Article
Oncology
Yoon Jung Kim, Hyongmin Oh, Sang Jin Lee, Kyung-Min Kim, Ho Kang, Chul-Kee Park, Hee-Pyoung Park
Summary: This study retrospectively collected data from 335 glioblastoma patients and found that high postoperative PNI was associated with improved overall survival, indicating the importance of perioperative changes in PNI for prognostic prediction in GBM patients.
Article
Medicine, General & Internal
Georgiana Serban, Flaviu Tamas, Rodica Balasa, Doina Manu, Corina Tamas, Adrian Balasa
Summary: This retrospective study assessed the impact of clinical and imaging features on the survival of 75 patients with glioblastoma multiforme (GBM). The results showed that tumor size, pre- and postoperative KPSI had a significant impact on survival rate.
Article
Oncology
Nicholas F. Brown, Diego Ottaviani, John Tazare, John Gregson, Neil Kitchen, Sebastian Brandner, Naomi Fersht, Paul Mulholland
Summary: The study examined the survival of 490 real-world patients with glioblastoma and identified factors such as age, surgery, post-surgical treatment, and MGMT promotor methylation as predictors of longer survival. The average survival of patients was 9 months.
Article
Clinical Neurology
Changjun Rao, Jinghao Jin, Jianglong Lu, Chengde Wang, Zerui Wu, Zhangzhang Zhu, Ming Tu, Zhipeng Su, Qun Li
Summary: This study constructed a risk score based on preoperative peripheral blood tests and conventional MRI to predict the prognosis of GBM patients. The developed nomogram model exhibited appropriate predictive power, and vascular endothelial growth factor A (VEGFA) was identified as the key peripheral blood test-related gene associated with poor prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Zhuo-yi Liu, Song-shan Feng, Yi-hao Zhang, Li-yang Zhang, Sheng-chao Xu, Jing Li, Hui Cao, Jun Huang, Fan Fan, Li Cheng, Jun-yi Jiang, Quan Cheng, Zhi-xiong Liu
Summary: This study identified prognostic factors and optimal treatment for elderly patients with glioblastoma (GBM) through analyzing data from a large cohort. Factors such as age, race, tumor size, and tumor location were found to affect GBM-related mortality, with gross total resection, radiotherapy, chemotherapy, and chemoRT being protective factors for GBM-related death. A nomogram was developed to predict mortality rates, with GTR followed by chemoRT being suggested as the optimal treatment option.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Xiaodong Niu, Tao Chang, Yuan Yang, Qing Mao
Summary: A predictive nomogram model was developed to investigate prognostic factors and survival probability in elderly GBM patients. The model can provide clinical references for treatment strategies and prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Marco Chiappetta, Vittorio Aprile, Filippo Lococo, Edoardo Zanfrini, Dania Nachira, Elisa Meacci, Stylianos Korasidis, Marcello Ambrogi, Marco Lucchi, Stefano Margaritora
Summary: The number of involved structures and concomitant involvement of the pericardium may be correlated with poor prognosis in surgically treated advanced thymoma patients.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Waseem Masalha, Dieter Henrik Heiland, Christine Steiert, Marie T. Krueger, Daniel Schnell, Christian Scheiwe, Oliver Schnell, Anca-L Grosu, Juergen Beck, Juergen Grauvogel
Summary: The study concluded that gross total resection is the most important prognostic factor for lower recurrence rates and longer progression-free survival in patients with spheno-orbital meningioma. Tumors invading the cavernous sinus and intraconal region showed significantly worse PFS compared to other locations. Postoperative high-precision radiotherapy did not lead to significantly better PFS outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Oriane Lie, Thierry Virolle, Mathieu Gabut, Claude Pasquier, Ilyess Zemmoura, Corinne Auge-Gouillou
Summary: This study investigates the expression of SETMAR protein in glioblastoma tissues and its potential as a prognostic marker. The results suggest that the level of S-SETMAR in the perilesional brain is associated with better survival outcomes in glioblastoma patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Isabella Frigerio, Giuseppe Malleo, Matteo de Pastena, Giacomo Deiro, Niccolo Surci, Filippo Scopelliti, Alessandro Esposito, Paolo Regi, Alessandro Giardino, Valentina Allegrini, Claudio Bassi, Roberto Girelli, Roberto Salvia, Giovanni Butturini
Summary: This study investigated the oncologic outcomes of patients with initially oligometastatic pancreatic ductal adenocarcinoma who underwent background resection following complete regression of liver metastases. The results showed promising outcomes, and factors such as absence of vascular involvement of the primary tumor, good nutritional status, and low inflammatory index scores could be useful in selecting candidates for resection.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Clinical Neurology
Sotirios Katsigiannis, Stefan Grau, Boris Krischek, Kadir Er, Bogdan Pintea, Roland Goldbrunner, Pantelis Stavrinou
Summary: Stratifying GBM patients according to their MGMT promoter methylation status revealed different prognostic factors and resection thresholds. Extent of resection was an independent predictor of survival for unmethylated MGMT patients, while residual tumor volume, Karnofsky Performance Score, and age were independent prognostic factors for methylated MGMT patients.
Article
Multidisciplinary Sciences
Celine Garrett, Therese M. Becker, David Lynch, Joseph Po, Wei Xuan, Kieran F. Scott, Paul de Souza
Summary: This study analyzed the correlation between pre- and post-operative inflammatory markers NLR and PNI, and other prognostic clinicopathological variables in GBM patients. It was found that extent of resection, post-operative ECOG, daily dexamethasone use, and IDH mutation were significant prognostic factors for patient survival. Post-operative PNI may have a better predictive value for survival outcome.
Article
Oncology
Jiahui Huang, Yiwei Tong, Xiaosong Chen, Kunwei Shen
Summary: In the recent era of breast cancer treatment, the rate of LRR is relatively low. Tumor size and lymph node status are associated with the risk of LRR, and salvage surgery for selected LRR patients can achieve excellent outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiuchang Sun, Yinsheng Chen, Chaofeng Liang, Yuanshen Zhao, Xiaofei Lv, Yan Zou, Kai Yan, Hairong Zheng, Dong Liang, Zhi-Cheng Li
Summary: This study investigated the biological significance of radiomics in glioblastomas using four datasets. By analyzing MRI and RNA sequencing data, four prognostic radiomics phenotypes correlated with distinct biological pathways were identified, and the importance of the RadGene score in prognosis was confirmed.
Article
Oncology
Emilie Le Rhun, Felix Boakye Oppong, Maureen Vanlancker, Roger Stupp, Burt Nabors, Olivier Chinot, Wolfgang Wick, Matthias Preusser, Thierry Gorlia, Michael Weller
Summary: Myelosuppression during temozolomide chemoradiotherapy is associated with the survival of patients with newly diagnosed glioblastoma. Female patients experience more marrow toxicity than males. Lymphopenia is related to the overall survival of patients.
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)