Article
Endocrinology & Metabolism
Anahid Hamidianjahromi, Nicholas A. Tritos
Summary: Dopamine agonists (DAs), commonly used for hyperprolactinemia and prolactinomas, may lead to impulse control disorders (ICDs) such as gambling addiction, compulsive shopping, and hypersexuality. Diagnosing ICDs in patients receiving DAs requires suspicion and screening questionnaires. Patients with ICDs should discontinue or reduce DA therapy and receive psychiatric consultation and cognitive behavioral therapy.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Endocrinology & Metabolism
Matheo Augusto Morandi Stumpf, Felipe Moura Maia Pinheiro, Gilberto Ochman Silva, Valter Angelo Sperling Cescato, Nina Rosa Castro Musolino, Malebranche Berardo Carneiro Cunha-Neto, Andrea Glezer
Summary: Dopamine agonists (DA) are the preferred treatment for prolactinoma and hyperprolactinemia. However, intolerance to DA can occur in 3 to 12% of cases, leading to treatment discontinuation. This review discusses the definition, pathogenesis, frequency, and management of DA intolerance, as well as introduces a case report on the use of intravaginal cabergoline.
Article
Endocrinology & Metabolism
Craig Edward Stiles, Guy Lloyd, Sanjeev Bhattacharyya, Richard Paul Steeds, Kambiz Boomla, Jonathan Paul Bestwick, William Martyn Drake
Summary: The study found that there was no significant association between low-dose cabergoline treatment for prolactinoma and clinically significant valvulopathy. Results showed that the proportion of patients undergoing valve surgery or heart failure was similar between cabergoline-treated patients and the control group, and statistical analysis did not demonstrate a clear correlation between cabergoline treatment and cardiac complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Yanyang Zeng, Qingliang Huang, Yunzhi Zou, Jiacong Tan, Wu Zhou, Meihua Li
Summary: This study conducted a systematic review and meta-analysis and found that CV is as effective as cabergoline and bromocriptine in treating hyperprolactinemia, with no significant side effects. Therefore, this drug could be considered as an alternative first-line or rescue treatment in the future.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Camille Hage, Roberto Salvatori
Summary: The study found that there is a significant decrease in prolactin levels in prolactinomas patients upon initiating treatment with dopamine agonists, making it difficult to establish a definitive threshold for the diagnosis of prolactinoma.
Article
Clinical Neurology
Bahar K. Force, Kristen Staggers, Sherly Sebastian, Masayoshi Takashima, Daniel Yoshor, Susan L. Samson
Summary: Endoscopic endonasal resection is a viable option for managing patients with prolactinomas in a high-volume pituitary center, with minimal postoperative complications. The primary indications for surgery include patient preference, DA intolerance, and DA failure. The majority of patients achieved early remission and only a small number experienced recurrence during follow-up.
WORLD NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Hira Irfan, Waqas Shafiq, Ahmed Imran Siddiqi, Sara Ashfaq, Sadaf Attaullah, Asim Munir Alvi, Sardar Ali Khan, Muhammad Abu Bakar, Umal Azmat
Summary: This study reviewed the clinical presentation, treatment modalities, and therapeutic outcomes of patients with prolactinomas in the South Asia region. The results showed that menstrual irregularity/amenorrhea and visual disturbance were the most common symptoms. Dopamine agonists effectively reduced the size of prolactinomas and normalized prolactin levels. Cabergoline was more effective than bromocriptine in the treatment of prolactinomas.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
Yunzhi Zou, Depei Li, Jiayu Gu, Siyu Chen, Xia Wen, Jiajun Dong, Xiaobing Jiang
Summary: The study revealed a very low recurrence rate of prolactinomas after withdrawal of DAs, with a recurrence proportion of 2%. More prospective studies with larger sample sizes and longer follow-up periods are encouraged to confirm this finding.
BMC ENDOCRINE DISORDERS
(2021)
Article
Medicine, General & Internal
Tse-Yu Chen, Chung-Hsin Lee, Meng-Yin Yang, Chiung-Chyi Shen, Yin-Ping Yang, Yueh Chien, Yu-Fen Huang, Chih-Ming Lai, Wen-Yu Cheng
Summary: This study evaluated the effectiveness of cabergoline and transsphenoidal surgery in treating hyperprolactinemia, finding that cabergoline alone was effective and well-tolerated, but long-term remission rates were more favorable with surgical intervention.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Review
Pharmacology & Pharmacy
Mariana Millan Fachi, Lays de Deus Bueno, Denise Colaco de Oliveira, Leticia Lazarin da Silva, Aline F. Bonetti
Summary: This is the first network meta-analysis evaluating the efficacy and safety of dopaminergic agonists in the treatment of hyperprolactinemia. The results showed similar efficacy among these drugs, with cabergoline having a better safety profile.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Bertrand Baussart, Chiara Villa, Anne Jouinot, Marie-Laure Raffin-Sanson, Luc Foubert, Laure Cazabat, Michele Bernier, Fideline Bonnet, Anthony Dohan, Jerome Bertherat, Guillaume Assie, Stephan Gaillard
Summary: This study presents the outcomes of a large series of consecutive noninvasive microprolactinoma patients treated by pituitary surgery, demonstrating that preoperative prolactinemia is a significant predictive factor for remission. The surgery was effective and safe, with no severe complications reported.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Oncology
Fangfang Jian, Yuhao Sun, Qingfang Sun, Benyan Zhang, Liuguan Bian
Summary: NEK2 is upregulated in prolactinomas and promotes cell proliferation, affecting cellular sensitivity to dopamine receptor agonists. NEK2 regulates cell proliferation via the Wnt signaling pathway and interacts with USP7 to maintain stability.
Article
Spectroscopy
M. Rizk, Zainab M. Mahmoud, Marwa M. Azab
Summary: Simple, economic, and selective spectrofluorimetric and thin layer chromatographic methods were developed for the determination of Cabergoline. Method A measured the fluorescence intensity at 338nm after excitation at 280nm, while method B used TLC silica gel plates exposed to concentrated hydrochloric acid vapor. Both methods were successfully validated according to ICH guidelines.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Medicine, Research & Experimental
Zhengzheng Xiao, Jing Liang, Qing Deng, Chaojun Song, Xiaoli Yang, Zebin Liu, Zheng Shao, Kun Zhang, Xiaobin Wang, Zhengwei Li
Summary: Pimozide in combination with bromocriptine can significantly inhibit cell growth and proliferation, increase apoptosis and cell cycle arrest in bromocriptine-resistant prolactinoma cells, by targeting STAT5/Bcl-xL and STAT5/cyclin D1 signaling pathways. Furthermore, pimozide also has inhibitory effects on spheroid formation of pituitary adenoma stem-like cells and the expression of cancer stem cell markers, CD133 and nestin, suggesting its potential as a therapeutic agent for prolactinomas.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Farah Al Sabie, Zunera Tariq, Dana Erickson, Diane Donegan
Summary: This study found that patients with prolactinomas have a higher BMI and increased prevalence of obesity, especially among male patients. Weight gain can be a presenting symptom for patients with newly diagnosed prolactinomas.
ENDOCRINE PRACTICE
(2021)
Article
Clinical Neurology
Hyunjung Kim, Jhii-Hyun Ahn, Sung Min Ko, Jin Woo Kim
Summary: The pre-navigation balloon technique significantly reduces the occurrence of distal embolism and increases the first-pass effect (FPE) during stent retriever thrombectomy. This technique is particularly effective for patients with ICA occlusion, improving clinical outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Review
Clinical Neurology
Mehdi Khaleghi, Joshua Vignolles-Jeong, Bradley Otto, Ricardo Carrau, Daniel Prevedello
Summary: This study presented a rare case of symptomatic ectopic Rathke's cleft cyst (RCC), which was located posterior to the pituitary gland and caused extensive clival erosion. The surgical technique of wide marsupialization of the cyst using intraoperative ultrasound-assisted endoscopic endonasal transclival approach was described, and a systematic literature review of intracranial ectopic RCCs was conducted.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Oscar H. Del Brutto, Denisse A. Rumbea, Aldo F. Costa, Maitri Patel, Mark J. Sedler, Robertino M. Mera
Summary: This study found an association between cognitive impairment and mortality risk in adults of Amerindian ancestry living in rural Ecuador.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
Article
Clinical Neurology
Yangjingyi Xia, Li Li, Yunze Li, Manyan Hu, Tianrui Zhang, Qinghua Feng, Wenlei Li, Yuan Zhu, Minghua Wu
Summary: This study shows that fasting blood glucose (FBG) level is significantly associated with unfavorable outcome after acute ischemic stroke (AIS) in patients. The risk of unfavorable outcome increases significantly when FBG is above 5.5 mmol/L.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2024)
