Article
Anatomy & Morphology
Brenton Hordacre, Mitchell R. Goldsworthy, Lynton Graetz, Michael C. Ridding
Summary: This research investigated the impact of baseline resting state functional connectivity on responses to continuous theta burst stimulation (cTBS). The results showed that a low beta frequency band model of connectivity played a crucial role in determining responses to spaced cTBS, suggesting that M1-frontocentral networks may have an important role in the effects of cTBS on corticospinal excitability.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Clinical Neurology
Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Summary: The study examined the effects of subthreshold rTMS on structural synaptic plasticity in the mouse motor cortex of young and aged mice. The results showed that subthreshold rTMS can alter the rate of dendritic spine losses and gains, and effectively drive structural synaptic plasticity in both young adult and aged mice.
Article
Multidisciplinary Sciences
Pasquale Cardellicchio, Elisa Dolfini, Alessandro D'Ausilio
Summary: Evidence suggests that human sensorimotor interaction requires mutual behavioral adaptation and shared cognitive task representations. It has been shown that the left dorsal premotor cortex plays a role in sculpting movements and modulating stopping performance in joint action coordination.
Article
Neurosciences
Elana R. Goldenkoff, Joseph A. Deluisi, Danielle P. Destiny, Taraz G. Lee, Katherine J. Michon, James A. Brissenden, Stephan F. Taylor, Thad A. Polk, Michael Vesia
Summary: This study investigates the interaction between stimulation and brain state by applying intermittent theta burst stimulation to the parietal cortex. The results show that parietal stimulation during a behavioral manipulation can increase the excitability of downstream motor cortex and improve motor performance, compared to stimulation during rest.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Behavioral Sciences
Antonio Martin, Timothy J. Lane, Tzu-Yu Hsu
Summary: Neuroimaging and lesion studies suggest that the dorsolateral prefrontal and posterior parietal cortices play a role in visual metacognitive awareness. However, the causal evidence provided by non-invasive brain stimulation is inconsistent. This study re-evaluated a figure discrimination experiment and added a new task to investigate the effects of bilateral continuous theta-burst transcranial magnetic stimulation (cTBS) on perceptual metacognition.
Article
Neurosciences
Nicholas Yeh, Jessica D. Payne, Sara Y. Kim, Elizabeth A. Kensinger, Joshua D. Koen, Nathan S. Rose
Summary: This study investigated the role of mPFC in emotional memory encoding using transcranial magnetic stimulation. The results showed that mPFC activity interacts with consolidation processes to enhance the preservation of negatively salient information.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Carl Johan Ekman, Katarzyna Popiolek, Robert Boden, Axel Nordenskjold, Johan Lundberg
Summary: This study investigated the effectiveness and tolerability of intermittent Theta-burst stimulation (iTBS) in a clinical setting. The results showed that iTBS was safe and well-tolerated, and the response rate was similar to that reported in clinical trials. Older age and milder illness predicted a better treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Andrea Guerra, Francesco Asci, Alessandro Zampogna, Valentina D'Onofrio, Alfredo Berardelli, Antonio Suppa
Summary: The study showed that the effects of transcranial alternating current stimulation (tACS) on long-term potentiation (LTP)-like plasticity of the primary motor cortex (M1) are significantly reduced in older adults compared to young adults.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Katarina Hosel, Francois Tremblay
Summary: This study investigates the lasting facilitation of corticospinal excitability induced by 30 Hz/6 Hz iTBS. Most participants showed MEP facilitation post iTBS, and recruitment of early I-waves appears to predict this facilitation effect.
Article
Neurosciences
Carly A. Lasagna, Stephan F. Taylor, Taraz G. Lee, Saige Rutherford, Tristan Greathouse, Pan Gu, Ivy F. Tso
Summary: The study found that cTBS applied to V2 does not create blind spots in the central visual field during a simple detection task. Future research should investigate subtler changes to vision and downstream visual perception.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Cheng-Ta Li, Chi-Hung Juan, Hui-Ching Lin, Chih-Ming Cheng, Hui-Ting Wu, Bang-Hung Yang, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This study is the first to reveal the underlying molecular mechanisms of the fronto-limbic circuit in individuals with major depressive disorder and demonstrates the differential modulation of neurotransmitter systems by rTMS and iTBS.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Prabhjot Dhami, Sravya Atluri, Jonathan Lee, Yuliya Knyahnytska, Paul E. Croarkin, Daniel M. Blumberger, Zafiris J. Daskalakis, Faranak Farzan
Summary: The study found that cortical reactivity in the left DLPFC was associated with changes in depressive symptoms. TBS treatment was shown to alter cortical reactivity in the right IPL, distal to the treatment sites, and was correlated with baseline fMRI connectivity.
