Lysine residues in the N-terminal huntingtin amphipathicα-helix play a key role in peptide aggregation

A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy

(2014) Randy Singh Atwal et al.   Autophagy

Aggregation Behavior of Chemically Synthesized, Full-Length Huntingtin Exon1

(2014) Bankanidhi Sahoo et al.   BIOCHEMISTRY

Membrane Interactions of the Amphipathic Amino Terminus of Huntingtin

(2013) Matthias Michalek et al.   BIOCHEMISTRY

Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner

(2013) Kathleen A. Burke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR Approach

(2013) Matthias Michalek et al.   BIOPHYSICAL JOURNAL

The Interaction of Polyglutamine Peptides with Lipid Membranes Is Regulated by Flanking Sequences Associated with Huntingtin

(2013) Kathleen A. Burke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Hairpin-Mediated Nucleation of Polyglutamine Amyloid Formation

(2013) Karunakar Kar et al.   JOURNAL OF MOLECULAR BIOLOGY

The Effects of Flanking Sequences in the Interaction of Polyglutamine Peptides with a Membrane Bilayer

(2013) Anu Nagarajan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Pepsin Immobilized on High-Strength Hybrid Particles for Continuous Flow Online Digestion at 10 000 psi

(2012) Joomi Ahn et al.   ANALYTICAL CHEMISTRY

Site-Specific Analysis of Gas-Phase Hydrogen/Deuterium Exchange of Peptides and Proteins by Electron Transfer Dissociation

(2012) Kasper D. Rand et al.   ANALYTICAL CHEMISTRY

Structure and Dynamics of Small Soluble Aβ(1–40) Oligomers Studied by Top-Down Hydrogen Exchange Mass Spectrometry

(2012) Jingxi Pan et al.   BIOCHEMISTRY

Kinetically Competing Huntingtin Aggregation Pathways Control Amyloid Polymorphism and Properties

(2012) Murali Jayaraman et al.   BIOCHEMISTRY

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry

(2012) John R. Engen et al.   INTERNATIONAL REVIEWS IN PHYSICAL CHEMISTRY

Identification of Novel Potentially Toxic Oligomers Formedin Vitrofrom Mammalian-derived Expanded huntingtin Exon-1 Protein

(2012) Leslie G. Nucifora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Features and Domain Organization of Huntingtin Fibrils

(2012) Charles W. Bugg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of the ETD/PTR reactions in top-down proteomics as a faster alternative to bottom-up nanoLC-MS/MS protein identification

(2012) A. Drabik et al.   JOURNAL OF MASS SPECTROMETRY

Serine Phosphorylation Suppresses Huntingtin Amyloid Accumulation by Altering Protein Aggregation Properties

(2012) Rakesh Mishra et al.   JOURNAL OF MOLECULAR BIOLOGY

Platform Dependencies in Bottom-up Hydrogen/Deuterium Exchange Mass Spectrometry

(2012) Kyle M. Burns et al.   MOLECULAR & CELLULAR PROTEOMICS

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

(2011) Yury O. Tsybin et al.   ANALYTICAL CHEMISTRY

Conformer-Specific Hydrogen Exchange Analysis of Aβ(1–42) Oligomers by Top-Down Electron Capture Dissociation Mass Spectrometry

(2011) Jingxi Pan et al.   ANALYTICAL CHEMISTRY

Structural Insights into the Pre-Amyloid Tetramer of β-2-Microglobulin from Covalent Labeling and Mass Spectrometry

(2011) Vanessa Leah Mendoza et al.   BIOCHEMISTRY

Hydrogen/Deuterium Exchange and Electron-Transfer Dissociation Mass Spectrometry Determine the Interface and Dynamics of Apolipoprotein E Oligomerization

(2011) Richard Y-C. Huang et al.   BIOCHEMISTRY

Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptides

(2011) Andreas Vitalis et al.   BIOPHYSICAL CHEMISTRY

Conformations of the Huntingtin N-term in aqueous solution from atomistic simulations

(2011) Giulia Rossetti et al.   FEBS LETTERS

Structural Characterization of Polyglutamine Fibrils by Solid-State NMR Spectroscopy

(2011) Robert Schneider et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibiting the Nucleation of Amyloid Structure in a Huntingtin Fragment by Targeting α-Helix-Rich Oligomeric Intermediates

(2011) Rakesh Mishra et al.   JOURNAL OF MOLECULAR BIOLOGY

Slow Amyloid Nucleation via α-Helix-Rich Oligomeric Intermediates in Short Polyglutamine-Containing Huntingtin Fragments

(2011) Murali Jayaraman et al.   JOURNAL OF MOLECULAR BIOLOGY

Secondary Structures of Native and Pathogenic Huntingtin N-Terminal Fragments

(2011) Maciej Długosz et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

(2011) V. N. Sivanandam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Automated Hydrogen/Deuterium Exchange Electron Transfer Dissociation High Resolution Mass Spectrometry Measured at Single-Amide Resolution

(2011) Rachelle R. Landgraf et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Conformational Transitions in the Membrane Scaffold Protein of Phospholipid Bilayer Nanodiscs

(2011) Christopher R. Morgan et al.   MOLECULAR & CELLULAR PROTEOMICS

Kinase inhibitors modulate huntingtin cell localization and toxicity

(2011) Randy Singh Atwal et al.   Nature Chemical Biology

Charge state dependent top-down characterisation using electron transfer dissociation

(2011) Marko Rožman et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Characterizing Short-Lived Protein Folding Intermediates by Top-Down Hydrogen Exchange Mass Spectrometry

(2010) Jingxi Pan et al.   ANALYTICAL CHEMISTRY

Structure of the Preamyloid Dimer of β-2-Microglobulin from Covalent Labeling and Mass Spectrometry

(2010) Vanessa Leah Mendoza et al.   BIOCHEMISTRY

Investigation of amide hydrogen back-exchange in Asp and His repeats measured by hydrogen (1H/2H) exchange mass spectrometry

(2010) Kasper D. Rand et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Mannerin Vitroandin Vivo

(2010) Justin Legleiter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool

(2010) Maya A. Olshina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated

(2010) Ravindra Kodali et al.   JOURNAL OF MOLECULAR BIOLOGY

Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy

(2010) Kathleen A. Burke et al.   METHODS

Surrogate H/D Detection Strategy for Protein Conformational Analysis Using MS/MS Data

(2009) Andrew J. Percy et al.   ANALYTICAL CHEMISTRY

The Predicted Structure of the Headpiece of the Huntingtin Protein and Its Implications on Huntingtin Aggregation

(2009) Nicholas W. Kelley et al.   JOURNAL OF MOLECULAR BIOLOGY

Modulation of Polyglutamine Conformations and Dimer Formation by the N-Terminus of Huntingtin

(2009) Tim E. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

Hydrogen/Deuterium Exchange Mass Spectrometry with Top-Down Electron Capture Dissociation for Characterizing Structural Transitions of a 17 kDa Protein

(2009) Jingxi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

(2009) Ashwani K Thakur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

(2009) Xiaofeng Gu et al.   NEURON

Secondary Structure of Huntingtin Amino-Terminal Region

(2009) Mee Whi Kim et al.   STRUCTURE

Throughput and Efficiency of a Mass Spectrometry-Based Screening Assay for Protein–Ligand Binding Detection

(2008) E HOPPER et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY