Journal
CLINICAL NEUROPATHOLOGY
Volume 33, Issue 2, Pages 108-111Publisher
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/NP300758
Keywords
gliomas; genomic; aberrations; molecular biomarker; ATRX; IDH; 1p/19q
Categories
Ask authors/readers for more resources
Genome-wide molecular approaches have substantially elucidated molecular alterations and pathways involved in the oncogenesis of brain tumors. In gliomas, several molecular biomarkers including IDH mutation, 1p/19q co-deletion, and MGMT promotor methylation status have been introduced into neuropathological practice. Recently, mutations of the ATRX gene have been found in various subtypes and grades of gliomas and were shown to refine the prognosis of malignant gliomas in combination with IDH and 1p/19q status. Mutations of ATRX are associated with loss of nuclear ATRX protein expression, detectable by a commercially available antibody, thus turning ATRX into a promising prognostic candidate biomarker in the routine neuropathological setting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available