DEPRESSION AND ANXIETY
(2021)
Article
Cell Biology
Tian Rui Zhang, Evelyn Guilherme, Aydan Kesici, Alyssa M. Ash, Fidel Vila-Rodriguez, Jason S. Snyder
Summary: This study investigated the acute effects of ECS and rTMS on cell proliferation and neurogenesis in the adult hippocampus, finding that ECS transiently increased cell proliferation at 3 days post-stimulation and significantly increased proliferating neuronal precursor cells at 7 days post-stimulation. Contrastingly, iTBS and rTMS did not affect the number of cells, proliferating cells, or immature neurons at any time point post-stimulation.
Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Sabrina Sghirripa, Lynton Graetz, Ashley Merkin, Nigel C. Rogasch, Michael C. Ridding, John G. Semmler, Mitchell R. Goldsworthy
Summary: The study found that neural resources are directed towards processing task-relevant information and ignoring distractors during working memory tasks. Parieto-occipital alpha power increases before the presentation of a distractor, but there is no evidence that alpha power is further modulated by distractor strength.
Article
Neurosciences
Ann-Maree Vallence, Kathryn Dansie, Mitchell R. Goldsworthy, Suzanne M. McAllister, Ruiting Yang, John C. Rothwell, Michael C. Ridding
Summary: The study found no significant differences in corticospinal excitability or GABAergic inhibition when triggering transcranial magnetic stimuli on the up- or down-going phase of a tACS-induced alpha oscillation.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Mitchell R. Goldsworthy, Brenton Hordacre, John C. Rothwell, Michael C. Ridding
Summary: Repetitive transcranial magnetic stimulation (rTMS) has opened up exciting possibilities for inducing neuroplasticity in the human cortex, but the large inter-individual variability in its effects raises questions about its reliability in guiding therapeutic application. Despite advancements in neuroimaging approaches, the high variability of rTMS effects outside the motor cortex remains a significant issue for the field to address.
Article
Clinical Neurology
Ashleigh E. Smith, Dorothea Dumuid, Mitchell R. Goldsworthy, Lynton Graetz, Nicolette Hodyl, Nicollette L. R. Thornton, Michael C. Ridding
Summary: The study found that engaging in more physical activity, particularly light physical activities, at the expense of sleep and sedentary behavior is associated with greater motor cortical neuroplasticity in older adults. This suggests the promotion of physical activity among older adults to support brain neuroplasticity.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Anatomy & Morphology
Brenton Hordacre, Mitchell R. Goldsworthy, Lynton Graetz, Michael C. Ridding
Summary: This research investigated the impact of baseline resting state functional connectivity on responses to continuous theta burst stimulation (cTBS). The results showed that a low beta frequency band model of connectivity played a crucial role in determining responses to spaced cTBS, suggesting that M1-frontocentral networks may have an important role in the effects of cTBS on corticospinal excitability.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Medicine, General & Internal
Ashleigh E. Smith, Alexandra T. Wade, Timothy Olds, Dorothea Dumuid, Michael J. Breakspear, Kate Laver, Mitchell R. Goldsworthy, Michael C. Ridding, Monica Fabiani, Jillian Dorrian, Montana Hunter, Bryan Paton, Mahmoud Abdolhoseini, Fayeem Aziz, Maddison L. Mellow, Clare Collins, Karen J. Murphy, Gabriele Gratton, Hannah Keage, Ross T. Smith, Frini Karayanidis
Summary: This study aims to explore the associations between time-use and diet compositions with cognition and brain function, and identify optimal time-use behaviors and diet compositions for optimizing cognition and brain function.
Review
Geriatrics & Gerontology
Maddison L. Mellow, Alyson J. Crozier, Dorothea Dumuid, Alexandra T. Wade, Mitchell R. Goldsworthy, Jillian Dorrian, Ashleigh E. Smith
Summary: This systematic review examines the associations between cognitive function and physical activity, sleep, and sedentary behavior in older adults. The findings indicate that increasing physical activity and reducing sedentary behavior are broadly linked to better cognitive outcomes in older adults. It is suggested that certain types of sedentary behavior, such as reading or computer use, may be positively associated with cognitive function. Sleep duration follows an inverted U-shaped relationship with cognition, as both too much and too little sleep are negatively associated with cognitive function.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Geriatrics & Gerontology
Ashley Merkin, Sabrina Sghirripa, Lynton Graetz, Ashleigh E. Smith, Brenton Hordacre, Richard Harris, Julia Pitcher, John Semmler, Nigel C. Rogasch, Mitchell Goldsworthy
Summary: The alpha-band oscillatory activity in human electroencephalography (EEG) becomes slower and lower in amplitude with age. This study investigated the role of aperiodic activity in age-related differences in resting EEG peak alpha frequency and power. The results showed that older adults had smaller aperiodic exponent and offset compared to younger participants, indicating a flatter slope and downward shift in power spectra with age. After correcting for aperiodic activity, peak alpha frequency remained slower in older adults, but there was no statistically significant difference in peak alpha power between age groups. These findings emphasize the importance of considering the aperiodic component when studying neural oscillatory activity in aging.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Marcus T. Wilson, Mitchell R. Goldsworthy, Ann-Maree Vallence, Alex Fornito, Nigel C. Rogasach
Summary: The study aimed to find the best fitting model for motor evoked potentials (MEPs) using measured input-output (IO) data. Existing IO data before and after intermittent and continuous theta-burst stimulation (iTBS & cTBS) were analyzed, and individual synaptic couplings and sensitivity parameters were fitted using variations of a biophysical model. The best performing model was selected and analyzed. Results showed that cTBS led to a broad reduction in MEPs for amplitudes larger than resting motor threshold (RMT), while iTBS caused strong potentiation near threshold. The model captured individual IO curves and found a correlation between change in excitatory-to-excitatory synaptic coupling and post-TBS response.
Article
Neurosciences
Maddison L. Mellow, Dorothea Dumuid, Alexandra T. Wade, Ty Stanford, Timothy S. Olds, Frini Karayanidis, Montana Hunter, Hannah A. D. Keage, Jillian Dorrian, Mitchell R. Goldsworthy, Ashleigh E. Smith
Summary: This study aimed to investigate the association between 24-h time-use composition and cognitive function in healthy older adults. The results showed no significant associations between time-use composition and global cognition, long-term memory, short-term memory, executive function, or processing speed outcomes, highlighting the need for longitudinal studies to uncover temporal effects.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Claire Xian, Chiara Barbi, Mitchell R. Goldsworthy, Massimo Venturelli, Simranjit K. Sidhu
Summary: This study investigated the effects of transcranial direct current stimulation (tDCS) on fatigue and corticospinal excitability in people with multiple sclerosis (pwMS). It was found that while cathodal tDCS priming followed by anodal tDCS increased corticospinal excitability in healthy individuals, this effect was not observed in pwMS, suggesting impaired metaplasticity. Furthermore, tDCS did not significantly impact the magnitude of fatigue, implying that fatigue development may not rely on changes in corticospinal excitability. These findings provide insights into the effects of tDCS in pwMS and highlight differences that may be relevant to the disease pathophysiology.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Geriatrics & Gerontology
Ann-Maree Vallence, Rachael D. Seidler, Mitchell Ryan Goldsworthy, John G. Semmler, George M. Opie
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Jago M. Van Dam, Lynton Graetz, Julia B. Pitcher, Mitchell R. Goldsworthy
Summary: The neuroplastic response to continuous theta burst stimulation (cTBS) is variable and age and sex may influence the association between I-wave recruitment and the response to cTBS.
Article
Neurosciences
Sabrina Sghirripa, Lynton Graetz, Nigel C. Rogasch, John G. Semmler, Mitchell R. Goldsworthy
Summary: Selective attention and working memory are susceptible to age-related decline. This study investigated whether cueing the presentation time of a memory set modulates alpha power. The results showed that predictive cues increased working memory storage and older adults exhibited weaker alpha suppression during the preparatory period.
BRAIN AND COGNITION
(2022)
Article
Psychology, Biological
Sabrina Sghirripa, Lynton Graetz, Ashley Merkin, Nigel C. Rogasch, John G. Semmler, Mitchell R. Goldsworthy
Summary: The study demonstrates that when verbal working memory performance is matched across age groups, alpha power and frequency are modulated in a similar task- and load-dependent manner in both young and older adults.
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
