonus is a result of abnormal electrical discharges in the sensorimotor cortex. Electrophysiological criteria for diagnosing cortical myoclonus have been proposed, but their application can be challenging. Combining observations from multiple tests is necessary to increase the diagnostic accuracy of cortical myoclonus. Further research is needed to standardize methods, resolve methodological issues, establish diagnostic criteria sensitivity and specificity, and develop additional methods to clarify the pathophysiology of myoclonus.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Anna Sadnicka, Mark John Edwards
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Po-Yu Fong, Danny Spampinato, Kevin Michell, Marco Mancuso, Katlyn Brown, Jaime Ibanez, Alessandro Di Santo, Anna Latorre, Kailash Bhatia, John C. Rothwell, Lorenzo Rocchi
Summary: The study found that magnetically-induced activity in the cerebral cortex can provide valuable insights into the connectivity between the cortex and the cerebellum, as well as the function of the cerebellum. By using this method, researchers were able to detect brain activity evoked by cerebellar stimulation and demonstrated its involvement in learning and executing complex behaviors.
Article
Clinical Neurology
Sara A. Finkelstein, Alan Carson, Mark J. Edwards, Kasia Kozlowska, Sarah C. Lidstone, David L. Perez, Ginger Polich, Jon Stone, Selma Aybek
NEUROLOGIC CLINICS
(2023)
Article
Geriatrics & Gerontology
Hsiang-Yu Chen, Jourdan H. Parent, Claire J. Ciampa, Martin J. Dahl, Dorothea Haemmerer, Anne Maass, Joseph R. Winer, Renat Yakupov, Ben Inglis, Matthew J. Betts, Anne S. Berry
Summary: This study explored the role of locus coeruleus (LC) structure in catecholamine function and cognitive performance. The findings suggest that LC structure is associated with cognitive performance, and the interaction between LC structure and catecholamine synthesis capacity is particularly important for executive function and processing speed.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
